Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.1
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
9
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Read More
9
We explored the effectiveness of echinochrome A (Ech A) in treating dry mouth, a common issue during menopause, using ovariectomized rats to simulate this condition. The study involved different groups of rats, including those treated with Ech A.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
Read More
8
We explored how iron treatments can address salivary gland issues that often arise after menopause. By observing ovariectomized rats, we found that using deferoxamine and ferrostatin-1 helped reduce inflammation and reverse some damage to the salivary glands.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Read More
Most Useful Reviews
8
Essential supplement
Iron 25 mg: This is not the first time I have ordered this brand. The quality is excellent and the ingredients have been tested for over a year – they are the best. A helpful companion for women during menopause – a necessary supplement. I have been purchasing it for many years as I am very satisfied with the quality... I will order this product again. Its efficiency and the improvement in health work for any age. The size of the packaging lasts a long time. I am pleased.
Read More
8
Doctor's recommendation
Good for maintaining iron levels in the blood. My gynaecologist prescribed me this product for menopause. I really like it.
Read More
7.5
Improved irregularity
I keep eating. I'm in my mid-40s, and since experiencing menopause, I have been taking evening primrose oil along with iron. My menstrual irregularity has improved slightly, and it feels like it is easing. I will continue to take it consistently.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.1
- All Researches
9
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Read More
9
We explored the effectiveness of echinochrome A (Ech A) in treating dry mouth, a common issue during menopause, using ovariectomized rats to simulate this condition. The study involved different groups of rats, including those treated with Ech A.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
Read More
8
We looked into how iron levels affect cognitive performance in women experiencing menopause. Our research involved non-anemic women who had either low or normal iron levels for their age and background. They provided blood samples, underwent MRI scans to assess brain iron levels, and participated in cognitive tasks while we recorded their brain activity through EEG.
What we found was quite interesting. Higher iron status in these women was linked to better cognitive performance and improved brain activity. This included benefits associated with oxygen transport, which is crucial for brain function. However, we didn’t discover any direct connections between iron levels in the blood and the iron present in the brain.
Despite the lack of a clear relationship between systemic and brain iron, our findings suggest that addressing low iron levels during the menopausal transition may help reduce the cognitive struggles, often referred to as "brain fog," that many women experience during this time. So, while the study didn’t evaluate specific iron treatments, it opens the door to thinking about iron status as a factor worth considering for overall cognitive health in menopausal women.
What we found was quite interesting. Higher iron status in these women was linked to better cognitive performance and improved brain activity. This included benefits associated with oxygen transport, which is crucial for brain function. However, we didn’t discover any direct connections between iron levels in the blood and the iron present in the brain.
Despite the lack of a clear relationship between systemic and brain iron, our findings suggest that addressing low iron levels during the menopausal transition may help reduce the cognitive struggles, often referred to as "brain fog," that many women experience during this time. So, while the study didn’t evaluate specific iron treatments, it opens the door to thinking about iron status as a factor worth considering for overall cognitive health in menopausal women.
Read More
8
We explored how iron treatments can address salivary gland issues that often arise after menopause. By observing ovariectomized rats, we found that using deferoxamine and ferrostatin-1 helped reduce inflammation and reverse some damage to the salivary glands.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Read More
8
Impact of periodontal therapy on ferritin
We investigated the impact of non-surgical periodontal therapy on serum ferritin levels in postmenopausal women dealing with chronic periodontitis.
In our cross-sectional study with 38 women, we measured ferritin levels and periodontal health before and three months after treatment.
Interestingly, we found that serum ferritin decreased significantly from 108.55 mcg/L to 98.28 mcg/L after therapy.
Alongside this, improvements in gum health were also noteworthy, showcasing that periodontal care can play an essential role in managing ferritin levels post-menopause.
In our cross-sectional study with 38 women, we measured ferritin levels and periodontal health before and three months after treatment.
Interestingly, we found that serum ferritin decreased significantly from 108.55 mcg/L to 98.28 mcg/L after therapy.
Alongside this, improvements in gum health were also noteworthy, showcasing that periodontal care can play an essential role in managing ferritin levels post-menopause.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
8
Essential supplement
Iron 25 mg: This is not the first time I have ordered this brand. The quality is excellent and the ingredients have been tested for over a year – they are the best. A helpful companion for women during menopause – a necessary supplement. I have been purchasing it for many years as I am very satisfied with the quality... I will order this product again. Its efficiency and the improvement in health work for any age. The size of the packaging lasts a long time. I am pleased.
Read More
8
Doctor's recommendation
Good for maintaining iron levels in the blood. My gynaecologist prescribed me this product for menopause. I really like it.
Read More
7.5
Improved irregularity
I keep eating. I'm in my mid-40s, and since experiencing menopause, I have been taking evening primrose oil along with iron. My menstrual irregularity has improved slightly, and it feels like it is easing. I will continue to take it consistently.
Read More
6
Noticeable boost
Gentle and not constipating: I don’t use this product often as I am in menopause and do not have monthly blood loss. However, when I feel run down or extremely fatigued, I add this to my B-complex, Folic Acid, and sublingual B12, and I notice a significant pick-me-up. It’s nice to have it on standby.
Read More
Frequently Asked Questions
6
Noticeable boost
Gentle and not constipating: I don’t use this product often as I am in menopause and do not have monthly blood loss. However, when I feel run down or extremely fatigued, I add this to my B-complex, Folic Acid, and sublingual B12, and I notice a significant pick-me-up. It’s nice to have it on standby.
7.5
Improved irregularity
I keep eating. I'm in my mid-40s, and since experiencing menopause, I have been taking evening primrose oil along with iron. My menstrual irregularity has improved slightly, and it feels like it is easing. I will continue to take it consistently.
