Solgar Zinc Picolinate

Balasubramanian A, Holbrook JT, Canning BJ, Que LG, Castro M, et al. Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial. ERJ Open Res. 2023;9. doi:10.1183/23120541.00678-2022

Zinc acetate ineffective for cough

We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.

Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.

Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.

Effective against cough

Most Useful Review

Very effective during my bad cold when the cough lingered. After four days, it was all gone, and the sputum that troubled me cleared up.

Influenza details

Nishi K, Yoshimoto S, Nishi S, Nishi T, Nishi R, et al. Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. In Vivo. 2022;36:2357. doi:10.21873/invivo.12967

Zinc may prevent influenza entry

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

Improved immunity

Most Useful Review

206 people found this helpful

I accepted zinc for two reasons: to strengthen my immune system and to improve my skin and hair. After suffering from the coronavirus, my health and appearance were affected. However, after taking zinc, I noticed a significant improvement in my immunity over the winter months, avoiding colds and influenza. My hair and skin also began to improve noticeably.

Whooping Cough details

Cough disappears quickly

The next day there is no cough❣️❣️❣️❣️❣️❣️

Cold Sores details

Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med. 2001;7:49.

Based on 9 Researches

Zinc cream alleviates cold sores

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

Strengthens immunity

Most Useful Review

214 people found this helpful

Helps the immune system and assists in quickly addressing cold sores. The results are excellent, with no side effects.

Heartburn details

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

Zinc's role in heartburn relief

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

No heartburn experienced

Most Useful Review

This dietary supplement is the ideal zinc for me. The tablets are small, easy to swallow, and have no taste or aftertaste. I’ve had no heartburn or gastrointestinal discomfort when taking them after meals. I recommend this zinc as it effectively supports my immune system and overall well-being.

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

Migraine relief

Most Useful Review

Excellent! Since I started taking this daily, my PMS migraines have vanished for months.

Sleep Apnea details

Zinc protects heart function in OSA

Chen TI, Chen MY. Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats. PLoS One. 2016;11:e0168600. doi:10.1371/journal.pone.0168600

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

Nocturia relief

Most Useful Review

10 people found this helpful

The best! I have struggled with nocturia for many years, but this particular Zinc helps me sleep through the night. It’s truly remarkable that I no longer need to visit the toilet after midnight. Solgar consistently provides excellent quality products; it’s surprising we don't have this level of quality available to us.

Abrasions details

1 people found this helpful

Works brilliantly! I was constantly plagued by the issue of minor wounds, abrasions, and scratches taking an age to heal, which became a significant concern. I had to apply ointments, adhesive plasters, and other such remedies. Upon starting zinc supplementation, I realised this was precisely what my body needed for my abrasions and cuts to heal quickly. I am truly satisfied and highly recommend this medication. Wishing you all good health!

Acne Rosacea details

Significant improvement

6 people found this helpful

Helped my acne rosacea. After researching rosacea, I found that many people struggle for years without success, which was my experience too. I discovered a potential connection between rosacea and zinc deficiencies and decided to try 22mg Solgar zinc picolinate tablets due to their good absorption and tolerability. I started taking one tablet daily with food upon receiving my order on 5 June 2015. As of 20 July 2015, my acne rosacea has nearly cleared up entirely. Before beginning this regimen, I would rate my rosacea severity at 10/10; now, it's about 1 or 1.5/10.

Adrenal Gland Disorder details

Supports adrenal health

This supplement is essential for us. With a fantastic composition, we take it during the SARS season, specifically to support our adrenal glands. I highly recommend it to anyone in need.

Erectile Dysfunction details

Mahajan SK, Abbasi AA, Prasad AS, Rabbani P, Briggs WA, et al. Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study. Ann Intern Med. 1982;97:357.

Zinc improves erectile dysfunction

We observed the effects of zinc on erectile dysfunction in a carefully designed study that involved a double-blind trial. Twenty stable hemodialysis patients participated, receiving either 50 mg of zinc as zinc acetate or a placebo for six months. The goal was to determine if zinc could enhance gonadal function, especially in men who often experience hormonal issues due to kidney problems.

