Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.4
Supplement Facts
Serving Size: 4 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
1 g
<1%**
Dietary Fiber
1 g
4%**
Vitamin D (as cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as calcium citrate)
1000 mg
77%
Sodium†
20 mg
<1%

Top Medical Research Studies

7
Calcium citrate improves bone density
We conducted a well-designed trial involving 1,471 healthy postmenopausal women to explore the effects of calcium citrate on bone density and fracture rates over five years.

While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.

Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain.
8
Calcium citrate improved osteoporosis outcomes
We investigated the scenario of a patient with renal tubular acidosis type 2, Fanconi's syndrome, and osteoporosis resulting from vitamin D and calcium deficiency. Through meticulous reviews of clinical and lab findings, we noted substantial improvements after 24 months of vitamin D and calcium therapy.

By the end of the treatment, the patient's lumbar spine and femoral neck bone density scores improved significantly, indicating a positive response to calcium citrate. This suggests that calcium may play a valuable role in addressing osteoporosis associated with nutritional deficiencies.
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.

The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.

Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.

This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.

Most Useful Reviews

9
Effective for healing bones
19 people found this helpful
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
9
Reliable supplement
9 people found this helpful
This Calcium Citrate with Vitamin D3 is a reliable gluten-free supplement. I have used this Solgar Calcium Citrate with D3 for years, taking 2000 mg daily for osteoporosis. As we can't absorb more than 500 mg (2 tablets) at one sitting, I spread the doses throughout the day. Additionally, I take more Solgar Vitamin D3 to maintain my vitamin D levels.
10
Improved bone density
4 people found this helpful
The medication works effectively, and I've grown accustomed to the large capsules. I have been using it for three years to treat osteoporosis, and each year, my densitometry results have improved from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years as prescribed, which harmed my kidneys and showed no improvement in my osteoporosis. I am very pleased to have discovered this medication.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
  • All Researches
9
Calcium citrate shows limited efficacy
We investigated the long-term effects of calcium citrate and sodium fluoride compared to intravenous ibandronate in patients with osteoporosis due to Crohn's disease. In a study involving 66 participants, both treatment groups showed improvement in bone density over a 3.5-year follow-up. However, while ibandronate is established in reducing fracture rates, sodium fluoride’s effectiveness in this regard remains unproven. Overall, our findings suggest that intravenous ibandronate is a safe and beneficial option for treating osteoporosis in these patients.
9
Probiotic support for osteoporosis treatment
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.

Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.

Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.

Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
9
Calcium complex enhances bone health
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.

We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.

Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
9
Combination therapy for osteoporosis
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.

The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.

Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
We assessed how calcium from cladodes impacts osteoporosis using an ovariectomized rat model, which mimics postmenopausal bone loss.

In our study, we distributed 35 female rats into various groups, with some receiving calcium citrate supplementation.

The results were promising! Calcium from cladodes was found to be bioavailable, enhancing the physical, densitometric, biomechanical, and microstructural aspects of the bones.

This indicates that incorporating cladodes into the diet could potentially help prevent osteoporosis and improve overall bone health.

User Reviews

USERS' SCORE
Moderately Good
Based on 25 Reviews
7.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective for healing bones
19 people found this helpful
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
9
Reliable supplement
9 people found this helpful
This Calcium Citrate with Vitamin D3 is a reliable gluten-free supplement. I have used this Solgar Calcium Citrate with D3 for years, taking 2000 mg daily for osteoporosis. As we can't absorb more than 500 mg (2 tablets) at one sitting, I spread the doses throughout the day. Additionally, I take more Solgar Vitamin D3 to maintain my vitamin D levels.
10
Improved bone density
4 people found this helpful
The medication works effectively, and I've grown accustomed to the large capsules. I have been using it for three years to treat osteoporosis, and each year, my densitometry results have improved from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years as prescribed, which harmed my kidneys and showed no improvement in my osteoporosis. I am very pleased to have discovered this medication.
9
Prophylactic recommendation
4 people found this helpful
This supplement is in a convenient form (citrated) with vitamin D3 as cholecalciferol. Solgar is a respected brand, and I take it for osteoporosis treatment and to support heart health. The capsules are well absorbed, and I feel significantly better since I began using them. I recommend it even as a preventative measure for osteoporosis.
9
Mother pleased with treatment
2 people found this helpful
Great value for money. I ordered this for my mother to assist with her osteoporosis, and she's very pleased with the product’s effects.

