Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More
8
We observed that magnesium plays a notable role in migraine prevention and treatment. Specifically, magnesium is recommended for both chronic migraine management and immediate intravenous relief during acute migraine episodes. The use of magnesium appears to be linked with mild gastrointestinal side effects, indicating that it is generally well-tolerated by those who use it.
Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
Read More
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Read More
Most Useful Reviews
9
Migraine relief
4 people found this helpful
I take this Magnesium at least twice daily after meals, or if I forget, I take two at night after dinner. I no longer experience my usual migraines or headaches. Previously, I thought it was normal to have a migraine once a week, especially due to work stress and before my monthly period. Now, I’ve forgotten when I last had a migraine. I'm grateful to my husband for suggesting Magnesium. ☺️
Read More
9
Menstrual migraines gone
3 people found this helpful
I’ve had severe migraines, but this definitely helps, particularly with those that occur before menstruation; they have almost disappeared.
Read More
9
Weather-related migraines
1 people found this helpful
I've always suffered migraines that reacted to the weather, leading to horrible headaches. Since I started taking magnesium, I can’t recall the last time my head hurt. I take three tablets each night and highly recommend this.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
- All Researches
9.5
In examining the role of vitamin B6 in migraine treatment, we delved into a unique regimen combining vitamin B complex with zinc sulfate. The study highlighted a group of 30 individuals suffering from migraines who were administered 75 mg of zinc sulfate daily for six weeks, alongside vitamin B-complex and vitamin A or E during the first ten days. This approach led to promising outcomes, with a significant number of participants showing relief from their migraine symptoms.
While vitamin B6 was part of the treatment protocol, it wasn't evaluated independently within the analysis. This lack of isolation makes it challenging to gauge the specific impact of vitamin B6 on migraine effectiveness.
Overall, the study suggests that there is potential for dietary interventions, particularly involving zinc and B vitamins, in alleviating migraine symptoms. However, more structured studies would be needed to determine the precise effectiveness of vitamin B6 on its own. Monitoring mineral levels may also enhance recovery strategies for individuals affected by migraines.
While vitamin B6 was part of the treatment protocol, it wasn't evaluated independently within the analysis. This lack of isolation makes it challenging to gauge the specific impact of vitamin B6 on migraine effectiveness.
Overall, the study suggests that there is potential for dietary interventions, particularly involving zinc and B vitamins, in alleviating migraine symptoms. However, more structured studies would be needed to determine the precise effectiveness of vitamin B6 on its own. Monitoring mineral levels may also enhance recovery strategies for individuals affected by migraines.
Read More
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Read More
9
We examined how magnesium oxide (MgO), both alone and with riboflavin, helps prevent migraines in pregnant individuals. This retrospective study included 203 patients treated between 2015 and 2020, analyzing outcomes such as migraine frequency, severity, and duration.
We found that both treatment options reduced migraines significantly, with 77% of participants experiencing improvement in associated symptoms. The results indicate that magnesium oxide can be an effective option for managing migraines during pregnancy, making it a potential consideration for expectant mothers suffering from this condition.
We found that both treatment options reduced migraines significantly, with 77% of participants experiencing improvement in associated symptoms. The results indicate that magnesium oxide can be an effective option for managing migraines during pregnancy, making it a potential consideration for expectant mothers suffering from this condition.
Read More
9
We delved into the potential benefits of vitamin B6 (pyridoxine) in treating migraines, particularly in how it relates to other B vitamins like folate and B12. By examining various studies, we focused on the efficacy of B6 alone and in combination with these other vitamins.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Migraine relief
4 people found this helpful
I take this Magnesium at least twice daily after meals, or if I forget, I take two at night after dinner. I no longer experience my usual migraines or headaches. Previously, I thought it was normal to have a migraine once a week, especially due to work stress and before my monthly period. Now, I’ve forgotten when I last had a migraine. I'm grateful to my husband for suggesting Magnesium. ☺️
Read More
9
Menstrual migraines gone
3 people found this helpful
I’ve had severe migraines, but this definitely helps, particularly with those that occur before menstruation; they have almost disappeared.
