Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin C
500 mg
556%

Top Medical Research Studies

7
Vitamin C may lower hypothyroidism risk
We set out to examine how total vitamin C intake might influence hypothyroidism in individuals with Hashimoto thyroiditis, using data from the National Health and Nutrition Examination Survey conducted between 2007 and 2012. Our study utilized multivariate logistic regression and restricted cubic spline analyses to uncover possible associations.

What we found was quite intriguing. There was a clear negative linear relationship between total vitamin C intake and hypothyroidism. Specifically, participants who consumed higher amounts of vitamin C had a significantly lower likelihood of developing hypothyroidism. Those in the top quartile of vitamin C intake were about 60% less likely to have hypothyroidism compared to those in the lowest quartile.

This pattern remained consistent across different age groups and sexes, further emphasizing the potential benefits of vitamin C for individuals with Hashimoto's. Our findings suggest that increasing vitamin C intake may be a simple and effective strategy for reducing the risk of hypothyroidism in those affected. The data indicates that consuming between 4.57 and 1258.9 mg/day of vitamin C could be beneficial.

Overall, our research adds to the understanding of how antioxidants like vitamin C can play a role in thyroid health, encouraging us to consider dietary sources of this vital vitamin for those managing Hashimoto's thyroiditis.
We investigated how vitamin C affects liver and kidney functions, as well as tissue oxidative damage, in rats with hypothyroidism. The research involved pregnant rats that were divided into five groups, with one group receiving a common thyroid-inhibiting drug and others receiving various doses of vitamin C alongside it. This setup allowed us to compare the effects of vitamin C against a control group.

Throughout a lactation period and into the first eight weeks of their young offspring's lives, we closely monitored several health markers, including thyroid hormone levels, protein concentrations, and oxidative stress indicators in the liver and kidneys. Our findings showed that hypothyroid rats had lower levels of crucial proteins, but those treated with vitamin C exhibited notable improvements.

Vitamin C not only raised the levels of important proteins and thyroid hormone but also reduced harmful oxidative markers in both the liver and kidneys. The doses of 100 mg/kg and 500 mg/kg significantly improved kidney function as indicated by lower creatinine levels and enhanced antioxidant enzyme activity. Overall, vitamin C appeared to protect these organs against oxidative damage and improve their function in hypothyroid conditions.
9
Vitamin C improves thyroid hormone absorption
We explored how vitamin C might assist in the absorption of levothyroxine (l-T4) in patients battling hypothyroidism, particularly those also dealing with gastritis. In this study, 31 patients—with an average age of about 48 years—consumed their prescribed dose of l-T4 mixed in water, sometimes supplemented with 500 mg of vitamin C.

After some time, we carefully measured changes in their thyroid hormone levels. The results were quite encouraging: we found that vitamin C appeared to positively influence serum levels of free T4, T3, and TSH, which are key indicators of thyroid function in these patients. This improvement suggests that vitamin C may play a valuable role in managing hypothyroidism, especially for individuals who have additional gastrointestinal health concerns.

Overall, this study highlights a potential avenue for better control of thyroid hormone levels in patients who struggle with conventional treatments due to malabsorption issues. We believe that incorporating vitamin C into treatment plans for these patients could enhance their overall management and quality of life.

Most Useful Reviews

9
Significant improvement
Excellent! The endocrinologist recommended it to me. I have hypothyroidism. My previous endocrinologists merely advised taking Eutirox, which was just okay. However, my new endocrinologist provided an in-depth explanation of my condition and suggested taking Eutirox with pure vitamin C to maximise its effectiveness (contrary to the recommendation of orange juice from elsewhere). Consequently, I've found that Eutirox has a more profound impact, and I'm experiencing a much better improvement in my condition. It doesn’t cause any side effects, is easy to take, and has no flavour. A success!!!
7.5
Less fatigue noticed
Excellent capsules for those of us with hypothyroidism. I take one daily along with Eutirox. I have observed significant improvement and now I feel less tired.
6
Hypothyroidism managed
Very good; I take it for hypothyroidism alongside thyroid medication, and I have managed to lower my levels.

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
  • All Researches
We explored the effects of vitamin C (VC) on hypothyroidism triggered by boldenone undecylenate (BL) in a study involving thirty adult male Wistar rats. The rats were divided into five groups, including a control group, a group treated with VC, and others treated with BL alone or with both BL and VC. Over eight weeks, we carefully examined the impacts on immune responses and thyroid function.

