Last update
4/8/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
Read More
9
We explored the potential benefits of vitamin B6—specifically pyridoxal-5'-phosphate (PLP)—as a treatment for hypertension, particularly its effect on the hormone angiotensin II. This hormone plays a key role in regulating blood pressure through its vasoconstrictive properties.
Our analysis involved examining how a modified form of angiotensin II, created by PLP, impacted blood pressure in rat models. We noticed that this modification led to reduced calcium ion entry into vascular smooth muscle cells, which is crucial for blood vessel contraction. Additionally, the modified hormone displayed a weaker attachment to its receptor compared to unaltered angiotensin II.
Interestingly, when spontaneously hypertensive rats were treated with PLP, their blood pressure showed a significant decrease. In another test, Wistar Kyoto rats receiving both angiotensin II and PLP did not develop increased blood pressure, suggesting that PLP can mitigate the hypertensive effects of angiotensin II.
This study points towards the potential of vitamin B6 as a cost-effective treatment for high blood pressure. While we see promising results in animal models, further exploration in humans will be essential to confirm these effects.
Our analysis involved examining how a modified form of angiotensin II, created by PLP, impacted blood pressure in rat models. We noticed that this modification led to reduced calcium ion entry into vascular smooth muscle cells, which is crucial for blood vessel contraction. Additionally, the modified hormone displayed a weaker attachment to its receptor compared to unaltered angiotensin II.
Interestingly, when spontaneously hypertensive rats were treated with PLP, their blood pressure showed a significant decrease. In another test, Wistar Kyoto rats receiving both angiotensin II and PLP did not develop increased blood pressure, suggesting that PLP can mitigate the hypertensive effects of angiotensin II.
This study points towards the potential of vitamin B6 as a cost-effective treatment for high blood pressure. While we see promising results in animal models, further exploration in humans will be essential to confirm these effects.
Read More
8
Magnesium effectively lowers blood pressure
We explored how magnesium supplementation can affect systolic blood pressure (SBP) in the general population. Through careful analysis of placebo-controlled, randomized clinical trials, we focused on understanding the optimal dosages and treatment durations necessary to achieve significant reductions in SBP. Past findings revealed that magnesium could reduce SBP by an average of 2.79 mm Hg, and our goal was to dive deeper into these results.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Read More
Most Useful Reviews
9
Supports hypertension management
My excellent husband has hypertension, and I've found this beneficial for his condition.
Read More
7.5
Better sleep quality
1 people found this helpful
Scattered men's socks are no longer a bother ... This medication is regularly prescribed to me by my neurologist due to blood vessel issues and hypertension, particularly in spring and autumn. As this vitamin aids in regulating nerve impulse transmission and muscle contraction, it is particularly beneficial for individuals under stress, both physically and mentally. I've been taking this brand of vitamin for three weeks, and I can say my sleep has improved; I now dream vividly (previously, I was working even in my dreams, but now I dream of travelling across seas and mountains). I find it easier to stay calm at work and I'm no longer irritated by scattered socks or my children's mistakes at school. Truly transformative! I take two capsules daily (morning and evening) with meals.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
- All Researches
9
We conducted a retrospective study to investigate how magnesium sulfate paired with labetalol affects vascular health and pregnancy outcomes in women with preeclampsia—a serious condition that can occur during pregnancy characterized by high blood pressure.
Our analysis focused on clinical data from 262 women treated for preeclampsia. The patients were divided into two groups: one group received magnesium sulfate alone, while the other group was treated with both magnesium sulfate and labetalol. By measuring key indicators such as nitric oxide and endothelin-1 levels, along with blood pressure readings, we aimed to determine the effectiveness of these treatments.
The results showed that the combination of magnesium sulfate and labetalol notably improved vascular function and pregnancy outcomes for these women. Not only did this treatment help in better controlling high blood pressure during pregnancy, but it also reduced the chances of adverse outcomes for both mothers and babies. Importantly, the study found this combined treatment to be as safe as using magnesium sulfate alone.
This reinforces the idea that magnesium can play a significant role in treating hypertension during pregnancy, especially when paired with other medications like labetalol.
Our analysis focused on clinical data from 262 women treated for preeclampsia. The patients were divided into two groups: one group received magnesium sulfate alone, while the other group was treated with both magnesium sulfate and labetalol. By measuring key indicators such as nitric oxide and endothelin-1 levels, along with blood pressure readings, we aimed to determine the effectiveness of these treatments.
The results showed that the combination of magnesium sulfate and labetalol notably improved vascular function and pregnancy outcomes for these women. Not only did this treatment help in better controlling high blood pressure during pregnancy, but it also reduced the chances of adverse outcomes for both mothers and babies. Importantly, the study found this combined treatment to be as safe as using magnesium sulfate alone.
