Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8.1
USERS' SCORE
Good
Based on 15 Reviews
8
Supplement Facts
Serving Size: 5 Tablets
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium citrate)
500 mg
119%
Sodium
20 mg
<1%
Top Medical Research Studies
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
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9
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
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9
Nanopowder eggshells improve bone health
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
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Most Useful Reviews
10
Good bone health
3 people found this helpful
This is an excellent product. When I went for my osteoporosis check-up, my doctor informed me that my bones are in great shape and advised me to return in two years for another evaluation.
Read More
9
No swelling experienced
1 people found this helpful
This is the best calcium I’ve tried. It doesn’t cause swelling or negatively impact the kidneys, making it excellent for osteoporosis. I certainly recommend it to anyone in need.
Read More
9
Essential for bones
I have taken it for nearly a year, and the combination of these two minerals with vitamin D is vital for bone health. The calcium citrate form is gentle on the stomach, unlike others I've tried. Since being diagnosed with osteoporosis, I have found this supplement from Solgar to be indispensable. I’ve purchased it at the best price from iHerb, and my experience has been without problems, as it arrives well packaged.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8.1
- All Researches
9.5
We looked into the effects of vitamin D3 on osteoporosis management, particularly in relation to glucocorticoid-induced complications. In a recent case involving an 85-year-old patient with IgG4-related disease, vitamin D3 was used alongside prednisone and azathioprine. The goal was to prevent bone density loss often seen with steroid treatments.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
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9
Vitamin D derivatives enhance bone health
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
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9
We explored how Nano Vitamin D3 influences osteoporosis, particularly in the context of treatments involving anastrozole, a medication often used in cancer therapy. In our study, we observed the effects of Nano Vitamin D3 compared to selenium nanoparticles in female albino rats.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
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9
We investigated the effects of vitamin D3 supplementation during pregnancy on offspring's bone mineral density (BMD) as they grow. In the MAVIDOS study, pregnant women with low levels of vitamin D were given either a daily dose of 1000 IU of cholecalciferol (vitamin D3) or a placebo from their second trimester until delivery.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
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9
Calcium and Vitamin D3 boost bone health
We conducted a comprehensive study to assess the effectiveness and safety of a daily regimen of calcium 600 mg combined with cholecalciferol (vitamin D3) 2000 IU in treating vitamin D deficiency, particularly in the context of osteoporosis. Our research included 302 adults who took these orodispersible tablets for at least 24 weeks.
The results showed that this combination therapy successfully increased serum levels of 25-hydroxivitamin D, an essential marker of vitamin D status. Notably, patients suffering from vitamin D deficiency experienced significant improvement in their vitamin D levels, reaching an optimal range conducive to better bone health.
We also observed that while the treatment led to improved vitamin D status, there were no significant adverse events reported, making it a safe option for long-term management of vitamin D deficiency and osteoporosis. Additionally, we found that reducing secondary hyperparathyroidism, a condition often associated with low vitamin D, was another positive outcome of this treatment.
Overall, the magnitude of increase in vitamin D levels directly correlated with the severity of the deficiency, indicating that those most in need benefited the most. Our study emphasizes the importance of addressing vitamin D deficiency, especially for individuals at risk of osteoporosis, without any notable burden of side effects.
The results showed that this combination therapy successfully increased serum levels of 25-hydroxivitamin D, an essential marker of vitamin D status. Notably, patients suffering from vitamin D deficiency experienced significant improvement in their vitamin D levels, reaching an optimal range conducive to better bone health.
We also observed that while the treatment led to improved vitamin D status, there were no significant adverse events reported, making it a safe option for long-term management of vitamin D deficiency and osteoporosis. Additionally, we found that reducing secondary hyperparathyroidism, a condition often associated with low vitamin D, was another positive outcome of this treatment.
Overall, the magnitude of increase in vitamin D levels directly correlated with the severity of the deficiency, indicating that those most in need benefited the most. Our study emphasizes the importance of addressing vitamin D deficiency, especially for individuals at risk of osteoporosis, without any notable burden of side effects.
