Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Medium or Average
Based on 5 Reviews
6.9
Supplement Facts
Serving Size: 2 Tablets
Serving Per Container: 30
Amount Per Serving
%DV
Magnesium (as magnesium citrate)
400 mg
95%
Sodium
10 mg
<1%
Top Medical Research Studies
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
Most Useful Reviews
0
Bad lot experience
4 people found this helpful
I have taken this magnesium for years and been very satisfied. Recently, however, I had a dreadful experience with lot# 264292-05 EXP 03/2022. It was bitter and felt like it was burning my mouth, resulting in horrible heartburn afterward. I hope it was just this particular lot and not a sign of decline in product quality.
Read More
0
Causes heartburn
The pellets are rather large, making them difficult to consume, and can lead to heartburn and stomachaches.
Read More
9
No drowsiness effect
5 people found this helpful
It creates a wonderful effect without causing any drowsiness, heartburn, or other unnecessary side effects!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
- All Researches
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
7
We investigated how different types of mineral waters might assist in treating patients with gastroesophageal reflux disease (GERD). Ninety patients were split into three groups: a control group receiving standard treatment, one group drinking boric sodium bicarbonate water, and another consuming highly mineralized sodium-magnesium water.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
Read More
7
We investigated the effectiveness of dietary changes and natural remedies in treating gastrointestinal symptoms in a 73-year-old woman with newly diagnosed Parkinson's disease. The patient faced constipation and acid reflux after starting medication. By increasing her vegetable intake, fiber, protein, and hydration while reducing sugars, she saw improvements in her symptoms. Notably, integrating apple cider vinegar, deglycyrrhizinated licorice, probiotics, and magnesium citrate helped alleviate her acid reflux significantly—50% improvement within just five days. Ultimately, she achieved complete symptom resolution in one month, highlighting the promise of diet and natural treatments.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 5 Reviews
6.9
- All Reviews
- Positive Reviews
- Negative Reviews
0
Bad lot experience
4 people found this helpful
I have taken this magnesium for years and been very satisfied. Recently, however, I had a dreadful experience with lot# 264292-05 EXP 03/2022. It was bitter and felt like it was burning my mouth, resulting in horrible heartburn afterward. I hope it was just this particular lot and not a sign of decline in product quality.
Read More
0
Causes heartburn
The pellets are rather large, making them difficult to consume, and can lead to heartburn and stomachaches.
Read More
9
No drowsiness effect
5 people found this helpful
It creates a wonderful effect without causing any drowsiness, heartburn, or other unnecessary side effects!
Read More
4
No effect noted
2 people found this helpful
I evaluated other reviews and decided to try these capsules, but I followed the directions and encountered issues. As soon as I lay down, I felt acid reflux and heartburn, making it impossible to rest. I hope to adjust to them, as they were recommended by my doctor, but if the heartburn persists, I may switch brands or doses.
Read More
2
Looking for alternatives
I experience heartburn when using this product, and the tablets are too large. However, it works reasonably well, and I am looking for another brand.
Read More
Frequently Asked Questions
9
No drowsiness effect
5 people found this helpful
It creates a wonderful effect without causing any drowsiness, heartburn, or other unnecessary side effects!
0
Bad lot experience
4 people found this helpful
I have taken this magnesium for years and been very satisfied. Recently, however, I had a dreadful experience with lot# 264292-05 EXP 03/2022. It was bitter and felt like it was burning my mouth, resulting in horrible heartburn afterward. I hope it was just this particular lot and not a sign of decline in product quality.
2
Looking for alternatives
I experience heartburn when using this product, and the tablets are too large. However, it works reasonably well, and I am looking for another brand.
0
Causes heartburn
The pellets are rather large, making them difficult to consume, and can lead to heartburn and stomachaches.
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
7
We investigated the effectiveness of dietary changes and natural remedies in treating gastrointestinal symptoms in a 73-year-old woman with newly diagnosed Parkinson's disease. The patient faced constipation and acid reflux after starting medication. By increasing her vegetable intake, fiber, protein, and hydration while reducing sugars, she saw improvements in her symptoms. Notably, integrating apple cider vinegar, deglycyrrhizinated licorice, probiotics, and magnesium citrate helped alleviate her acid reflux significantly—50% improvement within just five days. Ultimately, she achieved complete symptom resolution in one month, highlighting the promise of diet and natural treatments.
7
Our observational study focused on 40 patients suffering from gastroesophageal reflux disease (GERD) treated with a gel combining sodium hyaluronic acid and magnesium alginate. This gel works to hydrate and protect the mucosal tissues in the digestive tract.
We split our patients into two groups: one receiving the gel and the other using conventional treatments alongside proton pump inhibitors. Throughout the follow-up, many reported a significant reduction in heartburn symptoms, with some patients finding relief in just five days.
While the results are encouraging, further research is needed to fully understand the extent of magnesium’s benefits in treating GERD.
We split our patients into two groups: one receiving the gel and the other using conventional treatments alongside proton pump inhibitors. Throughout the follow-up, many reported a significant reduction in heartburn symptoms, with some patients finding relief in just five days.
While the results are encouraging, further research is needed to fully understand the extent of magnesium’s benefits in treating GERD.
References
- Raj JP, Saxena U, Belhekar MN, Mamde A, Darak H, et al. Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. Complement Med Res. 2025;32:26. doi:10.1159/000543367
- Kim Y, Bae S, Jeon I, Kwon J, Hong SH, et al. Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to the Enteric-Coated Esomeprazole. Clin Ther. 2024;46:870. doi:10.1016/j.clinthera.2024.08.006
- Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, et al. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2020;66:225. doi:10.23736/S1121-421X.20.02601-X
- Neiworth-Petshow EM, Baldwin-Sayre C. Naturopathic Treatment of Gastrointestinal Dysfunction in the Setting of Parkinson's Disease. Integr Med (Encinitas). 2018;17:44.
- Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.
- Aragona SE, Mereghetti G, Bianchetti M, Mangiavillano B, Zurlo T, et al. Regenerative medicine in the treatment of gastro-esophageal reflux disease and laryngo-pharyngeal reflux. From research to cure. J Biol Regul Homeost Agents. 2017;31:207.
