Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Read More
7
Magnesium reduces brain injury markers
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
Read More
9.5
Magnesium's role in brain tumor treatment
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Read More
Most Useful Reviews
9
Improves wellbeing
Significantly enhances well-being and sleep, with a positive impact on brain function.
Read More
8
Excellent nutrition
Excellent! It's outstanding nutrition for the brain, aiding thinking and immunity. I adore Solgar.
Read More
7.5
Reduces stress
Magnesium-B6 reduces stress by promoting the production of gamma-aminobutyric acid (GABA), an amino acid beneficial for brain metabolism and the central nervous system. Additionally, magnesium increases melatonin production, essential for improving sleep. As melatonin is a precursor to serotonin, it also helps enhance mood, aiding in overcoming depression. I highly recommend purchasing the magnesium from Solgar!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.1
- All Researches
9.5
Magnesium's role in brain tumor treatment
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Read More
8
We explored how magnesium sulfide nanoparticles (MgS NPs) affect the SH-SY5Y neuroblastoma cell line, which is a significant challenge in treating brain cancer. Using a green synthesis method, we created MgS NPs and tested their effects in cultured cells.
When applied at various doses, we observed that 75 µg/mL MgS NPs reduced cancer cell viability by nearly half. The treatment also increased oxidant levels in the cells, aligning with our findings from cytotoxicity tests. Overall, it appears that MgS NPs effectively hinder the growth of neuroblastoma cells.
When applied at various doses, we observed that 75 µg/mL MgS NPs reduced cancer cell viability by nearly half. The treatment also increased oxidant levels in the cells, aligning with our findings from cytotoxicity tests. Overall, it appears that MgS NPs effectively hinder the growth of neuroblastoma cells.
Read More
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Read More
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Read More
7
Magnesium reduces brain injury markers
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves wellbeing
Significantly enhances well-being and sleep, with a positive impact on brain function.
Read More
8
Excellent nutrition
Excellent! It's outstanding nutrition for the brain, aiding thinking and immunity. I adore Solgar.
Read More
7.5
Reduces stress
Magnesium-B6 reduces stress by promoting the production of gamma-aminobutyric acid (GABA), an amino acid beneficial for brain metabolism and the central nervous system. Additionally, magnesium increases melatonin production, essential for improving sleep. As melatonin is a precursor to serotonin, it also helps enhance mood, aiding in overcoming depression. I highly recommend purchasing the magnesium from Solgar!
Read More
7.5
Enhances memory
A very good magnesium supplement for brain function! It has improved my memory and concentration.
Read More
6
Helps neurological diseases
This product's formulation includes microcrystalline cellulose and vegetable ingredients, free of gluten and other allergens. Magnesium significantly benefits nerve cells in the brain and is effective for bipolar disorder and various neurological conditions.
Read More
Frequently Asked Questions
9
Improves wellbeing
Significantly enhances well-being and sleep, with a positive impact on brain function.
7.5
Enhances memory
A very good magnesium supplement for brain function! It has improved my memory and concentration.
7.5
Reduces stress
Magnesium-B6 reduces stress by promoting the production of gamma-aminobutyric acid (GABA), an amino acid beneficial for brain metabolism and the central nervous system. Additionally, magnesium increases melatonin production, essential for improving sleep. As melatonin is a precursor to serotonin, it also helps enhance mood, aiding in overcoming depression. I highly recommend purchasing the magnesium from Solgar!
6
Helps neurological diseases
This product's formulation includes microcrystalline cellulose and vegetable ingredients, free of gluten and other allergens. Magnesium significantly benefits nerve cells in the brain and is effective for bipolar disorder and various neurological conditions.
7
Magnesium reduces brain injury markers
We examined how intravenous magnesium sulfate (MgSO4) affects patients undergoing surgery for brain tumors. Sixty patients were divided into two groups: one received magnesium treatment, while the other received a placebo.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
The results showed that magnesium lowered significant protein levels linked to brain injury after surgery. However, it didn’t substantially change the overall functional outcomes for the patients. While MgSO4 appears safe and beneficial in reducing specific markers, more research is necessary to fully grasp magnesium's role in brain injury recovery.
9.5
Magnesium's role in brain tumor treatment
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
References
- Nalci OB, Nadaroglu H, Genc S, Hacimuftuoglu A, Alayli A. The effects of MgS nanoparticles-Cisplatin-bio-conjugate on SH-SY5Y neuroblastoma cell line. Mol Biol Rep. 2020;47:9715. 10.1007/s11033-020-05987-2
- Zappia F, Verzicco I, Simoni R, Ferrari M, Coghi P, et al. Posterior reversible encephalopathy syndrome in an oncological normotensive patient: evidence for a pathogenic role of concomitant low magnesium serum levels and chemotherapy treatment. Acta Biomed. 2020;91:365. 10.23750/abm.v91i2.8685
- Mirrahimi B, Mortazavi A, Nouri M, Ketabchi E, Amirjamshidi A, et al. Effect of magnesium on functional outcome and paraclinical parameters of patients undergoing supratentorial craniotomy for brain tumors: a randomized controlled trial. Acta Neurochir (Wien). 2015;157:985. 10.1007/s00701-015-2376-x
- Moosa NY, Azeem SA, Lodge JK, Cheung W, Ahmed SU. Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures. Int J Mol Sci. 2024;25. 10.3390/ijms251910428
- Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. 10.1080/00207454.2023.2263815
