Solgar Zinc Picolinate 22 mg

Zinc cream alleviates cold sores

Based on 9 Researches

A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

9.5

Strengthens immunity

Most Useful Review

Helps the immune system and assists in quickly addressing cold sores. The results are excellent, with no side effects.

Chronic Cough

Relieves chronic cough

Most Useful Review

Great remedy for chronic rhinosinusitis. Zinc helps to clear the sinuses effectively, removing surprising amounts of mucus. After giving it to my child, all the nasty green stuff comes out after just three days. 👍

Influenza

Zinc may prevent influenza entry

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.

Most Relevant Research

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

9.5

Improved immunity

Most Useful Review

I accepted zinc for two reasons: to strengthen my immune system and to improve my skin and hair. After suffering from the coronavirus, my health and appearance were affected. However, after taking zinc, I noticed a significant improvement in my immunity over the winter months, avoiding colds and influenza. My hair and skin also began to improve noticeably.

Rash

Mast-style Solgar zinc is now a staple in my purchases. It doesn't cause nausea or swelling. Best taken at night after meals, it effectively heals mucous membranes. If you suffer from erosive lesions, recurrent rash, or acne, it will help. I take it before important events for clear skin. Tiny tablets dissolve quickly and have little taste. Zinc deficiency signs include white dots on nails and hair loss. It also supports thyroid function in hypothyroidism.

Acne

Zinc effective for acne treatment

Based on 16 Researches

Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.

Most Relevant Research

We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!

9.5

Clearer skin

Most Useful Review

Zinc is essential for improving immunity, especially in autumn and winter. I combined it with selenium and noticed significant skin improvements after two months. My skin became cleaner and less oily in the T-zone, and I no longer needed foundation to cover acne and blemishes. I had no side effects from this zinc, as long as I took it after meals. Highly recommend it for your skin and nails!

Chronic Fatigue Syndrome

Zinc supplementation may benefit CFS

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Most Relevant Research

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

9.5

Boosted energy

Most Useful Review

I find this zinc very effective as it causes no gastrointestinal side effects, which is crucial for my chronic fatigue syndrome. I take it in the morning after breakfast with vitamin C for absorption and feel it helps prevent illness. The tablets are easy to swallow, and the glass bottle is a bonus.

Whooping Cough

Cough disappears quickly

Most Useful Review

The next day there is no cough❣️❣️❣️❣️❣️❣️

Heartburn

Zinc's role in heartburn relief

Esophageal ulcer related to zinc deficiency following a total gastrectomy.

Most Relevant Research

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

9.5

No heartburn experienced

Most Useful Review

This dietary supplement is the ideal zinc for me. The tablets are small, easy to swallow, and have no taste or aftertaste. I’ve had no heartburn or gastrointestinal discomfort when taking them after meals. I recommend this zinc as it effectively supports my immune system and overall well-being.

Leg Cramps

Zinc is crucial for women, particularly for alleviating menstrual cramps. It regulates progesterone secretion and can help with premenstrual syndrome (PMS). By taking zinc supplements, I significantly reduced the negative effects of menstruation, including dysmenorrhea and leg cramps.

Nausea

Zinc treatment reduces nausea risk

Based on 4 Researches

Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.

Most Relevant Research

We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.

9.5

Nausea relief

Most Useful Review

Zinc from Solgar is excellent for my needs. I no longer experience nausea or swelling when taking it. I find it beneficial for healing mucous membranes and improving my skin, reducing acne and oily shine. This zinc has aided in my overall health, especially regarding recurrent issues like rhinitis and tonsillitis. It's easy to take, tiny tablets that dissolve quickly. I highly recommend it for anyone struggling with skin issues or related health problems.

Cold

Zinc’s effects on colds

Zinc for prevention and treatment of the common cold: Summary of a Cochrane review.

Most Relevant Research

We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.

9.5

Reliable cold prevention

Most Useful Review

After years of taking this product daily, I can confidently recommend it as a dependable immune booster. At 81 years old, I haven’t caught a cold or flu in many years, despite not receiving a flu shot!

Autoimmune Disorder

Zinc supplementation benefits MS models

Based on 6 Researches

Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.

