Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
USERS' SCORE
Good
Based on 12 Reviews
8
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%

Top Medical Research Studies

8
Magnesium intake benefits diabetes patients
We investigated the link between dietary magnesium intake and the risk of heart disease and death in over 149,000 individuals, including those with type 2 diabetes. Through careful analysis over a median of 12 years, we found that higher magnesium intake was associated with significantly lower risks of heart disease and mortality in individuals with diabetes.

However, this benefit wasn't seen in those without diabetes. Our findings highlight the potential for magnesium to play a crucial role in health management for people living with type 2 diabetes, signaling the need for tailored dietary guidance.
Read More
9
Magnesium/Copper sponge accelerates healing
We explored the effectiveness of a chondroitin sulfate sponge designed for managing diabetic wounds. This sponge was created to slowly release magnesium and copper ions, aiming to reduce inflammation and speed up healing.

Our findings showed that this innovative sponge significantly enhanced wound healing by accelerating collagen production and new blood vessel formation.

With an impressive absorption capacity, this sponge provides a promising, advanced method for overcoming the challenges of diabetic wound management and has important clinical implications.
Read More
We looked into how magnesium levels relate to diabetes, specifically focusing on adults with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia. Conducted as a cross-sectional study, we analyzed data from 294 individuals, including T2DM patients, prediabetics, and nondiabetic controls. Our goal was to uncover the prevalence of magnesium deficiency and its potential effects on various metabolic factors.

The findings revealed a striking difference in magnesium levels across the groups. T2DM patients exhibited notably lower magnesium than those with prediabetes and nondiabetic controls. This deficiency was linked to worse metabolic outcomes, including higher fasting glucose and glycated hemoglobin (HbA1c) levels, as well as increased insulin resistance.

We noted a strong negative correlation between magnesium levels and both glucose and HbA1c, suggesting that as magnesium levels decrease, diabetes control worsens. Interestingly, our analysis indicated that magnesium levels could effectively predict higher HbA1c values, highlighting the need for regular monitoring of magnesium in diabetes management.

While our study emphasizes the significant impact of magnesium deficiency on the metabolic health of T2DM patients, it also opens the door for further exploration regarding the benefits of magnesium supplementation in diabetes care. Overall, these insights push us to consider the broader implications of maintaining proper magnesium levels for better diabetes management.
Read More

Most Useful Reviews

9
Enhances insulin sensitivity
3 people found this helpful
I am very pleased with Magnesium combined with Vitamin B6! This product has been a real saviour for me and my family. It has notably aided my family members with diabetes by improving their insulin sensitivity and helping manage their blood sugar levels, making it easier for them to control their condition. Additionally, it offers benefits for other family members, supporting heart health, strengthening bones, and enhancing overall well-being.
Read More
9
Effective combinations
Contains magnesium and B6, which, according to the information available, can effectively treat diabetes.
Read More
7.5
Improves insulin function
Magnesium plays a crucial role in over 300 metabolic reactions, affecting insulin secretion and function. Those with diabetes often have lower magnesium levels, and higher magnesium correlates with better glycated hemoglobin levels. Low plasma magnesium (below 0.80 mmol/l) is linked to disruptions, while high calcium intake can impair magnesium absorption. For individuals at risk of deficiency, it’s advisable to take calcium supplements at night rather than with meals to maintain magnesium levels.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
  • All Researches
9
Magnesium/Copper sponge accelerates healing
We explored the effectiveness of a chondroitin sulfate sponge designed for managing diabetic wounds. This sponge was created to slowly release magnesium and copper ions, aiming to reduce inflammation and speed up healing.

Our findings showed that this innovative sponge significantly enhanced wound healing by accelerating collagen production and new blood vessel formation.

With an impressive absorption capacity, this sponge provides a promising, advanced method for overcoming the challenges of diabetic wound management and has important clinical implications.
Read More
We looked into how magnesium levels relate to diabetes, specifically focusing on adults with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia. Conducted as a cross-sectional study, we analyzed data from 294 individuals, including T2DM patients, prediabetics, and nondiabetic controls. Our goal was to uncover the prevalence of magnesium deficiency and its potential effects on various metabolic factors.

The findings revealed a striking difference in magnesium levels across the groups. T2DM patients exhibited notably lower magnesium than those with prediabetes and nondiabetic controls. This deficiency was linked to worse metabolic outcomes, including higher fasting glucose and glycated hemoglobin (HbA1c) levels, as well as increased insulin resistance.

We noted a strong negative correlation between magnesium levels and both glucose and HbA1c, suggesting that as magnesium levels decrease, diabetes control worsens. Interestingly, our analysis indicated that magnesium levels could effectively predict higher HbA1c values, highlighting the need for regular monitoring of magnesium in diabetes management.

