Last update
3/16/2026
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Infographics
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
L-Lysine (as L-lysine HCl) (Free Form)
500 mg
**
Top Medical Research Studies
9
We explored the effects of G2 lysine dendrimer on acne and how it can help restore balance to our skin microbiome. Acne is a persistent skin condition that brings about discomfort and concerns for many. Traditional treatments can often lose their effectiveness over time or lead to unwanted side effects. So, our goal was to see if this new approach could offer a gentler solution.
Our focus was on how G2 dendrimer specifically targets the troublesome bacteria associated with acne while preserving the healthy bacteria we rely on for healthy skin. Through our studies, we found that G2 dendrimer notably reduced inflammatory markers linked to acne, such as IL-8. What’s more, it didn’t harm the beneficial bacteria on the skin, which is essential for maintaining overall skin health.
We also conducted comparisons with standard over-the-counter treatments. The G2 dendrimer showed promising results in both limiting acne outbreaks and supporting the survival of good bacteria. Through metagenomic analysis, we confirmed that using G2 in a cosmetic product can effectively help rebalance the acne-prone microbiota without disrupting the friendly bacteria.
Overall, these findings highlight the potential of G2 lysine dendrimer as a non-aggressive option for acne prevention while respecting our skin's natural microbiome.
Our focus was on how G2 dendrimer specifically targets the troublesome bacteria associated with acne while preserving the healthy bacteria we rely on for healthy skin. Through our studies, we found that G2 dendrimer notably reduced inflammatory markers linked to acne, such as IL-8. What’s more, it didn’t harm the beneficial bacteria on the skin, which is essential for maintaining overall skin health.
We also conducted comparisons with standard over-the-counter treatments. The G2 dendrimer showed promising results in both limiting acne outbreaks and supporting the survival of good bacteria. Through metagenomic analysis, we confirmed that using G2 in a cosmetic product can effectively help rebalance the acne-prone microbiota without disrupting the friendly bacteria.
Overall, these findings highlight the potential of G2 lysine dendrimer as a non-aggressive option for acne prevention while respecting our skin's natural microbiome.
Read More
8
Our exploration centered on how a specific compound derived from l-lysine, known as G2 dendrimer, influences Cutibacterium acnes, the bacteria linked to acne vulgaris. We found that this compound can alter the behavior of acneic strains of C. acnes by changing their membrane fluidity and reducing biofilm formation. Interestingly, it does not have the same effects on non-acneic strains, indicating a targeted action.
In our investigations using skin samples, we observed that G2 dendrimer significantly lowers indicators of inflammation, such as IL1α and TLR-2, and promotes better skin cell turnover after colonization by acneic strains. To solidify our findings, we performed a 28-day treatment with a G2 cream and measured changes in bacteria diversity through metagenomic analysis.
The results showed not only an increase in the diversity of C. acnes strains but also a shift regarding the balance between different phylotypes associated with acne. Overall, our findings highlight the potential for using gentle, soft compounds like the G2 dendrimer as a new strategy to manage and possibly prevent acne outbreaks by modifying the bacterial population on the skin.
In our investigations using skin samples, we observed that G2 dendrimer significantly lowers indicators of inflammation, such as IL1α and TLR-2, and promotes better skin cell turnover after colonization by acneic strains. To solidify our findings, we performed a 28-day treatment with a G2 cream and measured changes in bacteria diversity through metagenomic analysis.
The results showed not only an increase in the diversity of C. acnes strains but also a shift regarding the balance between different phylotypes associated with acne. Overall, our findings highlight the potential for using gentle, soft compounds like the G2 dendrimer as a new strategy to manage and possibly prevent acne outbreaks by modifying the bacterial population on the skin.
Read More
Most Useful Reviews
10
Hormonal acne cure
15 people found this helpful
Cures hormonal acne! I’ve been amazed by this supplement. After struggling with hormonal acne for two years, I found that it has practically cured my cystic pimples. Despite being cautious with my diet, the breakouts stopped once I began taking this. I went for the 500 mg size since I have trouble swallowing large pills, and one a day does the trick.