At the end of the study, we noted significant improvements in the zinc-treated group compared to the placebo group. Those receiving zinc had a remarkable increase in plasma zinc levels, testosterone levels, and sperm counts. Specifically, testosterone levels rose from 2.8 to 5.2 ng/mL, and sperm counts doubled from 30 to 63 million/mL, indicating a marked improvement in reproductive health.

Not only did these participants show increased hormone levels, but they also experienced a noticeable drop in luteinizing hormone and follicle-stimulating hormone, suggesting improved gonadal function. Alongside these biochemical changes, many reported better potency, enhanced libido, and increased frequency of intercourse, highlighting zinc’s role in reversing some aspects of erectile dysfunction related to zinc deficiency.

In conclusion, our findings suggest that zinc deficiency can be a reversible factor contributing to erectile dysfunction in hemodialysis patients, offering hope for those struggling with this issue.

Effective treatment

Most Useful Review

3 people found this helpful

I found the tablets easy to take, with little smell. I took one in the morning and one at night, totalling 44mg, which is above the recommended intake, so I took them after meals to avoid stomach upset. They were effective in preventing erectile dysfunction and enhancing libido.

Irritable Bowel Syndrome details

Zinc intake may reduce IBS risk

Zhuang Y, Li L, Ran Y, Zhang Y, Chen J, et al. Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank. Am J Epidemiol. 2024. doi:10.1093/aje/kwae412

We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.

Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.

However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.

Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.

Zinc aids symptoms

Most Useful Review

I have irritable bowel syndrome, compounded by adrenal fatigue syndrome. If you experience diarrhoea, gas, and bloating, and notice significant hair loss, I highly recommend taking zinc. It has been very beneficial for me in managing these symptoms.

Sinusitis details

Zinc Levels and Sinusitis Effects

Ghazizadeh M, Roshanaie E, Barati B. Comparison of serum zinc levels between patients with sinonasal neutrophilic and eosinophilic inflammatory polyposis and healthy individuals. Immun Inflamm Dis. 2024;12:e70016. doi:10.1002/iid3.70016

We explored the connection between zinc levels and chronic rhinosinusitis, particularly focusing on patients with nasal polyps. The study involved 105 participants divided into three groups: those with eosinophilic polyps, those with neutrophilic polyps, and a control group of individuals who underwent surgery for reasons other than polyposis.

We measured the serum zinc concentrations in these groups to see if there were any significant differences. Our findings revealed that patients suffering from chronic rhinosinusitis and having neutrophilic polyps had notably lower zinc levels compared to the general population. However, the zinc levels in patients with eosinophilic polyps did not show a significant difference when compared to healthy controls.

While we saw a clear distinction in zinc levels between the neutrophilic group and the control group, the overall data suggests that zinc's role in sinusitis, especially for those with eosinophilic polyps, may not be as pronounced. As such, while zinc might contribute to inflammation in specific cases, its effectiveness as a standalone treatment for sinusitis remains uncertain.

Sinusitis relief

Most Useful Review

My long-lasting sinusitis has vanished! I experienced symptoms since contracting COVID this year. It truly works. I took 1 capsule daily and my sense of smell returned. I’ve also noticed an improvement in my eyesight.

Abscess details

An abscess always emerged, but as soon as I started taking this zinc, it ceased. My face became clearer, and my hair stopped falling out.

Chronic Fatigue Syndrome details

Zinc supplementation may benefit CFS

Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

Boosted energy

Most Useful Review

328 people found this helpful

I find this zinc very effective as it causes no gastrointestinal side effects, which is crucial for my chronic fatigue syndrome. I take it in the morning after breakfast with vitamin C for absorption and feel it helps prevent illness. The tablets are easy to swallow, and the glass bottle is a bonus.

