Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 ml
Amount Per Serving
%DV
Vitamin B1 (as thiamine HCl)
4 mg
333%
Riboflavin (as riboflavin 5'-phosphate sodium)
4 mg
308%
Niacin (as niacinamide)
20 mg
125%
Vitamin B6 (as pyridoxine HCl)
10 mg
588%
Folate
333 mcg DFE(200 mcg folic acid)
83%
Vitamin B12 (as cyanocobalamin)
2,000 mcg
83,333%
Biotin
300 mcg
1,000%
Pantothenic Acid (as dexpanthenol)
30 mg
600%
Top Medical Research Studies
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
Read More
8
We looked into how Vitamin B could change behaviors and brain chemistry in rats experiencing depression-like symptoms. Rats were split into groups to compare a control group, one exposed to chronic mild stress, and a group receiving Vitamin B injections.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Read More
8
We explored how vitamin B12 influences stress resilience and depression using sophisticated methods in a mouse model. Our findings linked vitamin B12 supplementation to changes in a gene called Ttr, which plays a role in managing stress.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Read More
Most Useful Reviews
9
Energy boost for depression
Solgar's liquid vitamin B12 is outstanding; it energises quickly, is beneficial for the nervous system, and helps with depression. I wholeheartedly recommend it!
Read More
7.5
Enhances mood quickly
This is an excellent product if you have low stomach acid. It absorbs quickly under the tongue and is beneficial for mood and depression.
Read More
6
Supports neurological health
The vitamin B family is crucial for the neurological system, aiding in managing depression and anxiety.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
- All Researches
8
We looked into how Vitamin B could change behaviors and brain chemistry in rats experiencing depression-like symptoms. Rats were split into groups to compare a control group, one exposed to chronic mild stress, and a group receiving Vitamin B injections.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Read More
8
We explored how vitamin B12 influences stress resilience and depression using sophisticated methods in a mouse model. Our findings linked vitamin B12 supplementation to changes in a gene called Ttr, which plays a role in managing stress.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Read More
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
Read More
8
We explored whether a single dose of vitamin B12 can combat symptoms of depression. Through tests on mice, we found that acute vitamin B12 supplementation improved behavior linked to depression while reversing stress effects on a specific gene connected to mood regulation.
However, it’s crucial to note that not all results correlated in vivo, and causation remains unproven at this stage. While our findings are promising for vitamin B12 as a potential antidepressant model, further studies are needed.
However, it’s crucial to note that not all results correlated in vivo, and causation remains unproven at this stage. While our findings are promising for vitamin B12 as a potential antidepressant model, further studies are needed.
Read More
7
Multivitamins improve depression symptoms
We explored the impact of multivitamins on mood among 70 male patients undergoing Methadone Maintenance Treatment (MMT). Over 12 weeks, participants received either multivitamins or a placebo in a double-blind study.
Our findings highlighted significant improvements in depression levels, while anxiety scores showed no noteworthy changes. This suggests that while multivitamin supplementation can be beneficial for enhancing mood in those dealing with depression during MMT, it may not alleviate anxiety symptoms effectively.
Our findings highlighted significant improvements in depression levels, while anxiety scores showed no noteworthy changes. This suggests that while multivitamin supplementation can be beneficial for enhancing mood in those dealing with depression during MMT, it may not alleviate anxiety symptoms effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Energy boost for depression
Solgar's liquid vitamin B12 is outstanding; it energises quickly, is beneficial for the nervous system, and helps with depression. I wholeheartedly recommend it!
Read More
7.5
Enhances mood quickly
This is an excellent product if you have low stomach acid. It absorbs quickly under the tongue and is beneficial for mood and depression.
Read More
6
Supports neurological health
The vitamin B family is crucial for the neurological system, aiding in managing depression and anxiety.
Read More
Frequently Asked Questions
9
Energy boost for depression
Solgar's liquid vitamin B12 is outstanding; it energises quickly, is beneficial for the nervous system, and helps with depression. I wholeheartedly recommend it!
7.5
Enhances mood quickly
This is an excellent product if you have low stomach acid. It absorbs quickly under the tongue and is beneficial for mood and depression.
6
Supports neurological health
The vitamin B family is crucial for the neurological system, aiding in managing depression and anxiety.
7
B vitamins may reduce depression
We examined the connection between depression and the intake of antioxidants and B vitamins in a large cohort of 14,737 adults. Our analysis revealed that higher consumption of vitamins, particularly B6 and B12, as well as antioxidants, is linked to lower rates of depression.