Read More
8
Reduced acne
This is a genuine find for those experiencing hair loss. It enhances the condition of my nails and skin. My teenage daughter and I have noticed significantly less acne, and our skin has noticeably improved. My hair, which was previously falling out, has become thicker!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
We explored the effects of G2 lysine dendrimer on acne and how it can help restore balance to our skin microbiome. Acne is a persistent skin condition that brings about discomfort and concerns for many. Traditional treatments can often lose their effectiveness over time or lead to unwanted side effects. So, our goal was to see if this new approach could offer a gentler solution.
Our focus was on how G2 dendrimer specifically targets the troublesome bacteria associated with acne while preserving the healthy bacteria we rely on for healthy skin. Through our studies, we found that G2 dendrimer notably reduced inflammatory markers linked to acne, such as IL-8. What’s more, it didn’t harm the beneficial bacteria on the skin, which is essential for maintaining overall skin health.
We also conducted comparisons with standard over-the-counter treatments. The G2 dendrimer showed promising results in both limiting acne outbreaks and supporting the survival of good bacteria. Through metagenomic analysis, we confirmed that using G2 in a cosmetic product can effectively help rebalance the acne-prone microbiota without disrupting the friendly bacteria.
Overall, these findings highlight the potential of G2 lysine dendrimer as a non-aggressive option for acne prevention while respecting our skin's natural microbiome.
Our focus was on how G2 dendrimer specifically targets the troublesome bacteria associated with acne while preserving the healthy bacteria we rely on for healthy skin. Through our studies, we found that G2 dendrimer notably reduced inflammatory markers linked to acne, such as IL-8. What’s more, it didn’t harm the beneficial bacteria on the skin, which is essential for maintaining overall skin health.
We also conducted comparisons with standard over-the-counter treatments. The G2 dendrimer showed promising results in both limiting acne outbreaks and supporting the survival of good bacteria. Through metagenomic analysis, we confirmed that using G2 in a cosmetic product can effectively help rebalance the acne-prone microbiota without disrupting the friendly bacteria.
Overall, these findings highlight the potential of G2 lysine dendrimer as a non-aggressive option for acne prevention while respecting our skin's natural microbiome.
Read More
8
Our exploration centered on how a specific compound derived from l-lysine, known as G2 dendrimer, influences Cutibacterium acnes, the bacteria linked to acne vulgaris. We found that this compound can alter the behavior of acneic strains of C. acnes by changing their membrane fluidity and reducing biofilm formation. Interestingly, it does not have the same effects on non-acneic strains, indicating a targeted action.
In our investigations using skin samples, we observed that G2 dendrimer significantly lowers indicators of inflammation, such as IL1α and TLR-2, and promotes better skin cell turnover after colonization by acneic strains. To solidify our findings, we performed a 28-day treatment with a G2 cream and measured changes in bacteria diversity through metagenomic analysis.
The results showed not only an increase in the diversity of C. acnes strains but also a shift regarding the balance between different phylotypes associated with acne. Overall, our findings highlight the potential for using gentle, soft compounds like the G2 dendrimer as a new strategy to manage and possibly prevent acne outbreaks by modifying the bacterial population on the skin.
In our investigations using skin samples, we observed that G2 dendrimer significantly lowers indicators of inflammation, such as IL1α and TLR-2, and promotes better skin cell turnover after colonization by acneic strains. To solidify our findings, we performed a 28-day treatment with a G2 cream and measured changes in bacteria diversity through metagenomic analysis.
The results showed not only an increase in the diversity of C. acnes strains but also a shift regarding the balance between different phylotypes associated with acne. Overall, our findings highlight the potential for using gentle, soft compounds like the G2 dendrimer as a new strategy to manage and possibly prevent acne outbreaks by modifying the bacterial population on the skin.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Hormonal acne cure
15 people found this helpful
Cures hormonal acne! I’ve been amazed by this supplement. After struggling with hormonal acne for two years, I found that it has practically cured my cystic pimples. Despite being cautious with my diet, the breakouts stopped once I began taking this. I went for the 500 mg size since I have trouble swallowing large pills, and one a day does the trick.
Read More
8
Reduced acne
This is a genuine find for those experiencing hair loss. It enhances the condition of my nails and skin. My teenage daughter and I have noticed significantly less acne, and our skin has noticeably improved. My hair, which was previously falling out, has become thicker!
