Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.9
USERS' SCORE
Moderately Good
Based on 40 Reviews
7.7
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin B2 (riboflavin)
100 mg
7,692%
Top Medical Research Studies
9.5
We evaluated the effectiveness of Vitamin B2 supplementation in preventing migraines through a comprehensive review of existing studies.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
Read More
9.5
We evaluated how effective riboflavin is for children and teens suffering from migraines by examining 42 patients over a year at Dell Children's Medical Center.
Our findings revealed that riboflavin significantly reduced headache frequency, intensity, and duration.
Patients missed fewer school days and required less acute medication after treatment. Overall, riboflavin stands out as a safe, cost-effective option to help manage pediatric migraines.
Our findings revealed that riboflavin significantly reduced headache frequency, intensity, and duration.
Patients missed fewer school days and required less acute medication after treatment. Overall, riboflavin stands out as a safe, cost-effective option to help manage pediatric migraines.
Read More
9
We explored the effects of naproxen sodium (NxS) as a short-term treatment for women with pure menstrual migraine. Involving 25 participants, we administered NxS daily around their menstrual cycle for three cycles.
Our findings revealed a significant drop in migraine attack frequency, duration, and intensity. The average number of attacks decreased markedly, from 1.7 to 1.1. Additionally, the duration of each migraine lessened from nearly 26 hours to about 13 hours, demonstrating promising results for using NxS in managing menstrual migraines.
Our findings revealed a significant drop in migraine attack frequency, duration, and intensity. The average number of attacks decreased markedly, from 1.7 to 1.1. Additionally, the duration of each migraine lessened from nearly 26 hours to about 13 hours, demonstrating promising results for using NxS in managing menstrual migraines.
Read More
Most Useful Reviews
10
Miraculous improvement
33 people found this helpful
A miracle cure for my chronic morning migraines. I highly recommend this to anyone with chronic migraine issues. My neurologist suggested trying this before resorting to high-dose anti-seizure drugs. I'm so glad I tried B2! I take 200mg in the morning and 200mg before bed, and my migraines have almost completely vanished!
Read More
7.5
Helps with migraine
9 people found this helpful
Excellent vitamin B2! It aids recovery from viral infections, calms the nervous system, and assists in migraine relief. One capsule contains 100 mg of vegetarian B2, and I take it with food daily. The symptoms of deficiency include dry eyes and irritability. Solgar's quality is impressive, and I've repeatedly found it beneficial.
Read More
7.5
Effective prevention
9 people found this helpful
Good quality product helping prevent migraines. I take B2 for migraine prevention, and it's hard to find. This high-quality product is reasonably priced. It helps curb the frequency, duration, and intensity of my migraines in conjunction with magnesium, as directed by my neurologist.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.9
- All Researches
9.5
We evaluated the effectiveness of Vitamin B2 supplementation in preventing migraines through a comprehensive review of existing studies.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
Read More
9.5
We evaluated how effective riboflavin is for children and teens suffering from migraines by examining 42 patients over a year at Dell Children's Medical Center.
Our findings revealed that riboflavin significantly reduced headache frequency, intensity, and duration.
Patients missed fewer school days and required less acute medication after treatment. Overall, riboflavin stands out as a safe, cost-effective option to help manage pediatric migraines.
Our findings revealed that riboflavin significantly reduced headache frequency, intensity, and duration.
Patients missed fewer school days and required less acute medication after treatment. Overall, riboflavin stands out as a safe, cost-effective option to help manage pediatric migraines.
Read More
9
Peripheral cannabinoids may relieve migraines
We examined the effects of a new type of cannabinoid, designed to specifically target peripheral receptors without affecting the brain. Using mouse models, we observed that this treatment could effectively prevent certain symptoms of migraine and avoid complications often seen with traditional medications.
Notably, when we administered these peripherally restricted cannabinoids before migraine-triggering agents, we noted a significant reduction in pain sensitivity and biochemical responses typically associated with migraines. Interestingly, these cannabinoids did not seem to cause any negative side effects linked to tolerance development.
This study supports the idea that targeting peripheral cannabinoid receptors could be a viable new approach for managing migraines and related medication overuse headaches.
Notably, when we administered these peripherally restricted cannabinoids before migraine-triggering agents, we noted a significant reduction in pain sensitivity and biochemical responses typically associated with migraines. Interestingly, these cannabinoids did not seem to cause any negative side effects linked to tolerance development.