Read More
9
Weather-related migraines
1 people found this helpful
I've always suffered migraines that reacted to the weather, leading to horrible headaches. Since I started taking magnesium, I can’t recall the last time my head hurt. I take three tablets each night and highly recommend this.
Read More
9
Effective supplement
A nice supplement; it works well for migraines. The only downside is that you need to take several capsules a day, which can be easy to forget.
Read More
9
Migraine treatment aid
I ordered these vitamins after a neurologist prescribed them to treat my migraine, alongside other medications.
Read More
Frequently Asked Questions
9
Migraine relief
4 people found this helpful
I take this Magnesium at least twice daily after meals, or if I forget, I take two at night after dinner. I no longer experience my usual migraines or headaches. Previously, I thought it was normal to have a migraine once a week, especially due to work stress and before my monthly period. Now, I’ve forgotten when I last had a migraine. I'm grateful to my husband for suggesting Magnesium. ☺️
9
Menstrual migraines gone
3 people found this helpful
I’ve had severe migraines, but this definitely helps, particularly with those that occur before menstruation; they have almost disappeared.
9
Effective supplement
A nice supplement; it works well for migraines. The only downside is that you need to take several capsules a day, which can be easy to forget.
9
Weather-related migraines
1 people found this helpful
I've always suffered migraines that reacted to the weather, leading to horrible headaches. Since I started taking magnesium, I can’t recall the last time my head hurt. I take three tablets each night and highly recommend this.
9
Migraine treatment aid
I ordered these vitamins after a neurologist prescribed them to treat my migraine, alongside other medications.
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
8
Magnesium treatment for migraines
We explored the isolated impact of magnesium treatment on individuals suffering from migraines. The study aimed to determine how magnesium could potentially alleviate the severity or frequency of migraine episodes. By focusing specifically on this mineral, we sought to see if there was measurable improvement among participants who incorporated magnesium into their treatment plans.
Through careful analysis, we noted that magnesium treatment showed promising results for some, with participants reporting a reduction in migraine occurrences. This suggests that magnesium might be an effective alternative or complement to traditional migraine therapies.
However, we must also highlight that not all individuals experienced the same level of relief. The results did show variability, indicating that while magnesium might help many, it’s not a universal solution for everyone dealing with migraine issues. This important detail underscores the need for a personalized approach to migraine management—what works for one person may not work for another.
Overall, our findings contribute valuable insights into alternative treatment options for migraines, providing individuals and healthcare providers with useful information for shared decision-making regarding migraine treatment strategies.
Through careful analysis, we noted that magnesium treatment showed promising results for some, with participants reporting a reduction in migraine occurrences. This suggests that magnesium might be an effective alternative or complement to traditional migraine therapies.
However, we must also highlight that not all individuals experienced the same level of relief. The results did show variability, indicating that while magnesium might help many, it’s not a universal solution for everyone dealing with migraine issues. This important detail underscores the need for a personalized approach to migraine management—what works for one person may not work for another.
Overall, our findings contribute valuable insights into alternative treatment options for migraines, providing individuals and healthcare providers with useful information for shared decision-making regarding migraine treatment strategies.
7
We explored the role of magnesium as a potential treatment for migraines through a review of existing literature. Migraines can be intense and debilitating, impacting many individuals' day-to-day lives. Our focus was on understanding whether supplementing magnesium could help in preventing or managing these attacks.
Some studies suggest that low levels of magnesium may be linked to more frequent or severe migraine episodes. When people suffer from migraines, inflammation and oxidative stress might contribute to their pain, and magnesium appears to play a role in helping regulate these processes. By supporting brain health and energy metabolism, magnesium could potentially mitigate some of the triggers associated with migraines.
Although the evidence does point to benefits from magnesium supplementation, we noted that more extensive, well-controlled studies are necessary to draw firm conclusions. Overall, while magnesium shows promise, it may not be a standalone solution and could work best in combination with other treatments.
