Overview
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.7
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
5,000 mcg
208,333%
Top Medical Research Studies
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
Read More
2
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
Read More
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
Most Useful Reviews
9
Improved mood noted
The lesson is excellent, presented very well. God willing, it will improve nerves and mood and eliminate depression.
Read More
9
Depression resolved
My wife had depression and difficulty absorbing Vitamin B12. With this sublingual form, her issues have ended.
Read More
7.5
Mood improved
1 people found this helpful
I purchased these after reducing my intake from 10,000 mcg to 1,000 mcg and noticed an increase in my depression. They are thicker and take longer to dissolve under the tongue compared to the 1,000 mcg nuggets, which is a bit inconvenient. However, I've observed an improvement in my mood and energy levels so far.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
- All Researches
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
We explored the relationship between vitamin B12 levels and major depressive disorder (MDD) by examining serum vitamin B12, homocysteine (Hcy), and blood profiles in 59 patients diagnosed with MDD. The severity of depression was evaluated using the HAM-D scale, which allows for a clear understanding of how vitamin B12 might be linked to depressive symptoms.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Read More
8
We looked into how Vitamin B could change behaviors and brain chemistry in rats experiencing depression-like symptoms. Rats were split into groups to compare a control group, one exposed to chronic mild stress, and a group receiving Vitamin B injections.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Read More
8
We explored how vitamin B12 influences stress resilience and depression using sophisticated methods in a mouse model. Our findings linked vitamin B12 supplementation to changes in a gene called Ttr, which plays a role in managing stress.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Read More
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved mood noted
The lesson is excellent, presented very well. God willing, it will improve nerves and mood and eliminate depression.
Read More
9
Depression resolved
My wife had depression and difficulty absorbing Vitamin B12. With this sublingual form, her issues have ended.
Read More
7.5
Mood improved
1 people found this helpful
I purchased these after reducing my intake from 10,000 mcg to 1,000 mcg and noticed an increase in my depression. They are thicker and take longer to dissolve under the tongue compared to the 1,000 mcg nuggets, which is a bit inconvenient. However, I've observed an improvement in my mood and energy levels so far.
Read More
0
Quality concerns flagged
2 people found this helpful
I discovered that Solgar may not use the highest quality ingredients in their vitamins. While Vitamin B12 is active, it may not be suitable for people with polymorphisms in the methylation cycle. It’s crucial to check if the methyl form is right for you before taking it, as inappropriate use could result in side effects like depression, aggression, and irritability. If these occur, the supplement should be discontinued.
Read More
7.5
Nervous system support
Solgar B12 with Methylcobalamin is an exceptional supplement designed to support nervous system health. Its high-quality ingredients assist in normal nervous function and combat stress and depression. The capsules are convenient for everyday use, promoting optimal nervous system health and well-being.
Read More
Frequently Asked Questions
7.5
Mood improved
1 people found this helpful
I purchased these after reducing my intake from 10,000 mcg to 1,000 mcg and noticed an increase in my depression. They are thicker and take longer to dissolve under the tongue compared to the 1,000 mcg nuggets, which is a bit inconvenient. However, I've observed an improvement in my mood and energy levels so far.
7.5
Nervous system support
Solgar B12 with Methylcobalamin is an exceptional supplement designed to support nervous system health. Its high-quality ingredients assist in normal nervous function and combat stress and depression. The capsules are convenient for everyday use, promoting optimal nervous system health and well-being.
9
Depression resolved
My wife had depression and difficulty absorbing Vitamin B12. With this sublingual form, her issues have ended.
0
Quality concerns flagged
2 people found this helpful
I discovered that Solgar may not use the highest quality ingredients in their vitamins. While Vitamin B12 is active, it may not be suitable for people with polymorphisms in the methylation cycle. It’s crucial to check if the methyl form is right for you before taking it, as inappropriate use could result in side effects like depression, aggression, and irritability. If these occur, the supplement should be discontinued.
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
7
We reviewed studies that investigated how dietary intake of vitamins B1, B2, B6, and B12 relates to depression risk. Analyzing 18 studies, we found that higher intake of these vitamins was associated with a lower chance of depression. This effect was particularly significant for women with B2, B6, and B12, while results for men were less conclusive.
Although the findings are promising, further research is needed to firmly establish these connections. This suggests that our diet might play a role in our mental health.
Although the findings are promising, further research is needed to firmly establish these connections. This suggests that our diet might play a role in our mental health.
2
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
7
We examined the relationship between vitamin B12 levels during pregnancy and the likelihood of experiencing postpartum depression (PPD). Our study focused on a group of healthy pregnant women from Catalonia, Spain, as part of a larger initiative called the ECLIPSES Study.
The findings revealed that the prevalence of probable PPD was around 21%. Notably, after analyzing various factors such as sociodemographic and lifestyle characteristics, we found a significant connection between high serum vitamin B12 levels and lower EPDS scores, indicating reduced depressive symptoms.
Our results suggest that maintaining adequate vitamin B12 levels during early pregnancy might help prevent PPD. This insight highlights the importance of proper nutritional intake during pregnancy, as it plays a crucial role in mental health outcomes for new mothers.
The findings revealed that the prevalence of probable PPD was around 21%. Notably, after analyzing various factors such as sociodemographic and lifestyle characteristics, we found a significant connection between high serum vitamin B12 levels and lower EPDS scores, indicating reduced depressive symptoms.
Our results suggest that maintaining adequate vitamin B12 levels during early pregnancy might help prevent PPD. This insight highlights the importance of proper nutritional intake during pregnancy, as it plays a crucial role in mental health outcomes for new mothers.
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
- Laird EJ, O'Halloran AM, Molloy AM, Healy M, Hernandez B, et al. Low vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. Br J Nutr. 2023;130:268. doi:10.1017/S0007114521004748
- Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. doi:10.1016/j.jad.2021.10.027
- Wu Y, Li S, Wang W, Zhang D. Associations of dietary B vitamins intakes with depression in adults. Int J Vitam Nutr Res. 2023;93:142. doi:10.1024/0300-9831/a000720
- Wu Y, Zhang L, Li S, Zhang D. Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutr Rev. 2022;80:351. doi:10.1093/nutrit/nuab014
- Dhiman P, Pillai RR, Wilson AB, Premkumar N, Bharadwaj B, et al. Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women. BMC Pregnancy Childbirth. 2021;21:146. doi:10.1186/s12884-021-03622-x
- Bou Khalil R, Atallah E, Dirani E, Kallab M, Kassab A, et al. Can atypical dysgeusia in depression be related to a deafferentation syndrome?. Med Hypotheses. 2020;144:110047. doi:10.1016/j.mehy.2020.110047
- Trautmann C, Bock A, Urbach A, Hübner CA, Engmann O. Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2. Neuropharmacology. 2020;171:108112. doi:10.1016/j.neuropharm.2020.108112
- Esnafoglu E, Ozturan DD. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 2020;25:249. doi:10.1111/camh.12387
- Lv P, Xiang F, Zhang S, Lei D, Zhou C, et al. Valeriana jatamansi jones improves depressive behavior in CUMS mice by modulating vitamin B12-related ileal homeostasis. J Ethnopharmacol. 2025;342:119392. doi:10.1016/j.jep.2025.119392
- Alzahrani H. Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. Cureus. 2024;16:e73350. doi:10.7759/cureus.73350
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. doi:10.2147/NDT.S480417
- Hui J, Zhang N, Kang M, Gou Y, Liu C, et al. Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16132042
- Harikaran S, Basu S, Mukherjee MP, Kar R, Nair S, et al. Vitamin B12 and homocysteine in patients with major depressive disorder. J Family Med Prim Care. 2024;13:2049. doi:10.4103/jfmpc.jfmpc_1460_23
- Gao Y, Yang J, Sun H, Zhou H. Efficacy of Danzhixiaoyao tablets combined with methylcobalamin tablets in the treatment of burning mouth syndrome: an open-label, randomized controlled trial. BMC Oral Health. 2024;24:603. doi:10.1186/s12903-024-04318-2
- Cruz-Rodríguez J, Canals-Sans J, Hernández-Martínez C, Arija V. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study. J Reprod Infant Psychol. 2024. doi:10.1080/02646838.2024.2324043
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. doi:10.12968/bjcn.2024.29.3.137
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
- Tan Y, Zhou L, Gu K, Xie C, Wang Y, et al. Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2023;21:617. doi:10.9758/cpn.22.1040