Most Relevant Research

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

9.5

Significant energy boost

Most Useful Review

Many thanks to iHerb for the swift delivery and dependable packaging. Solgar's vitamins have truly transformed my health. I used to suffer from frequent colds and felt constantly fatigued, but after taking these vitamins, my energy levels soared, my complexion improved, and I’ve found it easier to manage my autoimmune disorder. My routine includes potassium, magnesium, a B-complex, and zinc in the evening.

Constipation

Zinc may mitigate granisetron constipation

Carbon monoxide contributes to the constipating effects of granisetron in rat colon.

Most Relevant Research

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

8.8

Effective for digestion

Most Useful Review

Inexpensive, transparent ingredients, and good quality! This nutritional supplement effectively improves digestion and helps with constipation. Its lack of taste makes it easy to swallow, and the packaging blocks sunlight. It's affordable and offers a high CP level, making it a worthwhile purchase.

Erectile Dysfunction

Zinc improves erectile dysfunction

Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study.

Most Relevant Research

We observed the effects of zinc on erectile dysfunction in a carefully designed study that involved a double-blind trial. Twenty stable hemodialysis patients participated, receiving either 50 mg of zinc as zinc acetate or a placebo for six months. The goal was to determine if zinc could enhance gonadal function, especially in men who often experience hormonal issues due to kidney problems.

At the end of the study, we noted significant improvements in the zinc-treated group compared to the placebo group. Those receiving zinc had a remarkable increase in plasma zinc levels, testosterone levels, and sperm counts. Specifically, testosterone levels rose from 2.8 to 5.2 ng/mL, and sperm counts doubled from 30 to 63 million/mL, indicating a marked improvement in reproductive health.

Not only did these participants show increased hormone levels, but they also experienced a noticeable drop in luteinizing hormone and follicle-stimulating hormone, suggesting improved gonadal function. Alongside these biochemical changes, many reported better potency, enhanced libido, and increased frequency of intercourse, highlighting zinc’s role in reversing some aspects of erectile dysfunction related to zinc deficiency.

In conclusion, our findings suggest that zinc deficiency can be a reversible factor contributing to erectile dysfunction in hemodialysis patients, offering hope for those struggling with this issue.

9.5

Effective treatment

Most Useful Review

I found the tablets easy to take, with little smell. I took one in the morning and one at night, totalling 44mg, which is above the recommended intake, so I took them after meals to avoid stomach upset. They were effective in preventing erectile dysfunction and enhancing libido.

Hashimoto

Zinc's link to Hashimoto's thyroiditis

Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis.

Most Relevant Research

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

8.8

Reduced symptoms

Most Useful Review

Excellent! Zinc and selenium are crucial for my Hashimoto's treatment. Initially, I experienced symptoms like abdominal discomfort and gas. After incorporating these supplements, my situation improved, especially after I stopped consuming milk, which I later realised was affecting my absorption. Now, I feel much better.

Migraine

Zinc reduces migraine symptoms

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

Migraine relief

Most Useful Review

Excellent! Since I started taking this daily, my PMS migraines have vanished for months.

Pneumonia

I took zinc with antibiotics for pneumonia, and it was effective. Zinc is good for prostate health and joint issues, so I endorse it!

Psoriasis

Zinc conditioner benefits scalp psoriasis

Based on 5 Researches

Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial.

Most Relevant Research

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

9.5

Restored sense smell

Most Useful Review

Magic zinc! Zinc is essential for strengthening the immune system, cell renewal, protein synthesis, collagen formation, and addressing skin issues like psoriasis and acne. After taking zinc picolinate for a month and a half, I noticed remarkable changes: my hair stopped shedding, skin cleared up entirely, and my sense of smell returned after losing it due to Covid. I highly recommend this supplement!

Rosacea

Zinc penetrates skin in rosacea

Zinc penetration through the skin barrier in atopic dermatitis and rosacea using reflectance confocal microscopy.

Most Relevant Research

We investigated how well zinc penetrates the skin in individuals with rosacea, a common condition that affects skin barrier function. Using a non-invasive technique called reflectance confocal microscopy, we compared the skin barrier permeability between those with rosacea, atopic dermatitis, and healthy individuals.

Our results revealed that zinc penetration was greater in patients with rosacea compared to those with healthy skin. Specifically, we observed higher intensity readings of zinc at a depth of 8 micrometers in the skin of rosacea patients. This indicates that their skin barrier might be more compromised in the upper layers.

