Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate (800 mcg L-methylfolate) (as L-methylfolate as Metafolin®)
1,333 mcg DFE
333%
Top Medical Research Studies
8
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Read More
7
We explored how important substances in the folate-driven one-carbon cycle might serve as indicators of depression in the elderly. By analyzing serum samples from 95 older adults, we aimed to reveal whether certain folate-related biomarkers could help identify those with depressive tendencies.
We measured levels of key metabolites such as folate, S-adenosylmethionine (SAM), and total bile acids, among others. We categorized participants based on their scores from the Hamilton Depression Rating Scale (HAMD-17), comparing those with low depression levels to those with higher scores.
Our findings showed significant differences in serum folate concentrations and SAM/SAH ratios between groups. We found critical thresholds for serum folate and SAM/SAH ratios that could indicate greater depressive tendencies: a folate level below 15.5 nmol/L and a SAM/SAH ratio below 13.0 were associated with higher depression scores.
Overall, our study suggests that measuring these folate-related biomarkers could be useful in recognizing depressive tendencies in older individuals.
We measured levels of key metabolites such as folate, S-adenosylmethionine (SAM), and total bile acids, among others. We categorized participants based on their scores from the Hamilton Depression Rating Scale (HAMD-17), comparing those with low depression levels to those with higher scores.
Our findings showed significant differences in serum folate concentrations and SAM/SAH ratios between groups. We found critical thresholds for serum folate and SAM/SAH ratios that could indicate greater depressive tendencies: a folate level below 15.5 nmol/L and a SAM/SAH ratio below 13.0 were associated with higher depression scores.
Overall, our study suggests that measuring these folate-related biomarkers could be useful in recognizing depressive tendencies in older individuals.
Read More
7
We explored how different levels of depressive symptoms could influence folate levels in the body, focusing on findings from the NHANES database collected between 2017 and 2020. Our analysis involved nearly 5,000 participants and examined their serum and erythrocyte folate levels in relation to the severity of their depressive symptoms.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Read More
Most Useful Reviews
9
Improves mood significantly
25 people found this helpful
Totally satisfied. A neurologist recommended this product alongside Methyl B. I noticed a significant improvement in my overall wellbeing, particularly in sleep quality and my bouts of depression and anxiety, which I no longer experience.
Read More
9
Stabilises mood
3 people found this helpful
A must for my depression. Works well for stabilising my mood. I take it with P-5-P and 5-HTP.
Read More
9
Happy with results
1 people found this helpful
Methylfolate I bought for depression. I am happy with it.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
- All Researches
8
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Read More
8
We explored how a combination of chlorzoxazone, a medication that activates potassium channels, and folic acid affects anxiety and depression in a mouse model of spinocerebellar ataxia type 3 (SCA3). Specifically, we investigated whether this combination could improve mood and cognitive function in SCA3-84Q mice, which are known to exhibit symptoms linked to cerebellar cognitive affective syndrome.
Our results indicated that both chlorzoxazone and the combination with folic acid positively influenced motor coordination and cerebellar function. However, it was only the combination treatment that significantly alleviated anxiety and depressive symptoms, while also enhancing recognition memory in these mice. This suggests that while chlorzoxazone alone has benefits, the added folic acid plays a crucial role in addressing mood-related issues.
Overall, our findings underline the importance of combining therapies to target both motor and non-motor symptoms in complex conditions like SCA3. This combination approach could be beneficial for developing future treatments that address the full spectrum of the disease's impact on individuals.
Our results indicated that both chlorzoxazone and the combination with folic acid positively influenced motor coordination and cerebellar function. However, it was only the combination treatment that significantly alleviated anxiety and depressive symptoms, while also enhancing recognition memory in these mice. This suggests that while chlorzoxazone alone has benefits, the added folic acid plays a crucial role in addressing mood-related issues.
Overall, our findings underline the importance of combining therapies to target both motor and non-motor symptoms in complex conditions like SCA3. This combination approach could be beneficial for developing future treatments that address the full spectrum of the disease's impact on individuals.
Read More
7
We explored how different levels of depressive symptoms could influence folate levels in the body, focusing on findings from the NHANES database collected between 2017 and 2020. Our analysis involved nearly 5,000 participants and examined their serum and erythrocyte folate levels in relation to the severity of their depressive symptoms.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Read More
7
We conducted a study aiming to explore how low-dose methylfolate could improve treatment outcomes for patients struggling with depressive disorder when paired with standard antidepressants. In our open-label clinical trial, we involved 44 participants who received one of several evidence-based antidepressant treatments over four weeks.
Those in the experimental group also received 800 µg of methylfolate daily. Throughout the study, we measured improvements in depressive symptoms using the Patient Health Questionnaire-9 at various intervals. This approach allowed us to gauge changes in their scores over time, as well as remission rates and other important factors.
