Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc gluconate)
50 mg
455%
Top Medical Research Studies
8
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Read More
9
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
Read More
9
We examined the potential of zinc compounds, particularly zinc-amino acid complexes, to effectively treat acne. This study focused on how these zinc formulations could not only help with acne but also ensure safety for the skin.
Initially, we checked the cytotoxicity of the zinc complexes on human skin cells, demonstrating their safety. We then evaluated their antibacterial properties, which are crucial for combating acne-causing bacteria. After finding promising results, we selected zinc complexes with glycine and histidine to create unique gel formulations.
The next steps involved thorough testing of these gel preparations for stability, purity, and tolerability. We confirmed that they maintained their quality over time, showed no irritation or allergic reactions in a patch test with 25 volunteers, and exhibited high microbiological purity.
Ultimately, our findings suggest that these zinc-based gels can be a valuable topical option for acne treatment due to their strong antibacterial performance and minimal toxicity to skin cells. Our dermatological formulations appear safe and effective, contributing positively to acne management.
Initially, we checked the cytotoxicity of the zinc complexes on human skin cells, demonstrating their safety. We then evaluated their antibacterial properties, which are crucial for combating acne-causing bacteria. After finding promising results, we selected zinc complexes with glycine and histidine to create unique gel formulations.
The next steps involved thorough testing of these gel preparations for stability, purity, and tolerability. We confirmed that they maintained their quality over time, showed no irritation or allergic reactions in a patch test with 25 volunteers, and exhibited high microbiological purity.
Ultimately, our findings suggest that these zinc-based gels can be a valuable topical option for acne treatment due to their strong antibacterial performance and minimal toxicity to skin cells. Our dermatological formulations appear safe and effective, contributing positively to acne management.
Read More
Most Useful Reviews
9
Cleared skin
4 people found this helpful
Zinc is a miracle! I suggest it for maintaining healthy skin, hair, and nails. My subcutaneous acne has vanished, and my hair and nails are thriving.
Read More
9
Strong zinc effects
4 people found this helpful
I eliminated my acne after taking just one pill. Just remember to eat beforehand, as it’s a potent zinc supplement but doesn't cause hunger afterwards.
Read More
9
Quick acne relief
3 people found this helpful
I didn’t undergo tests but noticed a remarkable change after a week of taking zinc. My painful acne cleared up completely after years of discomfort.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
- All Researches
9.5
We investigated the effectiveness of a novel microneedle patch designed for acne treatment, which incorporates zinc-based nanoparticles. This patch combines sodium hyaluronate with zinc porphyrin-based metal-organic frameworks and zinc oxide. By using ultrasound to release activated oxygen, we observed a remarkable antibacterial efficiency, achieving a 99.73% reduction in acne-causing bacteria within just 15 minutes.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Read More
9
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Read More
9
We assessed the potential of zinc oxide nanoparticles in combating acne. Using biogenically synthesized zinc oxide, we mixed it with a polymer to create a topical nanogel aimed at treating acne. Through rigorous testing against acne-causing bacteria, we observed that these biogenic nanoparticles showed a promising antibacterial effect, particularly against Gram-positive bacteria.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Read More
We wanted to find out how effective a cleansing gel containing salicylic acid, zinc gluconate, and lipohydroxy acids is for treating truncal acne. Conducted over 84 days, our study included 51 individuals with mild to moderate acne, and we tracked various skin conditions like the number of acne lesions and the overall skin barrier health.
After regular use of the gel, we observed a significant reduction in total acne lesions—over half were improved by the end of the study. While non-inflammatory lesions saw a drop of 64% and inflammatory lesions were reduced by nearly 30%, the key point is that zinc gluconate was part of a trio of ingredients, making it challenging to pinpoint its specific contribution.
When we considered skin barrier function, a notable improvement was also measured—21.26% better at Day 84. Patients reported no significant side effects or intolerances, suggesting that the ingredients within the gel, including zinc, were well tolerated.
Overall, the evidence hints at zinc's potential benefits as part of a combination treatment against acne. But since it was used together with other active ingredients, we can't solely credit zinc for the results observed.
After regular use of the gel, we observed a significant reduction in total acne lesions—over half were improved by the end of the study. While non-inflammatory lesions saw a drop of 64% and inflammatory lesions were reduced by nearly 30%, the key point is that zinc gluconate was part of a trio of ingredients, making it challenging to pinpoint its specific contribution.
When we considered skin barrier function, a notable improvement was also measured—21.26% better at Day 84. Patients reported no significant side effects or intolerances, suggesting that the ingredients within the gel, including zinc, were well tolerated.
Overall, the evidence hints at zinc's potential benefits as part of a combination treatment against acne. But since it was used together with other active ingredients, we can't solely credit zinc for the results observed.
