We conducted a well-designed trial involving 1,471 healthy postmenopausal women to explore the effects of calcium citrate on bone density and fracture rates over five years.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain.
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8
Calcium citrate improved osteoporosis outcomes
Renal tubular acidosis type 2 with Fanconi's syndrome, osteomalacia, osteoporosis, and secondary hyperaldosteronism in an adult consequent to vitamin D and calcium deficiency: effect of vitamin D and calcium citrate therapy.
We investigated the scenario of a patient with renal tubular acidosis type 2, Fanconi's syndrome, and osteoporosis resulting from vitamin D and calcium deficiency. Through meticulous reviews of clinical and lab findings, we noted substantial improvements after 24 months of vitamin D and calcium therapy.
By the end of the treatment, the patient's lumbar spine and femoral neck bone density scores improved significantly, indicating a positive response to calcium citrate. This suggests that calcium may play a valuable role in addressing osteoporosis associated with nutritional deficiencies.
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8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
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Most Useful Reviews
9
Effective for healing bones
19 people found this helpful
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
Read More
9
Reliable supplement
9 people found this helpful
This Calcium Citrate with Vitamin D3 is a reliable gluten-free supplement. I have used this Solgar Calcium Citrate with D3 for years, taking 2000 mg daily for osteoporosis. As we can't absorb more than 500 mg (2 tablets) at one sitting, I spread the doses throughout the day. Additionally, I take more Solgar Vitamin D3 to maintain my vitamin D levels.
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10
Improved bone density
4 people found this helpful
The medication works effectively, and I've grown accustomed to the large capsules. I have been using it for three years to treat osteoporosis, and each year, my densitometry results have improved from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years as prescribed, which harmed my kidneys and showed no improvement in my osteoporosis. I am very pleased to have discovered this medication.
We investigated the long-term effects of calcium citrate and sodium fluoride compared to intravenous ibandronate in patients with osteoporosis due to Crohn's disease. In a study involving 66 participants, both treatment groups showed improvement in bone density over a 3.5-year follow-up. However, while ibandronate is established in reducing fracture rates, sodium fluoride’s effectiveness in this regard remains unproven. Overall, our findings suggest that intravenous ibandronate is a safe and beneficial option for treating osteoporosis in these patients.
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9
Probiotic support for osteoporosis treatment
increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice.
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
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9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
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9
Combination therapy for osteoporosis
Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats.
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
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8
Calcium-rich cladodes benefit bone health
Calcium Bioavailability of Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss.
We assessed how calcium from cladodes impacts osteoporosis using an ovariectomized rat model, which mimics postmenopausal bone loss.
In our study, we distributed 35 female rats into various groups, with some receiving calcium citrate supplementation.
The results were promising! Calcium from cladodes was found to be bioavailable, enhancing the physical, densitometric, biomechanical, and microstructural aspects of the bones.
This indicates that incorporating cladodes into the diet could potentially help prevent osteoporosis and improve overall bone health.
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
Read More
9
Reliable supplement
9 people found this helpful
This Calcium Citrate with Vitamin D3 is a reliable gluten-free supplement. I have used this Solgar Calcium Citrate with D3 for years, taking 2000 mg daily for osteoporosis. As we can't absorb more than 500 mg (2 tablets) at one sitting, I spread the doses throughout the day. Additionally, I take more Solgar Vitamin D3 to maintain my vitamin D levels.
Read More
10
Improved bone density
4 people found this helpful
The medication works effectively, and I've grown accustomed to the large capsules. I have been using it for three years to treat osteoporosis, and each year, my densitometry results have improved from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years as prescribed, which harmed my kidneys and showed no improvement in my osteoporosis. I am very pleased to have discovered this medication.
Read More
9
Prophylactic recommendation
4 people found this helpful
This supplement is in a convenient form (citrated) with vitamin D3 as cholecalciferol. Solgar is a respected brand, and I take it for osteoporosis treatment and to support heart health. The capsules are well absorbed, and I feel significantly better since I began using them. I recommend it even as a preventative measure for osteoporosis.
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9
Mother pleased with treatment
2 people found this helpful
Great value for money. I ordered this for my mother to assist with her osteoporosis, and she's very pleased with the product’s effects.