This study supports the idea that targeting peripheral cannabinoid receptors could be a viable new approach for managing migraines and related medication overuse headaches.
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9
We explored the impact of ginkgolide B, an extract from Ginkgo biloba, on migraine with aura. In a six-month study with fifty women, we observed beneficial results after participants took a combination of ginkgolide B, coenzyme Q10, and vitamin B2.
Notably, migraine aura frequency dropped from an average of 3.7 to 1.2 episodes by the end of the treatment. Moreover, the duration of migraines significantly decreased as well. Overall, ginkgolide B showed promise in reducing the occurrence and duration of migraines with aura.
Notably, migraine aura frequency dropped from an average of 3.7 to 1.2 episodes by the end of the treatment. Moreover, the duration of migraines significantly decreased as well. Overall, ginkgolide B showed promise in reducing the occurrence and duration of migraines with aura.
Read More
9
We explored the effects of naproxen sodium (NxS) as a short-term treatment for women with pure menstrual migraine. Involving 25 participants, we administered NxS daily around their menstrual cycle for three cycles.
Our findings revealed a significant drop in migraine attack frequency, duration, and intensity. The average number of attacks decreased markedly, from 1.7 to 1.1. Additionally, the duration of each migraine lessened from nearly 26 hours to about 13 hours, demonstrating promising results for using NxS in managing menstrual migraines.
Our findings revealed a significant drop in migraine attack frequency, duration, and intensity. The average number of attacks decreased markedly, from 1.7 to 1.1. Additionally, the duration of each migraine lessened from nearly 26 hours to about 13 hours, demonstrating promising results for using NxS in managing menstrual migraines.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 40 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Miraculous improvement
33 people found this helpful
A miracle cure for my chronic morning migraines. I highly recommend this to anyone with chronic migraine issues. My neurologist suggested trying this before resorting to high-dose anti-seizure drugs. I'm so glad I tried B2! I take 200mg in the morning and 200mg before bed, and my migraines have almost completely vanished!
Read More
7.5
Helps with migraine
9 people found this helpful
Excellent vitamin B2! It aids recovery from viral infections, calms the nervous system, and assists in migraine relief. One capsule contains 100 mg of vegetarian B2, and I take it with food daily. The symptoms of deficiency include dry eyes and irritability. Solgar's quality is impressive, and I've repeatedly found it beneficial.
Read More
7.5
Effective prevention
9 people found this helpful
Good quality product helping prevent migraines. I take B2 for migraine prevention, and it's hard to find. This high-quality product is reasonably priced. It helps curb the frequency, duration, and intensity of my migraines in conjunction with magnesium, as directed by my neurologist.
Read More
10
Significant relief
5 people found this helpful
Taking 400mg daily has made me feel much better! I'm happy with my purchase. No migraines at all since I started this routine.
Read More
9
Significant migraine reduction
4 people found this helpful
I have used this migraine remedy for many years, and it works well. I take 300mg of B2 with 300mg of magnesium at night, which has reduced my migraines from one a week to about two a year. The capsules are small and easy to swallow.
Read More
Frequently Asked Questions
7.5
Migraine frequency reduction
1 people found this helpful
I recommend riboflavin for migraine sufferers. I took 400 mg for two months before reducing to 100 mg, which helped lessen the frequency and severity of my migraine attacks. It's also beneficial for eyesight.
9
Fast migraine relief
Riboflavin stabilises brain vessels. After suffering from intense migraines for years, I've found that taking triptans with vitamin B2 during attacks stops the pain quickly, preventing it from returning the next day. I plan to take 400mg daily for 6 to 12 weeks for further relief.
9
Game changer for migraines
2 people found this helpful
This B2 supplement was a game changer for my frequent migraines. After regular use, I found I could prevent migraines by taking one under my tongue at the first sign. The quality is superb, and the capsules are small. I've switched back from another brand, as this works best for me.
8
Fewer migraines
I take two B2 pills each day to prevent migraines. After following my naturopathic doctor's advice, my migraines decreased from over twelve a month to only two to three now.
6
Dizziness relief
1 people found this helpful
Great for migraines! I take 400 mg daily and it has helped tremendously with dizziness and headaches, along with light sensitivity.
