We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
Most Useful Reviews
9
Life-changing vitamin
1 people found this helpful
I wholeheartedly recommend vitamin C. My life transformed when I began taking it regularly. Previously, I suffered from colds and flu throughout the year, but I’ve forgotten about these ailments since it became my ally, boosting my immunity. I encourage all my family and friends to embrace this wonderful vitamin.
Read More
9
Energy boost
1 people found this helpful
I have been taking these tablets since April 2016 and have been free from cold and flu. They provide plenty of energy and do not upset my stomach—highly recommended! I began taking them alongside Magnesium Malate and have eliminated all my allergies.
Read More
10
Highly effective
I highly recommend vitamin C. It is perfect for treating influenza and is beneficial throughout the year!
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Read More
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
Read More
4
Vitamin C shows moderate influenza inhibition
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More
User Reviews
USERS' SCORE
Good
Based on 80 Reviews
8.1
All Reviews
Positive Reviews
Negative Reviews
9
Life-changing vitamin
1 people found this helpful
I wholeheartedly recommend vitamin C. My life transformed when I began taking it regularly. Previously, I suffered from colds and flu throughout the year, but I’ve forgotten about these ailments since it became my ally, boosting my immunity. I encourage all my family and friends to embrace this wonderful vitamin.
Read More
9
Energy boost
1 people found this helpful
I have been taking these tablets since April 2016 and have been free from cold and flu. They provide plenty of energy and do not upset my stomach—highly recommended! I began taking them alongside Magnesium Malate and have eliminated all my allergies.
Read More
10
Highly effective
I highly recommend vitamin C. It is perfect for treating influenza and is beneficial throughout the year!
Read More
10
Keeps flu away
Excellent vitamin from Solgar! The whole family took it last year, and we avoided the flu and colds. I recommend it to anyone who cares about their health!
Read More
10
Immunity booster
While taking this, my immunity has dramatically improved; I haven't experienced flu, even with others around me being ill.
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Vitamin C is often touted as a remedy for the common cold and flu, but the scientific evidence supporting its effectiveness is mixed. Some studies suggest that taking Vitamin C may reduce the duration and severity of flu-like symptoms, particularly in people who are under physical stress, such as athletes. However, for the average person, the benefits of high-dose Vitamin C in preventing or treating the flu are not conclusively supported by research. It's generally recommended to maintain an adequate intake of Vitamin C as part of a balanced diet, but relying solely on supplements is not a guaranteed method for preventing the flu.
Incorporating Vitamin C-rich foods, such as citrus fruits, strawberries, and bell peppers, can support your immune system and overall health. It's important to note that while Vitamin C can contribute to your well-being, it should not replace conventional flu prevention measures, like vaccination and good hygiene practices. If you're already experiencing flu symptoms, it's advisable to consult with a healthcare professional for appropriate treatment options.
When it comes to seeing results from vitamin C supplements for flu, user reviews suggest a range of experiences. Many users report that they begin to notice improvements in their immunity and overall health within a short time after starting the supplement. Some claim to have experienced fewer colds and faster recovery times, indicating a noticeable benefit just weeks into regular use. For example, one user noticed significant improvements after taking the supplement for about two months Read Review. Others have asserted that they remained flu-free despite others around them falling ill, implying that a consistent regimen could bolster immune health quickly Read Review.
However, the timeline can vary depending on individual health conditions and consistency in taking the supplement. Some users reported that they felt more vigorous after an hour of taking the vitamin C, which suggests acute benefits, alongside long-term immunity improvements with regular intake. It seems that while immediate effects can be observed for some, those who commit to longer-term usage often see the most pronounced benefits Read Review. Overall, users generally emphasize the importance of incorporating vitamin C into their daily routine to maximize its immune-boosting effects.
The scientific research surrounding vitamin C suggests it may offer some benefits in managing flu symptoms and possibly reducing flu incidence. In a study, vitamin C supplementation was associated with a 4% reduction in the likelihood of catching an acute respiratory infection, including influenza, and it showed promise in shortening the duration of flu symptoms by about 9% [1]. However, it's important to note that these results indicate vitamin C should not be viewed as a standalone solution, and further research is warranted to fully understand its role in flu prevention and treatment.
Additional studies have highlighted vitamin C's potential in enhancing immune responses against the flu virus. Vitamin C was shown to work in combination with red ginseng to elevate immune cell activation and reduce lung inflammation during influenza infections [3]. Furthermore, novel compounds combining vitamin C with other agents indicated promising anti-influenza activity and interfered with the virus's ability to attach to cells [4]. Overall, while vitamin C may not outright cure the flu, it appears to contribute positively to immune function and could aid in managing flu symptoms, particularly when used alongside other treatments.