Read More
Frequently Asked Questions
8
Reduced acne
This is a genuine find for those experiencing hair loss. It enhances the condition of my nails and skin. My teenage daughter and I have noticed significantly less acne, and our skin has noticeably improved. My hair, which was previously falling out, has become thicker!
9
We explored the effects of G2 lysine dendrimer on acne and how it can help restore balance to our skin microbiome. Acne is a persistent skin condition that brings about discomfort and concerns for many. Traditional treatments can often lose their effectiveness over time or lead to unwanted side effects. So, our goal was to see if this new approach could offer a gentler solution.
Our focus was on how G2 dendrimer specifically targets the troublesome bacteria associated with acne while preserving the healthy bacteria we rely on for healthy skin. Through our studies, we found that G2 dendrimer notably reduced inflammatory markers linked to acne, such as IL-8. What’s more, it didn’t harm the beneficial bacteria on the skin, which is essential for maintaining overall skin health.
We also conducted comparisons with standard over-the-counter treatments. The G2 dendrimer showed promising results in both limiting acne outbreaks and supporting the survival of good bacteria. Through metagenomic analysis, we confirmed that using G2 in a cosmetic product can effectively help rebalance the acne-prone microbiota without disrupting the friendly bacteria.
Overall, these findings highlight the potential of G2 lysine dendrimer as a non-aggressive option for acne prevention while respecting our skin's natural microbiome.
Our focus was on how G2 dendrimer specifically targets the troublesome bacteria associated with acne while preserving the healthy bacteria we rely on for healthy skin. Through our studies, we found that G2 dendrimer notably reduced inflammatory markers linked to acne, such as IL-8. What’s more, it didn’t harm the beneficial bacteria on the skin, which is essential for maintaining overall skin health.
We also conducted comparisons with standard over-the-counter treatments. The G2 dendrimer showed promising results in both limiting acne outbreaks and supporting the survival of good bacteria. Through metagenomic analysis, we confirmed that using G2 in a cosmetic product can effectively help rebalance the acne-prone microbiota without disrupting the friendly bacteria.
Overall, these findings highlight the potential of G2 lysine dendrimer as a non-aggressive option for acne prevention while respecting our skin's natural microbiome.
8
Our exploration centered on how a specific compound derived from l-lysine, known as G2 dendrimer, influences Cutibacterium acnes, the bacteria linked to acne vulgaris. We found that this compound can alter the behavior of acneic strains of C. acnes by changing their membrane fluidity and reducing biofilm formation. Interestingly, it does not have the same effects on non-acneic strains, indicating a targeted action.
In our investigations using skin samples, we observed that G2 dendrimer significantly lowers indicators of inflammation, such as IL1α and TLR-2, and promotes better skin cell turnover after colonization by acneic strains. To solidify our findings, we performed a 28-day treatment with a G2 cream and measured changes in bacteria diversity through metagenomic analysis.
The results showed not only an increase in the diversity of C. acnes strains but also a shift regarding the balance between different phylotypes associated with acne. Overall, our findings highlight the potential for using gentle, soft compounds like the G2 dendrimer as a new strategy to manage and possibly prevent acne outbreaks by modifying the bacterial population on the skin.
In our investigations using skin samples, we observed that G2 dendrimer significantly lowers indicators of inflammation, such as IL1α and TLR-2, and promotes better skin cell turnover after colonization by acneic strains. To solidify our findings, we performed a 28-day treatment with a G2 cream and measured changes in bacteria diversity through metagenomic analysis.
The results showed not only an increase in the diversity of C. acnes strains but also a shift regarding the balance between different phylotypes associated with acne. Overall, our findings highlight the potential for using gentle, soft compounds like the G2 dendrimer as a new strategy to manage and possibly prevent acne outbreaks by modifying the bacterial population on the skin.
References
- Leignadier J, Drago M, Lesouhaitier O, Barreau M, Dashi A, et al. Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin. Pharmaceutics. 2023;15. 10.3390/pharmaceutics15082083
- Attia-Vigneau J, Barreau M, Le Toquin E, Feuilloley MGJ, Loing E, et al. Polylysine dendrigraft is able to differentially impact Cutibacterium acnes strains preventing acneic skin. Exp Dermatol. 2022;31:1056. 10.1111/exd.14554
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