Common Cold details

Zinc shortens cold duration variability

Based on 6 Researches

Hemilä H, Chalker E, Tukiainen J. Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration. Front Pharmacol. 2022;13:817522. doi:10.3389/fphar.2022.817522

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

Increased strength

Most Useful Review

256 people found this helpful

I am grateful to iHerb for their fast delivery and reliable packaging. Solgar's vitamins have truly strengthened my health; I previously suffered frequent colds and weakness. Since taking these vitamins, my complexion is healthy, and I handle colds better.

Herpes details

Quick relief from pain

8 people found this helpful

Picolinate Zinka effectively manages my herpes flare-ups. I have herpes on my facial nerve, and during an exacerbation, I take three tablets three times a day. The pain subsides swiftly.

Insomnia details

Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, et al. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Mol Nutr Food Res. 2015;59:2087. doi:10.1002/mnfr.201500082

Zinc promotes sleep in mice

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

Insomnia relief

Most Useful Review

After ordering zinc post-covid, I noticed improvements within a week. Insomnia vanished, and my hair stopped falling out. Excellent product, thank you.

Low Libido details

Prevented erectile dysfunction

3 people found this helpful

It was easy to take and had little smell. I took one tablet in the morning and one at night. The total dosage was 44mg, which is above the standard recommended intake, so it’s advisable to take it after meals to avoid stomach upset. It effectively prevented erectile dysfunction and improved my libido.

Polycystic Ovary Syndrome details

Very good product for balancing androgens. I have Polycystic ovary syndrome, and it was recommended by a registered dietician.

Psoriasis details

Zinc conditioner benefits scalp psoriasis

Based on 5 Researches

Yu C, Yu N, Jiang X, Gao X, Lv S, et al. Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial. Clin Exp Dermatol. 2023;48:1138. doi:10.1093/ced/llad168

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

Restored sense smell

Most Useful Review

166 people found this helpful

Magic zinc! Zinc is essential for strengthening the immune system, cell renewal, protein synthesis, collagen formation, and addressing skin issues like psoriasis and acne. After taking zinc picolinate for a month and a half, I noticed remarkable changes: my hair stopped shedding, skin cleared up entirely, and my sense of smell returned after losing it due to Covid. I highly recommend this supplement!

Rosacea details

Ahn HJ, Shin MK. Zinc penetration through the skin barrier in atopic dermatitis and rosacea using reflectance confocal microscopy. Exp Dermatol. 2024;33:e14971. doi:10.1111/exd.14971

Zinc penetrates skin in rosacea

We investigated how well zinc penetrates the skin in individuals with rosacea, a common condition that affects skin barrier function. Using a non-invasive technique called reflectance confocal microscopy, we compared the skin barrier permeability between those with rosacea, atopic dermatitis, and healthy individuals.

Our results revealed that zinc penetration was greater in patients with rosacea compared to those with healthy skin. Specifically, we observed higher intensity readings of zinc at a depth of 8 micrometers in the skin of rosacea patients. This indicates that their skin barrier might be more compromised in the upper layers.

Interestingly, when comparing both conditions, we found that patients with atopic dermatitis showed greater zinc penetration at deeper layers of the skin. This suggests subtle differences in how these two conditions affect skin barriers. Overall, the findings suggest that patients with rosacea experience increased permeability in the upper layers of the skin due to weakened barrier function.

Significant improvement

Most Useful Review

193 people found this helpful

Helped my rosacea. After researching online, I found that many struggle with this condition for years. This was my experience too. I discovered a potential link between rosacea and deficiencies in zinc and lysine. Following recommendations, I ordered Solgar zinc picolinate and NOW Foods L-lysine. I began taking one of each daily with food. Since starting on 5 June 2015, my rosacea has nearly cleared up by 20 July 2015. If I was a 10/10 on the rosacea scale before, I would now rate myself at about 1 or 1.5/10. I'm also sharing this recommendation on the NOW Foods site.