Osteoporosis is a medical condition characterized by weakened bones, making them fragile and more prone to fractures. This condition occurs when the body loses too much bone mass, doesn't make enough bone, or a combination of both. As bones lose density, they can break more easily, often as a result of minor falls or injury. Osteoporosis is often referred to as a "silent disease" because bone loss occurs without any symptoms until a fracture occurs, often in the hip, spine, or wrist.
Risk factors for developing osteoporosis include age, gender (it’s more common in women), family history, low body weight, and certain medical conditions and medications. Lifestyle choices such as smoking, excessive alcohol consumption, and a diet low in calcium and vitamin D can also contribute to bone loss. Regular weight-bearing exercise, ensuring adequate nutrition, and, in some cases, medications can help prevent or manage osteoporosis. If you believe you may be at risk, it is important to consult with a healthcare professional for appropriate screening and intervention options.
Calcium citrate is a calcium salt of citric acid, widely used as a dietary supplement to provide an additional source of calcium for individuals who may not get enough of this essential mineral from their diets. It is particularly popular for its enhanced bioavailability, which means that the body can absorb calcium from calcium citrate more effectively than from other forms of calcium, such as calcium carbonate. This supplement is especially beneficial for those with decreased stomach acid, such as older adults, as it does not require acid for absorption.
In addition to aiding in bone health, calcium plays a crucial role in muscle function, nerve transmission, and blood clotting. Typically, calcium citrate is available in tablet and powder forms, making it easy to incorporate into daily routines. It’s important to follow dosing recommendations and possibly consult with a healthcare provider before starting any supplement regimen to ensure it meets individual dietary needs and health objectives.
Calcium citrate is a dietary supplement that contains calcium in a form that is more easily absorbed by the body compared to other forms of calcium. It's often recommended for individuals looking to increase their calcium intake to support bone health, particularly in those at risk for osteoporosis. Research suggests that adequate calcium intake, combined with other important nutrients like vitamin D, may help maintain bone density and reduce the risk of fractures associated with osteoporosis.
However, while calcium citrate can be beneficial, it should not be seen as a standalone solution for osteoporosis. It's essential to approach bone health holistically, which typically includes a balanced diet, weight-bearing exercises, and other medications or treatments recommended by healthcare providers depending on individual needs. Before starting any supplement regimen, it’s advisable to consult with a healthcare professional to ensure it aligns with your overall health strategy.
Based on user reviews, the timeframe to notice results from taking calcium citrate with vitamin D3 for osteoporosis can vary. Some users report improvements within as little as 1.5 months after starting the supplement. For instance, one user mentioned they experienced positive results regarding their bone health after this period (see Read Review). Another user stated that after using the supplement for a year, their densitometry results showed significant improvement, which indicates a longer timeline for more pronounced effects (see Read Review).
Overall, while some users noted quick benefits, such as reduced joint pain and improved energy levels within a month (see Read Review), others observed gradual improvements over a year of use (see Read Review). This suggests that if you are considering this supplement, you may start to feel results in a couple of months, but more substantial or measurable changes might take longer to manifest.
This supplement is supported by scientific research for osteoporosis, particularly in the form of calcium citrate and its associated compounds. Several studies have demonstrated that calcium citrate can enhance bone health, particularly in postmenopausal women, by improving bone density and reducing bone turnover markers. For instance, one study found that calcium citrate significantly increased serum calcium levels and was effective in decreasing bone turnover [4]. Another study involving ovariectomized rats showed that calcium from cladodes improved bone density and strength, indicating its potential for osteoporosis prevention [1].
Moreover, studies combining calcium citrate with other supplements such as vitamin D or collagen have shown enhanced protective effects against bone loss. For example, the combination of bovine collagen peptides and calcium citrate provided substantial improvements in both bone density and architecture, which is vital in osteoporosis management [2]. Additionally, a research study on the impact of fortified milk with nano-calcium citrate indicated improved calcium absorption and bone strength, highlighting its effectiveness as a dietary intervention [3]. Overall, the available evidence supports the use of calcium citrate and its combinations as promising options in osteoporotic treatments.