Based on user reviews, many individuals have reported notable improvements in their symptoms after incorporating vitamin C into their daily routines. Users consistently mention a marked reduction in the frequency of colds and flu, with some stating they have been free from these ailments for extended periods Read Review. One user highlighted that they no longer suffer from allergies and had a consistent boost in energy levels while taking vitamin C Read Review. Others have echoed similar sentiments, stating that they experienced improved immunity and fewer illnesses even when surrounded by others who were ill Read Review.
Additionally, anecdotal evidence suggests that some users have found specific formulations, like Ester-C, to be gentle on their stomachs while still providing robust immune support Read Review. Several reviews pointed out that with regular intake, users not only noticed reduced illness frequency but also faster recovery times from minor infections Read Review. While these experiences highlight the benefits many users attribute to vitamin C, it's important to note that individual results may vary, depending on health conditions and other factors.
Users report positive experiences when combining vitamin C with other supplements for managing flu symptoms. Many have noted that pairing vitamin C with zinc and other supplements enhances its effectiveness. For instance, one user shared that they take vitamin C along with zinc and lysine, which notably reduced their herpes duration during flu season Read Review. Another review mentions taking vitamin C in conjunction with zinc and achieving significant immune support and flu resistance Read Review.
Others found that their overall immunity improved through regular intake of vitamin C alongside magnesium malate, which helped in eliminating allergies as well Read Review. Users often emphasize a multifaceted approach to supplementing—combining vitamin C with different formulations for stronger immune benefits. This method seems to yield varied and favorable outcomes, reinforcing users' commitment to a personalized supplementation regimen during flu seasons.
The optimal dose for Vitamin C in treating flu symptoms is still under examination, though current research indicates that doses anywhere from 125 to 250 mg/kg may be beneficial. A study highlighted that administering these doses in stressed mice resulted in significantly reduced pneumonia symptoms caused by the influenza virus H1N1, suggesting that Vitamin C could help modulate the immune response during flu infections [5]. Moreover, while Vitamin C supplementation has shown promise in reducing both the incidence of flu and the duration of its symptoms, specific optimal dosages for human treatment still require further investigation [1].
9
Strengthens immunity
Having used it for about two months, I find it very effective for strengthening my immunity against the flu, which is why this is my second order.
9
Prevents illness
My first winter with vitamin C involved taking one tablet daily, and despite the rest of the office catching the flu, I didn’t fall ill.
9
Rapid recovery from flu
Excellent! I use it regularly and during illness, increasing the dose. I haven't had the flu in ages, but it helped my husband considerably. After an hour, he felt more vigorous.
9
Life-changing vitamin
1 people found this helpful
I wholeheartedly recommend vitamin C. My life transformed when I began taking it regularly. Previously, I suffered from colds and flu throughout the year, but I’ve forgotten about these ailments since it became my ally, boosting my immunity. I encourage all my family and friends to embrace this wonderful vitamin.
9
Energy boost
1 people found this helpful
I have been taking these tablets since April 2016 and have been free from cold and flu. They provide plenty of energy and do not upset my stomach—highly recommended! I began taking them alongside Magnesium Malate and have eliminated all my allergies.
10
Immunity booster
While taking this, my immunity has dramatically improved; I haven't experienced flu, even with others around me being ill.
9
Boosts immunity
Solgar Ester-C 1000mg is a lifesaver during cold and flu season! It’s gentle on my stomach compared to other Vitamin C supplements, and I genuinely believe it boosts my immunity. I've experienced fewer colds and quicker recovery times since I began taking it daily. Highly recommend!
9
Quick rash relief
Excellent Vitamin C! I take this vitamin during the flu epidemic and when herpes appears. I drink it alongside zinc and lysine. It works remarkably well, reducing the duration of the rash to three days.
9
Effective combination
The 1000mg dosage is suitable, and the quality is excellent with no acidity. It's an effective antioxidant that is gentle on the stomach. My immunity has improved. I use this alongside zinc and have not experienced the flu for quite some time.
7
Vitamin C's promise against flu
Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
9
Immune booster for flu treatment
Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
8
Vitamin C triterpene flu inhibitors
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
8
Vitamin C mitigates flu pneumonia
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
References
Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. 10.1136/bmjgh-2020-003176
Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. 10.3390/molecules25184248
Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. 10.1111/jphp.12529
Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. 10.1016/j.ejmech.2016.01.005
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. 10.1155/2015/675149