This reinforces the idea that magnesium can play a significant role in treating hypertension during pregnancy, especially when paired with other medications like labetalol.
Read More
9
We examined an experimental model of pulmonary arterial hypertension (PAH) induced by monocrotaline in rats. Our research focused on the combined effects of Magnesium sulfate along with Rosuvastatin and Sildenafil, which were administered two weeks after the initial MCT injection.
Using measures like the Fulton Index and various cardiac dimensions, we observed improvements in right ventricular function and markers of oxidative stress. Notably, Magnesium sulfate appeared to work well with Rosuvastatin, which is known for its anti-inflammatory properties, enhancing the overall treatment effectiveness on pulmonary hypertension.
However, since Magnesium was administered in combination with these other treatments, we could not determine its isolated benefits on hypertension specifically. The study did highlight the importance of multi-pronged approaches in tackling such complex conditions, suggesting that further research might clarify Magnesium's unique contributions to managing hypertension.
Using measures like the Fulton Index and various cardiac dimensions, we observed improvements in right ventricular function and markers of oxidative stress. Notably, Magnesium sulfate appeared to work well with Rosuvastatin, which is known for its anti-inflammatory properties, enhancing the overall treatment effectiveness on pulmonary hypertension.
However, since Magnesium was administered in combination with these other treatments, we could not determine its isolated benefits on hypertension specifically. The study did highlight the importance of multi-pronged approaches in tackling such complex conditions, suggesting that further research might clarify Magnesium's unique contributions to managing hypertension.
Read More
9
We examined a cohort of neonates born at or above 36 weeks gestation to assess the impact of antenatal magnesium sulfate on hypoxic-ischemic encephalopathy linked to hypertensive disorders of pregnancy.
Our analysis revealed that these disorders significantly increase the risk of moderate to severe brain injury. Importantly, we observed that receiving magnesium sulfate reduced the odds of developing hypoxic-ischemic encephalopathy in affected infants.
However, it’s crucial to understand that while our study shows an association, it does not establish a cause-and-effect relationship.
Our analysis revealed that these disorders significantly increase the risk of moderate to severe brain injury. Importantly, we observed that receiving magnesium sulfate reduced the odds of developing hypoxic-ischemic encephalopathy in affected infants.
However, it’s crucial to understand that while our study shows an association, it does not establish a cause-and-effect relationship.
Read More
9
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
Read More
9
We explored the potential benefits of vitamin B6—specifically pyridoxal-5'-phosphate (PLP)—as a treatment for hypertension, particularly its effect on the hormone angiotensin II. This hormone plays a key role in regulating blood pressure through its vasoconstrictive properties.
Our analysis involved examining how a modified form of angiotensin II, created by PLP, impacted blood pressure in rat models. We noticed that this modification led to reduced calcium ion entry into vascular smooth muscle cells, which is crucial for blood vessel contraction. Additionally, the modified hormone displayed a weaker attachment to its receptor compared to unaltered angiotensin II.
Interestingly, when spontaneously hypertensive rats were treated with PLP, their blood pressure showed a significant decrease. In another test, Wistar Kyoto rats receiving both angiotensin II and PLP did not develop increased blood pressure, suggesting that PLP can mitigate the hypertensive effects of angiotensin II.
This study points towards the potential of vitamin B6 as a cost-effective treatment for high blood pressure. While we see promising results in animal models, further exploration in humans will be essential to confirm these effects.
Our analysis involved examining how a modified form of angiotensin II, created by PLP, impacted blood pressure in rat models. We noticed that this modification led to reduced calcium ion entry into vascular smooth muscle cells, which is crucial for blood vessel contraction. Additionally, the modified hormone displayed a weaker attachment to its receptor compared to unaltered angiotensin II.
Interestingly, when spontaneously hypertensive rats were treated with PLP, their blood pressure showed a significant decrease. In another test, Wistar Kyoto rats receiving both angiotensin II and PLP did not develop increased blood pressure, suggesting that PLP can mitigate the hypertensive effects of angiotensin II.
This study points towards the potential of vitamin B6 as a cost-effective treatment for high blood pressure. While we see promising results in animal models, further exploration in humans will be essential to confirm these effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports hypertension management
My excellent husband has hypertension, and I've found this beneficial for his condition.