Weight Loss details

Great! I take it as part of my and my doctor’s weight loss efforts. It really works in reducing cravings for sweets!

Angina details

Eby GA, Halcomb WW. High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition. Med Hypotheses. 2006;66:169.

High-dose zinc alleviates angina

We explored the effects of high-dose zinc treatment on angina pectoris, particularly in patients suffering from severe atherosclerotic disease. This study reviewed existing literature and focused on how zinc might help reduce symptoms associated with this condition.

Zinc plays a crucial role in fighting oxidative stress, which is known to be a key player in arteriosclerosis and subsequent angina. Our observations indicated that when patients were given high doses of zinc sulfate, increasing their serum zinc levels significantly, many experienced notable improvements in their angina symptoms.

In fact, 12 out of 16 patients reported better outcomes after treatment. Moreover, it was found that long-term exposure to zinc in the environment appeared to lower incidences of exertional angina, reinforcing the idea that zinc could be beneficial.

We hypothesize that zinc may help prevent the oxidation of harmful LDL cholesterol, therefore slowing down the atherosclerosis process crucial to angina development. Additionally, zinc's effects may relate to its ability to inhibit inflammatory markers, which are often elevated in older adults.

7.5

Angina relief

Most Useful Review

3 people found this helpful

Zinc has greatly helped me; within a short time, my angina improved, my appetite decreased, and my skin looks better. I experienced no side effects.

Celiac details

Strengthened immunity

1 people found this helpful

Excellent brand and product Zinc Picolinate in its best and most absorbable form. I take one daily, and my hair, skin, and nails have greatly benefited. It helps maintain a strong immune system and reduces allergies and colds. Solgar is one of my favourite brands, particularly due to being celiac and their products being gluten-free. I highly recommend this product.

Depression details

Zinc deficiency impacts brain function

Gąsior Ł, Pochwat B, Zaręba-Kozioł M, Włodarczyk J, Grabrucker AM, et al. Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. Pharmacol Rep. 2025;77:145. doi:10.1007/s43440-024-00681-7

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

Positive effects

Most Useful Review

Only a positive response to this supplement. I use zinc to assist with depression due to low levels in my tests. Solgar vitamins are always of high quality, so I continue to buy them.

Hashimoto details

Zinc's link to Hashimoto's thyroiditis

Rostami R, Beiranvand A, Nourooz-Zadeh S, Rostami M, Mohammadi A, et al. Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis. Int J Endocrinol Metab. 2024;22:e145599. doi:10.5812/ijem-145599

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

7.5

Reduced symptoms

Most Useful Review

7 people found this helpful

Excellent! Zinc and selenium are crucial for my Hashimoto's treatment. Initially, I experienced symptoms like abdominal discomfort and gas. After incorporating these supplements, my situation improved, especially after I stopped consuming milk, which I later realised was affecting my absorption. Now, I feel much better.

Pelvic Pain details

It alleviates pelvic pain and has a delightful taste. The ingredients are berries, and the quality is excellent. I use it as needed, and the size is just right. The packaging is lovely.

Pneumonia details

I took zinc with antibiotics for pneumonia, and it was effective. Zinc is good for prostate health and joint issues, so I endorse it!

Acne details

Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. doi:10.1111/dth.14252

Based on 16 Researches

Zinc effective for acne treatment

We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!

Clearer skin

Most Useful Review

530 people found this helpful

Zinc is essential for improving immunity, especially in autumn and winter. I combined it with selenium and noticed significant skin improvements after two months. My skin became cleaner and less oily in the T-zone, and I no longer needed foundation to cover acne and blemishes. I had no side effects from this zinc, as long as I took it after meals. Highly recommend it for your skin and nails!

Bacterial Infection details

27 people found this helpful

The drug is excellent; I use it alongside other supplements post-coronavirus infection. I genuinely felt much better after starting this combination.

Constipation details

Zinc may mitigate granisetron constipation

Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333.