Some studies suggest that low levels of magnesium may be linked to more frequent or severe migraine episodes. When people suffer from migraines, inflammation and oxidative stress might contribute to their pain, and magnesium appears to play a role in helping regulate these processes. By supporting brain health and energy metabolism, magnesium could potentially mitigate some of the triggers associated with migraines.
Although the evidence does point to benefits from magnesium supplementation, we noted that more extensive, well-controlled studies are necessary to draw firm conclusions. Overall, while magnesium shows promise, it may not be a standalone solution and could work best in combination with other treatments.
References
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- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. doi:10.3389/fnut.2024.1433390
- Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. doi:10.1007/s10072-024-07794-0
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- Kurhade PI, Kodape SM, Das A, Bansod PG. Synergistic action of sumatriptan delivery and targeting magnesium deficiency using green, pH-responsive MgO nanoparticles synthesized from mahua flower extracts. Environ Sci Pollut Res Int. 2023. doi:10.1007/s11356-023-30648-9
- Umemoto KK, Tawk K, Mazhari N, Abouzari M, Djalilian HR. Management of Migraine-Associated Vestibulocochlear Disorders. Audiol Res. 2023;13:528. doi:10.3390/audiolres13040047
- Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. doi:10.1007/s00482-023-00738-1
- Shenoy NN, Gheewala GK, Kedambadi R, Pai S, Zulfikli KM, et al. Can Serum Magnesium Level and Visual Evoked Potentials (P100) be a Predictive in Migraineurs?: Evidence Based Study. Neurol India. 2023;71:463. doi:10.4103/0028-3886.378668
- Frank M, Abouzari M, Djalilian HR. Meniere's disease is a manifestation of migraine. Curr Opin Otolaryngol Head Neck Surg. 2023;31:313. doi:10.1097/MOO.0000000000000908
- Pawar V, Ashraf H, Dorsala S, Mary P, Hameed N, et al. Motorist's Vestibular Disorientation Syndrome (MVDS)-Proposed Diagnostic Criteria. J Pers Med. 2023;13. doi:10.3390/jpm13050732
- Hoshino MT, Bochio MG, Spagnol Bonache J, Ludwig L, Leandro de Campos M, et al. Plasma and erythrocyte magnesium levels: from validation of the method to analysis in volunteers diagnosed to migraine. Magnes Res. 2022;35:51. doi:10.1684/mrh.2022.0502
- Mahajan R, Anand KS, Mahajan RK, Garg J, Juneja A. Serum Magnesium Levels During the Ictal and Interictal Phase in Patients of Migraine: A Prospective Observational Study. Neurol India. 2022;70:1852. doi:10.4103/0028-3886.359247
- Bhurat R, Premkumar S, Manokaran RK. Serum Magnesium Levels in Children With and Without Migraine: A Cross-Sectional Study. Indian Pediatr. 2022;59:623.
- Mazza GR, Solorio C, Stek AM, Kalayjian LA, Wilson ML, et al. Assessing the efficacy of magnesium oxide and riboflavin as preventative treatment of migraines in pregnancy. Arch Gynecol Obstet. 2023;308:1749. doi:10.1007/s00404-022-06872-y
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. doi:10.1007/s11916-022-01019-9
- Guerrero-Toro C, Koroleva K, Ermakova E, Gafurov O, Abushik P, et al. Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain. Int J Mol Sci. 2022;23. doi:10.3390/ijms23031529
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Karim MR, Bhattacharjee M, Islam MS, Banerjee S, Hossain S, et al. Relation between Serum Magnesium Level and Migraine. Mymensingh Med J. 2021;30:301.
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. doi:10.18502/cjn.v21i2.10494
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Askari G, Nasiri M, Mozaffari-Khosravi H, Rezaie M, Bagheri-Bidakhavidi M, et al. The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition. 2017;38:74. doi:10.1016/j.nut.2017.01.007
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. doi:10.1136/bcr-2016-217477
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. doi:10.1186/s10194-016-0652-7
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. doi:10.1097/FPC.0b013e3283576b6b
- Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses. 2011;77:147. doi:10.1016/j.mehy.2011.03.050
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. doi:10.1097/FPC.0b013e32832af5a3