8
Essential supplement
Iron 25 mg: This is not the first time I have ordered this brand. The quality is excellent and the ingredients have been tested for over a year – they are the best. A helpful companion for women during menopause – a necessary supplement. I have been purchasing it for many years as I am very satisfied with the quality... I will order this product again. Its efficiency and the improvement in health work for any age. The size of the packaging lasts a long time. I am pleased.
8
Doctor's recommendation
Good for maintaining iron levels in the blood. My gynaecologist prescribed me this product for menopause. I really like it.
8
We looked into how iron levels affect cognitive performance in women experiencing menopause. Our research involved non-anemic women who had either low or normal iron levels for their age and background. They provided blood samples, underwent MRI scans to assess brain iron levels, and participated in cognitive tasks while we recorded their brain activity through EEG.
What we found was quite interesting. Higher iron status in these women was linked to better cognitive performance and improved brain activity. This included benefits associated with oxygen transport, which is crucial for brain function. However, we didn’t discover any direct connections between iron levels in the blood and the iron present in the brain.
Despite the lack of a clear relationship between systemic and brain iron, our findings suggest that addressing low iron levels during the menopausal transition may help reduce the cognitive struggles, often referred to as "brain fog," that many women experience during this time. So, while the study didn’t evaluate specific iron treatments, it opens the door to thinking about iron status as a factor worth considering for overall cognitive health in menopausal women.
What we found was quite interesting. Higher iron status in these women was linked to better cognitive performance and improved brain activity. This included benefits associated with oxygen transport, which is crucial for brain function. However, we didn’t discover any direct connections between iron levels in the blood and the iron present in the brain.
Despite the lack of a clear relationship between systemic and brain iron, our findings suggest that addressing low iron levels during the menopausal transition may help reduce the cognitive struggles, often referred to as "brain fog," that many women experience during this time. So, while the study didn’t evaluate specific iron treatments, it opens the door to thinking about iron status as a factor worth considering for overall cognitive health in menopausal women.
7
We examined the connection between iron levels and cognitive performance in women going through menopause. Non-anemic participants, with varying iron levels, provided blood samples and completed cognitive tests while brain scans measured iron content.
Our findings revealed that higher iron levels were linked to improved cognitive abilities. However, we did not observe a direct relationship between systemic iron and brain iron levels.
This suggests that increasing iron might be a viable strategy to help combat the "brain fog" that often accompanies menopause.
Our findings revealed that higher iron levels were linked to improved cognitive abilities. However, we did not observe a direct relationship between systemic iron and brain iron levels.
This suggests that increasing iron might be a viable strategy to help combat the "brain fog" that often accompanies menopause.
9
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
7
We explored the relationship between iron accumulation and the effectiveness of hormone replacement therapy (HRT) in postmenopausal women facing atherosclerosis.
Our findings indicated that excess iron can hinder estrogen receptor activity, reducing the effectiveness of HRT.
In a mouse model, we noted that combining estradiol treatment with iron further diminished estrogen receptor expression and worsened atherosclerosis.
Interestingly, iron chelation showed promise in alleviating the issues caused by HRT ineffectiveness in late postmenopausal stages. Thus, managing iron levels may enhance HRT benefits for some women.
Our findings indicated that excess iron can hinder estrogen receptor activity, reducing the effectiveness of HRT.
In a mouse model, we noted that combining estradiol treatment with iron further diminished estrogen receptor expression and worsened atherosclerosis.
Interestingly, iron chelation showed promise in alleviating the issues caused by HRT ineffectiveness in late postmenopausal stages. Thus, managing iron levels may enhance HRT benefits for some women.
References
- Barnett AL, Wenger MJ, Miles P, Wu D, Isingizwe ZR, et al. Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause. medRxiv. 2025. doi:10.1101/2025.01.28.25321122
- Honari N, Sayadi M, Sajjadi SM, Solhjoo S, Sarab GA. Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation. Sci Rep. 2025;15:2449. doi:10.1038/s41598-025-86333-z
- Barnett AL, Wenger MJ, Miles P, Wu D, Isingizwe ZR, et al. Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause. Nutrients. 2025;17. doi:10.3390/nu17050745
- Kastrati L, Groothof D, Quezada-Pinedo HG, Raeisi-Dehkordi H, Bally L, et al. Utility of iron biomarkers in differentiating menopausal status: Findings from CoLaus and PREVEND. Maturitas. 2024;179:107872. doi:10.1016/j.maturitas.2023.107872
- Xu T, Cai J, Wang L, Xu L, Zhao H, et al. Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition. Elife. 2023;12. doi:10.7554/eLife.80494
- Cheon YI, Kim JM, Shin SC, Kim HS, Lee JC, et al. Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats. Aging (Albany NY). 2023;15:2418. doi:10.18632/aging.204641
- Kim JM, Shin SC, Cheon YI, Kim HS, Park GC, et al. Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats. Mar Drugs. 2022;20. doi:10.3390/md20120729
- Faramarzi M, Shirmohammadi A, Khorramdel A, Sadighi M, Bargahi E. Effect of non-surgical periodontal therapy on serum ferritin levels in postmenopausal women with chronic periodontitis. J Dent Res Dent Clin Dent Prospects. 2021;15:178. doi:10.34172/joddd.2021.030
- Liu LL, Liu GW, Liu H, Zhao K, Xu YJ. Iron accumulation deteriorated bone loss in estrogen-deficient rats. J Orthop Surg Res. 2021;16:525. doi:10.1186/s13018-021-02663-4
