Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 5 Tablets
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium citrate)
500 mg
119%
Sodium
20 mg
<1%
Top Medical Research Studies
9
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
Read More
9
We examined the role of magnesium alginate in treating laryngopharyngeal reflux (LPR), which causes symptoms like voice issues, swallowing difficulties, and coughing. In a study involving 100 outpatients, patients were treated with alginate for two months, visiting at the start and then at 15, 30, and 60 days.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
Read More
8
We conducted a multicenter crossover study to see if magnesium alginate could alleviate reflux symptoms in infants. A total of 72 infants participated, receiving either magnesium alginate or a thickened formula in alternating phases.
Our findings showed a significant reduction in reflux symptoms across all infant groups. However, there was no significant difference in effectiveness between the two treatments. Importantly, using magnesium alginate also yielded cost savings of about €4.60 per infant compared to the thickened formula.
Thus, magnesium alginate appears to be a cost-effective option without sacrificing symptom relief.
Our findings showed a significant reduction in reflux symptoms across all infant groups. However, there was no significant difference in effectiveness between the two treatments. Importantly, using magnesium alginate also yielded cost savings of about €4.60 per infant compared to the thickened formula.
Thus, magnesium alginate appears to be a cost-effective option without sacrificing symptom relief.
Read More
Most Useful Reviews
7.5
Reliable reflux relief
2 people found this helpful
More than anything, I feel healthy after eating. Thank you so much, my herb! It's quality—do I need to say more? The product I started using this time, which is important to swallow after eating, is effective as well. In the past, however, it was difficult when I was suffering from reflux esophagitis for a long period, but this product is reliable. I often face unexpected stresses in daily life and want to address this without succumbing to pressure. Thus, I aim to maintain a healthy mind and body through various challenges, not just exercise, with help from this product. The size and effect are certain.
Read More
6
Great for reflux
I have repurchased this product many times, consistently taking these calcium and magnesium tablets. Since the ingredient is calcium citrate, I feel it is more suitable for individuals with gastroesophageal reflux than calcium carbonate. The quality is excellent.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
- All Researches
9.5
Gaviscon DA effectively neutralizes acid
We explored how Gaviscon Double Action, a combination of alginate and antacid, affects gastric acid levels. In a carefully designed crossover study, we monitored intragastric pH in healthy volunteers after administering Gaviscon DA versus a placebo.
The results showed a clear advantage for Gaviscon DA, with pH levels reaching 4 or higher nearly 47% of the time, compared to just 5% for the placebo. This confirms that Gaviscon DA effectively neutralizes gastric acid, enhancing the understanding of how its components work together for reflux relief.
The results showed a clear advantage for Gaviscon DA, with pH levels reaching 4 or higher nearly 47% of the time, compared to just 5% for the placebo. This confirms that Gaviscon DA effectively neutralizes gastric acid, enhancing the understanding of how its components work together for reflux relief.
Read More
9
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
Read More
9
We explored the effects of a multi-herbal Tibetan formula known as Cong zhi 6, which includes calcium carbonate, on individuals suffering from laryngopharyngeal reflux (LPR). Our focus was to understand whether calcium plays a role in alleviating reflux symptoms.
In our examination of ten patients who took Cong zhi 6, we observed significant improvements in both reflux symptoms as measured by the Reflux Symptom Index (RSI) and findings from laryngoscopy assessed via the Reflux Finding Score (RFS). While the results were promising, they did not isolate the specific impact of calcium.
Consequently, we cannot affirmatively state that calcium alone has a beneficial effect on reflux. The study indicated that LPR symptoms improved overall, but we remain uncertain about calcium's individual efficacy in this context. This highlights the need for further research to pinpoint the mechanisms at play in reducing reflux symptoms.
In our examination of ten patients who took Cong zhi 6, we observed significant improvements in both reflux symptoms as measured by the Reflux Symptom Index (RSI) and findings from laryngoscopy assessed via the Reflux Finding Score (RFS). While the results were promising, they did not isolate the specific impact of calcium.
Consequently, we cannot affirmatively state that calcium alone has a beneficial effect on reflux. The study indicated that LPR symptoms improved overall, but we remain uncertain about calcium's individual efficacy in this context. This highlights the need for further research to pinpoint the mechanisms at play in reducing reflux symptoms.
Read More
9
Banxia Houpu Decoction shows promise
We evaluated how Banxia Houpu Decoction, a traditional Chinese remedy, can help patients with refractory gastroesophageal reflux disease (RGERD). In our study involving 89 patients, we compared this decoction to standard Western treatments, including proton pump inhibitors with added magnesium aluminum carbonate.
Results showed that the decoction significantly improved throat burning, swallowing difficulties, and hiccups more effectively than Western treatments. However, the Western medicine group had better relief for heartburn and gastric burning sensations.