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

7.5

Effective for digestion

Most Useful Review

3 people found this helpful

Inexpensive, transparent ingredients, and good quality! This nutritional supplement effectively improves digestion and helps with constipation. Its lack of taste makes it easy to swallow, and the packaging blocks sunlight. It's affordable and offers a high CP level, making it a worthwhile purchase.

Hair Loss details

Matsuoka N, Mizutani T, Kawakami K. Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery. J Clin Med Res. 2023;15:116. doi:10.14740/jocmr4855

Based on 9 Researches

Zinc shows promise for hair loss

We explored how zinc acetate hydrate impacts hair loss for patients experiencing symptoms after COVID-19. In our analysis, we looked at 120 symptomatic outpatients over 12 weeks, observing their recovery patterns and any improvements in their symptoms. The focus was on various lingering effects, including fatigue and hair loss, particularly how zinc could potentially alleviate these issues.

Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.

Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.

Shiny hair quality

Most Useful Review

283 people found this helpful

The mood is good, and I have shiny hair without hair loss; my skin looks perfect. I'm very pleased with this manufacturer's zinc and plan to take it for three months, followed by a break and another three months in the autumn. I experienced no unpleasant side effects while taking 1 tablet a day as suggested by the manufacturer.

Nausea details

Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. doi:10.1016/j.jtemb.2024.127558

Based on 4 Researches

Zinc treatment reduces nausea risk

We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.

Nausea relief

Most Useful Review

338 people found this helpful

Zinc from Solgar is excellent for my needs. I no longer experience nausea or swelling when taking it. I find it beneficial for healing mucous membranes and improving my skin, reducing acne and oily shine. This zinc has aided in my overall health, especially regarding recurrent issues like rhinitis and tonsillitis. It's easy to take, tiny tablets that dissolve quickly. I highly recommend it for anyone struggling with skin issues or related health problems.

Osteoporosis details

Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. doi:10.1186/s12891-024-07768-5

Based on 10 Researches

Zinc intake may protect bones

We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.

Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.

Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.

Helpful for osteoporosis

Most Useful Review

I have been ordering this supplement for years on my endocrinologist's advice. Although I have no severe illnesses, there is a risk of osteoporosis due to my age and premenopausal state. Tests show it is absorbed well and very beneficial, with a natural composition.

Rash details

338 people found this helpful

Mast-style Solgar zinc is now a staple in my purchases. It doesn't cause nausea or swelling. Best taken at night after meals, it effectively heals mucous membranes. If you suffer from erosive lesions, recurrent rash, or acne, it will help. I take it before important events for clear skin. Tiny tablets dissolve quickly and have little taste. Zinc deficiency signs include white dots on nails and hair loss. It also supports thyroid function in hypothyroidism.

Sore Throat details

Zinc reduces postoperative sore throat

Based on 9 Researches

Sarkar T, Mandal T. Preoperative oral zinc tablet decreases incidence of postoperative sore throat. Indian J Anaesth. 2020;64:409. doi:10.4103/ija.IJA_959_19

We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.

Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.

Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.

Reduced throat issues

Most Useful Review

2 people found this helpful

Great vitamins! I was struggling with hair loss and tried everything. After reading about zinc, I decided to give it a go. After two weeks, I've noticed significant improvements: my hair loss has nearly stopped, my skin is better, and my immunity appears strengthened. I no longer suffer from a sore throat!

Allergies details

Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408

Zinc may relieve allergy symptoms

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

No allergic reactions

Most Useful Review

6 people found this helpful

After trying this zinc supplement for the first time, I was impressed by the results. It is easily absorbed, and I had no allergic reactions. While treating a Covid infection, I noticed that my fatigue and loss of taste improved. Overall, I felt fantastic after taking it.

Autoimmune Disorder details

Zinc supplementation benefits MS models

Based on 6 Researches

Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

Significant energy boost

Most Useful Review

256 people found this helpful

Many thanks to iHerb for the swift delivery and dependable packaging. Solgar's vitamins have truly transformed my health. I used to suffer from frequent colds and felt constantly fatigued, but after taking these vitamins, my energy levels soared, my complexion improved, and I’ve found it easier to manage my autoimmune disorder. My routine includes potassium, magnesium, a B-complex, and zinc in the evening.

