Last update
3/14/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E(as d-Alpha Tocopherol)
268 mg
1,787%
Top Medical Research Studies
8
We examined the effects of vitamin E on atherosclerosis in the cerebellum of rabbits. In this study, forty rabbits were split into four groups, where specific groups received vitamin E alongside regular diets or added cholesterol.
The results revealed that cholesterol-treated rabbits experienced significant damage, evident through decreased fiber density and changes in brain cell structure. Surprisingly, while vitamin E showed some protective traits by reducing these changes, its overall impact on atherosclerosis was inconclusive.
The results revealed that cholesterol-treated rabbits experienced significant damage, evident through decreased fiber density and changes in brain cell structure. Surprisingly, while vitamin E showed some protective traits by reducing these changes, its overall impact on atherosclerosis was inconclusive.
Read More
9
We investigated a new compound called NATOH, which combines vitamin E with properties of natural anti-inflammatory agents.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
Read More
9
We investigated how a form of vitamin E, tocopheryl phosphate (TPM), impacts the development of atherosclerosis using apolipoprotein-E deficient mice. By comparing TPM with traditional vitamin E, we found that TPM significantly reduced atherosclerotic lesions and inflammation indicators.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
Read More
Most Useful Reviews
7.5
Positive effect
1 people found this helpful
I requested my parents in their 70s to begin with 100 IU of vitamin E due to my arteriosclerosis. After finishing that, I switched to this 400 IU as it appeared suitable, so I opted for the larger size. The container is substantial and noticeable.
Read More
9
Prevention noted
I have been taking this for many years, and it helps in preventing arteriosclerosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
- All Researches
9
We investigated a new compound called NATOH, which combines vitamin E with properties of natural anti-inflammatory agents.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
Read More
9
We explored the potential benefits of combining vitamins C and E on heart health in mice with arteriosclerosis. By monitoring mice on an atherogenic diet, we found that this combination significantly lowered unhealthy cholesterol and triglyceride levels.
The vitamins supported better function in high-density lipoprotein (HDL), reducing inflammation markers and helping to remodel HDL particles. This suggests a cardioprotective effect and improved overall health in the studied mice. However, the implications for human health remain unclear.
The vitamins supported better function in high-density lipoprotein (HDL), reducing inflammation markers and helping to remodel HDL particles. This suggests a cardioprotective effect and improved overall health in the studied mice. However, the implications for human health remain unclear.
Read More
9
We investigated how a form of vitamin E, tocopheryl phosphate (TPM), impacts the development of atherosclerosis using apolipoprotein-E deficient mice. By comparing TPM with traditional vitamin E, we found that TPM significantly reduced atherosclerotic lesions and inflammation indicators.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
Read More
8
We examined the effectiveness of tocotrienol and tocopherol, two forms of vitamin E, in treating atherosclerotic cardiovascular diseases. Our systematic review analyzed studies published between 2002 and early 2023 to evaluate their safety and health benefits.
Tocotrienol emerged as a promising option, significantly lowering cholesterol and markers of inflammation. In contrast, tocopherol's results were mixed and potentially indicated increased mortality risk. This evidence positions tocotrienol as a safer alternative for improving cardiovascular health.
Tocotrienol emerged as a promising option, significantly lowering cholesterol and markers of inflammation. In contrast, tocopherol's results were mixed and potentially indicated increased mortality risk. This evidence positions tocotrienol as a safer alternative for improving cardiovascular health.
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8
We examined the impact of vitamin E on patients with severe lower limb atherosclerosis after reconstructive surgery.
Sixty patients were divided into two groups: one received vitamin E daily for a month, while the other followed standard therapy.
After treatment, we found that vitamin E significantly reduced the level of the harmful Bax protein and raised the protective Bcl-2 protein.
This suggests that vitamin E could enhance recovery by balancing apoptosis markers in these patients.
Sixty patients were divided into two groups: one received vitamin E daily for a month, while the other followed standard therapy.
After treatment, we found that vitamin E significantly reduced the level of the harmful Bax protein and raised the protective Bcl-2 protein.