Read More
7.5
Better sleep quality
1 people found this helpful
Scattered men's socks are no longer a bother ... This medication is regularly prescribed to me by my neurologist due to blood vessel issues and hypertension, particularly in spring and autumn. As this vitamin aids in regulating nerve impulse transmission and muscle contraction, it is particularly beneficial for individuals under stress, both physically and mentally. I've been taking this brand of vitamin for three weeks, and I can say my sleep has improved; I now dream vividly (previously, I was working even in my dreams, but now I dream of travelling across seas and mountains). I find it easier to stay calm at work and I'm no longer irritated by scattered socks or my children's mistakes at school. Truly transformative! I take two capsules daily (morning and evening) with meals.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Kang H, Lee UJ, Park BY, Kim M, Yang M. Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes. Diabetes Metab Syndr. 2025;19:103203. 10.1016/j.dsx.2025.103203
- Liu Y, Li W, Sun Y, Wang Z. Effects of magnesium sulfate combined with labetalol on vascular endothelial function and pregnancy outcomes in pregnant women with preeclampsia. Am J Transl Res. 2024;16:7096. 10.62347/COZZ1407
- Behers BJ, Behers BM, Stephenson-Moe CA, Vargas IA, Meng Z, et al. Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length. Nutrients. 2024;16. 10.3390/nu16213617
- Hojda SE, Chis IC, Mîrza TV, Clichici S. Monocrotaline-induced pulmonary arterial hypertension: the benefic effects of magnesium sulfate, Rosuvastatin and Sildenafil. Med Pharm Rep. 2024;97:528. 10.15386/mpr-2804
- Gong Y, Zhou C, Wan Y, Yin H. Association of magnesium deficiency, tobacco smoke exposure and hypertension in children and adolescents: evidence from the NHANES 2007-2018. BMC Pediatr. 2024;24:647. 10.1186/s12887-024-05097-z
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. 10.1186/s12906-025-04809-x
- Dariy V, Serikov K, Kmyta O, Rybalko T, Kolesnyk O. PERSONIFICATION OF ANTIHYPERTENSIVE THERAPY IN ISCHEMIC CEREBRAL STROKE. Georgian Med News. 2024. PubMed
- Song J, Zhang Y, Lin Z, Tang J, Yang X, et al. Higher Magnesium Depletion Score Increases the Risk of All-cause and Cardiovascular Mortality in Hypertension Participants. Biol Trace Elem Res. 2025;203:1287. 10.1007/s12011-024-04254-w
- Minor KC, Liu J, Druzin ML, El-Sayed YY, Hintz SR, et al. Magnesium sulfate and risk of hypoxic-ischemic encephalopathy in a high-risk cohort. Am J Obstet Gynecol. 2024;231:647.e1. 10.1016/j.ajog.2024.04.001
- Wang Q, Si K, Xing X, Ye X, Liu Z, et al. Association between dietary magnesium intake and muscle mass among hypertensive population: evidence from the National Health and Nutrition Examination Survey. Nutr J. 2024;23:37. 10.1186/s12937-024-00940-6
- Yerubandi S, Devi Kallur S, Gala A, Chandra Ravula P, Surapaneni T, et al. Eclampsia reduction with maternal early warning trigger tool. Pregnancy Hypertens. 2024;35:6. 10.1016/j.preghy.2023.11.007
- Peng Z, Zhang J, Xiao Y, Dong W. Comparison of outcomes following intravenous magnesium compared with intravenous labetalol and oral nifedipine in 355 pregnant Han Chinese women with preeclampsia. Medicine (Baltimore). 2023;102:e35334. 10.1097/MD.0000000000035334
- Su HC, Lin CP, Ho WJ, Chou SH, Wu CT, et al. Factors affecting the intensity of chronic musculoskeletal pain in patients with cardiovascular disease and evaluation of the efficacy of magnesium emulsion cream for muscle cramps. Medicine (Baltimore). 2023;102:e35532. 10.1097/MD.0000000000035532
- Vongpatanasin W, Giacona JM, Pittman D, Murillo A, Khan G, et al. Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone. Hypertension. 2023;80:2611. 10.1161/HYPERTENSIONAHA.123.21932
- Behers BJ, Melchor J, Behers BM, Meng Z, Swanson PJ, et al. Vitamins and Minerals for Blood Pressure Reduction in the General, Normotensive Population: A Systematic Review and Meta-Analysis of Six Supplements. Nutrients. 2023;15. 10.3390/nu15194223
- Han M, Zhang Y, Fang J, Sun M, Liu Q, et al. Associations between dietary magnesium intake and hypertension, diabetes, and hyperlipidemia. Hypertens Res. 2024;47:331. 10.1038/s41440-023-01439-z
- Song Y, Choi JE, Park JM, Kwon YJ, Hong KW, et al. Genome-Wide Approach of Gene-Nutrient Intake Interaction Study for Essential Hypertension in a Large Korean Cohort (KoGES). Nutrients. 2024;16. 10.3390/nu16234147
- Lellig M, Rodríguez M, López-Baltanás R, Hermann J, Wollenhaupt J, et al. Pyridoxal-5'-phosphate: A cost-effective treatment candidate for hypertensive patients?. J Intern Med. 2024;296:435. 10.1111/joim.20015
- Zhang Y, Wang L, Li X, Geng J. Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats. Exp Ther Med. 2021;21:483. 10.3892/etm.2021.9914
Data last updated:
