Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 21 Reviews
8
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
8
We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Read More
8
Iron and vitamin D impact depression
We explored whether maternal iron and vitamin D levels during pregnancy could impact depression symptoms later on. By measuring various iron biomarkers and vitamin D metabolites, we assessed the mental health of nearly 2,000 pregnant participants in their third trimester. Our findings showed that higher levels of both iron and vitamin D were associated with significantly fewer depression symptoms. Interestingly, many women experienced lower vitamin D levels postpartum, suggesting the need for continued monitoring beyond pregnancy.
Read More
8
We investigated how dietary iron intake affects depressive symptoms among adults using data from the National Health and Nutrition Examination Survey. Our analysis revealed that higher iron intake is linked to lower rates of depression.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Read More
Most Useful Reviews
8.5
Improved mood
27 people found this helpful
Iron bisglycinate is the best form for absorption. After months of use due to low ferritin levels, I haven't yet retested my blood but did notice an initial excitement followed by stability in mood. My menstrual blood loss has decreased. A reasonable psychiatrist will check ferritin levels in those with depression, as low ferritin can be a contributing factor.
Read More
9
Fatigue relief
11 people found this helpful
I take this iron due to very low ferritin levels which caused fatigue and depression. After using it with probiotics at night, I've noticed cold hands and feet, mood swings, and constant tiredness are a thing of the past!
Read More
9
Anemia recovery
After my father's death, I became depressed and anaemic. Despite taking prescribed iron supplements, my condition worsened until I found a regimen that worked for me. Combining iron with Vitamin C, I experienced a significant rise in ferritin levels in just a month, so I continue to take it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
9
We evaluated how brain iron levels affect depression and cognitive function in unmedicated individuals with major depressive disorder (MDD) undergoing mindfulness-based cognitive therapy (MBCT).
Using advanced imaging techniques, we noticed participants with MDD had lower brain iron levels in specific regions compared to healthy controls.
Participants who started with lower iron levels experienced greater improvements in their depression after receiving MBCT. Our findings suggest that brain iron might play a role in MDD symptoms and treatment response.
Using advanced imaging techniques, we noticed participants with MDD had lower brain iron levels in specific regions compared to healthy controls.
Participants who started with lower iron levels experienced greater improvements in their depression after receiving MBCT. Our findings suggest that brain iron might play a role in MDD symptoms and treatment response.
Read More
8
We examined how Kaixinsan (KXS), a traditional Chinese medicine, affects depression-like behaviors in mice undergoing adriamycin treatment for breast cancer. By dividing forty mice into groups, we observed their responses through various tests.
The results showed that KXS significantly improved the depression-related behaviors linked to chemotherapy. It appeared to work by reducing ferroptosis—a type of cell death—in the prefrontal cortex, suggesting a protective role against these adverse effects.
The results showed that KXS significantly improved the depression-related behaviors linked to chemotherapy. It appeared to work by reducing ferroptosis—a type of cell death—in the prefrontal cortex, suggesting a protective role against these adverse effects.
Read More
8
Iron and vitamin D impact depression
We explored whether maternal iron and vitamin D levels during pregnancy could impact depression symptoms later on. By measuring various iron biomarkers and vitamin D metabolites, we assessed the mental health of nearly 2,000 pregnant participants in their third trimester. Our findings showed that higher levels of both iron and vitamin D were associated with significantly fewer depression symptoms. Interestingly, many women experienced lower vitamin D levels postpartum, suggesting the need for continued monitoring beyond pregnancy.
Read More
8
We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Read More
8
We investigated how dietary iron intake affects depressive symptoms among adults using data from the National Health and Nutrition Examination Survey. Our analysis revealed that higher iron intake is linked to lower rates of depression.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
8.5
Improved mood
27 people found this helpful
Iron bisglycinate is the best form for absorption. After months of use due to low ferritin levels, I haven't yet retested my blood but did notice an initial excitement followed by stability in mood. My menstrual blood loss has decreased. A reasonable psychiatrist will check ferritin levels in those with depression, as low ferritin can be a contributing factor.