Our findings revealed that BL significantly disrupted the immune system and altered thyroid function, leading to conditions resembling hypothyroidism. Specifically, we observed an increase in thyroid-stimulating hormone and thyroid peroxidase antibody levels, while the critical thyroid hormones decreased. BL also changed immune markers, which affected the overall health of the rats.

However, when we administered VC alongside BL, we noted some promising results: VC appeared to correct many of the disruptions caused by BL. Most immune parameters returned to normal, and the structure and function of the thyroid improved. This indicates that VC could play a protective role against the detrimental effects of BL abuse.

While this study highlights the potential benefits of VC, it's important to remember that it was tested in combination with BL, making it hard to pinpoint VC's effects on hypothyroidism alone. Nonetheless, VC shows promise for managing issues related to BL usage.
We investigated how vitamin C affects liver and kidney functions, as well as tissue oxidative damage, in rats with hypothyroidism. The research involved pregnant rats that were divided into five groups, with one group receiving a common thyroid-inhibiting drug and others receiving various doses of vitamin C alongside it. This setup allowed us to compare the effects of vitamin C against a control group.

Throughout a lactation period and into the first eight weeks of their young offspring's lives, we closely monitored several health markers, including thyroid hormone levels, protein concentrations, and oxidative stress indicators in the liver and kidneys. Our findings showed that hypothyroid rats had lower levels of crucial proteins, but those treated with vitamin C exhibited notable improvements.

Vitamin C not only raised the levels of important proteins and thyroid hormone but also reduced harmful oxidative markers in both the liver and kidneys. The doses of 100 mg/kg and 500 mg/kg significantly improved kidney function as indicated by lower creatinine levels and enhanced antioxidant enzyme activity. Overall, vitamin C appeared to protect these organs against oxidative damage and improve their function in hypothyroid conditions.
We aimed to investigate how vitamin C might help prevent neuronal damage caused by hypothyroidism in the brains of neonatal and juvenile rats. To carry out this study, we divided pregnant rats into four groups. The control group received regular drinking water, while the other groups were treated with varying amounts of propylthiouracil (PTU), a substance that induces hypothyroidism, alone or in combination with vitamin C.

After a treatment period coinciding with the lactation phase, we carefully examined the brains of some male pups. Our findings revealed that puppies given PTU showed a significant increase in dark neurons and apoptotic cells, indicating marked neuronal damage compared to the control group. Additionally, hypothyroidism caused a decrease in the volume of the hippocampus, a critical brain region linked to memory and learning.

Interestingly, we found that giving vitamin C at a dose of 100 mg/kg noticeably reduced the number of dark neurons and apoptotic cells. It also seemed to mitigate the decrease in hippocampal volume caused by hypothyroidism. This suggests that vitamin C may provide protective benefits against the damaging effects of hypothyroidism in developing brains.
Our study investigated how vitamin C affects learning and memory in juvenile rats with hypothyroidism. Using a detailed experimental design, we had different groups of pregnant rats treated either with propylthiouracil (PTU) to induce hypothyroidism or given various doses of vitamin C in addition to PTU. This allowed us to compare the effects of vitamin C alongside hypothyroidism treatment.

We found that PTU negatively impacted learning and memory, shown by increased time needed to navigate a maze and lowered performance in memory tests. However, when we introduced vitamin C, particularly in doses of 10, 100, and 500 mg/kg, we noted significant improvements. The rats receiving vitamin C showed faster navigation times, better memory test results, and enhanced brain health markers, such as increased levels of antioxidants.

These findings suggest that vitamin C could serve as a protective agent against learning and memory deficits associated with hypothyroidism in young rats. The improvements in both cognitive function and brain biochemistry highlight the potential of vitamin C as a beneficial treatment complementary to conventional methods for addressing the cognitive concerns tied to hypothyroidism.
9
Vitamin C improves thyroid hormone absorption
We explored how vitamin C might assist in the absorption of levothyroxine (l-T4) in patients battling hypothyroidism, particularly those also dealing with gastritis. In this study, 31 patients—with an average age of about 48 years—consumed their prescribed dose of l-T4 mixed in water, sometimes supplemented with 500 mg of vitamin C.

After some time, we carefully measured changes in their thyroid hormone levels. The results were quite encouraging: we found that vitamin C appeared to positively influence serum levels of free T4, T3, and TSH, which are key indicators of thyroid function in these patients. This improvement suggests that vitamin C may play a valuable role in managing hypothyroidism, especially for individuals who have additional gastrointestinal health concerns.

