Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
We explored the impact of a new treatment, MarialĀ®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the MarialĀ® formulation containing magnesium alginate. The results showed that both MarialĀ® and the combination therapy significantly reduced heartburn symptoms, with MarialĀ® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGardĀ® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGardĀ®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGardĀ® or a placebo without knowing which one they had.
Remarkably, those taking GutGardĀ® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGardĀ® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGardĀ® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGardĀ® may offer an effective, safe option for managing heartburn symptoms.
Read More
8
Vitamin B6's role in heartburn
We explored the potential benefits of vitamin B6 on heartburn symptoms, particularly its role in addressing issues tied to what is often referred to as 'Chinese Restaurant Syndrome.' This is a collection of symptoms that can include heartburn, stiffness, and headache, typically triggered by excessive monosodium glutamate intake.
The study highlighted how vitamin B6 supplementation could prevent these symptoms by improving the activity of certain enzymes, specifically glutamic oxaloacetic transaminase, which relies on pyridoxal phosphateāa form of vitamin B6.
While the link between vitamin B6 and heartburn appears promising in the context of this syndrome, itās essential to remember that the report we reviewed is part of a broader discussion on drug interactions and nutritional deficiencies. Thus, while there are indications of vitamin B6's helpful effects, further research would be necessary to affirm its effectiveness as a direct treatment for heartburn on its own.
The study highlighted how vitamin B6 supplementation could prevent these symptoms by improving the activity of certain enzymes, specifically glutamic oxaloacetic transaminase, which relies on pyridoxal phosphateāa form of vitamin B6.
While the link between vitamin B6 and heartburn appears promising in the context of this syndrome, itās essential to remember that the report we reviewed is part of a broader discussion on drug interactions and nutritional deficiencies. Thus, while there are indications of vitamin B6's helpful effects, further research would be necessary to affirm its effectiveness as a direct treatment for heartburn on its own.
Read More
Most Useful Reviews
9
No heartburn issues
Excellent quality! I have used this for a long time and it surpasses local alternatives. Importantly, it does not induce heartburn. The packaging was secure, arriving intact. I highly recommend it.
Read More
9
No discomfort experienced
A good product with a nice composition and convenient size. It does not cause stomach discomfort or heartburn. I plan to purchase more.
Read More
2
Caused heartburn
7 people found this helpful
I took this as an analogue of Magne B6, trusting its reputable brand. I was unaware of magnesium forms and their absorption rates. I later realised that there are better formulations exhibiting superior digestibility. Magnesium oxide, once ingested, acts as a laxative and can reactivate heartburn, which I had long controlled. After experiencing heartburn again, I decided not to continue with this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
- All Researches
9
We explored the impact of a new treatment, MarialĀ®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the MarialĀ® formulation containing magnesium alginate. The results showed that both MarialĀ® and the combination therapy significantly reduced heartburn symptoms, with MarialĀ® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGardĀ® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGardĀ®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGardĀ® or a placebo without knowing which one they had.
Remarkably, those taking GutGardĀ® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGardĀ® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGardĀ® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGardĀ® may offer an effective, safe option for managing heartburn symptoms.
Read More
8
Vitamin B6's role in heartburn
We explored the potential benefits of vitamin B6 on heartburn symptoms, particularly its role in addressing issues tied to what is often referred to as 'Chinese Restaurant Syndrome.' This is a collection of symptoms that can include heartburn, stiffness, and headache, typically triggered by excessive monosodium glutamate intake.
The study highlighted how vitamin B6 supplementation could prevent these symptoms by improving the activity of certain enzymes, specifically glutamic oxaloacetic transaminase, which relies on pyridoxal phosphateāa form of vitamin B6.
While the link between vitamin B6 and heartburn appears promising in the context of this syndrome, itās essential to remember that the report we reviewed is part of a broader discussion on drug interactions and nutritional deficiencies. Thus, while there are indications of vitamin B6's helpful effects, further research would be necessary to affirm its effectiveness as a direct treatment for heartburn on its own.
The study highlighted how vitamin B6 supplementation could prevent these symptoms by improving the activity of certain enzymes, specifically glutamic oxaloacetic transaminase, which relies on pyridoxal phosphateāa form of vitamin B6.