The results indicated that combining methylfolate with antidepressants could be a promising and safe strategy for treating depression. We noticed improvements, suggesting that this combination might help enhance the effectiveness of traditional antidepressants. However, it's essential to remember that as we continued our research, we couldn't isolate the effects of methylfolate alone, making it hard to draw definitive conclusions about its standalone benefits.
Those in the experimental group also received 800 µg of methylfolate daily. Throughout the study, we measured improvements in depressive symptoms using the Patient Health Questionnaire-9 at various intervals. This approach allowed us to gauge changes in their scores over time, as well as remission rates and other important factors.
The results indicated that combining methylfolate with antidepressants could be a promising and safe strategy for treating depression. We noticed improvements, suggesting that this combination might help enhance the effectiveness of traditional antidepressants. However, it's essential to remember that as we continued our research, we couldn't isolate the effects of methylfolate alone, making it hard to draw definitive conclusions about its standalone benefits.
Read More
7
Folate's complex impact on depression
In our investigation, we aimed to understand how serum total folate and vitamin D levels relate to depression in older adults, particularly those experiencing cognitive dysfunction. By analyzing data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2011 to 2014, we examined over 2,000 participants aged 60 and above.
Utilizing recognized assessment tools like the Patient Health Questionnaire for depression and cognitive tests for cognitive function, we looked for associations between nutrient levels and mental health outcomes. Our findings revealed a notable W-shaped relationship, suggesting that both low and high levels of folate might be linked to increased depression symptoms, whereas moderate levels could be beneficial.
This highlights the potential for folic acid supplementation, especially within a particular range, to aid in combating depression in this demographic. However, it’s essential to perform further clinical studies to confirm these insights and understand the nuances behind the role of nutrition in mental health management.
Utilizing recognized assessment tools like the Patient Health Questionnaire for depression and cognitive tests for cognitive function, we looked for associations between nutrient levels and mental health outcomes. Our findings revealed a notable W-shaped relationship, suggesting that both low and high levels of folate might be linked to increased depression symptoms, whereas moderate levels could be beneficial.
This highlights the potential for folic acid supplementation, especially within a particular range, to aid in combating depression in this demographic. However, it’s essential to perform further clinical studies to confirm these insights and understand the nuances behind the role of nutrition in mental health management.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves mood significantly
25 people found this helpful
Totally satisfied. A neurologist recommended this product alongside Methyl B. I noticed a significant improvement in my overall wellbeing, particularly in sleep quality and my bouts of depression and anxiety, which I no longer experience.
Read More
9
Stabilises mood
3 people found this helpful
A must for my depression. Works well for stabilising my mood. I take it with P-5-P and 5-HTP.
Read More
9
Happy with results
1 people found this helpful
Methylfolate I bought for depression. I am happy with it.
Read More
7.5
Essential for depression
19 people found this helpful
BIO affordable folic during pregnancy is vital, especially for those with an MTHFR mutation where ordinary folic acid isn't digested. MANDATORY to test homocysteine before pregnancy as its increase poses risks. This folate lowers cholesterol, stabilises blood pressure, helps combat depression, and enhances mood and memory. I take it three months before trying to conceive, along with vitamin C and E for better absorption.
Read More
9
Enhances mood effectively
From depression, this is the best mood enhancer. I have tried many supplements, but this, along with zinc and sulbutiamine, has been the most effective. Methylfolate treats those resistant to traditional antidepressants. Although the dosage may vary, one can assess its impact on mood by taking several tablets over time. Pairing it with niacin can help maintain serotonin levels.
Read More
Frequently Asked Questions
9
Improves mood significantly
25 people found this helpful
Totally satisfied. A neurologist recommended this product alongside Methyl B. I noticed a significant improvement in my overall wellbeing, particularly in sleep quality and my bouts of depression and anxiety, which I no longer experience.
9
Enhances mood effectively
From depression, this is the best mood enhancer. I have tried many supplements, but this, along with zinc and sulbutiamine, has been the most effective. Methylfolate treats those resistant to traditional antidepressants. Although the dosage may vary, one can assess its impact on mood by taking several tablets over time. Pairing it with niacin can help maintain serotonin levels.
9
Stabilises mood
3 people found this helpful
A must for my depression. Works well for stabilising my mood. I take it with P-5-P and 5-HTP.
7.5
Essential for depression
19 people found this helpful
BIO affordable folic during pregnancy is vital, especially for those with an MTHFR mutation where ordinary folic acid isn't digested. MANDATORY to test homocysteine before pregnancy as its increase poses risks. This folate lowers cholesterol, stabilises blood pressure, helps combat depression, and enhances mood and memory. I take it three months before trying to conceive, along with vitamin C and E for better absorption.
