' 
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Top Medical Research Studies
9
Vitamin B6 pathway affects cancer survival
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
High relevance to glioblastoma research
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
Read More
9
Vitamin B6 deficiency impacts cancer
Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila.
Direct link to cancer research
We examined how vitamin B6, specifically its active form pyridoxal 5'-phosphate (PLP), influences cancer development using Drosophila as a model. The study revealed that deficiency in PLP, triggered by specific compounds like 4-deoxypyridoxine (4DP), led to the transformation of benign tumors driven by oncogenic Ras into more aggressive cancer forms.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Read More
8
Vitamin B6 metal complexes effective
Metal complexes containing vitamin B6-based scaffold as potential DNA/BSA-binding agents inducing apoptosis in hepatocarcinoma (HepG2) cells.
Complex cancer treatment dynamics
We investigated a unique vitamin B6-based ligand and its metal complexes to understand their effects on cancer, particularly focusing on liver cancer cells (HepG2). The researchers designed their study by synthesizing a ligand from pyridoxal hydrochloride, the active form of vitamin B6, and then creating metal complexes with zinc, copper, and cobalt. These complexes were meticulously characterized using techniques like spectroscopy to confirm their structure and properties.
Our findings revealed that these metal complexes had the ability to interact with DNA and bovine serum albumin (BSA), suggesting potential pathways for therapeutic action. Notably, one complex showed strong binding to BSA, indicating it may effectively target cancerous tissues. We observed promising results for the copper complex, which displayed significant cancer cell toxicity, inducing cell cycle arrest at the G2/M phase and leading to apoptosis, the programmed cell death essential for eliminating cancer cells.
While we recognized the potential of vitamin B6 derivatives in cancer therapy through these metal complexes, it’s essential to note that the overall direct impact of vitamin B6 alone on cancer treatment remains complex and requires further investigation. Nonetheless, these insights open new avenues for exploring vitamin B6 in conjunction with metal complexes as cancer-fighting agents.
Our findings revealed that these metal complexes had the ability to interact with DNA and bovine serum albumin (BSA), suggesting potential pathways for therapeutic action. Notably, one complex showed strong binding to BSA, indicating it may effectively target cancerous tissues. We observed promising results for the copper complex, which displayed significant cancer cell toxicity, inducing cell cycle arrest at the G2/M phase and leading to apoptosis, the programmed cell death essential for eliminating cancer cells.
While we recognized the potential of vitamin B6 derivatives in cancer therapy through these metal complexes, it’s essential to note that the overall direct impact of vitamin B6 alone on cancer treatment remains complex and requires further investigation. Nonetheless, these insights open new avenues for exploring vitamin B6 in conjunction with metal complexes as cancer-fighting agents.
Read More
Most Useful Reviews
6.8
Medical backing
B-6 25 mg is highly convenient. My grandfather, a GP, believed quality balanced vitamins could prevent certain cancers, a view later supported by medical evidence. I personally require additional B-6 and find Solgar the sole manufacturer offering 25 mg strength. However, one must be cautious not to exceed recommended daily intakes due to potential risks to the nervous system and liver. I advise thorough research before purchasing vitamin B(s).
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
9.5
Vitamin B6 enhances chemotherapy effectiveness
Treatment of patients with carcinomas in advanced stages with 5-fluorouracil, folinic acid and pyridoxine in tandem.
Some benefit, but complex interplay
We studied how high-dose pyridoxine, also known as vitamin B6, influences the effectiveness of chemotherapy drugs like 5-fluorouracil (FUra) and folinic acid (FA) in patients with advanced-stage cancers. Our group of 50 patients included individuals with digestive tract and breast cancers, all characterized by poor prognoses.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
Read More
9
Vitamin B6 pathway affects cancer survival
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
High relevance to glioblastoma research
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
Read More
9
Vitamin B6 deficiency impacts cancer
Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila.
Direct link to cancer research
We examined how vitamin B6, specifically its active form pyridoxal 5'-phosphate (PLP), influences cancer development using Drosophila as a model. The study revealed that deficiency in PLP, triggered by specific compounds like 4-deoxypyridoxine (4DP), led to the transformation of benign tumors driven by oncogenic Ras into more aggressive cancer forms.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Read More
8
Vitamin B6 may improve survival
Serum Pyridoxal 5'-Phosphate and Pyridoxic Acid Ratio Index with Prognosis of Colorectal Cancer: A Prospective Cohort Study.