7.5
Migraine support
My GP has encouraged me to incorporate B2 into my routine for migraine relief, alongside magnesium. While it's not eliminating migraines entirely, it has reduced the intensity of my headaches. I trust Solgar and will continue using this vegan B2.
9.5
We evaluated the effectiveness of Vitamin B2 supplementation in preventing migraines through a comprehensive review of existing studies.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
7
We explored the effectiveness of vitamin B2 against sodium valproate for preventing migraines in a clinical trial with 90 participants. For three months, one group received 400 mg of vitamin B2 daily, while the other took 500 mg of sodium valproate.
Throughout the study, we measured migraine frequency, duration, and intensity, along with any side effects experienced.
Ultimately, we found both treatments similarly effective in reducing migraine attacks. However, vitamin B2 was associated with fewer complications, making it a safer option for patients who might struggle with sodium valproate.
Throughout the study, we measured migraine frequency, duration, and intensity, along with any side effects experienced.
Ultimately, we found both treatments similarly effective in reducing migraine attacks. However, vitamin B2 was associated with fewer complications, making it a safer option for patients who might struggle with sodium valproate.
8
We found that riboflavin, or vitamin B2, shows promise for preventing migraines in adults, with minimal side effects reported. While the evidence supports its use, there’s no proven benefit for children.
Coenzyme Q10 also appears to help with migraines, though evidence is limited. Other options like feverfew and magnesium may be beneficial, but they require more safety studies and have varied effectiveness. Melatonin's impact on migraines isn't clear, and butterbur has potential effectiveness but also risk of liver toxicity.
Coenzyme Q10 also appears to help with migraines, though evidence is limited. Other options like feverfew and magnesium may be beneficial, but they require more safety studies and have varied effectiveness. Melatonin's impact on migraines isn't clear, and butterbur has potential effectiveness but also risk of liver toxicity.
References
- Szabo E, Bolo NR, Borsook D, Burstein R, Ashina S. Peripherally acting anti-CGRP monoclonal antibodies attenuate cortical resting-state connectivity in migraine patients. Cephalalgia. 2025;45:3331024241313377. 10.1177/03331024241313377
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
- Son H, Zhang Y, Shannonhouse J, Gomez R, Kim YS. PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice. J Headache Pain. 2024;25:87. 10.1186/s10194-024-01786-3
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. 10.1080/1028415X.2021.1904542
- Yamamoto T, Mulpuri Y, Izraylev M, Li Q, Simonian M, et al. Selective targeting of peripheral cannabinoid receptors prevents behavioral symptoms and sensitization of trigeminal neurons in mouse models of migraine and medication overuse headache. Pain. 2021;162:2246. 10.1097/j.pain.0000000000002214
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. 10.1016/j.pediatrneurol.2020.09.009
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
- Cesarone MR, Dugall M, Hu S, Belcaro G, Hosoi M, et al. Episodic primary migraine headache: supplementary prophylaxis with Pycnogenol® prevents attacks and controls oxidative stress. Panminerva Med. 2020;62:102. 10.23736/S0031-0808.19.03745-5
- Namazi N, Heshmati J, Tarighat-Esfanjani A. Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review. Int J Vitam Nutr Res. 2015;85:79. 10.1024/0300-9831/a000225
- Rahimdel A, Zeinali A, Yazdian-Anari P, Hajizadeh R, Arefnia E. Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial. Electron Physician. 2015;7:1344. 10.14661/1344
- Tepper SJ. Nutraceutical and Other Modalities for the Treatment of Headache. Continuum (Minneap Minn). 2015;21:1018. 10.1212/CON.0000000000000211
- Yorns WR, Hardison HH. Mitochondrial dysfunction in migraine. Semin Pediatr Neurol. 2013;20:188. 10.1016/j.spen.2013.09.002
- Allais G, D'Andrea G, Maggio M, Benedetto C. The efficacy of ginkgolide B in the acute treatment of migraine aura: an open preliminary trial. Neurol Sci. 2013;34 Suppl 1:S161. 10.1007/s10072-013-1413-x
- D'Andrea G, Bussone G, Allais G, Aguggia M, D'Onofrio F, et al. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. Neurol Sci. 2009;30 Suppl 1:S121. 10.1007/s10072-009-0074-2
- Allais G, Bussone G, De Lorenzo C, Castagnoli Gabellari I, Zonca M, et al. Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations. Neurol Sci. 2007;28 Suppl 2:S225.
