Our exploration centered on how a specific compound derived from l-lysine, known as G2 dendrimer, influences Cutibacterium acnes, the bacteria linked to acne vulgaris. We found that this compound can alter the behavior of acneic strains of C. acnes by changing their membrane fluidity and reducing biofilm formation. Interestingly, it does not have the same effects on non-acneic strains, indicating a targeted action.
In our investigations using skin samples, we observed that G2 dendrimer significantly lowers indicators of inflammation, such as IL1α and TLR-2, and promotes better skin cell turnover after colonization by acneic strains. To solidify our findings, we performed a 28-day treatment with a G2 cream and measured changes in bacteria diversity through metagenomic analysis.
The results showed not only an increase in the diversity of C. acnes strains but also a shift regarding the balance between different phylotypes associated with acne. Overall, our findings highlight the potential for using gentle, soft compounds like the G2 dendrimer as a new strategy to manage and possibly prevent acne outbreaks by modifying the bacterial population on the skin.