Users have reported a variety of improvements in symptoms after incorporating calcium citrate with vitamin D3 into their routines, particularly for osteoporosis management. Many have noted significant benefits such as increased bone strength and improvements in bone density measurements over time. For instance, one user mentioned seeing their densitometry results improve from -2.6 to -1.4 over three years of use (Read Review). Additionally, others experienced reductions in joint pain and fatigue after just one month of use, which indicates the potential for quicker symptomatic relief (Read Review).
Moreover, several reviews highlight the supplement's role in preventing osteoporosis progression and supporting overall bone health. Users have expressed satisfaction with how their symptoms are managed, with one report stating that a user's mother has not experienced further deterioration of her osteoporosis after taking the supplement consistently (Read Review). While individual experiences vary, the general consensus suggests that this formulation of calcium and vitamin D3 can be a beneficial addition to one's regimen for maintaining and improving bone health.
Based on user reviews, many individuals have successfully combined calcium citrate with vitamin D3 alongside other supplements for managing osteoporosis. Users have reported notable improvements in bone health and overall well-being when this combination is used. One user mentioned using calcium citrate with a combination of vitamin D3, magnesium, and K2, which provided significant support for their osteoporosis (see Read Review). Another user specifically commented on the importance of pairing calcium with additional vitamin D and magnesium to aid absorption and effectiveness in preventing osteoporosis progression (see Read Review).
However, there are warnings from some users about potential deficiencies in vitamin D when relying solely on the amount provided in some calcium formulations, noting that additional vitamin D may be necessary for effective treatment (see Read Review). Overall, the consensus among users suggests that combining these supplements can enhance bone support, but attention should be given to ensure adequate vitamin D intake alongside calcium for maximum benefits.
User reviews suggest that the appropriate dosage of calcium citrate for osteoporosis treatment can vary, but many have reported positive effects from maintaining daily doses between 500 mg to 1200 mg, often combined with vitamin D for enhanced absorption. A user noted they take one tablet each evening for optimal absorption, emphasizing the combination's effectiveness in supporting bone health Read Review. Another individual mentioned that both their husband and mother experienced improvements in their condition after consistent use, indicating that adherence to a recommended intake helps yield results Read ReviewRead Review.
However, users also caution that excessively high doses might pose health risks, including potential heart problems and kidney issues. One reviewer suggested that around 500 mg of calcium may suffice when paired with 300-600 mg of vitamin D Read Review. It's clear from the feedback that individual needs can vary widely based on age and health conditions, so users are strongly encouraged to consult healthcare professionals before starting any supplement regimen to determine their specific needs Read Review.
9
Effective for healing bones
19 people found this helpful
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
7.5
Positive results noted
2 people found this helpful
My husband has been using this treatment for osteoporosis, supplemented with a special medicine to ensure calcium retains its place. Following a year, the results of his densitometry were encouraging, showing improvement.
6
Pain reduction noted
1 people found this helpful
I ordered this product for my mother, who has osteoporosis. After a month, I've noticed a slight reduction in her joint pain and less fatigue.
10
Improved bone density
4 people found this helpful
The medication works effectively, and I've grown accustomed to the large capsules. I have been using it for three years to treat osteoporosis, and each year, my densitometry results have improved from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years as prescribed, which harmed my kidneys and showed no improvement in my osteoporosis. I am very pleased to have discovered this medication.
7.5
Osteoporosis not progressing
1 people found this helpful
I have ordered this calcium supplement for several years. Combined with vitamin D3, calcium citrate is easily digestible and yields excellent results. My mother's osteoporosis has not progressed while using it. Although the tablets are large, one can adapt to swallowing them.
7.5
Bioavailable form
A good bioavailable form; I have been taking it for a long time with magnesium, K2, and vitamin D to help with osteoporosis.
7.5
Recommended for osteoporosis
This product was recommended by a doctor to a relative after a broken arm. I suggest it, especially alongside vitamin D for those showing osteoporosis signs. Consulting a healthcare professional is crucial.
4
Additional vitamin D needed
This supplement was taken to replenish calcium levels in osteoporosis, combined with additional vitamin D. However, the vitamin D contained may be insufficient for effective treatment.
