' 
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate (800 mcg L-methylfolate) (as L-methylfolate as Metafolin®)
1,333 mcg DFE
333%
The product is found useful for the following medical conditions
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 20 Reviews
8.6
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Most Relevant Research
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
9.5
Improves hormone levels
Most Useful Review
I use this vitamin in preparation for pregnancy as I found I can’t absorb ordinary folic acid well. My homocysteine levels, which increase the risk of cardiovascular disease, were elevated. Switching to Folate has positively impacted my hormone levels and overall health, affirming the need for vitamin checks.
Liver Disease
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 1 Reviews
8.5
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
8.8
Improved hormone tests
Most Useful Review
I take this vitamin for pregnancy preparation. Testing revealed that common folic acid is not absorbed by my body, leading to elevated homocysteine levels, which is detrimental to pregnancy and overall health, increasing the risk of heart diseases and liver disease. It’s fortunate that folate aids in absorption, and I have seen improvements in my hormone levels thanks to the vitamins I ordered. I recommend everyone check their vitamin levels and address deficiencies, as this is crucial for preventing illnesses like liver disease.
Heart Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 12 Reviews
8.2
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
9.5
Reduced homocysteine levels
Most Useful Review
I began taking one tablet daily alongside Solgar B12 and a few other vitamins to lower my homocysteine levels. After 1.5 months of this regimen, my levels dropped substantially from 10.6 to 5.6. I feel fantastic knowing that with lower homocysteine, my vessel health improves and the risk of heart disease decreases. My parents experienced similar results, confirming these vitamins' effectiveness.