Overall, this study highlights a potential avenue for better control of thyroid hormone levels in patients who struggle with conventional treatments due to malabsorption issues. We believe that incorporating vitamin C into treatment plans for these patients could enhance their overall management and quality of life.

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Significant improvement
Excellent! The endocrinologist recommended it to me. I have hypothyroidism. My previous endocrinologists merely advised taking Eutirox, which was just okay. However, my new endocrinologist provided an in-depth explanation of my condition and suggested taking Eutirox with pure vitamin C to maximise its effectiveness (contrary to the recommendation of orange juice from elsewhere). Consequently, I've found that Eutirox has a more profound impact, and I'm experiencing a much better improvement in my condition. It doesn’t cause any side effects, is easy to take, and has no flavour. A success!!!
7.5
Less fatigue noticed
Excellent capsules for those of us with hypothyroidism. I take one daily along with Eutirox. I have observed significant improvement and now I feel less tired.
6
Hypothyroidism managed
Very good; I take it for hypothyroidism alongside thyroid medication, and I have managed to lower my levels.

Frequently Asked Questions

7.5
Less fatigue noticed
Excellent capsules for those of us with hypothyroidism. I take one daily along with Eutirox. I have observed significant improvement and now I feel less tired.
6
Hypothyroidism managed
Very good; I take it for hypothyroidism alongside thyroid medication, and I have managed to lower my levels.
9
Significant improvement
Excellent! The endocrinologist recommended it to me. I have hypothyroidism. My previous endocrinologists merely advised taking Eutirox, which was just okay. However, my new endocrinologist provided an in-depth explanation of my condition and suggested taking Eutirox with pure vitamin C to maximise its effectiveness (contrary to the recommendation of orange juice from elsewhere). Consequently, I've found that Eutirox has a more profound impact, and I'm experiencing a much better improvement in my condition. It doesn’t cause any side effects, is easy to take, and has no flavour. A success!!!
7
Vitamin C may lower hypothyroidism risk
We set out to examine how total vitamin C intake might influence hypothyroidism in individuals with Hashimoto thyroiditis, using data from the National Health and Nutrition Examination Survey conducted between 2007 and 2012. Our study utilized multivariate logistic regression and restricted cubic spline analyses to uncover possible associations.

What we found was quite intriguing. There was a clear negative linear relationship between total vitamin C intake and hypothyroidism. Specifically, participants who consumed higher amounts of vitamin C had a significantly lower likelihood of developing hypothyroidism. Those in the top quartile of vitamin C intake were about 60% less likely to have hypothyroidism compared to those in the lowest quartile.

This pattern remained consistent across different age groups and sexes, further emphasizing the potential benefits of vitamin C for individuals with Hashimoto's. Our findings suggest that increasing vitamin C intake may be a simple and effective strategy for reducing the risk of hypothyroidism in those affected. The data indicates that consuming between 4.57 and 1258.9 mg/day of vitamin C could be beneficial.

Overall, our research adds to the understanding of how antioxidants like vitamin C can play a role in thyroid health, encouraging us to consider dietary sources of this vital vitamin for those managing Hashimoto's thyroiditis.
7
Vitamin C shows potential benefits
We investigated how vitamin C can influence hypothyroidism caused by methimazole (MMI) in male Wistar rats. In our study, we fed the rats MMI alone and in combination with vitamin C, vitamin E, or turmeric extract for comparison. By the end of the experiment, we looked at thyroid gland weights, levels of essential thyroid hormones (T4 and T3), and cholesterol levels.

The results showed that rats treated solely with MMI had significantly increased thyroid weights, alongside very low hormone levels and a rise in cholesterol. However, the rats that received vitamin C alongside MMI displayed promising changes; their thyroid weights were notably lower, and they had less suppression of T4 and T3 levels compared to the MMI-only group.

This suggests that vitamin C, as well as other antioxidants, may provide a protective effect on the thyroid, potentially due to their direct interaction with the gland. The findings indicate that incorporating vitamin C with treatments for hypothyroidism might be beneficial.
We investigated how vitamin C affects liver and kidney functions, as well as tissue oxidative damage, in rats with hypothyroidism. The research involved pregnant rats that were divided into five groups, with one group receiving a common thyroid-inhibiting drug and others receiving various doses of vitamin C alongside it. This setup allowed us to compare the effects of vitamin C against a control group.

