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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 25 Reviews
8.4
Supplement Facts
Serving Size: 4 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
1 g
<1%**
Dietary Fiber
1 g
4%**
Vitamin D (as cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as calcium citrate)
1000 mg
77%
Sodium†
20 mg
<1%
Top Medical Research Studies
8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
Highly relevant to osteoporosis treatment
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
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7
Vitamin D and osteoporosis insight
Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO.
High relevance for osteoporosis treatment
We explored the effects of vitamin D supplementation on osteoporosis, especially among individuals at risk for this condition. The Osteoporosis Research and Information Group (GRIO) highlighted the critical difference between daily and intermittent vitamin D dosing.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
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9
Probiotic support for osteoporosis treatment
increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice.
Probiotic effects on osteoporosis explored
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Read More
Most Useful Reviews
9.5
Effective for healing bones
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
Read More
9.5
Reliable supplement
This Calcium Citrate with Vitamin D3 is a reliable gluten-free supplement. I have used this Solgar Calcium Citrate with D3 for years, taking 2000 mg daily for osteoporosis. As we can't absorb more than 500 mg (2 tablets) at one sitting, I spread the doses throughout the day. Additionally, I take more Solgar Vitamin D3 to maintain my vitamin D levels.
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10
Improved bone density
The medication works effectively, and I've grown accustomed to the large capsules. I have been using it for three years to treat osteoporosis, and each year, my densitometry results have improved from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years as prescribed, which harmed my kidneys and showed no improvement in my osteoporosis. I am very pleased to have discovered this medication.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
9
Probiotic support for osteoporosis treatment
increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice.
Probiotic effects on osteoporosis explored
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Read More
9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Study shows complex enhances calcium
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
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9
Combination therapy for osteoporosis
Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats.
Relevant combination treatment exploration.
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
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8
Vitamin D aids cancer treatment outcomes
A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?
Moderate connection to osteoporosis effects
We explored the role of vitamin D (VD) supplementation in supporting cancer patients undergoing chemotherapy and radiotherapy, particularly regarding its effects on osteoporosis. The aim was to sift through scientific evidence to understand how vitamin D influences not just bone health but also alleviates the side effects of demanding cancer treatments.
Our findings indicated that adequate levels of VD are important for maintaining bone density in patients, especially those receiving preoperative chemoradiotherapy. Some studies showed that vitamin D supplementation could lessen certain severe side effects, like fatigue and nausea, often experienced during cancer treatments.
However, the evidence regarding the isolated effects of vitamin D on osteoporosis, specifically, was limited due to the varied designs of the included studies. Despite these challenges, it seems clear that vitamin D plays a valuable role in managing bone health and reducing treatment-related complications.
Our findings indicated that adequate levels of VD are important for maintaining bone density in patients, especially those receiving preoperative chemoradiotherapy. Some studies showed that vitamin D supplementation could lessen certain severe side effects, like fatigue and nausea, often experienced during cancer treatments.
However, the evidence regarding the isolated effects of vitamin D on osteoporosis, specifically, was limited due to the varied designs of the included studies. Despite these challenges, it seems clear that vitamin D plays a valuable role in managing bone health and reducing treatment-related complications.
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8
Vitamin D improves bone health
Chronically increased osteoclastogenesis in adult celiac disease patients does not hinder improvement in bone health induced by gluten-free diet: Role of vitamin D, OPG and IL-6.
Important context for osteoporosis study.
We investigated how vitamin D affects bone health, particularly focusing on individuals with celiac disease (CeD). Our study aimed to uncover the role of vitamin D alongside other key proteins in bone metabolism as patients transitioned to a gluten-free diet (GFD).
Through a careful examination, we observed notable changes in bone mineral density (BMD) among those who adhered to the GFD. Specifically, we found that patients after GFD treatment had improved serum levels of vitamin D, which correlated with healthier bone outcomes, including increased BMD and reduced markers of bone turnover.
Interestingly, even though the capacity for osteoclast formation—a type of cell responsible for bone resorption—remained elevated in these patients, their bone health still improved. This suggests that, while vitamin D plays a crucial role in bone strength, the connection between osteoclast activity and overall bone health might change with proper dietary management.
Our findings emphasized how vital vitamin D is for bone health, particularly in the context of managing celiac disease, where absorption can be compromised. Ultimately, we learned that a gluten-free lifestyle brings significant benefits for bone density, along with the supportive actions of vitamin D.
Through a careful examination, we observed notable changes in bone mineral density (BMD) among those who adhered to the GFD. Specifically, we found that patients after GFD treatment had improved serum levels of vitamin D, which correlated with healthier bone outcomes, including increased BMD and reduced markers of bone turnover.
Interestingly, even though the capacity for osteoclast formation—a type of cell responsible for bone resorption—remained elevated in these patients, their bone health still improved. This suggests that, while vitamin D plays a crucial role in bone strength, the connection between osteoclast activity and overall bone health might change with proper dietary management.
Our findings emphasized how vital vitamin D is for bone health, particularly in the context of managing celiac disease, where absorption can be compromised. Ultimately, we learned that a gluten-free lifestyle brings significant benefits for bone density, along with the supportive actions of vitamin D.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.4
10
Improved bone density
The medication works effectively, and I've grown accustomed to the large capsules. I have been using it for three years to treat osteoporosis, and each year, my densitometry results have improved from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years as prescribed, which harmed my kidneys and showed no improvement in my osteoporosis. I am very pleased to have discovered this medication.
Read More
9.5
Mother pleased with treatment
Great value for money. I ordered this for my mother to assist with her osteoporosis, and she's very pleased with the product’s effects.
9.5
Prevention of osteoporosis
Calcium is vital for the proper functioning of the musculoskeletal system, while magnesium regulates calcium transport and stimulates calcitonin secretion, promoting calcium intake in bone tissue. Vitamin D aids calcium absorption, supporting healthy bones and teeth. All three components work effectively together and are in easily absorbable forms. I recommend this complex for its quality and efficacy in preventing osteoporosis and strengthening teeth and bones.
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9.5
Effective for healing bones
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
Read More
9.5
Prophylactic recommendation
This supplement is in a convenient form (citrated) with vitamin D3 as cholecalciferol. Solgar is a respected brand, and I take it for osteoporosis treatment and to support heart health. The capsules are well absorbed, and I feel significantly better since I began using them. I recommend it even as a preventative measure for osteoporosis.
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