Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 4 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
1 g
<1%**
Dietary Fiber
1 g
4%**
Vitamin D (as cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as calcium citrate)
1000 mg
77%
Sodium†
20 mg
<1%
Top Medical Research Studies
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
8
We examined a combination product of carbonate antacids—specifically calcium carbonate and magnesium carbonate—with an extract from Opuntia ficus-indica, commonly known as prickly pear. This study looked at how this product could potentially protect esophageal cells from damage caused by both acidic and non-acidic reflux.
Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.
Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.
Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.
Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.
Read More
9
We explored the effects of a multi-herbal Tibetan formula known as Cong zhi 6, which includes calcium carbonate, on individuals suffering from laryngopharyngeal reflux (LPR). Our focus was to understand whether calcium plays a role in alleviating reflux symptoms.
In our examination of ten patients who took Cong zhi 6, we observed significant improvements in both reflux symptoms as measured by the Reflux Symptom Index (RSI) and findings from laryngoscopy assessed via the Reflux Finding Score (RFS). While the results were promising, they did not isolate the specific impact of calcium.
Consequently, we cannot affirmatively state that calcium alone has a beneficial effect on reflux. The study indicated that LPR symptoms improved overall, but we remain uncertain about calcium's individual efficacy in this context. This highlights the need for further research to pinpoint the mechanisms at play in reducing reflux symptoms.
In our examination of ten patients who took Cong zhi 6, we observed significant improvements in both reflux symptoms as measured by the Reflux Symptom Index (RSI) and findings from laryngoscopy assessed via the Reflux Finding Score (RFS). While the results were promising, they did not isolate the specific impact of calcium.
Consequently, we cannot affirmatively state that calcium alone has a beneficial effect on reflux. The study indicated that LPR symptoms improved overall, but we remain uncertain about calcium's individual efficacy in this context. This highlights the need for further research to pinpoint the mechanisms at play in reducing reflux symptoms.
Read More
Most Useful Reviews
9
No reflux experienced
Very nice product; I like it because I do not experience any side effects, which is usual for Calcium Carbonate. Additionally, I no longer suffer from stomach acid reflux, a problem I encountered when using Calcium Citrate from other vendors.
Read More
6
Stomach friendly tablets
This is a high-quality product and very gentle on my stomach, as I suffer from reflux. However, the tablets are quite large, making them difficult to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
- All Researches
9
We explored the effects of a multi-herbal Tibetan formula known as Cong zhi 6, which includes calcium carbonate, on individuals suffering from laryngopharyngeal reflux (LPR). Our focus was to understand whether calcium plays a role in alleviating reflux symptoms.
In our examination of ten patients who took Cong zhi 6, we observed significant improvements in both reflux symptoms as measured by the Reflux Symptom Index (RSI) and findings from laryngoscopy assessed via the Reflux Finding Score (RFS). While the results were promising, they did not isolate the specific impact of calcium.
Consequently, we cannot affirmatively state that calcium alone has a beneficial effect on reflux. The study indicated that LPR symptoms improved overall, but we remain uncertain about calcium's individual efficacy in this context. This highlights the need for further research to pinpoint the mechanisms at play in reducing reflux symptoms.
In our examination of ten patients who took Cong zhi 6, we observed significant improvements in both reflux symptoms as measured by the Reflux Symptom Index (RSI) and findings from laryngoscopy assessed via the Reflux Finding Score (RFS). While the results were promising, they did not isolate the specific impact of calcium.
Consequently, we cannot affirmatively state that calcium alone has a beneficial effect on reflux. The study indicated that LPR symptoms improved overall, but we remain uncertain about calcium's individual efficacy in this context. This highlights the need for further research to pinpoint the mechanisms at play in reducing reflux symptoms.
Read More
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
8
We examined a combination product of carbonate antacids—specifically calcium carbonate and magnesium carbonate—with an extract from Opuntia ficus-indica, commonly known as prickly pear. This study looked at how this product could potentially protect esophageal cells from damage caused by both acidic and non-acidic reflux.
Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.
Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.
Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.
Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
No reflux experienced
Very nice product; I like it because I do not experience any side effects, which is usual for Calcium Carbonate. Additionally, I no longer suffer from stomach acid reflux, a problem I encountered when using Calcium Citrate from other vendors.
Read More
6
Stomach friendly tablets
This is a high-quality product and very gentle on my stomach, as I suffer from reflux. However, the tablets are quite large, making them difficult to swallow.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. doi:10.21873/invivo.13056
- Lehner MD, Scheyhing U, Elsässer J. A combination of carbonates and Opuntia ficus-indica extract protects esophageal cells against simulated acidic and non-acidic reflux in vitro. Sci Rep. 2024;14:22355. doi:10.1038/s41598-024-74047-7
- Zürcher BF. The Tibetan Formula Cong zhi 6 in the ORL (ENT) Practice: Experiences with Laryngopharyngeal Reflux. Complement Med Res. 2024;31:84. doi:10.1159/000534212
