Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.5
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
Supplement Facts
Serving Size: 5 Tablets
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium citrate)
500 mg
119%
Sodium
20 mg
<1%
Top Medical Research Studies
2
We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Read More
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
We examined how the vitamin D analog TX527 affects diarrhea in a model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). In our study, we observed that TX527 significantly improved disease symptoms by reducing both bleeding and diarrhea.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Read More
Most Useful Reviews
4
Risk of diarrhoea
3 people found this helpful
This Ca/Mg2:1 supplement is of good quality and quite safe. The tablets are stable and have an impressive feel to them. Although it's an American dosage, they can be swallowed if chewed. The Japanese calcium standards suggest different doses, and I’ve found that taking five capsules can lead to loose stools and diarrhoea if consuming 500 mg of magnesium. Excess magnesium can also limit iron absorption, so I’d recommend limiting intake to about 200 mg per day, which should be safer.
Read More
2
Convenient liquid form
5 people found this helpful
I find magnesium to be extremely beneficial for my body, particularly because of my troublesome thyroid. However, I have one significant concern. The tablets are quite large, and I need to take five each day! When you already have numerous supplements, it turns into a handful. I've recently tried the same supplement in liquid form, which is much easier—just one spoonful! It’s worth noting that this magnesium has caused me some diarrhoea.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.5
- All Researches
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
We conducted a study to see how supplementing weaned pigs with 25-hydroxyvitamin D (25(OH)D) could help ease diarrhea linked to porcine epidemic diarrhea virus (PEDV) infection. Forty-two pigs were divided into six groups and fed different amounts of vitamin D3 for 26 days. On day 22, we introduced the virus to all but one control group, which only received saline.
Our findings were quite striking. We noted that pig weight gain significantly dropped due to the PEDV infection, which also led to severe diarrhea. This infection negatively impacted the pigs' gut health by reducing villous height and increasing crypt depth—a clear indicator of intestinal distress. However, in the group supplemented with the highest level of vitamin D3 (155.5 μg), we observed considerable improvements. Their intestinal damage was significantly less than that of the control group exposed to PEDV.
Furthermore, the vitamin D3 supplementation helped lower the presence of inflammatory markers in the pigs’ systems, suggesting that this vitamin plays a role in modulating the immune response. Overall, our results indicate that adding 25(OH)D to pig diets can be beneficial in reducing diarrhea and supporting gut health in the face of PEDV infection.
Our findings were quite striking. We noted that pig weight gain significantly dropped due to the PEDV infection, which also led to severe diarrhea. This infection negatively impacted the pigs' gut health by reducing villous height and increasing crypt depth—a clear indicator of intestinal distress. However, in the group supplemented with the highest level of vitamin D3 (155.5 μg), we observed considerable improvements. Their intestinal damage was significantly less than that of the control group exposed to PEDV.
Furthermore, the vitamin D3 supplementation helped lower the presence of inflammatory markers in the pigs’ systems, suggesting that this vitamin plays a role in modulating the immune response. Overall, our results indicate that adding 25(OH)D to pig diets can be beneficial in reducing diarrhea and supporting gut health in the face of PEDV infection.
Read More
9
We examined how the vitamin D analog TX527 affects diarrhea in a model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). In our study, we observed that TX527 significantly improved disease symptoms by reducing both bleeding and diarrhea.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Read More
9
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
9
In our exploration of how potassium-magnesium sulfate (PMS) impacts diarrhea in weaned piglets, we set out to understand its effects on growth performance, immunity, and gut health. A total of 216 piglets were divided into six groups, with varying levels of PMS in their diets.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
4
Risk of diarrhoea
3 people found this helpful
This Ca/Mg2:1 supplement is of good quality and quite safe. The tablets are stable and have an impressive feel to them. Although it's an American dosage, they can be swallowed if chewed. The Japanese calcium standards suggest different doses, and I’ve found that taking five capsules can lead to loose stools and diarrhoea if consuming 500 mg of magnesium. Excess magnesium can also limit iron absorption, so I’d recommend limiting intake to about 200 mg per day, which should be safer.