7.5
Mood stability
4 people found this helpful
MAGIC JAR-WASTE! I've been using Folic acid after positive reviews. It’s crucial for health and especially for pregnant women. Many lack Folate due to intestinal issues. Supplementation is necessary, supporting cardiovascular health and mood. Folic acid deficiency is linked to depression and cognitive decline. This vitamin plays a key role in neurotransmitter synthesis and gene regulation, making it essential for mental wellness and combating depression.
7
We explored how different levels of depressive symptoms could influence folate levels in the body, focusing on findings from the NHANES database collected between 2017 and 2020. Our analysis involved nearly 5,000 participants and examined their serum and erythrocyte folate levels in relation to the severity of their depressive symptoms.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
7
We conducted a study aiming to explore how low-dose methylfolate could improve treatment outcomes for patients struggling with depressive disorder when paired with standard antidepressants. In our open-label clinical trial, we involved 44 participants who received one of several evidence-based antidepressant treatments over four weeks.
Those in the experimental group also received 800 µg of methylfolate daily. Throughout the study, we measured improvements in depressive symptoms using the Patient Health Questionnaire-9 at various intervals. This approach allowed us to gauge changes in their scores over time, as well as remission rates and other important factors.
The results indicated that combining methylfolate with antidepressants could be a promising and safe strategy for treating depression. We noticed improvements, suggesting that this combination might help enhance the effectiveness of traditional antidepressants. However, it's essential to remember that as we continued our research, we couldn't isolate the effects of methylfolate alone, making it hard to draw definitive conclusions about its standalone benefits.
Those in the experimental group also received 800 µg of methylfolate daily. Throughout the study, we measured improvements in depressive symptoms using the Patient Health Questionnaire-9 at various intervals. This approach allowed us to gauge changes in their scores over time, as well as remission rates and other important factors.
The results indicated that combining methylfolate with antidepressants could be a promising and safe strategy for treating depression. We noticed improvements, suggesting that this combination might help enhance the effectiveness of traditional antidepressants. However, it's essential to remember that as we continued our research, we couldn't isolate the effects of methylfolate alone, making it hard to draw definitive conclusions about its standalone benefits.
7
Folate's complex impact on depression
In our investigation, we aimed to understand how serum total folate and vitamin D levels relate to depression in older adults, particularly those experiencing cognitive dysfunction. By analyzing data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2011 to 2014, we examined over 2,000 participants aged 60 and above.
Utilizing recognized assessment tools like the Patient Health Questionnaire for depression and cognitive tests for cognitive function, we looked for associations between nutrient levels and mental health outcomes. Our findings revealed a notable W-shaped relationship, suggesting that both low and high levels of folate might be linked to increased depression symptoms, whereas moderate levels could be beneficial.
This highlights the potential for folic acid supplementation, especially within a particular range, to aid in combating depression in this demographic. However, it’s essential to perform further clinical studies to confirm these insights and understand the nuances behind the role of nutrition in mental health management.
Utilizing recognized assessment tools like the Patient Health Questionnaire for depression and cognitive tests for cognitive function, we looked for associations between nutrient levels and mental health outcomes. Our findings revealed a notable W-shaped relationship, suggesting that both low and high levels of folate might be linked to increased depression symptoms, whereas moderate levels could be beneficial.
This highlights the potential for folic acid supplementation, especially within a particular range, to aid in combating depression in this demographic. However, it’s essential to perform further clinical studies to confirm these insights and understand the nuances behind the role of nutrition in mental health management.
8
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
References
- Yang Y, Qi H, Zhang J, Jia J, Yang Y, et al. Evaluating the association of depressive symptoms on serum folate and erythrocyte folate levels based on the 2017-2020 NHANES database. Front Nutr. 2025;12:1505700. doi:10.3389/fnut.2025.1505700
- Siddique A, Khokhar MM, Waheed A, Naeem U, Aziz SA. Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder. BMC Pharmacol Toxicol. 2025;26:14. doi:10.1186/s40360-025-00846-x
- Guo Q, Wang Y, Guo L, Xu K, Shang S. Association of serum total folate and serum vitamin D concentrations with W-shape in depressed older adults with cognitive dysfunction: A cross-sectional observational study. Clin Nutr ESPEN. 2025;65:50. doi:10.1016/j.clnesp.2024.11.021
- Xiong Y, Zhou G, Zhou L, Guo M, Lu H. Serum molecules of the folate-driven one-carbon cycle as indicators of depressive tendencies in the elderly. Heliyon. 2024;10:e36980. doi:10.1016/j.heliyon.2024.e36980
- Liu M, Wang G, Jiang C. Independent and combined effect of serum copper and folate on depression: cross-sectional data from the NHANES 2011-2016. Front Nutr. 2024;11:1389480. doi:10.3389/fnut.2024.1389480
- Gao S, Khalid A, Amini-Salehi E, Radkhah N, Jamilian P, et al. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses. Food Sci Nutr. 2024;12:3806. doi:10.1002/fsn3.4073
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. doi:10.1093/hmg/ddae079
