Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.1
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E(as d-Alpha Tocopherol)
268 mg
1,787%
Top Medical Research Studies
1
We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Read More
2
We conducted a study to assess whether vitamin E could help reduce the side effects associated with isotretinoin, a common treatment for severe acne. In this double-blind, randomized trial, we assigned 140 participants to receive either isotretinoin paired with a daily dose of 800 IU of vitamin E or a placebo over 20 weeks.
We closely monitored the participants for any side effects such as dry eyes and dry lips. Despite our hopes, the addition of vitamin E did not show any significant improvement in the side effects experienced by those taking isotretinoin. In essence, we found that vitamin E had little to no effect in alleviating the discomfort associated with isotretinoin treatment for acne.
This study thoroughly evaluated the potential benefits of combining vitamin E with isotretinoin but ultimately concluded that the vitamin does not mitigate the adverse side effects of the medication. It’s clear that vitamin E alone might not be the miracle solution for easing isotretinoin side effects as some had hoped.
We closely monitored the participants for any side effects such as dry eyes and dry lips. Despite our hopes, the addition of vitamin E did not show any significant improvement in the side effects experienced by those taking isotretinoin. In essence, we found that vitamin E had little to no effect in alleviating the discomfort associated with isotretinoin treatment for acne.
This study thoroughly evaluated the potential benefits of combining vitamin E with isotretinoin but ultimately concluded that the vitamin does not mitigate the adverse side effects of the medication. It’s clear that vitamin E alone might not be the miracle solution for easing isotretinoin side effects as some had hoped.
Read More
9
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
Most Useful Reviews
7.5
Visible difference
3 people found this helpful
This product works well for keeping my skin clear and healthy. After struggling with cystic acne for over a decade, I take two at night and awaken with glowing skin, noticing a big difference if I run out.
Read More
9
Pain relief
I've been taking two tablets daily for six months, initially to improve blood flow. However, it has been remarkably effective for my persistent and painful acne, which didn't heal despite various treatments. Just a month in, I noticed my acne healing more rapidly. Now, I'm pleased to say that I no longer experience large, painful spots. Additionally, my menstrual pain has improved significantly.
Read More
7.5
Visible improvement
3 people found this helpful
This product has significantly improved my skin's clarity and health. After suffering from cystic acne for over a decade, I take two at night and wake up with glowing skin. While my skin isn't flawless and I still experience occasional spots, I can definitely notice a difference when I run out. Among all my skincare products, this one yields the most visible results compared to any topical treatments.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.1
- All Researches
9
Lactoferrin and zinc reduce acne
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
Read More
9
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
9
We looked into how a combination of RetinSphere® and vitamin E affects mild comedonal acne (MCA). In our study, we measured important factors like sebum oxidation and inflammatory markers before and after treatment in 18 patients with MCA and 10 healthy controls.
Our findings showed that while the amount of sebum and squalene was similar before treatment between the groups, patients with MCA had higher levels of lipid peroxidation and oxidized squalene. These elevated markers contribute to inflammation and acne formation.
After 4 weeks, there was a notable decrease in oxidized lipids and inflammation markers in the lesions, bringing them in line with unaffected areas. These changes were accompanied by visible clinical improvement in the patients by the 8-week mark.
Yet, it’s important to recognize that while vitamin E was part of the treatment mix, this study did not isolate its specific effects. Thus, while we observed positive results, we cannot definitively attribute all improvements directly to vitamin E alone.
Our findings showed that while the amount of sebum and squalene was similar before treatment between the groups, patients with MCA had higher levels of lipid peroxidation and oxidized squalene. These elevated markers contribute to inflammation and acne formation.
After 4 weeks, there was a notable decrease in oxidized lipids and inflammation markers in the lesions, bringing them in line with unaffected areas. These changes were accompanied by visible clinical improvement in the patients by the 8-week mark.
Yet, it’s important to recognize that while vitamin E was part of the treatment mix, this study did not isolate its specific effects. Thus, while we observed positive results, we cannot definitively attribute all improvements directly to vitamin E alone.
Read More
8
We investigated the potential of a dietary supplement containing vitamin E and other ingredients to alleviate side effects from oral isotretinoin therapy in acne patients. The study involved forty-eight participants with nodular acne, divided into two groups. One group received isotretinoin combined with the supplement, while the other only received isotretinoin for six months.
Our findings revealed that the group taking the dietary supplement reported fewer side effects, experiencing less dryness and redness of the skin, as well as improved hydration levels. Participants also showed increased adherence to their treatment regimen when supplemented, which is encouraging for those battling the challenges of acne and its treatment.
The supplement's formulation, enriched with vitamin E and other antioxidants, seems to support skin health during isotretinoin therapy, helping to mitigate common discomforts like dry skin and erythema. This suggests that vitamin E plays a beneficial role when included in a combination supplement, enhancing overall treatment experience for patients undergoing isotretinoin therapy.