Read More
2
Convenient liquid form
5 people found this helpful
I find magnesium to be extremely beneficial for my body, particularly because of my troublesome thyroid. However, I have one significant concern. The tablets are quite large, and I need to take five each day! When you already have numerous supplements, it turns into a handful. I've recently tried the same supplement in liquid form, which is much easier—just one spoonful! It’s worth noting that this magnesium has caused me some diarrhoea.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Dario JGN, de Oliveira ER, de Souza RP, Theodorovicz S, Bernini GC, et al. Capsaicin and 1,25-Dihydroxyvitamin D Glycoside: Effects on the Reproductive Performance of Hyper-Prolific Sows. Animals (Basel). 2023;13. 10.3390/ani13172794
- Yang J, Chen D, Tian G, Mao X, He J, et al. 1,25-Dihydroxyvitamin D Negatively Regulates the Inflammatory Response to Porcine Epidemic Diarrhea Virus Infection by Inhibiting NF-κB and JAK/STAT Signaling Pathway in IPEC-J2 Porcine Epithelial Cells. Int J Mol Sci. 2022;23. 10.3390/ijms231810603
- Chan H, Li Q, Wang X, Liu WY, Hu W, et al. Vitamin D and carbamazepine protect against infection in mice by restoring macrophage lysosome acidification. Autophagy. 2022;18:2050. 10.1080/15548627.2021.2016004
- Yang J, Tian G, Chen D, Mao X, He J, et al. 1,25-Dihydroxyvitamin D inhibits porcine epidemic diarrhea virus replication by regulating cell cycle resumption in IPEC-J2 porcine epithelial cells. Microb Pathog. 2021;158:105017. 10.1016/j.micpath.2021.105017
- Khalighi Sikaroudi M, Mokhtare M, Shidfar F, Janani L, Faghihi Kashani A, et al. Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial. EXCLI J. 2020;19:652. 10.17179/excli2020-2247
- Khalighi Sikaroudi M, Mokhtare M, Janani L, Faghihi Kashani AH, Masoodi M, et al. Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial. Complement Med Res. 2020;27:302. 10.1159/000506149
- Mousavi S, Lobo de Sá FD, Schulzke JD, Bücker R, Bereswill S, et al. Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Induced Enterocolitis Model. Front Immunol. 2019;10:2094. 10.3389/fimmu.2019.02094
- Yang J, Tian G, Chen D, Zheng P, Yu J, et al. Dietary 25-Hydroxyvitamin D Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs. Animals (Basel). 2019;9. 10.3390/ani9090627
- Bucak IH, Ozturk AB, Almis H, Cevik MÖ, Tekin M, et al. Is there a relationship between low vitamin D and rotaviral diarrhea?. Pediatr Int. 2016;58:270. 10.1111/ped.12809
- Zhang H, Wu H, Liu L, Li H, Shih DQ, et al. 1,25-dihydroxyvitamin D3 regulates the development of chronic colitis by modulating both T helper (Th)1 and Th17 activation. APMIS. 2015;123:490. 10.1111/apm.12378
- van der Wilden GM, Fagenholz PJ, Velmahos GC, Quraishi SA, Schipper IB, et al. Vitamin D status and severity of Clostridium difficile infections: a prospective cohort study in hospitalized adults. JPEN J Parenter Enteral Nutr. 2015;39:465. 10.1177/0148607113519129
- Aluisio AR, Maroof Z, Chandramohan D, Bruce J, Mughal MZ, et al. Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial. Pediatrics. 2013;132:e832. 10.1542/peds.2012-3986
- Verlinden L, Leyssens C, Beullens I, Marcelis S, Mathieu C, et al. The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease. J Steroid Biochem Mol Biol. 2013;136:107. 10.1016/j.jsbmb.2012.09.017
- Duangjai A, Rawangkan A, Yosboonruang A, Ontawong A, Saokaew S, et al. Antispasmodic Activity of Light-Roasted Coffee Extract and Its Potential Use in Gastrointestinal Motility Disorders. Foods. 2024;13. 10.3390/foods13152307
- de Souza Goncalves L, Chu T, Master R, Chhetri PD, Gao Q, et al. Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells. J Clin Invest. 2024;134. 10.1172/JCI171249
- Wang Y, Xiao X, Lin Q, Song R, Wang X, et al. Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia. J Diabetes Investig. 2024;15:121. 10.1111/jdi.14084
- Costello R, Rosanoff A, Nielsen F, West C. Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults. Adv Nutr. 2023;14:973. 10.1016/j.advnut.2023.06.008
- Kamali F, Jamee M, Sayer JA, Sadeghi-Bojd S, Golchehre Z, et al. Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature. CEN Case Rep. 2023;12:413. 10.1007/s13730-023-00785-8
- Cao S, Huang K, Wen X, Gao J, Cui B, et al. Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets. Front Microbiol. 2022;13:961989. 10.3389/fmicb.2022.961989
- Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. 10.1136/spcare-2022-003685
- Sarkar KK, Mitra T, Rahman MA, Raja IM, Aktaruzzaman M, et al. Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes. Biomed Res Int. 2022;2022:1331758. 10.1155/2022/1331758