Flu details

Zinc treatment impacts flu virus entry

Based on 5 Researches

In our study, we examined how epipharyngeal abrasive therapy (EAT), which includes the use of zinc chloride, affects the expression of a key molecule known as Cav1.2. This molecule is essential for the influenza virus to enter cells, making it a crucial target in flu prevention strategies.

We compared two groups of patients: those who received EAT and those who did not. Our findings revealed that the levels of Cav1.2 were significantly lower in the EAT group, at a striking 4.19 times less than in the non-treated group. This suggests that the squamous metaplasia induced by EAT—which is a process of changing the epithelium—could be a beneficial approach to limiting flu infections.

The results of the study highlight zinc's potential indirect role in flu prevention by remarking on its contribution to lowering the expression of a critical receptor for the virus. Although we didn't isolate the effects of zinc alone, the findings indicate that treatments involving zinc, like EAT, may offer a straightforward way to help limit the impact of influenza.

Quick cold relief

Most Useful Review

5 people found this helpful

Great for fighting off a cold/flu! Whenever I feel one coming on, I take three at bedtime and three in the morning, and the cold/flu vanishes!

Premenstrual Syndrome details

Zinc alleviates cramps

5 people found this helpful

One of zinc's key benefits for women is its ability to relieve menstrual cramps. It regulates progesterone secretion, which can heighten the risk of premenstrual syndrome (PMS). Zinc supplements help alleviate the negative aspects of menstruation by preventing dysmenorrhea and menstrual discomfort.

Prostate Cancer details

Zinc's complex role in prostate cancer

Ghimire K, Awasthi BP, Yadav K, Lee J, Kim H, et al. Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming. Chem Biol Interact. 2025;408:111393. doi:10.1016/j.cbi.2025.111393

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

Fungi treatment aid

Most Useful Review

4 people found this helpful

My husband takes it for prostate health, and it helps with my candida issues. I take it more preventively and ensure not to overdo it to avoid copper and iron imbalance. Recommended by my doctor, this brand offers great quality at a good price.

Tonsillitis details

Zinc in supplement reduces tonsillitis symptoms

Cardinale F, Barattini DF, Martinucci V, Bordea MM, Barattini L, et al. The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17060804

This study took a closer look at the effects of a dietary supplement, PediaFlù, which includes honey, propolis, and zinc, on children suffering from acute tonsillopharyngitis, a common throat infection. We explored how well this supplement worked alongside standard care compared to standard care alone over six days.

The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.

However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.

Decreases tonsillitis frequency

Most Useful Review

Ever since my daughter fell ill, I struggled with tonsillitis. I started taking zinc and vitamin C, and since last winter, I've been much healthier. I don’t always stick to the correct dosage but when I feel a sore throat, I’ll take extra tablets. The small flavourless tablets are easy to carry around.

Adenoiditis details

Prevents winter colds

2 people found this helpful

I ordered zinc from this manufacturer to prevent winter colds and, for the first time in five years, I have passed the winter without relapse! Typically, I suffer from a sore throat several times each winter, but this zinc has remarkably improved my immunity.

Anemia details

Inoue M. Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report. Cureus. 2024;16:e66034. doi:10.7759/cureus.66034

Zinc deficiency linked to anemia

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

7.5

Supports immune function

Most Useful Review

10 people found this helpful

I take zinc daily to support immune function and combat illnesses. This brand's "Zinc Picolinate" aids absorption, making it a good choice for me. At 22 mg, it’s affordable without risking overdose. Zinc is crucial for men as our bodies don’t produce it, and I appreciate that it’s suitable for vegans. Overall, I’m satisfied with this product.