Interestingly, when comparing both conditions, we found that patients with atopic dermatitis showed greater zinc penetration at deeper layers of the skin. This suggests subtle differences in how these two conditions affect skin barriers. Overall, the findings suggest that patients with rosacea experience increased permeability in the upper layers of the skin due to weakened barrier function.

9.5

Significant improvement

Most Useful Review

Helped my rosacea. After researching online, I found that many struggle with this condition for years. This was my experience too. I discovered a potential link between rosacea and deficiencies in zinc and lysine. Following recommendations, I ordered Solgar zinc picolinate and NOW Foods L-lysine. I began taking one of each daily with food. Since starting on 5 June 2015, my rosacea has nearly cleared up by 20 July 2015. If I was a 10/10 on the rosacea scale before, I would now rate myself at about 1 or 1.5/10. I'm also sharing this recommendation on the NOW Foods site.

Sinusitis

Zinc Levels and Sinusitis Effects

Comparison of serum zinc levels between patients with sinonasal neutrophilic and eosinophilic inflammatory polyposis and healthy individuals.

Most Relevant Research

We explored the connection between zinc levels and chronic rhinosinusitis, particularly focusing on patients with nasal polyps. The study involved 105 participants divided into three groups: those with eosinophilic polyps, those with neutrophilic polyps, and a control group of individuals who underwent surgery for reasons other than polyposis.

We measured the serum zinc concentrations in these groups to see if there were any significant differences. Our findings revealed that patients suffering from chronic rhinosinusitis and having neutrophilic polyps had notably lower zinc levels compared to the general population. However, the zinc levels in patients with eosinophilic polyps did not show a significant difference when compared to healthy controls.

While we saw a clear distinction in zinc levels between the neutrophilic group and the control group, the overall data suggests that zinc's role in sinusitis, especially for those with eosinophilic polyps, may not be as pronounced. As such, while zinc might contribute to inflammation in specific cases, its effectiveness as a standalone treatment for sinusitis remains uncertain.

9.5

Sinusitis relief

Most Useful Review

My long-lasting sinusitis has vanished! I experienced symptoms since contracting COVID this year. It truly works. I took 1 capsule daily and my sense of smell returned. I’ve also noticed an improvement in my eyesight.

Sleep Apnea

Zinc protects heart function in OSA

Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats.

Most Relevant Research

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

9.5

Nocturia relief

Most Useful Review

The best! I have struggled with nocturia for many years, but this particular Zinc helps me sleep through the night. It’s truly remarkable that I no longer need to visit the toilet after midnight. Solgar consistently provides excellent quality products; it’s surprising we don't have this level of quality available to us.

Angina

High-dose zinc alleviates angina

High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition.

Most Relevant Research

We explored the effects of high-dose zinc treatment on angina pectoris, particularly in patients suffering from severe atherosclerotic disease. This study reviewed existing literature and focused on how zinc might help reduce symptoms associated with this condition.

Zinc plays a crucial role in fighting oxidative stress, which is known to be a key player in arteriosclerosis and subsequent angina. Our observations indicated that when patients were given high doses of zinc sulfate, increasing their serum zinc levels significantly, many experienced notable improvements in their angina symptoms.

In fact, 12 out of 16 patients reported better outcomes after treatment. Moreover, it was found that long-term exposure to zinc in the environment appeared to lower incidences of exertional angina, reinforcing the idea that zinc could be beneficial.

We hypothesize that zinc may help prevent the oxidation of harmful LDL cholesterol, therefore slowing down the atherosclerosis process crucial to angina development. Additionally, zinc's effects may relate to its ability to inhibit inflammatory markers, which are often elevated in older adults.

8.8

Angina relief

Most Useful Review

Zinc has greatly helped me; within a short time, my angina improved, my appetite decreased, and my skin looks better. I experienced no side effects.

Bruise

Wow!!! In just 10 days, the bruises under my eyes have vanished. I'm not sure if it was solely the zinc and magnesium I've been taking, but I haven't used anything else.

Depression

Zinc deficiency impacts brain function

Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency.

Most Relevant Research

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

9.5

Positive effects

Most Useful Review

Only a positive response to this supplement. I use zinc to assist with depression due to low levels in my tests. Solgar vitamins are always of high quality, so I continue to buy them.

Diarrhea

Zinc oxide mitigates diarrhea impacts

Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance.

Most Relevant Research

We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.

Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.

In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.