Read More
9
Fatigue relief
11 people found this helpful
I take this iron due to very low ferritin levels which caused fatigue and depression. After using it with probiotics at night, I've noticed cold hands and feet, mood swings, and constant tiredness are a thing of the past!
Read More
9
Anemia recovery
After my father's death, I became depressed and anaemic. Despite taking prescribed iron supplements, my condition worsened until I found a regimen that worked for me. Combining iron with Vitamin C, I experienced a significant rise in ferritin levels in just a month, so I continue to take it.
Read More
9
Mood improvement
Taking iron supplements has significantly helped my mood and motivation amidst my struggles with prenatal and postnatal depression due to iron deficiency. I continue to take iron regularly, and it makes a notable difference in my general well-being.
Read More
7
Enhanced vitality
13 people found this helpful
I take four tablets daily, noticing my complexion improves. Many Japanese face iron deficiency, leading to tiredness and issues. Although not anaemic, I experienced fatigue and shortness of breath on stairs, which has since improved. The supplement has no stomach discomfort, making it easy to take.
Read More
Frequently Asked Questions
9
Anemia recovery
After my father's death, I became depressed and anaemic. Despite taking prescribed iron supplements, my condition worsened until I found a regimen that worked for me. Combining iron with Vitamin C, I experienced a significant rise in ferritin levels in just a month, so I continue to take it.
6.5
Less fatigue
5 people found this helpful
Since starting this supplement a month ago, my fatigue has notably decreased. I realised that my tiredness could be linked to a lack of iron. I’m glad I began taking it and am optimistic about long-term results.
6
Resolved languor
5 people found this helpful
After switching to this supplement, I've noticed symptoms of depression related to iron and vitamin B deficiencies have lessened. I've been taking it for about a month and feel my tiredness has started to improve significantly.
8.5
Improved mood
27 people found this helpful
Iron bisglycinate is the best form for absorption. After months of use due to low ferritin levels, I haven't yet retested my blood but did notice an initial excitement followed by stability in mood. My menstrual blood loss has decreased. A reasonable psychiatrist will check ferritin levels in those with depression, as low ferritin can be a contributing factor.
9
Fatigue relief
11 people found this helpful
I take this iron due to very low ferritin levels which caused fatigue and depression. After using it with probiotics at night, I've noticed cold hands and feet, mood swings, and constant tiredness are a thing of the past!
7.5
Mood enhancement
I discovered that my low hemoglobin and ferritin levels were causing fatigue and irritability, leading to depression. After trying these vitamins, I felt great relief and noticeable improvement in my overall mood.
7.5
Effective treatment
I frequently deal with iron deficiencies that lead to low energy and depression. This supplement has effectively alleviated my symptoms, particularly when taken with vitamin C. It makes a substantial difference in how I feel.
7.5
Improved mental health
It was my first time taking an iron supplement, as I had been feeling depressed for some time. I chose this product for its quality, aware that it could cause stomach pain. I did experience severe stomach pain initially but found relief after taking it with dinner. I noticed that I sleep deeper at night and wake up feeling better. While it did help my depression, I struggled with the smell of iron and had a relapse of restless leg syndrome, which was concerning.
7.5
Boosts energy
This iron supplement is excellent for addressing iron deficiency, which contributes to feelings of depression and lethargy. It has made a positive impact on my overall energy levels.
7.5
Life-changing solution
After discovering my ferritin level was critically low, I started taking chelated iron and other supplements. My energy levels and mood improved significantly—depression and fatigue became manageable. I finally feel lively again.
8
Boosts mood
This iron supplement is of good quality with an optimal dosage of 25mg. I've noticed improvements in my mood and energy levels, and I no longer feel tired or depressed.
7
Enhanced vitality
13 people found this helpful
I take four tablets daily, noticing my complexion improves. Many Japanese face iron deficiency, leading to tiredness and issues. Although not anaemic, I experienced fatigue and shortness of breath on stairs, which has since improved. The supplement has no stomach discomfort, making it easy to take.
