Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
5,000 mcg
208,333%
Top Medical Research Studies
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
Most Useful Reviews
10
Severe anxiety resolved
10 people found this helpful
Great for sleep and mental health! I had a severe B12 deficiency impacting my mental health, including extreme anxiety and insomnia. My symptoms completely vanished after over 16 shots of 1000mg B12. My levels are now ideal, and I feel energised, sleep well, and my anxiety has dissipated. I trust Solgar for maintaining my optimal levels.
Read More
7.5
Improved mental well-being
1 people found this helpful
The SOLGAR Vitamin B12 Sublingual offers many benefits for overall health. It enhances energy levels crucially, supports the nervous system, and promotes a balanced mood. By aiding the production of red blood cells, it combats fatigue effectively. The quick absorption of the sublingual form leads to faster energy-boosting effects. Additionally, it helps maintain cognitive function and regulate mood, alleviating symptoms of depression and anxiety. I'm pleased with my iHerb experience, from shipping to product quality, and will continue ordering from them.
Read More
7.5
Supports neuropathy treatment
3 people found this helpful
I use this as backup to Thorne's B12 for managing neuropathy and require large doses. Being water-soluble, B12 is hard to overdose on. I recommend visiting a Neuropathy Clinic for supplement information. Alongside use of an oxygen barium chamber, it has been wonderful for my depression and anxiety, significantly aiding my condition.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
- All Researches
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
7
We set out to understand how Vitamin B affects behavior and brain chemistry in rats experiencing depression due to stress. In our study, 72 rats were divided into three groups: a control group, a group under stress, and a group under stress receiving Vitamin B injections.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Read More
7
B12 treatment showed no significant anxiety benefit
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Severe anxiety resolved
10 people found this helpful
Great for sleep and mental health! I had a severe B12 deficiency impacting my mental health, including extreme anxiety and insomnia. My symptoms completely vanished after over 16 shots of 1000mg B12. My levels are now ideal, and I feel energised, sleep well, and my anxiety has dissipated. I trust Solgar for maintaining my optimal levels.
Read More
7.5
Improved mental well-being
1 people found this helpful
The SOLGAR Vitamin B12 Sublingual offers many benefits for overall health. It enhances energy levels crucially, supports the nervous system, and promotes a balanced mood. By aiding the production of red blood cells, it combats fatigue effectively. The quick absorption of the sublingual form leads to faster energy-boosting effects. Additionally, it helps maintain cognitive function and regulate mood, alleviating symptoms of depression and anxiety. I'm pleased with my iHerb experience, from shipping to product quality, and will continue ordering from them.
Read More
7.5
Supports neuropathy treatment
3 people found this helpful
I use this as backup to Thorne's B12 for managing neuropathy and require large doses. Being water-soluble, B12 is hard to overdose on. I recommend visiting a Neuropathy Clinic for supplement information. Alongside use of an oxygen barium chamber, it has been wonderful for my depression and anxiety, significantly aiding my condition.
Read More
7.5
Alleviated postnatal anxiety
I found that Vitamin B12 helped me cope with anxiety after childbirth while avoiding meat products. It's undoubtedly wise to get tested for deficiencies to ensure proper intake.
Read More
Frequently Asked Questions
7.5
Alleviated postnatal anxiety
I found that Vitamin B12 helped me cope with anxiety after childbirth while avoiding meat products. It's undoubtedly wise to get tested for deficiencies to ensure proper intake.
7.5
Supports neuropathy treatment
3 people found this helpful
I use this as backup to Thorne's B12 for managing neuropathy and require large doses. Being water-soluble, B12 is hard to overdose on. I recommend visiting a Neuropathy Clinic for supplement information. Alongside use of an oxygen barium chamber, it has been wonderful for my depression and anxiety, significantly aiding my condition.
7.5
Improved mental well-being
1 people found this helpful
The SOLGAR Vitamin B12 Sublingual offers many benefits for overall health. It enhances energy levels crucially, supports the nervous system, and promotes a balanced mood. By aiding the production of red blood cells, it combats fatigue effectively. The quick absorption of the sublingual form leads to faster energy-boosting effects. Additionally, it helps maintain cognitive function and regulate mood, alleviating symptoms of depression and anxiety. I'm pleased with my iHerb experience, from shipping to product quality, and will continue ordering from them.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
7
B12 treatment showed no significant anxiety benefit
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
7
We set out to explore the role of serum vitamin B12 levels in relation to anxiety disorders, using a robust methodology that involved genetic data analysis. By pulling information from large-scale genome-wide association studies, we focused on identifying potential causal relationships between vitamin B12 and anxiety symptoms.
Our findings suggest that higher levels of vitamin B12 might be associated with an increased risk of anxiety disorders. Specifically, the analysis revealed that for every unit increase in serum vitamin B12, there's an odds ratio of 1.34 for anxiety disorders. This means that individuals with elevated vitamin B12 levels could be more likely to experience anxiety.
However, it’s essential to note that while there is a suggestive link, the relationship isn't fully straightforward. Other factors could be influencing this association, and we cannot eliminate the possibility that genetic variation might play a role in these findings. Thus, further studies are necessary to validate these results in broader and more diverse populations.
In conclusion, while our study highlights a potential connection between serum vitamin B12 levels and anxiety, it's crucial to approach these observations with caution until more research can provide clearer insights.
Our findings suggest that higher levels of vitamin B12 might be associated with an increased risk of anxiety disorders. Specifically, the analysis revealed that for every unit increase in serum vitamin B12, there's an odds ratio of 1.34 for anxiety disorders. This means that individuals with elevated vitamin B12 levels could be more likely to experience anxiety.
However, it’s essential to note that while there is a suggestive link, the relationship isn't fully straightforward. Other factors could be influencing this association, and we cannot eliminate the possibility that genetic variation might play a role in these findings. Thus, further studies are necessary to validate these results in broader and more diverse populations.
In conclusion, while our study highlights a potential connection between serum vitamin B12 levels and anxiety, it's crucial to approach these observations with caution until more research can provide clearer insights.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. 10.12182/20250160608
- Al Jassem O, Kheir K, Ismail A, Abou-Abbas L, Masri A, et al. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores. PLoS One. 2024;19:e0297976. 10.1371/journal.pone.0297976
- Tengelmann C, Joos S, Kaußner Y, Malzahn U, Lunden L, et al. Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). BMC Infect Dis. 2024;24:56. 10.1186/s12879-023-08925-2
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. 10.1016/j.bcp.2023.115832
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
- Young LM, Gauci S, Arnoldy L, Martin L, Perry N, et al. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients. 2022;14. 10.3390/nu14235079
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. 10.1186/s41927-022-00282-y
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
- Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. 10.1080/00207454.2024.2398564
- Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. 10.3390/nu16131986
- Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. 10.2147/NDT.S399378
