5/26/2025
Last update
5/26/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Top Medical Research Studies
9
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Read More
8
We investigated how a supplement containing magnesium, melatonin, and vitamin B6 impacts insomnia. The study involved 60 patients diagnosed with insomnia, who were split into a study group and a control group.
The study group received a daily dose of this supplement for three months, while both groups reported their insomnia severity using the Athens Insomnia Scale. Initially, the two groups showed similar scores, indicating mild to moderate insomnia.
After the three-month period, the results were telling. The study group reported a significant improvement, lowering their average insomnia score to mild levels, while the control group remained at moderate insomnia levels. However, it’s essential to note that while vitamin B6 was part of the supplement, we cannot conclusively state its isolated effect on insomnia treatment due to the combination with magnesium and melatonin.
Overall, the findings suggest that magnesium, melatonin, and vitamin B6 together can effectively alleviate insomnia symptoms, benefiting those struggling with sleep issues, regardless of the cause.
The study group received a daily dose of this supplement for three months, while both groups reported their insomnia severity using the Athens Insomnia Scale. Initially, the two groups showed similar scores, indicating mild to moderate insomnia.
After the three-month period, the results were telling. The study group reported a significant improvement, lowering their average insomnia score to mild levels, while the control group remained at moderate insomnia levels. However, it’s essential to note that while vitamin B6 was part of the supplement, we cannot conclusively state its isolated effect on insomnia treatment due to the combination with magnesium and melatonin.
Overall, the findings suggest that magnesium, melatonin, and vitamin B6 together can effectively alleviate insomnia symptoms, benefiting those struggling with sleep issues, regardless of the cause.
Read More
7
Vitamin B6's unclear insomnia effect
We observed that vitamin B6 deficiency might contribute to insomnia in patients suffering from acute intermittent porphyria (AIP). In a study involving several patients, insomnia was one of the notable symptoms experienced during acute attacks. While vitamin B6 was included in the treatment plan, its isolated effectiveness on insomnia couldn't be precisely determined because it was part of a broader therapeutic approach.
Patients received various treatments, including glucose, sodium chloride, and even phenothiazines, making it difficult to pinpoint whether vitamin B6 alone helped alleviate insomnia. Additionally, the overall improvement seen in these patients suggests that their recovery may result from a combination of therapies rather than solely from vitamin B6 itself. It’s essential to recognize that while vitamin B6 was part of the treatment strategy, we cannot conclusively say it specifically addressed insomnia with the information available.
Patients received various treatments, including glucose, sodium chloride, and even phenothiazines, making it difficult to pinpoint whether vitamin B6 alone helped alleviate insomnia. Additionally, the overall improvement seen in these patients suggests that their recovery may result from a combination of therapies rather than solely from vitamin B6 itself. It’s essential to recognize that while vitamin B6 was part of the treatment strategy, we cannot conclusively say it specifically addressed insomnia with the information available.
Read More
Most Useful Reviews
10
Sleeping pill alternative
63 people found this helpful
Excellent sleep aid! I had no idea a low dose of B6 in the evening could improve my sleep so much. After suffering from insomnia for over a decade, I used to manage about four hours a night, even with sleeping pills. Now, I’ve been able to cease taking them altogether, and I average about seven to eight hours of solid sleep!
Read More
7.5
Improved insomnia symptoms
18 people found this helpful
I take half a tablet of B6 at night with 1000 mg of GABA, as I read in a medical journal that B6 enhances GABA's effectiveness. This seems to improve my insomnia more than GABA alone.
Read More
9
Soothed nerves
I combine B6 with magnesium, which calms my nervous system and regulates my sleep patterns. My blood pressure is normal as well. If anyone is dealing with nervous tics, panic attacks, blood pressure issues, insomnia, or psychological stress, I highly recommend this combination.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
- All Researches
9
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Read More
8
We investigated how a supplement containing magnesium, melatonin, and vitamin B6 impacts insomnia. The study involved 60 patients diagnosed with insomnia, who were split into a study group and a control group.
The study group received a daily dose of this supplement for three months, while both groups reported their insomnia severity using the Athens Insomnia Scale. Initially, the two groups showed similar scores, indicating mild to moderate insomnia.
After the three-month period, the results were telling. The study group reported a significant improvement, lowering their average insomnia score to mild levels, while the control group remained at moderate insomnia levels. However, it’s essential to note that while vitamin B6 was part of the supplement, we cannot conclusively state its isolated effect on insomnia treatment due to the combination with magnesium and melatonin.
Overall, the findings suggest that magnesium, melatonin, and vitamin B6 together can effectively alleviate insomnia symptoms, benefiting those struggling with sleep issues, regardless of the cause.
The study group received a daily dose of this supplement for three months, while both groups reported their insomnia severity using the Athens Insomnia Scale. Initially, the two groups showed similar scores, indicating mild to moderate insomnia.
After the three-month period, the results were telling. The study group reported a significant improvement, lowering their average insomnia score to mild levels, while the control group remained at moderate insomnia levels. However, it’s essential to note that while vitamin B6 was part of the supplement, we cannot conclusively state its isolated effect on insomnia treatment due to the combination with magnesium and melatonin.
Overall, the findings suggest that magnesium, melatonin, and vitamin B6 together can effectively alleviate insomnia symptoms, benefiting those struggling with sleep issues, regardless of the cause.
Read More
7
Vitamin B6's unclear insomnia effect
We observed that vitamin B6 deficiency might contribute to insomnia in patients suffering from acute intermittent porphyria (AIP). In a study involving several patients, insomnia was one of the notable symptoms experienced during acute attacks. While vitamin B6 was included in the treatment plan, its isolated effectiveness on insomnia couldn't be precisely determined because it was part of a broader therapeutic approach.