Read More
9
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.
However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.
Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cleared skin
4 people found this helpful
Zinc is a miracle! I suggest it for maintaining healthy skin, hair, and nails. My subcutaneous acne has vanished, and my hair and nails are thriving.
Read More
9
Strong zinc effects
4 people found this helpful
I eliminated my acne after taking just one pill. Just remember to eat beforehand, as it’s a potent zinc supplement but doesn't cause hunger afterwards.
Read More
9
Quick acne relief
3 people found this helpful
I didn’t undergo tests but noticed a remarkable change after a week of taking zinc. My painful acne cleared up completely after years of discomfort.
Read More
7.5
Lightening post-acne
260 people found this helpful
Excellent! This supplement is effective for reducing post-acne marks, as my doctor advised. The pigmentation is noticeably fading.
Read More
7.5
Effective zinc support
3 people found this helpful
Zinc is quite effective! It has helped diminish my acne and makes my skin less oily. We usually take half a pill daily for best results.
Read More
Frequently Asked Questions
9
Quick acne relief
3 people found this helpful
I didn’t undergo tests but noticed a remarkable change after a week of taking zinc. My painful acne cleared up completely after years of discomfort.
9
Strong zinc effects
4 people found this helpful
I eliminated my acne after taking just one pill. Just remember to eat beforehand, as it’s a potent zinc supplement but doesn't cause hunger afterwards.
6
Visible results
We are trying to tackle initial acne issues for my 14-year-old. Some improvement is visible, but we need more time to assess the full effects.
6
Acne improvement
120 people found this helpful
Positive results! A colleague dealt with severe acne, following a beautician's advice and taking zinc. After a month, there was noticeable improvement.
9
Cleared skin
4 people found this helpful
Zinc is a miracle! I suggest it for maintaining healthy skin, hair, and nails. My subcutaneous acne has vanished, and my hair and nails are thriving.
7.5
Lightening post-acne
260 people found this helpful
Excellent! This supplement is effective for reducing post-acne marks, as my doctor advised. The pigmentation is noticeably fading.
7.5
Wound healing
3 people found this helpful
Excellent! Zinc boosts immunity and aids in acne healing. It also protects hair from environmental damage, making it thicker and shinier.
8
We explored how zinc treatment may help with inflammatory skin conditions like acne vulgaris, rosacea, and hidradenitis suppurativa. These conditions can appear quite similar, which makes diagnosing them a bit tricky. By examining gene expression data across these three disorders, we noticed that certain zinc-binding proteins were consistently elevated in all cases.
Our hypothesis centers around these proteins possibly sequestering zinc, which could promote inflammation due to local zinc deficiency. To investigate this further, we identified high-dose dietary zinc as a potential therapeutic option. This was tested and validated in an acne mouse model, showing promising results for its effectiveness in reducing the inflammation associated with acne.
Although the study specifically highlighted the isolated effect of zinc, it strongly suggests that incorporating high doses of dietary zinc might offer a new avenue for treatment. This could be an encouraging option for those struggling with acne, pointing to a novel approach grounded in scientific findings.
Our hypothesis centers around these proteins possibly sequestering zinc, which could promote inflammation due to local zinc deficiency. To investigate this further, we identified high-dose dietary zinc as a potential therapeutic option. This was tested and validated in an acne mouse model, showing promising results for its effectiveness in reducing the inflammation associated with acne.
Although the study specifically highlighted the isolated effect of zinc, it strongly suggests that incorporating high doses of dietary zinc might offer a new avenue for treatment. This could be an encouraging option for those struggling with acne, pointing to a novel approach grounded in scientific findings.
9
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
5
We explored the potential benefits of adding oral zinc to low-dose isotretinoin therapy for those dealing with acne vulgaris (AV). By comparing two groups of participants, one receiving zinc along with a lower dose of isotretinoin and another group on the standard dosage, we aimed to see if this combination could enhance treatment outcomes and reduce side effects.
After monitoring sixty AV patients, it was found that both groups showed similar reductions in acne lesions and grading scores, meaning the zinc didn’t provide an additional benefit in clearing up acne compared to the standard treatment alone. However, patients who took zinc experienced significantly fewer treatment-related side effects, with only 20% reporting issues versus 76.7% in the standard isotretinoin group.
In terms of patient satisfaction and relapse rates, there was no notable difference between the two groups. While we did observe improvements in both groups, the addition of zinc appeared to serve primarily as a means to lessen the adverse effects of isotretinoin rather than significantly enhancing treatment efficacy. Thus, while the findings are promising for a more tolerable treatment pathway, more research is necessary to fully understand zinc's impact when combined with isotretinoin at varying dosages.
