Overview
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
USERS' SCORE
Good
Based on 10 Reviews
8.6
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
1000 mcg
41,667%
Top Medical Research Studies
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
Read More
2
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
Read More
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
Most Useful Reviews
10
Depression alleviated
23 people found this helpful
A beautiful product! To be brief, my depression has passed, and I have experienced less hair loss.
Read More
9
Mood improved greatly
11 people found this helpful
Very effective! I can't say much about strengthening hair and nails, but it certainly has helped my nervous system! I've been taking them for two weeks, and during this time my apathy vanished. I now wake up in a good mood, and my postpartum depression is gone! I recommend it to anyone needing to heal their nerves.
Read More
10
Energising effects
1 people found this helpful
Verified purchase from Solgar! It works! My brain feels alert, I have more energy, and my depression has lifted! The taste is also pleasant.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
- All Researches
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
We explored the relationship between vitamin B12 levels and major depressive disorder (MDD) by examining serum vitamin B12, homocysteine (Hcy), and blood profiles in 59 patients diagnosed with MDD. The severity of depression was evaluated using the HAM-D scale, which allows for a clear understanding of how vitamin B12 might be linked to depressive symptoms.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Read More
8
We looked into how Vitamin B could change behaviors and brain chemistry in rats experiencing depression-like symptoms. Rats were split into groups to compare a control group, one exposed to chronic mild stress, and a group receiving Vitamin B injections.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Read More
8
We explored how vitamin B12 influences stress resilience and depression using sophisticated methods in a mouse model. Our findings linked vitamin B12 supplementation to changes in a gene called Ttr, which plays a role in managing stress.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Read More
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Depression alleviated
23 people found this helpful
A beautiful product! To be brief, my depression has passed, and I have experienced less hair loss.
Read More
9
Mood improved greatly
11 people found this helpful
Very effective! I can't say much about strengthening hair and nails, but it certainly has helped my nervous system! I've been taking them for two weeks, and during this time my apathy vanished. I now wake up in a good mood, and my postpartum depression is gone! I recommend it to anyone needing to heal their nerves.
Read More
10
Energising effects
1 people found this helpful
Verified purchase from Solgar! It works! My brain feels alert, I have more energy, and my depression has lifted! The taste is also pleasant.
Read More
9
Recommended for anxiety
1 people found this helpful
Excellent quality product, 100% recommended for anxiety, stress, memory loss, and depression. It contains perfect ingredients and quantity for two months. I suggest all those with these issues take this product; please share with others so they can benefit as well.
Read More
9
Postpartum relief
Solgar power! I can't comment on strengthening my hair and nails, but it has certainly helped my nervous system! I’ve been taking them for two weeks, and during this time my apathy has disappeared. I wake up feeling good, and my postpartum depression is gone! I highly recommend it for anyone needing to improve their nerves.
Read More
Frequently Asked Questions
9
Mood improved greatly
11 people found this helpful
Very effective! I can't say much about strengthening hair and nails, but it certainly has helped my nervous system! I've been taking them for two weeks, and during this time my apathy vanished. I now wake up in a good mood, and my postpartum depression is gone! I recommend it to anyone needing to heal their nerves.
10
Energising effects
1 people found this helpful
Verified purchase from Solgar! It works! My brain feels alert, I have more energy, and my depression has lifted! The taste is also pleasant.
10
Depression alleviated
23 people found this helpful
A beautiful product! To be brief, my depression has passed, and I have experienced less hair loss.
9
Recommended for anxiety
1 people found this helpful
Excellent quality product, 100% recommended for anxiety, stress, memory loss, and depression. It contains perfect ingredients and quantity for two months. I suggest all those with these issues take this product; please share with others so they can benefit as well.
6
Affordable mood support
1 people found this helpful
I was diagnosed with medium depressive disorder due to a lack of intrinsic factor in my stomach causing depression. My naturopath prescribed mecobalamin, which is expensive. I found methylcobalamin active coenzyme for half the price, and it has had the same uplifting effect on my mood.
7.5
Essential for depression
6 people found this helpful
Delicious B12! Very tiny pills with great taste in a glass jar. Get tested for B12, especially if you show signs of depression or have a relative with dementia. B12 is crucial, as levels of 500-800 pg/ml lower the risk of dementia, Alzheimer's, and depression. Thank you for reading.
6
Zinc assists depression
Zinc has been beneficial in helping my depression.
9
Postpartum relief
Solgar power! I can't comment on strengthening my hair and nails, but it has certainly helped my nervous system! I’ve been taking them for two weeks, and during this time my apathy has disappeared. I wake up feeling good, and my postpartum depression is gone! I highly recommend it for anyone needing to improve their nerves.
7.5
Balanced ingredients
Very good quality! The ingredients are well balanced, and the size met my needs. The research-backed ingredients improve depression and elevate my mood, while also benefiting my attention. The taste was fine. I highly recommend it, especially with the max dosage, as I have experienced increased energy and a slight decrease in cholesterol and stress, along with improved brain activity.
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
8
We explored how vitamin B12 influences stress resilience and depression using sophisticated methods in a mouse model. Our findings linked vitamin B12 supplementation to changes in a gene called Ttr, which plays a role in managing stress.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
4
We reviewed several studies that looked into how vitamin B12 supplementation might help with depression and mental health issues. By systematically searching major databases, we identified a total of 287 articles and selected five that rigorously assessed the effects of B12 alone and alongside other B vitamins like folic acid and B6.