While our study emphasizes the significant impact of magnesium deficiency on the metabolic health of T2DM patients, it also opens the door for further exploration regarding the benefits of magnesium supplementation in diabetes care. Overall, these insights push us to consider the broader implications of maintaining proper magnesium levels for better diabetes management.
Read More
8
Magnesium improves diabetic gastric function
We investigated how magnesium affects diabetes, particularly focusing on its role in gastrointestinal function. In our study, we observed the effects of magnesium supplements in combination with insulin treatment on type 2 diabetic rats. The experiment involved four groups of male Wistar rats, including a control group, a group with diabetes, and two groups receiving magnesium and insulin treatment, respectively.

Our findings showed that in diabetic rats, the levels of certain receptors in the stomach, specifically GABA-A, GABA-B, and NMDA, were significantly altered. Magnesium treatment alone was particularly effective, as it improved both nitric oxide synthase, which is involved in stomach function, and GABA receptor levels, bringing them back towards normal. Meanwhile, insulin treatment showed some positive effects but did not significantly change the NMDA receptor levels.

Overall, our results indicate that magnesium may play a crucial role in enhancing gastric function and could help alleviate gastrointestinal issues often seen in diabetes. While insulin treatment also had benefits, magnesium's effects appeared more pronounced in restoring receptor functions in diabetic rats.
Read More
8
Magnesium promotes diabetic wound healing
We explored the impact of a new sponge treatment for diabetic wounds that blends tranexamic acid with magnesium ions. This multifunctional scaffold, known as PT@Mg, showed promise in reducing inflammation and preventing excessive blood seepage, both common issues in diabetic wounds.

Our findings reveal that the PT@Mg sponge not only absorbs blood but also promotes faster healing by encouraging collagen formation and new blood vessel growth. This indicates that magnesium can effectively aid in diabetic wound healing by enhancing tissue repair and reducing inflammation.
Read More
8
Magnesium may protect liver health
We explored the relationship between dietary magnesium and liver fibrosis in type 2 diabetes patients, using data from the NHANES 2017-2018 survey.

Out of nearly 1,000 participants, we found that higher magnesium intake significantly reduced the odds of liver fibrosis, particularly among those with a history of liver fat accumulation.

These findings suggest that incorporating more magnesium-rich foods or supplements could support liver health in diabetes management. However, further studies are needed to confirm these results.
Read More

User Reviews

USERS' SCORE
Good
Based on 12 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Enhances insulin sensitivity
3 people found this helpful
I am very pleased with Magnesium combined with Vitamin B6! This product has been a real saviour for me and my family. It has notably aided my family members with diabetes by improving their insulin sensitivity and helping manage their blood sugar levels, making it easier for them to control their condition. Additionally, it offers benefits for other family members, supporting heart health, strengthening bones, and enhancing overall well-being.
Read More
9
Effective combinations
Contains magnesium and B6, which, according to the information available, can effectively treat diabetes.
Read More
7.5
Improves insulin function
Magnesium plays a crucial role in over 300 metabolic reactions, affecting insulin secretion and function. Those with diabetes often have lower magnesium levels, and higher magnesium correlates with better glycated hemoglobin levels. Low plasma magnesium (below 0.80 mmol/l) is linked to disruptions, while high calcium intake can impair magnesium absorption. For individuals at risk of deficiency, it’s advisable to take calcium supplements at night rather than with meals to maintain magnesium levels.
Read More
9
Reduces diabetes risk
Magnesium regulates blood pressure, protects heart health, decreases blood clot formation, and diminishes the risk of atherosclerosis and type 2 diabetes. It also aids in muscle contraction, bone health, boosts immunity, and alleviates premenstrual syndrome symptoms.
Read More
7.5
Relieves leg cramps
I have diabetes and suffer from leg cramps, and this product helps me significantly.
Read More