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User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Good bone health
3 people found this helpful
This is an excellent product. When I went for my osteoporosis check-up, my doctor informed me that my bones are in great shape and advised me to return in two years for another evaluation.
Read More
9
No swelling experienced
1 people found this helpful
This is the best calcium I’ve tried. It doesn’t cause swelling or negatively impact the kidneys, making it excellent for osteoporosis. I certainly recommend it to anyone in need.
Read More
9
Essential for bones
I have taken it for nearly a year, and the combination of these two minerals with vitamin D is vital for bone health. The calcium citrate form is gentle on the stomach, unlike others I've tried. Since being diagnosed with osteoporosis, I have found this supplement from Solgar to be indispensable. I’ve purchased it at the best price from iHerb, and my experience has been without problems, as it arrives well packaged.
Read More
9
Vitamin benefits for seniors
This drug is fantastic for osteoporosis! I buy it because the combination of calcium, magnesium, and vitamin D3 is beneficial for bone health. I recommend it to everyone, especially those over 50. The quality of Solgar products is undeniably excellent.
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7.5
Calcium absorption improvement
74 people found this helpful
Calcium and magnesium D3 by Solgar is an excellent nutrient complex crucial for the body; vitamin D3 aids in the absorption of calcium, while magnesium regulates its transport. After a few weeks of use, I've noticed an improvement in my overall condition. However, the large tablet size can make swallowing difficult, and the cost is notably high. Calcium is essential for strong bones and the health of the colon, heart, and nervous system. It is paramount for combating osteoporosis, particularly if one cannot receive enough calcium from dietary sources. One or two tablets daily is sufficient for prevention. Although large, they can be consumed with water relatively easily. I recommend this supplement!
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Frequently Asked Questions
7.5
Calcium absorption improvement
74 people found this helpful
Calcium and magnesium D3 by Solgar is an excellent nutrient complex crucial for the body; vitamin D3 aids in the absorption of calcium, while magnesium regulates its transport. After a few weeks of use, I've noticed an improvement in my overall condition. However, the large tablet size can make swallowing difficult, and the cost is notably high. Calcium is essential for strong bones and the health of the colon, heart, and nervous system. It is paramount for combating osteoporosis, particularly if one cannot receive enough calcium from dietary sources. One or two tablets daily is sufficient for prevention. Although large, they can be consumed with water relatively easily. I recommend this supplement!
9
Essential for bones
I have taken it for nearly a year, and the combination of these two minerals with vitamin D is vital for bone health. The calcium citrate form is gentle on the stomach, unlike others I've tried. Since being diagnosed with osteoporosis, I have found this supplement from Solgar to be indispensable. I’ve purchased it at the best price from iHerb, and my experience has been without problems, as it arrives well packaged.
9
Vitamin benefits for seniors
This drug is fantastic for osteoporosis! I buy it because the combination of calcium, magnesium, and vitamin D3 is beneficial for bone health. I recommend it to everyone, especially those over 50. The quality of Solgar products is undeniably excellent.
6
Hoping for improvement
1 people found this helpful
My daughter has been prescribed a therapeutic dose of calcium for her osteoporosis at 2000 mg per day. I have just started taking it as well. I'm hopeful for a positive outcome, although it’s too early to assess the effect.
7.5
Alleviated symptoms
I have ordered this product over three times. My mother suffers from osteoporosis and I find that my symptoms have alleviated significantly, despite not taking any medication. However, the pill is rather large.
7.5
Effective prevention method
8 people found this helpful
I am very pleased with the calcium combined with magnesium and vitamin D3. It assists in the prevention of osteoporosis. I also take fish oil capsules containing vitamin D3. I alternate between taking the calcium complex and the fish oil capsules, and I find this method effective. The large bottle contains 300 tablets, making it very economical. I definitely recommend it!
7.5
Strong bones support
Solgar's "Calcium Magnesium with Vitamin D3" includes citrate forms of calcium and magnesium, which are easily absorbed — even with low acidity in the stomach. The optimal 2:1 ratio ensures effective calcium absorption into bone tissue, supported by vitamin D3. This vital supplement not only enhances calcium absorption for bone and teeth health but also supports various systems, including the immune system and muscle function. Given a healthy diet and exercise, this product can reduce the risk of osteoporosis.