Our findings revealed that the group taking the dietary supplement reported fewer side effects, experiencing less dryness and redness of the skin, as well as improved hydration levels. Participants also showed increased adherence to their treatment regimen when supplemented, which is encouraging for those battling the challenges of acne and its treatment.
The supplement's formulation, enriched with vitamin E and other antioxidants, seems to support skin health during isotretinoin therapy, helping to mitigate common discomforts like dry skin and erythema. This suggests that vitamin E plays a beneficial role when included in a combination supplement, enhancing overall treatment experience for patients undergoing isotretinoin therapy.
Read More
8
We aimed to understand how plasma levels of vitamins A and E relate to acne conditions. To do this, we compared vitamin concentrations in 100 newly diagnosed acne patients with 100 healthy individuals of similar age. We utilized high-performance liquid chromatography to ensure accurate measurements, and acne severity was evaluated using the Global Acne Grading System.
Our findings revealed that acne patients had noticeably lower levels of both vitamin A and vitamin E compared to the controls. Specifically, vitamin A levels were 336.5 µg/L for patients versus 418.1 µg/L for healthy individuals, while vitamin E levels were 5.4 mg/L in patients against 5.9 mg/L in controls.
Additionally, we observed a clear link: as the severity of acne increased, the plasma levels of vitamins A and E tended to decrease. This suggests that these vitamins may play a role in the condition's progression, highlighting their potential importance in acne management.
However, it's essential to consider that while the correlation between low vitamin levels and acne severity is significant, the study does not confirm that vitamin E supplementation alone can effectively treat acne.
Our findings revealed that acne patients had noticeably lower levels of both vitamin A and vitamin E compared to the controls. Specifically, vitamin A levels were 336.5 µg/L for patients versus 418.1 µg/L for healthy individuals, while vitamin E levels were 5.4 mg/L in patients against 5.9 mg/L in controls.
Additionally, we observed a clear link: as the severity of acne increased, the plasma levels of vitamins A and E tended to decrease. This suggests that these vitamins may play a role in the condition's progression, highlighting their potential importance in acne management.
However, it's essential to consider that while the correlation between low vitamin levels and acne severity is significant, the study does not confirm that vitamin E supplementation alone can effectively treat acne.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Visible difference
3 people found this helpful
This product works well for keeping my skin clear and healthy. After struggling with cystic acne for over a decade, I take two at night and awaken with glowing skin, noticing a big difference if I run out.
Read More
9
Pain relief
I've been taking two tablets daily for six months, initially to improve blood flow. However, it has been remarkably effective for my persistent and painful acne, which didn't heal despite various treatments. Just a month in, I noticed my acne healing more rapidly. Now, I'm pleased to say that I no longer experience large, painful spots. Additionally, my menstrual pain has improved significantly.
Read More
7.5
Visible improvement
3 people found this helpful
This product has significantly improved my skin's clarity and health. After suffering from cystic acne for over a decade, I take two at night and wake up with glowing skin. While my skin isn't flawless and I still experience occasional spots, I can definitely notice a difference when I run out. Among all my skincare products, this one yields the most visible results compared to any topical treatments.
Read More
7.5
Convenient treatment
This product is great for combating acne. I took it alongside vitamin A, and it genuinely helps. There's no smell, and the glass jar is a convenient size. The dosage is clearly indicated, and I've noticed significant benefits.
Read More
7.5
Safe choice
I'm using vitamin E to help prevent my son's acne. Previously, I opted for a cheaper, artificial vitamin E, but I switched to this natural version. Although it's pricier, I want to ensure that he takes a product that is safe and effective for his condition.
Read More
Frequently Asked Questions
9
Pain relief
I've been taking two tablets daily for six months, initially to improve blood flow. However, it has been remarkably effective for my persistent and painful acne, which didn't heal despite various treatments. Just a month in, I noticed my acne healing more rapidly. Now, I'm pleased to say that I no longer experience large, painful spots. Additionally, my menstrual pain has improved significantly.
7.5
Visible improvement
3 people found this helpful
This product has significantly improved my skin's clarity and health. After suffering from cystic acne for over a decade, I take two at night and wake up with glowing skin. While my skin isn't flawless and I still experience occasional spots, I can definitely notice a difference when I run out. Among all my skincare products, this one yields the most visible results compared to any topical treatments.
7.5
Convenient treatment
This product is great for combating acne. I took it alongside vitamin A, and it genuinely helps. There's no smell, and the glass jar is a convenient size. The dosage is clearly indicated, and I've noticed significant benefits.
7.5
Safe choice
I'm using vitamin E to help prevent my son's acne. Previously, I opted for a cheaper, artificial vitamin E, but I switched to this natural version. Although it's pricier, I want to ensure that he takes a product that is safe and effective for his condition.
7
We examined the relationship between serum vitamin E levels and acne as part of a broader investigation into chronic inflammatory skin diseases. Our analysis included a number of studies that focused on vitamin E in patients, comparing their serum levels with those of healthy individuals.