This suggests that vitamin E could enhance recovery by balancing apoptosis markers in these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Positive effect
1 people found this helpful
I requested my parents in their 70s to begin with 100 IU of vitamin E due to my arteriosclerosis. After finishing that, I switched to this 400 IU as it appeared suitable, so I opted for the larger size. The container is substantial and noticeable.
Read More
9
Prevention noted
I have been taking this for many years, and it helps in preventing arteriosclerosis.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liu Q, Wu X, Wang Y, Wang X, Zhao F, et al. Association of dietary vitamin E intake with peripheral arterial disease: A retrospective cross-sectional study. PLoS One. 2025;20:e0320356. 10.1371/journal.pone.0320356
- Rafique S, Khan DA, Farhat K, Khan MA, Noor M, et al. Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans. J Pak Med Assoc. 2024;74:1124. 10.47391/JPMA.9227
- Kalinin RA, Suchkov IA, Klimentova ÉA, Shchul'kin AV, Egorov AA. [Effect of an antioxidant on vascular wall cell apoptosis markers after reconstructive operations]. Angiol Sosud Khir. 2021;27:8. 10.33529/ANGIO2021301
- Wang Y, Zhang S, Zhang G, Yu B, Gao X, et al. Association between type D personality and in-stent restenosis in patients treated with percutaneous coronary intervention: A mediation analysis of dietary patterns. J Psychosom Res. 2020;138:110244. 10.1016/j.jpsychores.2020.110244
- Nakatsu Y, Niida S, Tanaka K, Takenaka S, Kuwabara A. The Relationship between Serum Vitamin E Level and Risk Factors for Arteriosclerosis in Japanese Postmenopausal Women. J Nutr Sci Vitaminol (Tokyo). 2020;66:213. 10.3177/jnsv.66.213
- Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK. High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors. 2020;46:653. 10.1002/biof.1635
- Elbeltagy MAF, Elkholy WB, Salman AS. Effect of atherosclerosis and the protective effect of the antioxidant vitamin E on the rabbit cerebellum. Microscopy (Oxf). 2019;68:369. 10.1093/jmicro/dfz023
- Ranard KM, Kuchan MJ, Erdman JW. α-Tocopherol, but Not γ-Tocopherol, Attenuates the Expression of Selective Tumor Necrosis Factor-Alpha-Induced Genes in Primary Human Aortic Cell Lines. Lipids. 2019;54:289. 10.1002/lipd.12149
- Rodriguez-Duarte J, Galliussi G, Dapueto R, Rossello J, Malacrida L, et al. A novel nitroalkene-α-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in Apo E knockout mice. Br J Pharmacol. 2019;176:757. 10.1111/bph.14561
- Maugeri A, Hruskova J, Jakubik J, Kunzova S, Sochor O, et al. Dietary antioxidant intake decreases carotid intima media thickness in women but not in men: A cross-sectional assessment in the Kardiovize study. Free Radic Biol Med. 2019;131:274. 10.1016/j.freeradbiomed.2018.12.018
- Chai SC, Foley EM, Arjmandi BH. Anti-atherogenic properties of vitamin E, aspirin, and their combination. PLoS One. 2018;13:e0206315. 10.1371/journal.pone.0206315
- Contreras-Duarte S, Chen P, Andía M, Uribe S, Irarrázaval P, et al. Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice. Biol Res. 2018;51:34. 10.1186/s40659-018-0183-6
- Libinaki R, Vinh A, Tesanovic-Klajic S, Widdop R, Gaspari T. The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice. Clin Exp Pharmacol Physiol. 2017;44 Suppl 1:107. 10.1111/1440-1681.12821
- Del Carmen Baez M, Taran M, de La Paz Scribano M, Balceda A, Buonanotte C, et al. Inflammatory and Oxidative Stress Markers as Indicator of Atherogenesis in Rats: Antioxidants as Preventive Pharmacological Methods. Antiinflamm Antiallergy Agents Med Chem. 2017;16:87. 10.2174/1871523016666170616121133
- Minotti GC, Cortese F, Corsonello A, Guadalupi G, D Arcangelo AP, et al. The Influence of Dietary Components on Early Signs of Atherosclerosis in Apparently Healthy Young-adult Males: An Observational Study of 615 Subjects. Curr Vasc Pharmacol. 2017;15:482. 10.2174/1570161115666170201111809
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