Back Pain details

Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. doi:10.1002/14651858.CD010429.pub3

USERS' SCORE

Good

Based on 4 Reviews

Zinc may boost bone density

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

Clearer skin

Most Useful Review

2 people found this helpful

Zinc is essential for health and beauty! I decided to try it after reading positive reviews and was thrilled with the results. My skin cleared up, and I noticed improvements in my hair and nails. Zinc aids in skin cell renewal and is critical for overall wellness. Additionally, my back pain seemed less bothersome, and my vision improved. This product has great bioavailability and fewer side effects compared to others.

Cold details

Wieland LS. Zinc for prevention and treatment of the common cold: Summary of a Cochrane review. Explore (NY). 2025;21:103111. doi:10.1016/j.explore.2025.103111

Zinc’s effects on colds

We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.

Quickly combats cold

Most Useful Review

214 people found this helpful

Helps the immune system and quickly defeats the common cold. The results are excellent, with no side effects.

Diabetes details

Zinc alleviates diabetic muscle atrophy

USERS' SCORE

Good

Based on 9 Reviews

Yu X, Chen X, Wu W, Tang H, Su Y, et al. Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39. J Cachexia Sarcopenia Muscle. 2025;16:e13771. doi:10.1002/jcsm.13771

Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.

We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.

Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.

Blood sugar control

Most Useful Review

1 people found this helpful

My mother suffers from diabetes, and alongside her medication, I added this product. Since I started using it, her HBA1C glycosylated hemoglobin levels dropped from 7.2 to 6.5. I find it very effective.

High Cholesterol details

Khajeh M, Hassanizadeh S, Pourteymour Fard Tabrizi F, Hassanizadeh R, Vajdi M, et al. Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis. Biol Trace Elem Res. 2024;202:4877. doi:10.1007/s12011-024-04059-x

Based on 5 Researches

USERS' SCORE

Good

Based on 12 Reviews

Zinc improves cholesterol levels

We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.

Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.

While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.

In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.

Improved health indices.

Most Useful Review

10 people found this helpful

After giving birth, I encountered various deficiencies. Within a month of taking this zinc picolinate, all my indicators improved, and my hair and skin condition is notably better! I am thrilled! Solgar provides a perfect 22 mg dosage that meets my daily requirements. My whole family uses it during colds, and we maintain our health with zinc, vitamin C, and D3.

Hypothyroidism details

Zinc's uncertain role in hypothyroidism

Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. doi:10.47176/mjiri.38.133

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

Hormonal balance

Most Useful Review

3 people found this helpful

This form of zinc is well absorbed and effective! My child and I were prescribed it for hypothyroidism and hormonal balance. After three months, we saw positive changes without needing hormonal drugs. This zinc is even better than the chelated form. Despite the unpleasant taste, my child takes it willingly. Thanks to iHerb for quality and good pricing!

Menopause details

Zinc enhances vitamin D in menopause

Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

Supports women's health

Most Useful Review

Zinc picolinate is vital for skin, hair, and nail health and plays a significant role for women, especially regarding menopause. Maintaining adequate zinc levels is crucial for fertility and a smooth menstrual cycle. On average, the daily zinc intake should be 10-20 mg, with a maximum of 30 mg.

Anxiety details

Zinc may alleviate anxiety symptoms

Based on 8 Researches

Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82:612. doi:10.1093/nutrit/nuad076

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

Improved mood

Most Useful Review

Perfect zinc! It enhances mood, memory, and reduces anxiety. It also supports immunity and glucose control. My family takes it during colds and it’s easily digestible; I highly recommend it.

Diarrhea details

Zinc oxide mitigates diarrhea impacts

Zhang Y, Liu J, Li M, Dong Y, Li Z, et al. Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance. Vet Sci. 2025;12. doi:10.3390/vetsci12020115

We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.

Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.

In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.

Caused diarrhoea

Most Useful Review

1 people found this helpful

I bought this for folliculitis after stopping antibiotics, hoping to boost my immunity. The tablets are small and easy to take. After a week and taking two daily, I experienced diarrhoea, so now I take one at a time. No other side effects noticed.