Women showed a notable relationship between mood improvement and increased intake of vitamins A and C along with B vitamins. While the findings are promising, we must acknowledge potential biases related to diet recall and depression assessment.
Women showed a notable relationship between mood improvement and increased intake of vitamins A and C along with B vitamins. While the findings are promising, we must acknowledge potential biases related to diet recall and depression assessment.
7
We reviewed studies that investigated how dietary intake of vitamins B1, B2, B6, and B12 relates to depression risk. Analyzing 18 studies, we found that higher intake of these vitamins was associated with a lower chance of depression. This effect was particularly significant for women with B2, B6, and B12, while results for men were less conclusive.
Although the findings are promising, further research is needed to firmly establish these connections. This suggests that our diet might play a role in our mental health.
Although the findings are promising, further research is needed to firmly establish these connections. This suggests that our diet might play a role in our mental health.
8
We explored whether a single dose of vitamin B12 can combat symptoms of depression. Through tests on mice, we found that acute vitamin B12 supplementation improved behavior linked to depression while reversing stress effects on a specific gene connected to mood regulation.
However, it’s crucial to note that not all results correlated in vivo, and causation remains unproven at this stage. While our findings are promising for vitamin B12 as a potential antidepressant model, further studies are needed.
However, it’s crucial to note that not all results correlated in vivo, and causation remains unproven at this stage. While our findings are promising for vitamin B12 as a potential antidepressant model, further studies are needed.
5
This study examined the connection between vitamin B12 levels and postpartum depression in women who were six weeks postpartum.
We assessed 217 women diagnosed with probable postpartum depression and matched them with a control group of similar age and BMI.
Our findings suggest that low vitamin B12 status may indeed be linked to feelings of depression during this vulnerable time.
However, it’s important to note that while there seems to be an association, the study does not confirm that B12 directly causes depression.
We assessed 217 women diagnosed with probable postpartum depression and matched them with a control group of similar age and BMI.
Our findings suggest that low vitamin B12 status may indeed be linked to feelings of depression during this vulnerable time.
However, it’s important to note that while there seems to be an association, the study does not confirm that B12 directly causes depression.
7
We explored a unique case of a 67-year-old man whose severe depression was accompanied by an unusual sweet taste sensation. After discovering he had a vitamin B12 deficiency, we treated him with B12 supplementation alongside several antidepressants. Remarkably, his depressive symptoms improved, and the sweet taste sensation diminished by the time he was discharged.
This suggests that addressing vitamin B12 deficiency could be crucial for alleviating certain mood disorders and symptoms in older adults. However, further investigation is necessary to fully understand the link between vitamin B12 levels, depression, and sensory changes like atypical dysgeusia.
This suggests that addressing vitamin B12 deficiency could be crucial for alleviating certain mood disorders and symptoms in older adults. However, further investigation is necessary to fully understand the link between vitamin B12 levels, depression, and sensory changes like atypical dysgeusia.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
- Laird EJ, O'Halloran AM, Molloy AM, Healy M, Hernandez B, et al. Low vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. Br J Nutr. 2023;130:268. doi:10.1017/S0007114521004748
- Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. doi:10.1016/j.jad.2021.10.027
- Wu Y, Li S, Wang W, Zhang D. Associations of dietary B vitamins intakes with depression in adults. Int J Vitam Nutr Res. 2023;93:142. doi:10.1024/0300-9831/a000720
- Wu Y, Zhang L, Li S, Zhang D. Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutr Rev. 2022;80:351. doi:10.1093/nutrit/nuab014
- Dhiman P, Pillai RR, Wilson AB, Premkumar N, Bharadwaj B, et al. Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women. BMC Pregnancy Childbirth. 2021;21:146. doi:10.1186/s12884-021-03622-x
- Bou Khalil R, Atallah E, Dirani E, Kallab M, Kassab A, et al. Can atypical dysgeusia in depression be related to a deafferentation syndrome?. Med Hypotheses. 2020;144:110047. doi:10.1016/j.mehy.2020.110047
- Trautmann C, Bock A, Urbach A, Hübner CA, Engmann O. Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2. Neuropharmacology. 2020;171:108112. doi:10.1016/j.neuropharm.2020.108112
- Esnafoglu E, Ozturan DD. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 2020;25:249. doi:10.1111/camh.12387