8
We explored the mechanisms by which vitamin D3 might regulate bone metabolism and help combat osteoporosis, particularly in light of vitamin D insufficiency. By utilizing various mouse models, including those genetically modified to express certain genes related to vitamin D, we assessed how these factors contributed to bone health.
Our findings revealed that a deficiency in active vitamin D, or 1,25-dihydroxyvitamin D, led to decreased levels of an important protein called Sirt1, which is crucial for bone health. This drop in Sirt1 resulted in accelerated bone loss. Encouragingly, we discovered that overexpressing Sirt1 in mesenchymal stem cells could actually reverse this bone loss. It achieved this by reducing oxidative stress and promoting healthy bone formation while minimizing bone resorption.
Additionally, our study showed that vitamin D3 boosts Sirt1 levels through a direct interaction with its gene promoter. This means that adequate vitamin D not only supports Sirt1 levels but also plays a key role in regulating its activity in bone cells. We also examined the effects of resveratrol, a compound that activates Sirt1, and found it could mitigate the negative impact of vitamin D insufficiency on bone health.
Overall, we observed that the vitamin D-Sirt1/PGC1α axis is vital for maintaining bone health, especially when vitamin D levels are insufficient. These insights highlight the potential for targeting this pathway as a promising strategy for preventing and treating osteoporosis.
Our findings revealed that a deficiency in active vitamin D, or 1,25-dihydroxyvitamin D, led to decreased levels of an important protein called Sirt1, which is crucial for bone health. This drop in Sirt1 resulted in accelerated bone loss. Encouragingly, we discovered that overexpressing Sirt1 in mesenchymal stem cells could actually reverse this bone loss. It achieved this by reducing oxidative stress and promoting healthy bone formation while minimizing bone resorption.
Additionally, our study showed that vitamin D3 boosts Sirt1 levels through a direct interaction with its gene promoter. This means that adequate vitamin D not only supports Sirt1 levels but also plays a key role in regulating its activity in bone cells. We also examined the effects of resveratrol, a compound that activates Sirt1, and found it could mitigate the negative impact of vitamin D insufficiency on bone health.
Overall, we observed that the vitamin D-Sirt1/PGC1α axis is vital for maintaining bone health, especially when vitamin D levels are insufficient. These insights highlight the potential for targeting this pathway as a promising strategy for preventing and treating osteoporosis.
8
We conducted a multicenter, randomized, controlled clinical trial involving 226 patients with osteoporosis to assess the effectiveness of acupuncture alongside calcium and vitamin D3 supplementation. Participants were divided into two groups: one receiving standard treatment of calcium and vitamin D3, while the other group received the same treatment plus additional acupuncture.
Our findings showed that, after six months, while acupuncture led to improvements in bone density, balance, and muscle strength, the specific effects of vitamin D3 remained hard to isolate. This is because all participants received vitamin D3, and the concurrent acupuncture treatment makes it challenging to determine how much of the improvement can be attributed specifically to vitamin D3 on its own.
While vitamin D3 is a key player in bone health, it’s clear from our study that the additional acupuncture treatment offered unique benefits that may enhance overall patient outcomes. Therefore, although we can't pinpoint the exact effectiveness of vitamin D3 alone, it does play an essential role when combined with other therapies.
Our findings showed that, after six months, while acupuncture led to improvements in bone density, balance, and muscle strength, the specific effects of vitamin D3 remained hard to isolate. This is because all participants received vitamin D3, and the concurrent acupuncture treatment makes it challenging to determine how much of the improvement can be attributed specifically to vitamin D3 on its own.
While vitamin D3 is a key player in bone health, it’s clear from our study that the additional acupuncture treatment offered unique benefits that may enhance overall patient outcomes. Therefore, although we can't pinpoint the exact effectiveness of vitamin D3 alone, it does play an essential role when combined with other therapies.
9
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
References
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