While the link between vitamin B6 and heartburn appears promising in the context of this syndrome, itās essential to remember that the report we reviewed is part of a broader discussion on drug interactions and nutritional deficiencies. Thus, while there are indications of vitamin B6's helpful effects, further research would be necessary to affirm its effectiveness as a direct treatment for heartburn on its own.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
7
We investigated how different types of mineral waters might assist in treating patients with gastroesophageal reflux disease (GERD). Ninety patients were split into three groups: a control group receiving standard treatment, one group drinking boric sodium bicarbonate water, and another consuming highly mineralized sodium-magnesium water.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
No heartburn issues
Excellent quality! I have used this for a long time and it surpasses local alternatives. Importantly, it does not induce heartburn. The packaging was secure, arriving intact. I highly recommend it.
Read More
9
No discomfort experienced
A good product with a nice composition and convenient size. It does not cause stomach discomfort or heartburn. I plan to purchase more.
Read More
2
Caused heartburn
7 people found this helpful
I took this as an analogue of Magne B6, trusting its reputable brand. I was unaware of magnesium forms and their absorption rates. I later realised that there are better formulations exhibiting superior digestibility. Magnesium oxide, once ingested, acts as a laxative and can reactivate heartburn, which I had long controlled. After experiencing heartburn again, I decided not to continue with this product.
Read More
Frequently Asked Questions
9
No heartburn issues
Excellent quality! I have used this for a long time and it surpasses local alternatives. Importantly, it does not induce heartburn. The packaging was secure, arriving intact. I highly recommend it.
9
No discomfort experienced
A good product with a nice composition and convenient size. It does not cause stomach discomfort or heartburn. I plan to purchase more.
2
Caused heartburn
7 people found this helpful
I took this as an analogue of Magne B6, trusting its reputable brand. I was unaware of magnesium forms and their absorption rates. I later realised that there are better formulations exhibiting superior digestibility. Magnesium oxide, once ingested, acts as a laxative and can reactivate heartburn, which I had long controlled. After experiencing heartburn again, I decided not to continue with this product.
8
GutGardĀ® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGardĀ®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGardĀ® or a placebo without knowing which one they had.
Remarkably, those taking GutGardĀ® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGardĀ® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGardĀ® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGardĀ® may offer an effective, safe option for managing heartburn symptoms.
7
Our observational study focused on 40 patients suffering from gastroesophageal reflux disease (GERD) treated with a gel combining sodium hyaluronic acid and magnesium alginate. This gel works to hydrate and protect the mucosal tissues in the digestive tract.
We split our patients into two groups: one receiving the gel and the other using conventional treatments alongside proton pump inhibitors. Throughout the follow-up, many reported a significant reduction in heartburn symptoms, with some patients finding relief in just five days.
While the results are encouraging, further research is needed to fully understand the extent of magnesiumās benefits in treating GERD.
We split our patients into two groups: one receiving the gel and the other using conventional treatments alongside proton pump inhibitors. Throughout the follow-up, many reported a significant reduction in heartburn symptoms, with some patients finding relief in just five days.
While the results are encouraging, further research is needed to fully understand the extent of magnesiumās benefits in treating GERD.
9
We explored the impact of a new treatment, MarialĀ®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the MarialĀ® formulation containing magnesium alginate. The results showed that both MarialĀ® and the combination therapy significantly reduced heartburn symptoms, with MarialĀ® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
References
- Raj JP, Saxena U, Belhekar MN, Mamde A, Darak H, et al. Efficacy and Safety of GutGardĀ® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. Complement Med Res. 2025;32:26. 10.1159/000543367
- Kim Y, Bae S, Jeon I, Kwon J, Hong SH, et al. Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to the Enteric-Coated Esomeprazole. Clin Ther. 2024;46:870. 10.1016/j.clinthera.2024.08.006
- Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, et al. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2020;66:225. 10.23736/S1121-421X.20.02601-X
- Neiworth-Petshow EM, Baldwin-Sayre C. Naturopathic Treatment of Gastrointestinal Dysfunction in the Setting of Parkinson's Disease. Integr Med (Encinitas). 2018;17:44.
- Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.
- Aragona SE, Mereghetti G, Bianchetti M, Mangiavillano B, Zurlo T, et al. Regenerative medicine in the treatment of gastro-esophageal reflux disease and laryngo-pharyngeal reflux. From research to cure. J Biol Regul Homeost Agents. 2017;31:207.
- Ebadi M, Gessert CF, Al-Sayegh A. Drug-pyridoxal phosphate interactions. Q Rev Drug Metab Drug Interact. 1982;4:289.