Study indicates mixed results.
We explored the relationship between serum levels of vitamin B6, specifically pyridoxal 5'-phosphate (PLP), and survival rates in colorectal cancer patients. The study involved 1,286 colorectal cancer patients from the Guangdong Colorectal Cancer Cohort, tracked for their overall and cancer-specific mortality until December 2023.
Our findings revealed that higher levels of PLP were linked to better overall survival and colorectal cancer-specific survival. In contrast, the pyridoxic acid ratio (PAr) did not show a significant association with survival outcomes. We observed that PLP levels correlated positively with longevity in patients, as evidenced by improved survival rates. Moreover, the impact of vitamin B6 varied based on alcohol consumption among patients.
While these results suggest that maintaining adequate vitamin B6 levels may benefit those with colorectal cancer, it is essential to note that the correlation does not establish a definitive cause-and-effect relationship. Thus, while vitamin B6 shows promising signs in enhancing survival, further research is needed to confirm its efficacy.
Our findings revealed that higher levels of PLP were linked to better overall survival and colorectal cancer-specific survival. In contrast, the pyridoxic acid ratio (PAr) did not show a significant association with survival outcomes. We observed that PLP levels correlated positively with longevity in patients, as evidenced by improved survival rates. Moreover, the impact of vitamin B6 varied based on alcohol consumption among patients.
While these results suggest that maintaining adequate vitamin B6 levels may benefit those with colorectal cancer, it is essential to note that the correlation does not establish a definitive cause-and-effect relationship. Thus, while vitamin B6 shows promising signs in enhancing survival, further research is needed to confirm its efficacy.
Read More
8
Vitamin B6 metal complexes effective
Metal complexes containing vitamin B6-based scaffold as potential DNA/BSA-binding agents inducing apoptosis in hepatocarcinoma (HepG2) cells.
Complex cancer treatment dynamics
We investigated a unique vitamin B6-based ligand and its metal complexes to understand their effects on cancer, particularly focusing on liver cancer cells (HepG2). The researchers designed their study by synthesizing a ligand from pyridoxal hydrochloride, the active form of vitamin B6, and then creating metal complexes with zinc, copper, and cobalt. These complexes were meticulously characterized using techniques like spectroscopy to confirm their structure and properties.
Our findings revealed that these metal complexes had the ability to interact with DNA and bovine serum albumin (BSA), suggesting potential pathways for therapeutic action. Notably, one complex showed strong binding to BSA, indicating it may effectively target cancerous tissues. We observed promising results for the copper complex, which displayed significant cancer cell toxicity, inducing cell cycle arrest at the G2/M phase and leading to apoptosis, the programmed cell death essential for eliminating cancer cells.
While we recognized the potential of vitamin B6 derivatives in cancer therapy through these metal complexes, it’s essential to note that the overall direct impact of vitamin B6 alone on cancer treatment remains complex and requires further investigation. Nonetheless, these insights open new avenues for exploring vitamin B6 in conjunction with metal complexes as cancer-fighting agents.
Our findings revealed that these metal complexes had the ability to interact with DNA and bovine serum albumin (BSA), suggesting potential pathways for therapeutic action. Notably, one complex showed strong binding to BSA, indicating it may effectively target cancerous tissues. We observed promising results for the copper complex, which displayed significant cancer cell toxicity, inducing cell cycle arrest at the G2/M phase and leading to apoptosis, the programmed cell death essential for eliminating cancer cells.
While we recognized the potential of vitamin B6 derivatives in cancer therapy through these metal complexes, it’s essential to note that the overall direct impact of vitamin B6 alone on cancer treatment remains complex and requires further investigation. Nonetheless, these insights open new avenues for exploring vitamin B6 in conjunction with metal complexes as cancer-fighting agents.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.3
6.8
Medical backing
B-6 25 mg is highly convenient. My grandfather, a GP, believed quality balanced vitamins could prevent certain cancers, a view later supported by medical evidence. I personally require additional B-6 and find Solgar the sole manufacturer offering 25 mg strength. However, one must be cautious not to exceed recommended daily intakes due to potential risks to the nervous system and liver. I advise thorough research before purchasing vitamin B(s).
Read More