7.5
Condition improved
I take these vitamins as my doctor prescribed them due to sharply lowered ferritin and haemoglobin levels. I experienced weakness and depression, but my condition improved markedly after starting this treatment, and my haemoglobin levels have stabilised.
7
We studied how nutrient supplements, particularly iron, and physical exercise influence depression among older adults in China. Our analysis included 8,427 participants, and we used established tools to measure depression and collect information about their supplement and exercise habits.
Interestingly, we found that 26.2% of the older adults reported suffering from depression. Among the various nutrients studied, we discovered that receiving nutrient supplements, like calcium and multivitamins, was linked to lower depression scores and reduced risk of depression. However, the effects of iron alone could not be isolated due to the combination with other nutrients in the supplements.
Our analysis revealed that physical exercise played a role in mediating the relationship between certain nutrients and depression. This means that for some participants, staying active could enhance the positive effects of nutrient supplementation on their mood. Nevertheless, it is essential to note that there wasn't enough evidence to conclusively state that iron specifically improves depression despite being part of the nutrient mix explored.
Interestingly, we found that 26.2% of the older adults reported suffering from depression. Among the various nutrients studied, we discovered that receiving nutrient supplements, like calcium and multivitamins, was linked to lower depression scores and reduced risk of depression. However, the effects of iron alone could not be isolated due to the combination with other nutrients in the supplements.
Our analysis revealed that physical exercise played a role in mediating the relationship between certain nutrients and depression. This means that for some participants, staying active could enhance the positive effects of nutrient supplementation on their mood. Nevertheless, it is essential to note that there wasn't enough evidence to conclusively state that iron specifically improves depression despite being part of the nutrient mix explored.
7
We set out to explore the connection between iron levels and mental health in pregnant women, focusing on how iron treatment may influence depressive symptoms. Our study recruited participants in their first trimester and followed them through their second and third trimesters, assessing their iron status and psychosocial wellbeing along the way.
Findings revealed that improvements in ferritin levels during the first and second trimesters were associated with fewer depressive symptoms and a better overall quality of life. This suggests that boosting iron levels in early pregnancy could potentially benefit mental health. Moreover, we discovered that increases in hemoglobin were linked to reduced anxiety, particularly feelings of fear, highlighting another positive aspect of improved iron status.
However, the results were more mixed in the later stages of pregnancy. While improvements in transferrin saturation from the second to the third trimester were connected to greater anxiety and a decline in quality of life, the initial positive effects underline the importance of monitoring and managing iron levels throughout pregnancy.
Overall, our findings hint at a beneficial relationship between iron status and psychosocial wellbeing, particularly in early pregnancy. However, more extensive studies are needed to confirm these promising results and better understand the nuances of this connection.
Findings revealed that improvements in ferritin levels during the first and second trimesters were associated with fewer depressive symptoms and a better overall quality of life. This suggests that boosting iron levels in early pregnancy could potentially benefit mental health. Moreover, we discovered that increases in hemoglobin were linked to reduced anxiety, particularly feelings of fear, highlighting another positive aspect of improved iron status.
However, the results were more mixed in the later stages of pregnancy. While improvements in transferrin saturation from the second to the third trimester were connected to greater anxiety and a decline in quality of life, the initial positive effects underline the importance of monitoring and managing iron levels throughout pregnancy.
Overall, our findings hint at a beneficial relationship between iron status and psychosocial wellbeing, particularly in early pregnancy. However, more extensive studies are needed to confirm these promising results and better understand the nuances of this connection.
7
We undertook a detailed study to examine the effects of iron on major depressive disorder (MDD) and recurrent depression (rMDD) using a method called Mendelian randomisation. This approach allows us to look at how genetic data can help us understand the causal relationships between micronutrient levels and depression.