7.5
Recommended for calcium absorption
8 people found this helpful
Calcium citrate is absorbed much better than calcium carbonate and pairs well with vitamin D. I've found a great calcium supplement! Although the tablets are large, I take them whole. With my osteoporosis, I require calcium; I take 1 tablet each evening for optimal absorption. I recommend this for everyone!
7.5
Stronger nails and hair
Good product. Doctors recommended my mother a consistent intake of calcium due to her age and osteoporosis. We chose this one, produced by a reliable company, containing a well-absorbed calcium form. Despite taking fewer capsules than recommended, I’ve noticed her nails and hair have become stronger, and osteoporosis has not worsened. No unpleasant side effects have occurred.
6
Natural prevention methods
Using calcium is part of many natural methods for preventing and treating osteoporosis. I recommend consuming up to 1200 mg daily. However, some research suggests high calcium doses may increase the risk of heart attack and kidney stones. Therefore, a lower dose of around 500 mg may be sufficient, with 300-600 mg of vitamin D to enhance calcium absorption.
7
Calcium citrate benefits bone turnover
Acute and 3-month effects of microcrystalline hydroxyapatite, calcium citrate and calcium carbonate on serum calcium and markers of bone turnover: a randomised controlled trial in postmenopausal women.
We examined how calcium citrate, along with other calcium supplements, impacts bone health in postmenopausal women. Over a three-month period, we found that calcium citrate notably increased serum calcium levels for up to eight hours after ingestion and maintained these effects consistently.
When compared to microcrystalline hydroxyapatite, both calcium citrate and carbonate led to similar decreases in bone turnover markers, suggesting they are effective for bone health. However, none of the supplements demonstrated a significant advantage in improving bone turnover beyond these initial effects.
8
Calcium-rich cladodes benefit bone health
Calcium Bioavailability of Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss.
We assessed how calcium from cladodes impacts osteoporosis using an ovariectomized rat model, which mimics postmenopausal bone loss.
In our study, we distributed 35 female rats into various groups, with some receiving calcium citrate supplementation.
The results were promising! Calcium from cladodes was found to be bioavailable, enhancing the physical, densitometric, biomechanical, and microstructural aspects of the bones.
This indicates that incorporating cladodes into the diet could potentially help prevent osteoporosis and improve overall bone health.
8
Calcium citrate and collagen peptides help
Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats.
We set out to determine if combining bovine collagen peptides (CPs) with calcium citrate provides better protection against bone loss than using them alone. In our study, ovariectomized rats received different treatments over three months.
The results showed that both CPs and the combination of CPs with calcium citrate significantly improved bone density and architecture. Notably, the combined treatment offered the most robust protection, suggesting it could be an effective strategy for addressing osteoporosis, particularly in postmenopausal women.
7
Calcium citrate improves bone health
Absorption and Bioavailability of Nano-Size Reduced Calcium Citrate Fortified Milk Powder in Ovariectomized and Ovariectomized-Osteoporosis Rats.
We set out to understand how fortified milk powder, enhanced with nano-sized calcium citrate, affects calcium absorption and bone health in ovariectomized rats, a common model for menopause and osteoporosis. The study involved formulating a milk powder enriched with calcium citrate and essential nutrients. Through rigorous testing, we found that this fortified milk improved calcium absorption and enhanced bone stiffness and strength in the rats. Overall, it shows promise as an effective dietary option for supporting bone health during menopause.