8.3

Caused diarrhoea

Most Useful Review

I bought this for folliculitis after stopping antibiotics, hoping to boost my immunity. The tablets are small and easy to take. After a week and taking two daily, I experienced diarrhoea, so now I take one at a time. No other side effects noticed.

Gastroenteritis

Zinc's limited role in diarrhea

Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial.

Most Relevant Research

We explored how adding zinc to probiotics affects children suffering from acute infectious diarrhea, focusing on the severity of their illness. Our study involved children diagnosed with mild to moderate or severe gastroenteritis, who were then randomly assigned to either receive probiotics with zinc or probiotics alone for one week. The probiotics included live strains that are often used for gut health.

After evaluating the outcomes, we found that the combination of probiotics and zinc did not show a significant impact on disease severity at the two-week mark. However, what we did observe was that children who received the probiotics plus zinc seemed to recover more quickly compared to those who received probiotics alone. This finding suggests that while zinc didn't reduce the overall severity of the illness, it may help speed up recovery.

Overall, our research provides insights but also highlights the limited role zinc may play when combined with probiotics in treating gastroenteritis in young children.

9.5

Quick recovery noted

Most Useful Review

Recommended by a friend, I had a cold and gastroenteritis some time ago. In addition to food and medicine, I incorporated this product, which helped me heal very quickly.

Hives

Zinc insulin alleviates hives

Chronic urticaria from isophane insulin therapy; sensitivity associated with noninsulin components in commercial preparations.

Most Relevant Research

We observed a fascinating case of a young woman with diabetes who experienced chronic hives after switching her insulin type. Initially, she moved from a standard isophane insulin to a beef-pork version, which then triggered her hives. Even after she returned to her original insulin, the hives continued to be a problem.

During her hospital stay, we noted that her hives reappeared daily after insulin injections. This situation changed when we introduced a purer form of insulin called zinc single-peak beef insulin suspension. Surprisingly, the urticaria cleared up quickly after this switch.

Through skin testing, we discovered her sensitivity was primarily to the beef and pork forms of the isophane insulin. However, she showed no sensitivity to the zinc insulin forms. Although she did experience a brief return of the hives after taking antibiotics, this time they did not reappear at the insulin injection sites.

This case provides valuable insight into how certain insulin components can lead to hives, and how switching to a zinc preparation offered the young woman some relief.

Hives significantly improved

Most Useful Review

Fantastic for heavy metal detoxes. With my doctor's guidance, I began taking Zinc Picolinate for hives and other issues. Gradually increasing from one tablet to five per day, I noticed a clear reduction in my hives within two weeks. After struggling with this problem for years, I am thrilled that there is now no sign of them on my skin. I highly recommend consulting a doctor for individual advice while sharing my positive experience with this form of Zinc.

Hypothyroidism

Zinc's uncertain role in hypothyroidism

The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.

Most Relevant Research

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

9.5

Hormonal balance

Most Useful Review

This form of zinc is well absorbed and effective! My child and I were prescribed it for hypothyroidism and hormonal balance. After three months, we saw positive changes without needing hormonal drugs. This zinc is even better than the chelated form. Despite the unpleasant taste, my child takes it willingly. Thanks to iHerb for quality and good pricing!

Insomnia

Zinc promotes sleep in mice

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice.

Most Relevant Research

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

9.5

Insomnia relief

Most Useful Review

After ordering zinc post-covid, I noticed improvements within a week. Insomnia vanished, and my hair stopped falling out. Excellent product, thank you.

Tonsillitis

Zinc in supplement reduces tonsillitis symptoms

The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.

Most Relevant Research

This study took a closer look at the effects of a dietary supplement, PediaFlù, which includes honey, propolis, and zinc, on children suffering from acute tonsillopharyngitis, a common throat infection. We explored how well this supplement worked alongside standard care compared to standard care alone over six days.

The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.

However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.

9.5

Decreases tonsillitis frequency

Most Useful Review

Ever since my daughter fell ill, I struggled with tonsillitis. I started taking zinc and vitamin C, and since last winter, I've been much healthier. I don’t always stick to the correct dosage but when I feel a sore throat, I’ll take extra tablets. The small flavourless tablets are easy to carry around.

Cough

Zinc acetate ineffective for cough

Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.

Most Relevant Research

We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.

Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.

Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.