Our findings suggest that there’s some weak evidence indicating that higher levels of serum iron might actually protect against the risk of experiencing major depression. We observed that with each standard increase in serum iron, the odds of developing rMDD decreased slightly. This implies that maintaining good iron levels could potentially play a role in mood regulation.
However, it's important to note that while we found some positive associations related to iron, our results didn't show a strong or definitive effect of iron or other micronutrients on depression overall. In fact, the study also raised concerns about the possibility of adverse effects from excessive selenium and magnesium levels, which warrants further investigation.
Overall, while iron might have some beneficial associations regarding depression, the evidence isn’t robust enough to recommend supplementation without considering the potential risks involved. Future studies should focus on larger-scale trials to provide clearer insights into the efficacy and safety of micronutrient treatments for depression.
Our findings suggest that there’s some weak evidence indicating that higher levels of serum iron might actually protect against the risk of experiencing major depression. We observed that with each standard increase in serum iron, the odds of developing rMDD decreased slightly. This implies that maintaining good iron levels could potentially play a role in mood regulation.
However, it's important to note that while we found some positive associations related to iron, our results didn't show a strong or definitive effect of iron or other micronutrients on depression overall. In fact, the study also raised concerns about the possibility of adverse effects from excessive selenium and magnesium levels, which warrants further investigation.
Overall, while iron might have some beneficial associations regarding depression, the evidence isn’t robust enough to recommend supplementation without considering the potential risks involved. Future studies should focus on larger-scale trials to provide clearer insights into the efficacy and safety of micronutrient treatments for depression.
8
We investigated how dietary iron intake affects depressive symptoms among adults using data from the National Health and Nutrition Examination Survey. Our analysis revealed that higher iron intake is linked to lower rates of depression.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
References
- Huang S, Guo J, Jiang R, Ma K, Lin F, et al. Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: a nationwide cross-sectional analysis. BMC Public Health. 2024;24:3469. doi:10.1186/s12889-024-20995-8
- Pobee RA, Setorglo J, Klevor M, Murray-Kolb LE. Associations between iron status and psychosocial wellbeing among pregnant women in Cape Coast, Ghana: a longitudinal study. Public Health Nutr. 2024. doi:10.1017/S1368980024002088
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
- Ouyang M, Cui J, Wang H, Liang Z, Pi D, et al. [ alleviates adriamycin-induced depression-like behaviors in mice by reducing ferroptosis in the prefrontal cortex]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:1441. doi:10.12122/j.issn.1673-4254.2024.08.02
- Evanchuk JL, Kozyrskyj A, Vaghef-Mehrabani E, Lamers Y, Giesbrecht GF, et al. Maternal Iron and Vitamin D Status during the Second Trimester Is Associated with Third Trimester Depression Symptoms among Pregnant Participants in the APrON Cohort. J Nutr. 2024;154:174. doi:10.1016/j.tjnut.2023.10.029
- Ciulei MA, Ahluwalia N, McCormick BJJ, Teti DM, Murray-Kolb LE. Iron Deficiency is Related to Depressive Symptoms in United States Nonpregnant Women of Reproductive Age: A Cross-Sectional Analysis of NHANES 2005-2010. J Nutr. 2023;153:3521. doi:10.1016/j.tjnut.2023.09.023
- Zeng T, Li J, Xie L, Dong Z, Chen Q, et al. Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression. J Neuroinflammation. 2023;20:212. doi:10.1186/s12974-023-02875-x
- Tian S, Wu L, Zheng H, Zhong X, Yu X, et al. Body mass index modifies the relationship between dietary iron intake and depressive symptoms among adults: A national population-based cohort. J Affect Disord. 2023;340:907. doi:10.1016/j.jad.2023.08.105
- Jakary A, Lupo JM, Mackin S, Yin A, Murray D, et al. Evaluation of major depressive disorder using 7 Tesla phase sensitive neuroimaging before and after mindfulness-based cognitive therapy. J Affect Disord. 2023;335:383. doi:10.1016/j.jad.2023.05.038