The results were mixed, showing that while some groups benefited from these vitamins, overall evidence was inconclusive. Notably, some studies indicated that combining vitamin B12 with folic acid and B6 could effectively prevent post-stroke depression. However, many trials examined specific populations, highlighting that B12 may be especially helpful for certain high-risk groups rather than a one-size-fits-all solution.
In conclusion, while the findings are promising for some, we need more research to determine how vitamin B12 supplementation could be beneficial for broader mental health improvement. Overall, vitamin B12’s role in treating depression is still a topic that requires further exploration.
The results were mixed, showing that while some groups benefited from these vitamins, overall evidence was inconclusive. Notably, some studies indicated that combining vitamin B12 with folic acid and B6 could effectively prevent post-stroke depression. However, many trials examined specific populations, highlighting that B12 may be especially helpful for certain high-risk groups rather than a one-size-fits-all solution.
In conclusion, while the findings are promising for some, we need more research to determine how vitamin B12 supplementation could be beneficial for broader mental health improvement. Overall, vitamin B12’s role in treating depression is still a topic that requires further exploration.
7
We explored the effects of methylcobalamin, a form of vitamin B12, on patients suffering from burning mouth syndrome (BMS), alongside a traditional Chinese medicine, danzhixiaoyao pills. In our randomized controlled trial, we included 78 participants, mostly women, and divided them into a trial group receiving both the danzhixiaoyao pills and methylcobalamin, and a control group who only received the methylcobalamin.
After 6 weeks of treatment, we observed that those in the trial group experienced a notable decrease in measures of pain and depression, which were evaluated using established scales. However, we did not find any significant difference in anxiety levels between the two groups, suggesting that while vitamin B12 might play a role in addressing some symptoms of BMS, it doesn't have a strong impact on depression by itself in this context.
The trial showed a total effective rate of 73.68% in the test group compared to 52.94% in the control group, indicating that combining danzhixiaoyao pills with methylcobalamin could enhance treatment outcomes for BMS. Importantly, neither group reported any adverse effects, which highlights the safety of the treatments evaluated.
After 6 weeks of treatment, we observed that those in the trial group experienced a notable decrease in measures of pain and depression, which were evaluated using established scales. However, we did not find any significant difference in anxiety levels between the two groups, suggesting that while vitamin B12 might play a role in addressing some symptoms of BMS, it doesn't have a strong impact on depression by itself in this context.
The trial showed a total effective rate of 73.68% in the test group compared to 52.94% in the control group, indicating that combining danzhixiaoyao pills with methylcobalamin could enhance treatment outcomes for BMS. Importantly, neither group reported any adverse effects, which highlights the safety of the treatments evaluated.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
- Laird EJ, O'Halloran AM, Molloy AM, Healy M, Hernandez B, et al. Low vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. Br J Nutr. 2023;130:268. doi:10.1017/S0007114521004748
- Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. doi:10.1016/j.jad.2021.10.027
- Wu Y, Li S, Wang W, Zhang D. Associations of dietary B vitamins intakes with depression in adults. Int J Vitam Nutr Res. 2023;93:142. doi:10.1024/0300-9831/a000720
- Wu Y, Zhang L, Li S, Zhang D. Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutr Rev. 2022;80:351. doi:10.1093/nutrit/nuab014
- Dhiman P, Pillai RR, Wilson AB, Premkumar N, Bharadwaj B, et al. Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women. BMC Pregnancy Childbirth. 2021;21:146. doi:10.1186/s12884-021-03622-x
- Bou Khalil R, Atallah E, Dirani E, Kallab M, Kassab A, et al. Can atypical dysgeusia in depression be related to a deafferentation syndrome?. Med Hypotheses. 2020;144:110047. doi:10.1016/j.mehy.2020.110047
- Trautmann C, Bock A, Urbach A, Hübner CA, Engmann O. Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2. Neuropharmacology. 2020;171:108112. doi:10.1016/j.neuropharm.2020.108112
- Esnafoglu E, Ozturan DD. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 2020;25:249. doi:10.1111/camh.12387
- Lv P, Xiang F, Zhang S, Lei D, Zhou C, et al. Valeriana jatamansi jones improves depressive behavior in CUMS mice by modulating vitamin B12-related ileal homeostasis. J Ethnopharmacol. 2025;342:119392. doi:10.1016/j.jep.2025.119392
- Alzahrani H. Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. Cureus. 2024;16:e73350. doi:10.7759/cureus.73350
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. doi:10.2147/NDT.S480417
- Hui J, Zhang N, Kang M, Gou Y, Liu C, et al. Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16132042
- Harikaran S, Basu S, Mukherjee MP, Kar R, Nair S, et al. Vitamin B12 and homocysteine in patients with major depressive disorder. J Family Med Prim Care. 2024;13:2049. doi:10.4103/jfmpc.jfmpc_1460_23
- Gao Y, Yang J, Sun H, Zhou H. Efficacy of Danzhixiaoyao tablets combined with methylcobalamin tablets in the treatment of burning mouth syndrome: an open-label, randomized controlled trial. BMC Oral Health. 2024;24:603. doi:10.1186/s12903-024-04318-2
- Cruz-Rodríguez J, Canals-Sans J, Hernández-Martínez C, Arija V. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study. J Reprod Infant Psychol. 2024. doi:10.1080/02646838.2024.2324043
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. doi:10.12968/bjcn.2024.29.3.137
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
- Tan Y, Zhou L, Gu K, Xie C, Wang Y, et al. Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2023;21:617. doi:10.9758/cpn.22.1040