9.5

Reduces cough allergy

Most Useful Review

Amazing for flu season and allergies. This product has helped my mother tremendously, as she has suffered greatly with allergies, often leading to persistent coughing. Her allergies have improved significantly, allowing her to navigate the flu season without any issues.

Flu

Zinc treatment impacts flu virus entry

Based on 5 Researches

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.

Most Relevant Research

In our study, we examined how epipharyngeal abrasive therapy (EAT), which includes the use of zinc chloride, affects the expression of a key molecule known as Cav1.2. This molecule is essential for the influenza virus to enter cells, making it a crucial target in flu prevention strategies.

We compared two groups of patients: those who received EAT and those who did not. Our findings revealed that the levels of Cav1.2 were significantly lower in the EAT group, at a striking 4.19 times less than in the non-treated group. This suggests that the squamous metaplasia induced by EAT—which is a process of changing the epithelium—could be a beneficial approach to limiting flu infections.

The results of the study highlight zinc's potential indirect role in flu prevention by remarking on its contribution to lowering the expression of a critical receptor for the virus. Although we didn't isolate the effects of zinc alone, the findings indicate that treatments involving zinc, like EAT, may offer a straightforward way to help limit the impact of influenza.

9.5

Quick cold relief

Most Useful Review

Great for fighting off a cold/flu! Whenever I feel one coming on, I take three at bedtime and three in the morning, and the cold/flu vanishes!

Allergies

Zinc may relieve allergy symptoms

Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.

Most Relevant Research

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

9.5

No allergic reactions

Most Useful Review

After trying this zinc supplement for the first time, I was impressed by the results. It is easily absorbed, and I had no allergic reactions. While treating a Covid infection, I noticed that my fatigue and loss of taste improved. Overall, I felt fantastic after taking it.

Arthritis

Zinc alleviates arthritis symptoms

Based on 5 Researches

Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis.

Most Relevant Research

We explored the effects of zinc supplements—specifically zinc aspartate and zinc citrate—on reducing the symptoms of rheumatoid arthritis. In our study, we induced arthritis in male Wistar rats using a collagen-related method and then treated the rats with these zinc compounds over a four-week period. Our objective was to evaluate how these compounds could impact the disease's severity and markers associated with rheumatoid arthritis.

The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.

Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.

8.8

Supports arthritis treatment

Most Useful Review

I took zinc along with antibiotics for bilateral pneumonia, which also alleviated inflammation. Zinc is beneficial for prostate gland diseases and arthritis, as it aids in cartilage tissue formation in the joints. I highly recommend it!

Breast Cancer

Zinc compounds enhance breast cancer treatment

Based on 12 Researches

Albumin-based nanocarriers loaded with novel Zn(II)-thiosemicarbazone compounds chart a new path for precision breast cancer therapy.

Most Relevant Research

Our exploration delves into the effects of zinc-based compounds, specifically Zn(II)-thiosemicarbazones, on breast cancer treatment. By utilizing bovine serum albumin as a nanocarrier, we aimed to enhance the stability and effectiveness of these compounds against breast cancer cells.

We observed that when these zinc compounds were loaded onto albumin, they performed significantly better in killing cancer cells compared to their standalone forms. The small size of the nanocarriers—32 nm for Alb-ZnTcA and 43 nm for Alb-ZnTcB—appeared to facilitate cellular uptake, which likely contributed to their increased potency. In particular, Alb-ZnTcA stood out with the highest levels of cytotoxicity.

Furthermore, our examinations suggested that both types of albumin-bound compounds primarily induce cell death through apoptosis—a natural process of cellular self-destruction. This mechanism is advantageous, as it prevents the uncontrolled proliferation of cancer cells that characterizes breast cancer.

Overall, our findings suggest that zinc compounds packaged within albumin nanocarriers could pave a promising path for effective, targeted breast cancer therapies. The ability of these compounds to work at lower concentrations indicates a potential to reduce side effects, offering a thoughtful approach to treatment.

8.8

Reduces breast pain

Most Useful Review

Super 💪 I never tire of praising Solgar products! This zinc is fantastic: easily absorbed, one tablet a day, sufficient for a full three-month course. My skin isn’t oily, and my nails and hair are strong. Most importantly, I noticed my breasts no longer feel full or painful before menstruation. Perhaps this is due to taking selenium and vitamin E alongside the zinc, also from Solgar. I felt the benefits within the first month. I even give zinc to my husband, who isn't keen on pills but values the combo for its health benefits.