References
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Liu J, Wang Y, Song S, Wang X, Qin Y, et al. Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. PLoS One. 2015;10:e0135019. 10.1371/journal.pone.0135019
Erfanian A, Mirhosseini H, Rasti B, Hair-Bejo M, Bin Mustafa S, et al. Absorption and Bioavailability of Nano-Size Reduced Calcium Citrate Fortified Milk Powder in Ovariectomized and Ovariectomized-Osteoporosis Rats. J Agric Food Chem. 2015;63:5795. 10.1021/acs.jafc.5b01468
Bristow SM, Gamble GD, Stewart A, Horne L, House ME, et al. Acute and 3-month effects of microcrystalline hydroxyapatite, calcium citrate and calcium carbonate on serum calcium and markers of bone turnover: a randomised controlled trial in postmenopausal women. Br J Nutr. 2014;112:1611. 10.1017/S0007114514002785
Sakhaee K, Pak C. Superior calcium bioavailability of effervescent potassium calcium citrate over tablet formulation of calcium citrate after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2013;9:743. 10.1016/j.soard.2011.11.011
Klaus J, Reinshagen M, Herdt K, Adler G, von Boyen GB, et al. Intravenous ibandronate or sodium-fluoride--a 3.5 years study on bone density and fractures in Crohn's disease patients with osteoporosis. J Gastrointestin Liver Dis. 2011;20:141.
Sakhaee K, Griffith C, Pak CY. Biochemical control of bone loss and stone-forming propensity by potassium-calcium citrate after bariatric surgery. Surg Obes Relat Dis. 2012;8:67. 10.1016/j.soard.2011.05.001
Quesada Gómez JM, Blanch Rubió J, Díaz Curiel M, Díez Pérez A. Calcium citrate and vitamin D in the treatment of osteoporosis. Clin Drug Investig. 2011;31:285.
Yendt ER, Kovacs KA, Jones G. Secondary hyperparathyroidism in primary osteoporosis and osteopenia: optimizing calcium and vitamin D intakes to levels recommended by expert panels may not be sufficient for correction. Clin Endocrinol (Oxf). 2008;69:855. 10.1111/j.1365-2265.2008.03261.x
Taylor HC, Elbadawy EH. Renal tubular acidosis type 2 with Fanconi's syndrome, osteomalacia, osteoporosis, and secondary hyperaldosteronism in an adult consequent to vitamin D and calcium deficiency: effect of vitamin D and calcium citrate therapy. Endocr Pract. 2006;12:559.
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Vescini F, Buffa A, La Manna G, Ciavatti A, Rizzoli E, et al. Long-term potassium citrate therapy and bone mineral density in idiopathic calcium stone formers. J Endocrinol Invest. 2005;28:218.
Going S, Lohman T, Houtkooper L, Metcalfe L, Flint-Wagner H, et al. Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy. Osteoporos Int. 2003;14:637.
Afonso ML, Capelas ML, Pimenta NM, Santos T, Mäkitie A, et al. A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?. Nutrients. 2025;17. 10.3390/nu17040634
Wang H, Tian G, Pei Z, Yu X, Wang Y, et al. increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice. mSphere. 2025. 10.1128/msphere.01039-24
Skubica P, Hoffmanova I, Dankova P. Chronically increased osteoclastogenesis in adult celiac disease patients does not hinder improvement in bone health induced by gluten-free diet: Role of vitamin D, OPG and IL-6. J Nutr Biochem. 2025. 10.1016/j.jnutbio.2025.109871
Pickering ME, Souberbielle JC, Boutten A, Breuil V, Briot K, et al. Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO. Joint Bone Spine. 2025;92:105858. 10.1016/j.jbspin.2025.105858
Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. 10.1136/bmjopen-2024-092901
Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
Yang C, Chen L, Guo X, Sun H, Miao D. The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. J Orthop Translat. 2025;50:211. 10.1016/j.jot.2024.10.011
Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. 10.1248/bpb.b24-00536
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Ma M, Zhang Y, Liu J, Tian C, Duan Z, et al. Associations of the serum 25-hydroxyvitamin D with mortality among patients in osteopenia or osteoporosis. Bone. 2025. 10.1016/j.bone.2025.117408
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Chen L, Lin S, He X, Ye J, Huang Y, et al. A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.141634
Ma R, Romano E, Ashworth M, Vancampfort D, Solmi M, et al. Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study. Gen Hosp Psychiatry. 2025;94:56. 10.1016/j.genhosppsych.2025.02.009
Chen J, Wang J, Jia W, Zhang Y, Li H, et al. Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats. Eur J Med Res. 2025;30:115. 10.1186/s40001-025-02384-y
Joris V, Balmayor ER, van Griensven M. miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells. Mol Ther Nucleic Acids. 2025;36:102446. 10.1016/j.omtn.2024.102446