Patients received various treatments, including glucose, sodium chloride, and even phenothiazines, making it difficult to pinpoint whether vitamin B6 alone helped alleviate insomnia. Additionally, the overall improvement seen in these patients suggests that their recovery may result from a combination of therapies rather than solely from vitamin B6 itself. It’s essential to recognize that while vitamin B6 was part of the treatment strategy, we cannot conclusively say it specifically addressed insomnia with the information available.
Patients received various treatments, including glucose, sodium chloride, and even phenothiazines, making it difficult to pinpoint whether vitamin B6 alone helped alleviate insomnia. Additionally, the overall improvement seen in these patients suggests that their recovery may result from a combination of therapies rather than solely from vitamin B6 itself. It’s essential to recognize that while vitamin B6 was part of the treatment strategy, we cannot conclusively say it specifically addressed insomnia with the information available.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Sleeping pill alternative
63 people found this helpful
Excellent sleep aid! I had no idea a low dose of B6 in the evening could improve my sleep so much. After suffering from insomnia for over a decade, I used to manage about four hours a night, even with sleeping pills. Now, I’ve been able to cease taking them altogether, and I average about seven to eight hours of solid sleep!
Read More
7.5
Improved insomnia symptoms
18 people found this helpful
I take half a tablet of B6 at night with 1000 mg of GABA, as I read in a medical journal that B6 enhances GABA's effectiveness. This seems to improve my insomnia more than GABA alone.
Read More
9
Soothed nerves
I combine B6 with magnesium, which calms my nervous system and regulates my sleep patterns. My blood pressure is normal as well. If anyone is dealing with nervous tics, panic attacks, blood pressure issues, insomnia, or psychological stress, I highly recommend this combination.
Read More
9
Beneficial combination
I have struggled with insomnia for years. This product has proven very beneficial for me, especially when combined with Oryzanol.
Read More
Frequently Asked Questions
9
Beneficial combination
I have struggled with insomnia for years. This product has proven very beneficial for me, especially when combined with Oryzanol.
9
Soothed nerves
I combine B6 with magnesium, which calms my nervous system and regulates my sleep patterns. My blood pressure is normal as well. If anyone is dealing with nervous tics, panic attacks, blood pressure issues, insomnia, or psychological stress, I highly recommend this combination.
8
We investigated how a supplement containing magnesium, melatonin, and vitamin B6 impacts insomnia. The study involved 60 patients diagnosed with insomnia, who were split into a study group and a control group.
The study group received a daily dose of this supplement for three months, while both groups reported their insomnia severity using the Athens Insomnia Scale. Initially, the two groups showed similar scores, indicating mild to moderate insomnia.
After the three-month period, the results were telling. The study group reported a significant improvement, lowering their average insomnia score to mild levels, while the control group remained at moderate insomnia levels. However, it’s essential to note that while vitamin B6 was part of the supplement, we cannot conclusively state its isolated effect on insomnia treatment due to the combination with magnesium and melatonin.
Overall, the findings suggest that magnesium, melatonin, and vitamin B6 together can effectively alleviate insomnia symptoms, benefiting those struggling with sleep issues, regardless of the cause.
The study group received a daily dose of this supplement for three months, while both groups reported their insomnia severity using the Athens Insomnia Scale. Initially, the two groups showed similar scores, indicating mild to moderate insomnia.
After the three-month period, the results were telling. The study group reported a significant improvement, lowering their average insomnia score to mild levels, while the control group remained at moderate insomnia levels. However, it’s essential to note that while vitamin B6 was part of the supplement, we cannot conclusively state its isolated effect on insomnia treatment due to the combination with magnesium and melatonin.
Overall, the findings suggest that magnesium, melatonin, and vitamin B6 together can effectively alleviate insomnia symptoms, benefiting those struggling with sleep issues, regardless of the cause.
9
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
7
Vitamin B6's unclear insomnia effect
We observed that vitamin B6 deficiency might contribute to insomnia in patients suffering from acute intermittent porphyria (AIP). In a study involving several patients, insomnia was one of the notable symptoms experienced during acute attacks. While vitamin B6 was included in the treatment plan, its isolated effectiveness on insomnia couldn't be precisely determined because it was part of a broader therapeutic approach.
Patients received various treatments, including glucose, sodium chloride, and even phenothiazines, making it difficult to pinpoint whether vitamin B6 alone helped alleviate insomnia. Additionally, the overall improvement seen in these patients suggests that their recovery may result from a combination of therapies rather than solely from vitamin B6 itself. It’s essential to recognize that while vitamin B6 was part of the treatment strategy, we cannot conclusively say it specifically addressed insomnia with the information available.
Patients received various treatments, including glucose, sodium chloride, and even phenothiazines, making it difficult to pinpoint whether vitamin B6 alone helped alleviate insomnia. Additionally, the overall improvement seen in these patients suggests that their recovery may result from a combination of therapies rather than solely from vitamin B6 itself. It’s essential to recognize that while vitamin B6 was part of the treatment strategy, we cannot conclusively say it specifically addressed insomnia with the information available.
References
- Djokic G, Vojvodić P, Korcok D, Agic A, Rankovic A, et al. The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia. Open Access Maced J Med Sci. 2019;7:3101. 10.3889/oamjms.2019.771
- Lemoine P, Bablon JC, Da Silva C. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Complement Ther Med. 2019;45:104. 10.1016/j.ctim.2019.05.024
- Mydlík M, Derzsiová K. Kidney damage in acute intermittent porphyria. Przegl Lek. 2011;68:610.