Cancer

Zinc's role in cancer immunity

Based on 6 Researches

cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.

Most Relevant Research

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

Prostate cancer prevention

Most Useful Review

Excellent! This highly absorbable form of zinc is especially beneficial for men. Zinc aids skin health, helps with acne, blackheads, eczema, and wound healing. Additionally, it may prevent prostate cancer and has other significant benefits.

Irritable Bowel Syndrome

Zinc intake may reduce IBS risk

Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank.

Most Relevant Research

We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.

Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.

However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.

Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.

9.5

Zinc aids symptoms

Most Useful Review

I have irritable bowel syndrome, compounded by adrenal fatigue syndrome. If you experience diarrhoea, gas, and bloating, and notice significant hair loss, I highly recommend taking zinc. It has been very beneficial for me in managing these symptoms.

Liver Disease

Zinc's Role in Liver Health

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.

Most Relevant Research

We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.

To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.

Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).

Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.

8.8

Improved immunity

Most Useful Review

The manufacturer and the supplement are superb! I ordered it for my husband, who frequently suffers from rashes on his face due to liver disease. Thanks to this product, we've noticed visible results, and his immunity has improved during the winter.

Menopause

Zinc enhances vitamin D in menopause

Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.

Most Relevant Research

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

9.5

Supports women's health

Most Useful Review

Zinc picolinate is vital for skin, hair, and nail health and plays a significant role for women, especially regarding menopause. Maintaining adequate zinc levels is crucial for fertility and a smooth menstrual cycle. On average, the daily zinc intake should be 10-20 mg, with a maximum of 30 mg.

Warts

Nitric-zinc solution shows effectiveness

Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases.

Most Relevant Research

We explored a new treatment approach for plantar warts using a nitric-zinc complex solution. In this study involving 72 patients, we aimed to observe how effective this solution is in achieving complete healing of warts.

The results were promising, showing a 59.2% cure rate after treatments. On average, patients received about 5.9 applications of the solution over a duration of around 9.4 weeks. Additionally, the recurrence rate was relatively low, noted at 6.7%.

Although we can’t isolate the specific contributions of zinc alone since it was part of a combined treatment with nitric acid, these findings suggest that the nitric-zinc complex could serve as a viable option for those suffering from plantar warts. This treatment may be considered among the first-line options for managing this common skin condition.

Gentle wart treatment

Most Useful Review

Gentle on tummies. This is the only form of zinc that doesn’t upset our stomachs. Amazingly enough, we find it effective in eliminating warts.

Anemia

Zinc deficiency linked to anemia

Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report.

Most Relevant Research

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

8.8

Supports immune function

Most Useful Review

I take zinc daily to support immune function and combat illnesses. This brand's "Zinc Picolinate" aids absorption, making it a good choice for me. At 22 mg, it’s affordable without risking overdose. Zinc is crucial for men as our bodies don’t produce it, and I appreciate that it’s suitable for vegans. Overall, I’m satisfied with this product.

Heart Disease

Zinc benefits heart health post-cisplatin

Based on 4 Researches

Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.

Most Relevant Research

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

Supports heart health

Most Useful Review

Good excellent quality. The ingredients are impressive and very beneficial for treating heart disease. Coenzyme Q10 is an antioxidant that also offers perks for the skin.

Osteoporosis

Zinc intake may protect bones

Based on 10 Researches

The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.

Most Relevant Research

We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.

Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.

Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.

9.5

Helpful for osteoporosis

Most Useful Review

I have been ordering this supplement for years on my endocrinologist's advice. Although I have no severe illnesses, there is a risk of osteoporosis due to my age and premenopausal state. Tests show it is absorbed well and very beneficial, with a natural composition.

Tinnitus

Zinc intake affects tinnitus risk

The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus.

Most Relevant Research

We examined how dietary intakes of vitamins and minerals, particularly zinc, could influence the onset and presence of tinnitus, a condition characterized by phantom sounds in the ears. In a study involving nearly 3,000 participants over the age of 50, we identified cases of tinnitus to determine if their dietary habits played a role in their experience of this condition.

The findings indicated that while there were no significant associations between overall vitamin and mineral intake and existing tinnitus prevalence, zinc intake stood out in relation to developing tinnitus over time. Specifically, we observed that lower zinc consumption was linked to a 44% increased risk of experiencing tinnitus over a ten-year period.