Factors like age and gastroesophageal flap valve grade also impacted treatment effectiveness.
Results showed that the decoction significantly improved throat burning, swallowing difficulties, and hiccups more effectively than Western treatments. However, the Western medicine group had better relief for heartburn and gastric burning sensations.
Factors like age and gastroesophageal flap valve grade also impacted treatment effectiveness.
Read More
9
We examined the role of magnesium alginate in treating laryngopharyngeal reflux (LPR), which causes symptoms like voice issues, swallowing difficulties, and coughing. In a study involving 100 outpatients, patients were treated with alginate for two months, visiting at the start and then at 15, 30, and 60 days.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
The results were promising, showing a significant reduction in all symptoms assessed. This suggests that magnesium alginate could be a safe and effective alternative for managing LPR, especially for those who cannot fully rely on conventional treatments like proton pump inhibitors.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reliable reflux relief
2 people found this helpful
More than anything, I feel healthy after eating. Thank you so much, my herb! It's quality—do I need to say more? The product I started using this time, which is important to swallow after eating, is effective as well. In the past, however, it was difficult when I was suffering from reflux esophagitis for a long period, but this product is reliable. I often face unexpected stresses in daily life and want to address this without succumbing to pressure. Thus, I aim to maintain a healthy mind and body through various challenges, not just exercise, with help from this product. The size and effect are certain.
Read More
6
Great for reflux
I have repurchased this product many times, consistently taking these calcium and magnesium tablets. Since the ingredient is calcium citrate, I feel it is more suitable for individuals with gastroesophageal reflux than calcium carbonate. The quality is excellent.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. 10.21873/invivo.13056
- Lehner MD, Scheyhing U, Elsässer J. A combination of carbonates and Opuntia ficus-indica extract protects esophageal cells against simulated acidic and non-acidic reflux in vitro. Sci Rep. 2024;14:22355. 10.1038/s41598-024-74047-7
- Zürcher BF. The Tibetan Formula Cong zhi 6 in the ORL (ENT) Practice: Experiences with Laryngopharyngeal Reflux. Complement Med Res. 2024;31:84. 10.1159/000534212
- Raj JP, Saxena U, Belhekar MN, Mamde A, Darak H, et al. Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. Complement Med Res. 2025;32:26. 10.1159/000543367
- Song S, Zhang Y, Zhang J, Jiang Y, Gong A. Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refractory gastroesophageal reflux disease. Medicine (Baltimore). 2024;103:e38045. 10.1097/MD.0000000000038045
- Pizzorni N, Ambrogi F, Eplite A, Rama S, Robotti C, et al. Magnesium alginate versus proton pump inhibitors for the treatment of laryngopharyngeal reflux: a non-inferiority randomized controlled trial. Eur Arch Otorhinolaryngol. 2022;279:2533. 10.1007/s00405-021-07219-0
- Ciprandi G, Damiani V, Passali FM, Crisanti A, Motta G, et al. Magnesium alginate in patients with laryngopharyngeal reflux. J Biol Regul Homeost Agents. 2021;35:61. 10.23812/21-1supp2-12
- Deraman MA, Abdul Hafidz MI, Lawenko RM, Ma ZF, Wong MS, et al. Randomised clinical trial: the effectiveness of Gaviscon Advance vs non-alginate antacid in suppression of acid pocket and post-prandial reflux in obese individuals after late-night supper. Aliment Pharmacol Ther. 2020;51:1014. 10.1111/apt.15746
- Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, et al. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2020;66:225. 10.23736/S1121-421X.20.02601-X
- Baldassarre ME, Di Mauro A, Pignatelli MC, Fanelli M, Salvatore S, et al. Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants. Int J Environ Res Public Health. 2019;17. 10.3390/ijerph17010083
- Wilkinson J, Abd-Elaziz K, den Daas I, Wemer J, van Haastert M, et al. Two placebo-controlled crossover studies in healthy subjects to evaluate gastric acid neutralization by an alginate-antacid formulation (Gaviscon Double Action). Drug Dev Ind Pharm. 2019;45:430. 10.1080/03639045.2018.1546314
- Wilkie MD, Fraser HM, Raja H. Gaviscon® Advance alone versus co-prescription of Gaviscon® Advance and proton pump inhibitors in the treatment of laryngopharyngeal reflux. Eur Arch Otorhinolaryngol. 2018;275:2515. 10.1007/s00405-018-5079-0
- Zhuang XY, Yang HZ, Wang HG, Li CW. [Clinical observation of Weisu granules in treating laryngopharyngeal reflux]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018;32:369. 10.13201/j.issn.1001-1781.2018.05.012
- Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.