Frequently Asked Questions

9
Enhances insulin sensitivity
3 people found this helpful
I am very pleased with Magnesium combined with Vitamin B6! This product has been a real saviour for me and my family. It has notably aided my family members with diabetes by improving their insulin sensitivity and helping manage their blood sugar levels, making it easier for them to control their condition. Additionally, it offers benefits for other family members, supporting heart health, strengthening bones, and enhancing overall well-being.
7.5
Doctor's recommendation
We order regularly, as my husband has diabetes, and the doctor recommends that he takes it consistently.
7.5
Improves insulin function
Magnesium plays a crucial role in over 300 metabolic reactions, affecting insulin secretion and function. Those with diabetes often have lower magnesium levels, and higher magnesium correlates with better glycated hemoglobin levels. Low plasma magnesium (below 0.80 mmol/l) is linked to disruptions, while high calcium intake can impair magnesium absorption. For individuals at risk of deficiency, it’s advisable to take calcium supplements at night rather than with meals to maintain magnesium levels.
7.5
Relieves leg cramps
I have diabetes and suffer from leg cramps, and this product helps me significantly.
6
Supports energy regulation
Magnesium is vital for numerous systems in the body and biochemical reactions. It works best with Vitamin B6, enhancing each other's effects. Together, they benefit the nervous and muscular systems, especially during stress and insomnia. They also support cardiovascular health and metabolism regulation. This is particularly advantageous for individuals with diabetes, relieving muscles and vessels' spasms while alleviating sleep issues and irritability.
7
Magnesium water enhances metabolic health
We explored the effects of magnesium (Mg) derived from deep ocean sources on adults dealing with hypertension, diabetes, or high cholesterol in a carefully designed clinical trial. Participants consumed either magnesium-enriched water (MEW) with 80 mg of Mg or a placebo containing only 6 mg of Mg daily for four weeks.

Throughout the study, we observed that MEW led to notable improvements in several health markers, such as body mass index (BMI), insulin levels, triglycerides, and fatigue. Interestingly, regardless of magnesium levels in the water, consuming more fluids helped reduce harmful substances in the body, like a byproduct of polycyclic aromatic hydrocarbons (PAHs) and an oxidative stress indicator called malondialdehyde.

Moreover, we noted significant changes in the gut microbiome of those drinking MEW, indicating a more diverse and balanced microbial environment. The presence of beneficial bacteria associated with magnesium intake suggested potential long-term health benefits, implying that MEW could play a role in preventing cardiovascular disease and type 2 diabetes.

Overall, it seems that magnesium-enriched water not only supports metabolic health but may also enhance gut flora, which is crucial for maintaining overall wellness.
We looked into how magnesium levels relate to diabetes, specifically focusing on adults with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia. Conducted as a cross-sectional study, we analyzed data from 294 individuals, including T2DM patients, prediabetics, and nondiabetic controls. Our goal was to uncover the prevalence of magnesium deficiency and its potential effects on various metabolic factors.

The findings revealed a striking difference in magnesium levels across the groups. T2DM patients exhibited notably lower magnesium than those with prediabetes and nondiabetic controls. This deficiency was linked to worse metabolic outcomes, including higher fasting glucose and glycated hemoglobin (HbA1c) levels, as well as increased insulin resistance.

We noted a strong negative correlation between magnesium levels and both glucose and HbA1c, suggesting that as magnesium levels decrease, diabetes control worsens. Interestingly, our analysis indicated that magnesium levels could effectively predict higher HbA1c values, highlighting the need for regular monitoring of magnesium in diabetes management.

While our study emphasizes the significant impact of magnesium deficiency on the metabolic health of T2DM patients, it also opens the door for further exploration regarding the benefits of magnesium supplementation in diabetes care. Overall, these insights push us to consider the broader implications of maintaining proper magnesium levels for better diabetes management.
7
Magnesium's potential in diabetes
We looked into how magnesium (Mg) could potentially influence lipid profiles in individuals living with type 2 diabetes mellitus (T2DM). In our study, thirty participants followed a three-month dietary intervention that emphasized the incorporation of magnesium-rich foods into their diet. This initiative was part of a broader effort to enhance their overall health.

Our findings showed a noteworthy trend: as magnesium intake increased, cholesterol levels, including total cholesterol and low-density lipoprotein cholesterol, tended to decrease. This suggests that magnesium could play a beneficial role in managing lipid levels for those with T2DM. Not only can increasing magnesium be a simple dietary change, but our approach also highlights the importance of nutritional education.

We believe that educating patients on the benefits of magnesium can be an effective, low-cost strategy to improve health and wellness. Our results encourage further research with larger groups to explore how sustainable dietary magnesium interventions can impact life with diabetes over the long term.
7
Magnesium supplements may lower heart risks
We explored how nonprescription magnesium supplements influence heart failure (HF) risk in diabetics. Analyzing a significant cohort of over 94,000 veterans revealed that those taking magnesium showed an 8% lower incidence of HF compared to non-users.

Additionally, magnesium supplement users also experienced a reduced risk of major cardiac events. Although these findings are promising, it's important to note that further randomized controlled trials are needed to confirm these results.