Furthermore, we noted that iron intake also showed a significant correlation, with lower iron levels raising incident tinnitus risk by approximately 35%. These results highlight the potential importance of maintaining adequate zinc and iron levels in our diets to help reduce the risk of developing tinnitus.

7.5

Improved tinnitus symptoms

Most Useful Review

I only take it because it's beneficial for my tinnitus, and it appears to be improving.

Anxiety

Zinc may alleviate anxiety symptoms

Based on 8 Researches

A systematic review of the association between zinc and anxiety.

Most Relevant Research

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

9.5

Improved mood

Most Useful Review

Perfect zinc! It enhances mood, memory, and reduces anxiety. It also supports immunity and glucose control. My family takes it during colds and it’s easily digestible; I highly recommend it.

Back Pain

Zinc may boost bone density

Treatment for osteoporosis in people with beta-thalassaemia.

Most Relevant Research

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

9.5

Clearer skin

Most Useful Review

Zinc is essential for health and beauty! I decided to try it after reading positive reviews and was thrilled with the results. My skin cleared up, and I noticed improvements in my hair and nails. Zinc aids in skin cell renewal and is critical for overall wellness. Additionally, my back pain seemed less bothersome, and my vision improved. This product has great bioavailability and fewer side effects compared to others.

Eczema

Zinc enhances eczema recovery

Transient symptomatic zinc deficiency in an exclusively breastfed infant.

Most Relevant Research

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

8.8

Eczema improvement

Most Useful Review

I started taking zinc as a preventive measure and noticed my eczema improved, prompting me to double the dose to twice a day. Zinc effectively heals skin and promotes hair growth. I also take it with Omega 3.

Prostate Cancer

Zinc's complex role in prostate cancer

Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.

Most Relevant Research

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

6.3

Prostate problem solution

Most Useful Review

The "Picolinate" form of zinc is suggested by nutritionists for those with prostate issues.

Chest Pain

Zinc treatment for angina pectoris

High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition.

Most Relevant Research

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

9.5

Reduced chest pain

Most Useful Review

Since stopping the COC, my hair became oily and I experienced acne. After starting zinc and copper, I saw improvements within a week. My hair no longer becomes greasy by evening, and it has stopped falling out. I also found that before my period, my chest pain was absent. I'll continue using it for sure! My skin has improved tremendously as well. My sister also started taking it and has seen a reduction in inflammatory acne, though she struggled with nausea when taking zinc with copper.

Pelvic Pain

RESULTS. At first, I experienced discomfort in my stomach and changes in stool. I even considered stopping the supplement but was reassured by my doctor that this can happen. After a week, my body's condition improved; I felt less tired and more energetic. I didn't catch any colds during this period, and I didn't have any allergies. While I cannot say there were changes in my hair and nails, my complexion did improve slightly.

Ulcer

New treatment reduces digital dermatitis

Based on 10 Researches

Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds.

Most Relevant Research

We embarked on an investigation to understand whether a new hoof care product featuring iron, zinc, and aluminum can effectively reduce and prevent digital dermatitis (DD) in dairy cows. In a controlled trial involving over 130 dairy cows, we treated one hind foot of each cow twice a week with this product while leaving the other foot untreated for comparison.

The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.

Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.

While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.

6.8

Gastritis and ulcers

Most Useful Review

This zinc is bioavailable and was prescribed for acne, though I didn't see improvements there. However, it works well for respiratory issues and heals gastritis and ulceration of the intestinal mucosa. I advise caution with long-term high doses.

Bone Pain

I began taking zinc in the autumn to alleviate bone pain, and surprisingly, it also helped with my other condition. After my thyroid was removed, my periods didn't stop, leading to continuous daubing. I’ve been taking zinc for a month, and this cycle was almost perfect. I only had some light bleeding for two days before my period started, and the rest of the month was fine. I didn’t expect such results, but zinc has been beneficial.

Gastritis

Zinc protects against gastritis damage

Based on 8 Researches

Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.

Most Relevant Research

We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.

Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.

Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.

Beneficial for ulcers

Most Useful Review

I began taking zinc due to loss of smell, and it proved excellent for my stomach and ulcers. I took it for five months alongside licorice, and it has been tremendously beneficial, confirmed by my colonoscopy results.

Yeast Infection