Ear Infection details

Zinc's mixed impact on ear infections

Based on 8 Researches

Abba K, Gulani A, Sachdev HS. Zinc supplements for preventing otitis media. Cochrane Database Syst Rev. 2010. doi:10.1002/14651858.CD006639.pub2

We explored whether zinc supplements could help prevent otitis media, which is a common ear infection affecting many, especially young children. Our examination included several randomized, placebo-controlled trials where participants received zinc supplements at least once a week for a minimum of a month.

In total, we identified 12 trials, but only 10 provided sufficient data for analysis. Among healthy children from low-income communities, most studies did not show a clear benefit of zinc on reducing ear infections. However, one trial with over 1600 participants did find a significantly lower incidence of otitis media in those taking zinc, suggesting that it might help. Additionally, a small study focusing on infants with severe malnutrition hinted at potential benefits, yet it is important to note this was based on limited data.

Overall, the evidence isn't definitive—while some results point towards positive effects, particularly in specific groups, many trials did not support the effectiveness of zinc in healthy children. Furthermore, zinc supplements appeared safe, with minimal reports of adverse effects.

Effective immune boost

Most Useful Review

6 people found this helpful

Zinc strengthens the immune system and improves skin condition. My family takes it during the cold season to enhance our immunity. Solgar's zinc picolinate helps maintain our health. We took it for two months without anyone getting ill during the epidemic, and it clearly works: I've seen an improvement in my daughter's skin conditions and wound healing.

Chest Pain details

Eby GA, Halcomb WW. High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition. Med Hypotheses. 2006;66:169.

Zinc treatment for angina pectoris

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

Reduced chest pain

Most Useful Review

6 people found this helpful

Since stopping the COC, my hair became oily and I experienced acne. After starting zinc and copper, I saw improvements within a week. My hair no longer becomes greasy by evening, and it has stopped falling out. I also found that before my period, my chest pain was absent. I'll continue using it for sure! My skin has improved tremendously as well. My sister also started taking it and has seen a reduction in inflammatory acne, though she struggled with nausea when taking zinc with copper.

Reflux details

Relieves reflux issues

Reflux helps alleviate reflux and stomach aches.

Eczema details

Crisóstomo M, Santos MC, Tavares E, Cunha F. Transient symptomatic zinc deficiency in an exclusively breastfed infant. BMJ Case Rep. 2021;14. doi:10.1136/bcr-2021-241754

Zinc enhances eczema recovery

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

7.5

Eczema improvement

Most Useful Review

10 people found this helpful

I started taking zinc as a preventive measure and noticed my eczema improved, prompting me to double the dose to twice a day. Zinc effectively heals skin and promotes hair growth. I also take it with Omega 3.

Bloating details

6 people found this helpful

Excellent! Solgar's zinc has become a staple in my purchases. It does not induce nausea or bloating and is best taken at night after meals. Zinc effectively heals mucous membranes and can alleviate issues like rhinitis and sore throat. I take it before important events to enhance my skin’s appearance, reducing acne and inflammation. White spots on nails, unexplained bloating, and low energy might indicate zinc deficiency, which can also improve thyroid function in hypothyroidism.

Bone Pain details

5 people found this helpful

I began taking zinc in the autumn to alleviate bone pain, and surprisingly, it also helped with my other condition. After my thyroid was removed, my periods didn't stop, leading to continuous daubing. I’ve been taking zinc for a month, and this cycle was almost perfect. I only had some light bleeding for two days before my period started, and the rest of the month was fine. I didn’t expect such results, but zinc has been beneficial.

Ulcer details

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

Based on 16 Researches

Zinc helps heal esophageal ulcers

We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.

After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.

Faster healing

Most Useful Review

I love this! I started taking it for mouth ulcers; it seems to help them heal quicker. I now take it daily for my immunity and have noticed smoother skin since. I experienced no adverse effects like nausea.

Gastritis details