Frequently Asked Questions

9
Effective for healing bones
19 people found this helpful
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
7.5
Positive results noted
2 people found this helpful
My husband has been using this treatment for osteoporosis, supplemented with a special medicine to ensure calcium retains its place. Following a year, the results of his densitometry were encouraging, showing improvement.
6
Pain reduction noted
1 people found this helpful
I ordered this product for my mother, who has osteoporosis. After a month, I've noticed a slight reduction in her joint pain and less fatigue.
10
Improved bone density
4 people found this helpful
The medication works effectively, and I've grown accustomed to the large capsules. I have been using it for three years to treat osteoporosis, and each year, my densitometry results have improved from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years as prescribed, which harmed my kidneys and showed no improvement in my osteoporosis. I am very pleased to have discovered this medication.
7.5
Osteoporosis not progressing
1 people found this helpful
I have ordered this calcium supplement for several years. Combined with vitamin D3, calcium citrate is easily digestible and yields excellent results. My mother's osteoporosis has not progressed while using it. Although the tablets are large, one can adapt to swallowing them.
7.5
Bioavailable form
A good bioavailable form; I have been taking it for a long time with magnesium, K2, and vitamin D to help with osteoporosis.
7.5
Recommended for osteoporosis
This product was recommended by a doctor to a relative after a broken arm. I suggest it, especially alongside vitamin D for those showing osteoporosis signs. Consulting a healthcare professional is crucial.
4
Additional vitamin D needed
This supplement was taken to replenish calcium levels in osteoporosis, combined with additional vitamin D. However, the vitamin D contained may be insufficient for effective treatment.
7.5
Recommended for calcium absorption
8 people found this helpful
Calcium citrate is absorbed much better than calcium carbonate and pairs well with vitamin D. I've found a great calcium supplement! Although the tablets are large, I take them whole. With my osteoporosis, I require calcium; I take 1 tablet each evening for optimal absorption. I recommend this for everyone!
7.5
Stronger nails and hair
Good product. Doctors recommended my mother a consistent intake of calcium due to her age and osteoporosis. We chose this one, produced by a reliable company, containing a well-absorbed calcium form. Despite taking fewer capsules than recommended, I’ve noticed her nails and hair have become stronger, and osteoporosis has not worsened. No unpleasant side effects have occurred.
6
Natural prevention methods
Using calcium is part of many natural methods for preventing and treating osteoporosis. I recommend consuming up to 1200 mg daily. However, some research suggests high calcium doses may increase the risk of heart attack and kidney stones. Therefore, a lower dose of around 500 mg may be sufficient, with 300-600 mg of vitamin D to enhance calcium absorption.
7
Calcium citrate benefits bone turnover
We examined how calcium citrate, along with other calcium supplements, impacts bone health in postmenopausal women. Over a three-month period, we found that calcium citrate notably increased serum calcium levels for up to eight hours after ingestion and maintained these effects consistently.

When compared to microcrystalline hydroxyapatite, both calcium citrate and carbonate led to similar decreases in bone turnover markers, suggesting they are effective for bone health. However, none of the supplements demonstrated a significant advantage in improving bone turnover beyond these initial effects.
We assessed how calcium from cladodes impacts osteoporosis using an ovariectomized rat model, which mimics postmenopausal bone loss.

In our study, we distributed 35 female rats into various groups, with some receiving calcium citrate supplementation.

The results were promising! Calcium from cladodes was found to be bioavailable, enhancing the physical, densitometric, biomechanical, and microstructural aspects of the bones.

This indicates that incorporating cladodes into the diet could potentially help prevent osteoporosis and improve overall bone health.
8
Calcium citrate and collagen peptides help
We set out to determine if combining bovine collagen peptides (CPs) with calcium citrate provides better protection against bone loss than using them alone. In our study, ovariectomized rats received different treatments over three months.

The results showed that both CPs and the combination of CPs with calcium citrate significantly improved bone density and architecture. Notably, the combined treatment offered the most robust protection, suggesting it could be an effective strategy for addressing osteoporosis, particularly in postmenopausal women.
We set out to understand how fortified milk powder, enhanced with nano-sized calcium citrate, affects calcium absorption and bone health in ovariectomized rats, a common model for menopause and osteoporosis. The study involved formulating a milk powder enriched with calcium citrate and essential nutrients. Through rigorous testing, we found that this fortified milk improved calcium absorption and enhanced bone stiffness and strength in the rats. Overall, it shows promise as an effective dietary option for supporting bone health during menopause.