Throughout a lactation period and into the first eight weeks of their young offspring's lives, we closely monitored several health markers, including thyroid hormone levels, protein concentrations, and oxidative stress indicators in the liver and kidneys. Our findings showed that hypothyroid rats had lower levels of crucial proteins, but those treated with vitamin C exhibited notable improvements.

Vitamin C not only raised the levels of important proteins and thyroid hormone but also reduced harmful oxidative markers in both the liver and kidneys. The doses of 100 mg/kg and 500 mg/kg significantly improved kidney function as indicated by lower creatinine levels and enhanced antioxidant enzyme activity. Overall, vitamin C appeared to protect these organs against oxidative damage and improve their function in hypothyroid conditions.
9
Vitamin C improves thyroid hormone absorption
We explored how vitamin C might assist in the absorption of levothyroxine (l-T4) in patients battling hypothyroidism, particularly those also dealing with gastritis. In this study, 31 patients—with an average age of about 48 years—consumed their prescribed dose of l-T4 mixed in water, sometimes supplemented with 500 mg of vitamin C.

After some time, we carefully measured changes in their thyroid hormone levels. The results were quite encouraging: we found that vitamin C appeared to positively influence serum levels of free T4, T3, and TSH, which are key indicators of thyroid function in these patients. This improvement suggests that vitamin C may play a valuable role in managing hypothyroidism, especially for individuals who have additional gastrointestinal health concerns.

Overall, this study highlights a potential avenue for better control of thyroid hormone levels in patients who struggle with conventional treatments due to malabsorption issues. We believe that incorporating vitamin C into treatment plans for these patients could enhance their overall management and quality of life.

References

  1. Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024;132:1575. doi:10.1017/S0007114524001715
  2. Ibrahim NNAE, Estfanous RS, Abo-Alala AM, Elkattan AK, Amer RM. Effect of Electromagnetic Radiation of Wi-Fi Router on Thyroid Gland and the Possible Protective Role of Combined Vitamin C and Zinc Administration in Adult Male Albino Rats. J Microsc Ultrastruct. 2024;12:51. doi:10.4103/jmau.jmau_121_23
  3. El Deib MM, El-Sharkawy NI, Beheiry RR, Abd-Elhakim YM, Ismail SA, et al. Boldenone undecylenate disrupts the immune system and induces autoimmune clinical hypothyroidism in rats: Vitamin C ameliorative effects. Int Immunopharmacol. 2021;99:107939. doi:10.1016/j.intimp.2021.107939
  4. Esmaeilizadeh M, Hosseini M, Beheshti F, Alikhani V, Keshavarzi Z, et al. Vitamin C improves liver and renal functions in hypothyroid rats by reducing tissue oxidative injury. Int J Vitam Nutr Res. 2020;90:84. doi:10.1024/0300-9831/a000495
  5. Khordad E, Alipour F, Beheshti F, Hosseini M, Rajabzadeh AA, et al. Vitamin C prevents hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats: A stereological study. J Chem Neuroanat. 2018;93:48. doi:10.1016/j.jchemneu.2017.11.011
  6. Beheshti F, Karimi S, Vafaee F, Shafei MN, Sadeghnia HR, et al. The effects of vitamin C on hypothyroidism-associated learning and memory impairment in juvenile rats. Metab Brain Dis. 2017;32:703. doi:10.1007/s11011-017-9954-y
  7. Beheshti F, Hosseini M, Shafei MN, Soukhtanloo M, Ghasemi S, et al. The effects of Nigella sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats. Nutr Neurosci. 2017;20:49. doi:10.1179/1476830514Y.0000000144
  8. Jubiz W, Ramirez M. Effect of vitamin C on the absorption of levothyroxine in patients with hypothyroidism and gastritis. J Clin Endocrinol Metab. 2014;99:E1031. doi:10.1210/jc.2013-4360
  9. Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, et al. Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis. J Clin Endocrinol Metab. 2006;91:5076.
  10. Deshpande UR, Joseph LJ, Patwardhan UN, Samuel AM. Effect of antioxidants (vitamin C, E and turmeric extract) on methimazole induced hypothyroidism in rats. Indian J Exp Biol. 2002;40:735.
  11. Takahashi K, Akiba Y, Horiguchi M. Effects of supplemental ascorbic acid on performance, organ weight and plasma cholesterol concentration in broilers treated with propylthiouracil. Br Poult Sci. 1991;32:545.
image