References

  1. Kang H, Lee UJ, Park BY, Kim M, Yang M. Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes. Diabetes Metab Syndr. 2025;19:103203. doi:10.1016/j.dsx.2025.103203
  2. Smithiseth K, Leurcharusmee P, Sawaddiruk P, Chattipakorn N, Chattipakorn S. Unraveling the link between magnesium and diabetic neuropathy: Evidence from in vitro to clinical studies. Nutr Res. 2025;135:13. doi:10.1016/j.nutres.2025.01.005
  3. Al-Daghri NM, Yakout SM, Hussain SD, Alnaami AM, Veronese N, et al. Hypomagnesemia in adults with type 2 diabetes mellitus in Riyadh, Saudi Arabia: A cross-sectional study. Medicine (Baltimore). 2025;104:e41253. doi:10.1097/MD.0000000000041253
  4. Dobrovolska L, Boyarchuk O. Magnesium intake and serum magnesium concentration in children with type 1 diabetes mellitus: association with glycemic control and clinical symptoms. Front Nutr. 2024;11:1477814. doi:10.3389/fnut.2024.1477814
  5. Albajri E, Almasaudi AS, Mosli HH, Hakim NA, Basaqr RO, et al. Assessing the impact of magnesium-based nutritional education on lipid profiles in individuals with type 2 diabetes mellitus: a quasi-experimental study. Diabetol Metab Syndr. 2025;17:3. doi:10.1186/s13098-024-01566-8
  6. Saberi H, Mehranfard N, Rezazadeh H, Ghasemi M. Involvement of γ-Aminobutyric Acid and N-methyl-D-aspartate Receptors in Diabetic Gastropathy in Rats: Possible Beneficial Effect of Prolonged Treatment with Insulin and Magnesium Supplement. Arch Razi Inst. 2024;79:601. doi:10.32592/ARI.2024.79.3.601
  7. Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04476-y
  8. Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. doi:10.1038/s41387-025-00368-9
  9. Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870
  10. Zhu F, Wen Q, Hu Y, Gong J, Zhang X, et al. Chondroitin sulfate sponge scaffold for slow-release Mg/Cu in diabetic wound management: Hemostasis, effusion absorption, and healing. Int J Biol Macromol. 2024;282:137561. doi:10.1016/j.ijbiomac.2024.137561
  11. Khalid S, Bashir S, Mehboob R, Anwar T, Ali M, et al. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus. Front Endocrinol (Lausanne). 2024;15:1370733. doi:10.3389/fendo.2024.1370733
  12. Cao X, Lin L, Wu M, Liu J, Zhong C, et al. Interaction between Dietary Magnesium Intake and Genetic Risk Score on the Risk of Gestational Diabetes. Mol Nutr Food Res. 2024;68:e2400589. doi:10.1002/mnfr.202400589
  13. Li T, Wen Q, Zhu F, Hu Y, Gong J, et al. A tranexamic acid-functionalized acellular dermal matrix sponge co-loaded with magnesium ions: Enhancing hemostasis, vascular regeneration, and re-epithelialization for comprehensive diabetic wound healing. Biomater Adv. 2025;167:214096. doi:10.1016/j.bioadv.2024.214096
  14. Khalid S, Mehboob R, Bokhari SS, Ali M, Shabbir A, et al. Comparative Efficacy of Magnesium and Potassium Towards Cholesterol and Quality of Life in Patients With Type 2 Diabetes Mellitus: A Randomised Single-Blinded Controlled Clinical Trial. Endocrinol Diabetes Metab. 2024;7:e511. doi:10.1002/edm2.511
  15. Alarcón-Moreno JC, Flores-Muñoz M, Blázquez-Morales MSL, García-Rivera ME, Rodríguez-Alba JC, et al. "The effects of non-surgical periodontal treatment plus zinc and magnesium supplementation on oxidative stress and antioxidants enzymes in type 2 diabetes patients: a quasi-experimental study". BMC Oral Health. 2024;24:892. doi:10.1186/s12903-024-04688-7
  16. Chen Y, Weiqin E, Zhou J, He Z. Association between dietary magnesium intake and liver fibrosis among type 2 diabetes mellitus patients: a cross-sectional study from the NHANES database. Magnes Res. 2024;37:33. doi:10.1684/mrh.2024.0527
  17. Chen L, Nie J, Song H, Fu L. Association between dietary magnesium intake and all-cause mortality among patients with diabetic retinopathy: a retrospective cohort study of the NHANES 1999-2018. Magnes Res. 2024;37:22. doi:10.1684/mrh.2024.0525
  18. Huang R, Kong X, Geng R, Wu J, Li J, et al. Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank. Diabetes Metab. 2024;50:101554. doi:10.1016/j.diabet.2024.101554
  19. Rad MG, Sharifi M, Meamar R, Soltani N. Long term administration of thiamine disulfide improves FOXO1/PEPCK pathway in liver to reduce insulin resistance in type 1 diabetes rat model. Biomed Pharmacother. 2024;177:117053. doi:10.1016/j.biopha.2024.117053
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