Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.6
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%
Top Medical Research Studies
7
Magnesium reduces brain injury markers
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
Read More
9.5
Magnesium's role in brain tumor treatment
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Read More
9
We evaluated the potential of zinc in combination with a ketogenic diet and oxyresveratrol in fighting glioblastoma, a highly aggressive brain tumor. Through a series of carefully designed experiments, we examined how these treatments affect tumor growth and overall brain function.
In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.
The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.
In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.
The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.
Read More
Most Useful Reviews
9
Supports brain health
5 people found this helpful
I truly admire this manufacturer! Magnesium is very helpful for the brain and maintaining calm, particularly crucial in epilepsy. Zinc enhances skin condition, and calcium is vital, especially considering the quality of milk these days. The product quality is exceptional!
Read More
7.5
Enhanced sleep quality
Calcium magnesium zinc stabilises insomnia, depression, autonomic disorders, and more, especially during menopause or old age. Quality natural ingredients relieve stress, stimulate brain function, and improve concentration. GABA, a neurotransmitter, enhances sleep quality, providing deeper rest, especially since growth hormone is released at night. The dosage is optimal.
Read More
7.5
Promotes bone health
Calcium Magnesium Plus Zinc supports bone and brain health, balances body fluid levels, and aids immune function by enhancing white blood cell activity.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.6
- All Researches
9.5
Magnesium's role in brain tumor treatment
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Read More
9
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
Read More
9
We investigated the role of T-type calcium channels in medulloblastoma, a particularly aggressive brain tumor that primarily affects children. The study utilized various methodologies, including bulk and single-cell RNA sequencing, to assess T-type calcium channel expression.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Read More
9
We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
Read More
9
We evaluated the potential of zinc in combination with a ketogenic diet and oxyresveratrol in fighting glioblastoma, a highly aggressive brain tumor. Through a series of carefully designed experiments, we examined how these treatments affect tumor growth and overall brain function.
In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.
The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.
In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.
The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports brain health
5 people found this helpful
I truly admire this manufacturer! Magnesium is very helpful for the brain and maintaining calm, particularly crucial in epilepsy. Zinc enhances skin condition, and calcium is vital, especially considering the quality of milk these days. The product quality is exceptional!
Read More
7.5
Enhanced sleep quality
Calcium magnesium zinc stabilises insomnia, depression, autonomic disorders, and more, especially during menopause or old age. Quality natural ingredients relieve stress, stimulate brain function, and improve concentration. GABA, a neurotransmitter, enhances sleep quality, providing deeper rest, especially since growth hormone is released at night. The dosage is optimal.
Read More
7.5
Promotes bone health
Calcium Magnesium Plus Zinc supports bone and brain health, balances body fluid levels, and aids immune function by enhancing white blood cell activity.
Read More
6
Beneficial supplement
Good high-quality and beneficial food supplement. Natural ingredients, excellent size, and a delicious taste. Safe packaging to improve immunity levels. I loved it for my children, who also enjoyed the flavour. It can be used for any age, and the package size is suitable, containing vitamin D.
Read More
7.5
Increases calmness
I love this manufacturer! Magnesium greatly supports brain health and helps maintain calm. Zinc revitalises the skin, while calcium is important, especially given the current milk standards. The quality of the products is superb!
Read More
Frequently Asked Questions
9
Supports brain health
5 people found this helpful
I truly admire this manufacturer! Magnesium is very helpful for the brain and maintaining calm, particularly crucial in epilepsy. Zinc enhances skin condition, and calcium is vital, especially considering the quality of milk these days. The product quality is exceptional!
7.5
Enhanced sleep quality
Calcium magnesium zinc stabilises insomnia, depression, autonomic disorders, and more, especially during menopause or old age. Quality natural ingredients relieve stress, stimulate brain function, and improve concentration. GABA, a neurotransmitter, enhances sleep quality, providing deeper rest, especially since growth hormone is released at night. The dosage is optimal.
7.5
Promotes bone health
Calcium Magnesium Plus Zinc supports bone and brain health, balances body fluid levels, and aids immune function by enhancing white blood cell activity.
6
Beneficial supplement
Good high-quality and beneficial food supplement. Natural ingredients, excellent size, and a delicious taste. Safe packaging to improve immunity levels. I loved it for my children, who also enjoyed the flavour. It can be used for any age, and the package size is suitable, containing vitamin D.
9
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
9
We investigated the role of T-type calcium channels in medulloblastoma, a particularly aggressive brain tumor that primarily affects children. The study utilized various methodologies, including bulk and single-cell RNA sequencing, to assess T-type calcium channel expression.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
Our findings revealed that in more than 30% of patients, these calcium channels were upregulated. Notably, higher levels of T-type calcium channels were linked to poorer patient outcomes. We observed that inhibiting these channels with a drug called mibefradil significantly slowed down tumor growth, increased cell death, and reduced invasion.
Furthermore, through proteomic analysis, we mapped the signaling pathways affected by T-type calcium channel inhibition. Our results suggest that mibefradil not only acts on the calcium channels but also influences critical cancer pathways, confirming the potential of repurposing this existing drug for treating medulloblastoma. In animal models, oral administration of mibefradil led to a notable reduction in tumor size and extended survival.
9
We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.
Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.
7
Magnesium reduces brain injury markers
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
References
- Sun S, Qian S, Wang R, Zhao M, Li R, et al. Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogramming. Sci Transl Med. 2025;17:eado0020. doi:10.1126/scitranslmed.ado0020
- Dube CJ, Lai M, Zhang Y, Saha S, Yener U, et al. T-type calcium channels regulate medulloblastoma and can be targeted for therapy. J Neurooncol. 2025. doi:10.1007/s11060-025-04967-5
- Li S, Li W, Miao Y, Gao M, Jia Y, et al. Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth. Sci Transl Med. 2024;16:eadn6763. doi:10.1126/scitranslmed.adn6763
- Nalci OB, Nadaroglu H, Genc S, Hacimuftuoglu A, Alayli A. The effects of MgS nanoparticles-Cisplatin-bio-conjugate on SH-SY5Y neuroblastoma cell line. Mol Biol Rep. 2020;47:9715. doi:10.1007/s11033-020-05987-2
- Zappia F, Verzicco I, Simoni R, Ferrari M, Coghi P, et al. Posterior reversible encephalopathy syndrome in an oncological normotensive patient: evidence for a pathogenic role of concomitant low magnesium serum levels and chemotherapy treatment. Acta Biomed. 2020;91:365. doi:10.23750/abm.v91i2.8685
- Mirrahimi B, Mortazavi A, Nouri M, Ketabchi E, Amirjamshidi A, et al. Effect of magnesium on functional outcome and paraclinical parameters of patients undergoing supratentorial craniotomy for brain tumors: a randomized controlled trial. Acta Neurochir (Wien). 2015;157:985. doi:10.1007/s00701-015-2376-x
- Gujaran TV, Easwaran VB, Sankhe R, Bakthavatchalam P, Dsouza HS, et al. Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination. Oncol Res. 2025;33:381. doi:10.32604/or.2024.049538