The findings revealed that patients with acne had significantly lower levels of serum vitamin E compared to controls. This supports the idea that vitamin E might play a role in skin health, although we must note that the study did not delve into how vitamin E treatment specifically improves acne.
In short, while the lower vitamin E levels in acne patients are noteworthy, the study leaves us without conclusive evidence of vitamin E’s direct impact on treating acne. We highlight the importance of evaluating vitamin E status as part of managing skin health across various conditions, including acne.
The findings revealed that patients with acne had significantly lower levels of serum vitamin E compared to controls. This supports the idea that vitamin E might play a role in skin health, although we must note that the study did not delve into how vitamin E treatment specifically improves acne.
In short, while the lower vitamin E levels in acne patients are noteworthy, the study leaves us without conclusive evidence of vitamin E’s direct impact on treating acne. We highlight the importance of evaluating vitamin E status as part of managing skin health across various conditions, including acne.
9
Lactoferrin and zinc reduce acne
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
1
We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
2
We conducted a study to assess whether vitamin E could help reduce the side effects associated with isotretinoin, a common treatment for severe acne. In this double-blind, randomized trial, we assigned 140 participants to receive either isotretinoin paired with a daily dose of 800 IU of vitamin E or a placebo over 20 weeks.
We closely monitored the participants for any side effects such as dry eyes and dry lips. Despite our hopes, the addition of vitamin E did not show any significant improvement in the side effects experienced by those taking isotretinoin. In essence, we found that vitamin E had little to no effect in alleviating the discomfort associated with isotretinoin treatment for acne.
This study thoroughly evaluated the potential benefits of combining vitamin E with isotretinoin but ultimately concluded that the vitamin does not mitigate the adverse side effects of the medication. It’s clear that vitamin E alone might not be the miracle solution for easing isotretinoin side effects as some had hoped.
We closely monitored the participants for any side effects such as dry eyes and dry lips. Despite our hopes, the addition of vitamin E did not show any significant improvement in the side effects experienced by those taking isotretinoin. In essence, we found that vitamin E had little to no effect in alleviating the discomfort associated with isotretinoin treatment for acne.
This study thoroughly evaluated the potential benefits of combining vitamin E with isotretinoin but ultimately concluded that the vitamin does not mitigate the adverse side effects of the medication. It’s clear that vitamin E alone might not be the miracle solution for easing isotretinoin side effects as some had hoped.
References
- Liu X, Yang G, Luo M, Lan Q, Shi X, et al. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis. PLoS One. 2021;16:e0261259. doi:10.1371/journal.pone.0261259
- Chan H, Chan G, Santos J, Dee K, Co JK. A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. Int J Dermatol. 2017;56:686. doi:10.1111/ijd.13607
- Mills OH, Criscito MC, Schlesinger TE, Verdicchio R, Szoke E. Addressing Free Radical Oxidation in Acne Vulgaris. J Clin Aesthet Dermatol. 2016;9:25.
- Fabbrocini G, Cameli N, Lorenzi S, De Padova MP, Marasca C, et al. A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients. G Ital Dermatol Venereol. 2014;149:441.
- Capitanio B, Lora V, Ludovici M, Sinagra JL, Ottaviani M, et al. Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne. J Eur Acad Dermatol Venereol. 2014;28:1792. doi:10.1111/jdv.12431
- Goforoushan F, Azimi H, Goldust M. Efficacy of vitamin E to prevent dermal complications of isotretinoin. Pak J Biol Sci. 2013;16:548.
- Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I, et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014;33:99. doi:10.3109/15569527.2013.808656
- Aktürk AŞ, Güzel S, Bulca S, Demirsoy EO, Bayramgürler D, et al. Effects of isotretinoin on serum vitamin E levels in patients with acne. Int J Dermatol. 2013;52:363. doi:10.1111/j.1365-4632.2012.05676.x
- Erturan İ, Naziroğlu M, Akkaya VB. Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study. Cell Biochem Funct. 2012;30:552. doi:10.1002/cbf.2830
- El-Akawi Z, Abdel-Latif N, Abdul-Razzak K. Does the plasma level of vitamins A and E affect acne condition?. Clin Exp Dermatol. 2006;31:430.
- Strumia R. Dermatologic signs in patients with eating disorders. Am J Clin Dermatol. 2005;6:165.
- Kus S, Gün D, Demirçay Z, Sur H. Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris. Int J Dermatol. 2005;44:248.
- Bellei E, Rota C, Bergamini S, Manfredini P, Albertazzi A, et al. Effect of alpha-tocopherol and N-acetylcysteine on benzoyl peroxide toxicity in human keratinocytes. J Biochem Mol Toxicol. 2004;18:107.
- Weber SU, Thiele JJ, Han N, Luu C, Valacchi G, et al. Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. Free Radic Biol Med. 2003;34:170.
- Strauss JS, Gottlieb AB, Jones T, Koo JY, Leyden JJ, et al. Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial. J Am Acad Dermatol. 2000;43:777.
- Michaëlsson G, Edqvist LE. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment. Acta Derm Venereol. 1984;64:9.
