Last update
3/30/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 25 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1 g
<1%**
Vitamin C(as Ester C® calcium ascorbate)
1,000 mg
1,111%
Calcium(as Ester-C® calcium ascorbate)
100 mg
8%
Citrus BioflavonoidComplex
200 mg
***
Acerola Extract
25 mg
***
Rose Hips (fruit)
25 mg
***
Rutin
25 mg
***
Top Medical Research Studies
8
Vitamin C reduces heartburn symptoms
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
Read More
Most Useful Reviews
9
No heartburn issues
175 people found this helpful
Ester-C is a high-quality vitamin C in a mild form. It isn't sour and does not cause heartburn or other unpleasant sensations.
Read More
9
Good absorption
4 people found this helpful
I take this vitamin C alongside chelated iron as prescribed by my gynecologist. It enhances iron absorption and is well-tolerated. This Ester-C form does not cause heartburn or any stomach discomfort. I've been taking it for two months now and would recommend it for those seeking quality supplements.
Read More
9
No heartburn, good absorption
2 people found this helpful
I switched to Solgar’s Ester-C after experiencing issues with a different brand. It’s coated to prevent heartburn and is absorbed slowly, making it easy to take on an empty stomach despite the slightly higher price.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Vitamin C reduces heartburn symptoms
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
No heartburn issues
175 people found this helpful
Ester-C is a high-quality vitamin C in a mild form. It isn't sour and does not cause heartburn or other unpleasant sensations.
Read More
9
Good absorption
4 people found this helpful
I take this vitamin C alongside chelated iron as prescribed by my gynecologist. It enhances iron absorption and is well-tolerated. This Ester-C form does not cause heartburn or any stomach discomfort. I've been taking it for two months now and would recommend it for those seeking quality supplements.
Read More
9
No heartburn, good absorption
2 people found this helpful
I switched to Solgar’s Ester-C after experiencing issues with a different brand. It’s coated to prevent heartburn and is absorbed slowly, making it easy to take on an empty stomach despite the slightly higher price.
Read More
9
Ideal for sensitive stomachs
2 people found this helpful
This is a great product for those with a delicate digestive system as it doesn’t cause heartburn.
Read More
9
No acidity issues
1 people found this helpful
A good form of vitamin C that is comfortable to take and doesn’t cause heartburn. One capsule a day offers nice value.
Read More
Frequently Asked Questions
9
No heartburn, good absorption
2 people found this helpful
I switched to Solgar’s Ester-C after experiencing issues with a different brand. It’s coated to prevent heartburn and is absorbed slowly, making it easy to take on an empty stomach despite the slightly higher price.
9
No heartburn effects
1 people found this helpful
After trying other vitamin C, which caused a bit of heartburn, I found this product effective without any discomfort. It’s great for boosting immunity before vaccination, although the pills are on the larger side.
9
Good absorption
4 people found this helpful
I take this vitamin C alongside chelated iron as prescribed by my gynecologist. It enhances iron absorption and is well-tolerated. This Ester-C form does not cause heartburn or any stomach discomfort. I've been taking it for two months now and would recommend it for those seeking quality supplements.
9
No heartburn issues
175 people found this helpful
Ester-C is a high-quality vitamin C in a mild form. It isn't sour and does not cause heartburn or other unpleasant sensations.
8
Vitamin C reduces heartburn symptoms
We investigated how vitamin C, specifically in the form of a 2% vitamin C solution spray, could help alleviate heartburn symptoms following Lugol chromoendoscopy, a procedure that involves staining the esophagus to better visualize abnormalities. In a well-structured study with 240 participants, we used a randomized, double-blind approach to compare the effectiveness of vitamin C to normal saline and sodium thiosulfate solutions.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
Our results showed that vitamin C spray significantly reduced both acute heartburn symptoms and late discomfort when compared to the saline solution. Specifically, 33% of participants using vitamin C reported relief from acid regurgitation or heartburn, compared to just 15% with sodium thiosulfate. Additionally, patients noted an improvement in retrosternal pain, with 21% finding relief from the vitamin C treatment versus 9% from sodium thiosulfate.
Furthermore, vitamin C offered a quicker discoloration of the iodine-stained mucosa compared to saline, enhancing the overall experience of the procedure. These findings suggest that incorporating vitamin C spray into post-procedural care could be a helpful strategy for patients facing discomfort after undergoing Lugol chromoendoscopy.
References
- Jin D, Wang J, Zhan Q, Huang K, Wang H, et al. The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial. Gastrointest Endosc. 2020;92:554. 10.1016/j.gie.2019.11.028