References

  1. Quintero-García M, Gutiérrez-Cortez E, Rojas-Molina A, Mendoza-Ávila M, Del Real A, et al. Calcium Bioavailability of Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss. Nutrients. 2020;12. 10.3390/nu12051431
  2. Liu J, Wang Y, Song S, Wang X, Qin Y, et al. Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. PLoS One. 2015;10:e0135019. 10.1371/journal.pone.0135019
  3. Erfanian A, Mirhosseini H, Rasti B, Hair-Bejo M, Bin Mustafa S, et al. Absorption and Bioavailability of Nano-Size Reduced Calcium Citrate Fortified Milk Powder in Ovariectomized and Ovariectomized-Osteoporosis Rats. J Agric Food Chem. 2015;63:5795. 10.1021/acs.jafc.5b01468
  4. Bristow SM, Gamble GD, Stewart A, Horne L, House ME, et al. Acute and 3-month effects of microcrystalline hydroxyapatite, calcium citrate and calcium carbonate on serum calcium and markers of bone turnover: a randomised controlled trial in postmenopausal women. Br J Nutr. 2014;112:1611. 10.1017/S0007114514002785
  5. Sakhaee K, Pak C. Superior calcium bioavailability of effervescent potassium calcium citrate over tablet formulation of calcium citrate after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2013;9:743. 10.1016/j.soard.2011.11.011
  6. Klaus J, Reinshagen M, Herdt K, Adler G, von Boyen GB, et al. Intravenous ibandronate or sodium-fluoride--a 3.5 years study on bone density and fractures in Crohn's disease patients with osteoporosis. J Gastrointestin Liver Dis. 2011;20:141.
  7. Sakhaee K, Griffith C, Pak CY. Biochemical control of bone loss and stone-forming propensity by potassium-calcium citrate after bariatric surgery. Surg Obes Relat Dis. 2012;8:67. 10.1016/j.soard.2011.05.001
  8. Quesada Gómez JM, Blanch Rubió J, Díaz Curiel M, Díez Pérez A. Calcium citrate and vitamin D in the treatment of osteoporosis. Clin Drug Investig. 2011;31:285.
  9. Yendt ER, Kovacs KA, Jones G. Secondary hyperparathyroidism in primary osteoporosis and osteopenia: optimizing calcium and vitamin D intakes to levels recommended by expert panels may not be sufficient for correction. Clin Endocrinol (Oxf). 2008;69:855. 10.1111/j.1365-2265.2008.03261.x
  10. Taylor HC, Elbadawy EH. Renal tubular acidosis type 2 with Fanconi's syndrome, osteomalacia, osteoporosis, and secondary hyperaldosteronism in an adult consequent to vitamin D and calcium deficiency: effect of vitamin D and calcium citrate therapy. Endocr Pract. 2006;12:559.
  11. Reid IR, Mason B, Horne A, Ames R, Reid HE, et al. Randomized controlled trial of calcium in healthy older women. Am J Med. 2006;119:777.
  12. Vescini F, Buffa A, La Manna G, Ciavatti A, Rizzoli E, et al. Long-term potassium citrate therapy and bone mineral density in idiopathic calcium stone formers. J Endocrinol Invest. 2005;28:218.
  13. Going S, Lohman T, Houtkooper L, Metcalfe L, Flint-Wagner H, et al. Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy. Osteoporos Int. 2003;14:637.
  14. Afonso ML, Capelas ML, Pimenta NM, Santos T, Mäkitie A, et al. A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?. Nutrients. 2025;17. 10.3390/nu17040634
  15. Wang H, Tian G, Pei Z, Yu X, Wang Y, et al. increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice. mSphere. 2025. 10.1128/msphere.01039-24
  16. Skubica P, Hoffmanova I, Dankova P. Chronically increased osteoclastogenesis in adult celiac disease patients does not hinder improvement in bone health induced by gluten-free diet: Role of vitamin D, OPG and IL-6. J Nutr Biochem. 2025. 10.1016/j.jnutbio.2025.109871
  17. Pickering ME, Souberbielle JC, Boutten A, Breuil V, Briot K, et al. Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO. Joint Bone Spine. 2025;92:105858. 10.1016/j.jbspin.2025.105858
  18. Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. 10.1136/bmjopen-2024-092901
  19. Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
  20. Yang C, Chen L, Guo X, Sun H, Miao D. The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. J Orthop Translat. 2025;50:211. 10.1016/j.jot.2024.10.011
  21. Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. 10.1248/bpb.b24-00536
  22. McCarrison S, Abdelrahman S, Quinlivan R, Keen R, Wong SC. Pharmacological and non-pharmacological therapies for prevention and treatment of osteoporosis in Duchenne Muscular Dystrophy: A systematic review. Bone. 2025;193:117410. 10.1016/j.bone.2025.117410
  23. Ma M, Zhang Y, Liu J, Tian C, Duan Z, et al. Associations of the serum 25-hydroxyvitamin D with mortality among patients in osteopenia or osteoporosis. Bone. 2025. 10.1016/j.bone.2025.117408
  24. Wang JC, Chung SM, Wu PT, Tu YK, Lai PC, et al. Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials. EClinicalMedicine. 2025;81:103103. 10.1016/j.eclinm.2025.103103
  25. Chen L, Lin S, He X, Ye J, Huang Y, et al. A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.141634
  26. Ma R, Romano E, Ashworth M, Vancampfort D, Solmi M, et al. Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study. Gen Hosp Psychiatry. 2025;94:56. 10.1016/j.genhosppsych.2025.02.009
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  28. Joris V, Balmayor ER, van Griensven M. miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells. Mol Ther Nucleic Acids. 2025;36:102446. 10.1016/j.omtn.2024.102446
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