After monitoring sixty AV patients, it was found that both groups showed similar reductions in acne lesions and grading scores, meaning the zinc didn’t provide an additional benefit in clearing up acne compared to the standard treatment alone. However, patients who took zinc experienced significantly fewer treatment-related side effects, with only 20% reporting issues versus 76.7% in the standard isotretinoin group.
In terms of patient satisfaction and relapse rates, there was no notable difference between the two groups. While we did observe improvements in both groups, the addition of zinc appeared to serve primarily as a means to lessen the adverse effects of isotretinoin rather than significantly enhancing treatment efficacy. Thus, while the findings are promising for a more tolerable treatment pathway, more research is necessary to fully understand zinc's impact when combined with isotretinoin at varying dosages.
7
Zinc's effects on acne treatment
We explored the potential benefits of zinc in treating acne based on a review of available literature. This review examined various studies focusing on the use of zinc for acne vulgaris, along with its effectiveness for other skin conditions like leishmaniasis and hidradenitis suppurativa.
Through our search in MEDLINE, we found that zinc seems to have both antioxidant and immunomodulatory properties, which may contribute to its effectiveness in treating inflammatory conditions, including acne. While the evidence is promising, especially for those with zinc deficiency, it’s important to note that there’s still a need for further research to clarify how effective zinc can be when used on its own, without other treatments.
Patients experiencing acne might benefit from additional strategies, including zinc supplementation. However, the exact role of zinc as a standalone therapy still requires more investigation through large controlled trials.
Through our search in MEDLINE, we found that zinc seems to have both antioxidant and immunomodulatory properties, which may contribute to its effectiveness in treating inflammatory conditions, including acne. While the evidence is promising, especially for those with zinc deficiency, it’s important to note that there’s still a need for further research to clarify how effective zinc can be when used on its own, without other treatments.
Patients experiencing acne might benefit from additional strategies, including zinc supplementation. However, the exact role of zinc as a standalone therapy still requires more investigation through large controlled trials.
References
- Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high-dose dietary zinc as a therapeutic agent. Exp Dermatol. 2024;33:e15145. doi:10.1111/exd.15145
- Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. doi:10.1007/s00403-024-02895-4
- Akman TC, Yazici M, Atila A, Mertoglu C. Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects. Biol Trace Elem Res. 2024;202:4858. doi:10.1007/s12011-023-04053-9
- Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent. medRxiv. 2023. doi:10.1101/2023.11.28.23299152
- Shields A, Ly S, Wafae B, Chang YF, Manjaly P, et al. Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review. JAMA Dermatol. 2023;159:1373. doi:10.1001/jamadermatol.2023.3949
- Tan YY, Wong LS, Nyam KL, Wittayanarakul K, Zawawi NA, et al. Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using and Its Effect on Acne Vulgaris. Molecules. 2023;28. doi:10.3390/molecules28196749
- Xiang Y, Lu J, Mao C, Zhu Y, Wang C, et al. Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment. Sci Adv. 2023;9:eadf0854. doi:10.1126/sciadv.adf0854
- Towersey L, Correia P, Fajgenbaum Feiges M, Euzébio Gonçalves Junior J, Sant'Anna B, et al. Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study. Clin Cosmet Investig Dermatol. 2023;16:119. doi:10.2147/CCID.S394123
- Salah E. Oral Zinc as a Novel Adjuvant and Sparing Therapy for Systemic Isotretinoin in Acne Vulgaris: A Preliminary Comparative Study. J Clin Aesthet Dermatol. 2022;15:58.
- Naji HH, Al-Azawi RSA, Ibrahim NJ, Kzar HH. Investigation of the Role of Zn/Cu Index and its Correlation with Physiological Activity of SOD 1 and GRx in Males with Acne Vulgaris. Arch Razi Inst. 2022;77:623. doi:10.22092/ARI.2021.356857.1928
- Searle T, Ali FR, Al-Niaimi F. Zinc in dermatology. J Dermatolog Treat. 2022;33:2455. doi:10.1080/09546634.2022.2062282
- Poizeau F, Plantier F, Bell H, Moyal-Barracco M. Vulvar Fordyce adenitis: A cohort of 45 women. Ann Dermatol Venereol. 2021;148:221. doi:10.1016/j.annder.2021.04.001
- Tolino E, Skroza N, Mambrin A, Proietti I, Bernardini N, et al. An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris. J Clin Aesthet Dermatol. 2021;14:56.
- Maillard A, Pastor D, Merat R. Anti-PD-1-Induced Hidradenitis Suppurativa. Dermatopathology (Basel). 2021;8:37. doi:10.3390/dermatopathology8010007
- Abendrot M, Płuciennik E, Felczak A, Zawadzka K, Piątczak E, et al. Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations. Int J Mol Sci. 2021;22. doi:10.3390/ijms22041641
- Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. doi:10.1111/dth.14252
