Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 121 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc picolinate)
22 mg
200%

Top Medical Research Studies

8
Zinc effective for acne treatment
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Read More
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.

To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.

However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.

Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
Read More
We examined the potential of zinc compounds, particularly zinc-amino acid complexes, to effectively treat acne. This study focused on how these zinc formulations could not only help with acne but also ensure safety for the skin.

Initially, we checked the cytotoxicity of the zinc complexes on human skin cells, demonstrating their safety. We then evaluated their antibacterial properties, which are crucial for combating acne-causing bacteria. After finding promising results, we selected zinc complexes with glycine and histidine to create unique gel formulations.

The next steps involved thorough testing of these gel preparations for stability, purity, and tolerability. We confirmed that they maintained their quality over time, showed no irritation or allergic reactions in a patch test with 25 volunteers, and exhibited high microbiological purity.

Ultimately, our findings suggest that these zinc-based gels can be a valuable topical option for acne treatment due to their strong antibacterial performance and minimal toxicity to skin cells. Our dermatological formulations appear safe and effective, contributing positively to acne management.
Read More

Most Useful Reviews

9
Clearer skin
530 people found this helpful
Zinc is essential for improving immunity, especially in autumn and winter. I combined it with selenium and noticed significant skin improvements after two months. My skin became cleaner and less oily in the T-zone, and I no longer needed foundation to cover acne and blemishes. I had no side effects from this zinc, as long as I took it after meals. Highly recommend it for your skin and nails!
Read More
8
Improved immunity
491 people found this helpful
Solgar is a reputable brand, crucial for addressing zinc deficiency, which can lead to various health issues. Symptoms like frequent illness and skin conditions suggest zinc deficiency. I urge everyone to take zinc for better health. A healthy body should prioritize zinc!
Read More
8
Reduced inflammation
338 people found this helpful
Solgar's zinc is a staple for me. It doesn’t cause nausea or bloating, and I take it at night after meals. Zinc has helped heal mucous membranes and clears up acne, controlling oily skin. The tiny tablets are easy to take, and I've noticed the positive changes in my skin health!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
  • All Researches
9.5
Zinc's role in acne treatment
We investigated the effectiveness of a novel microneedle patch designed for acne treatment, which incorporates zinc-based nanoparticles. This patch combines sodium hyaluronate with zinc porphyrin-based metal-organic frameworks and zinc oxide. By using ultrasound to release activated oxygen, we observed a remarkable antibacterial efficiency, achieving a 99.73% reduction in acne-causing bacteria within just 15 minutes.

Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.

Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Read More
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.

Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.

However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.

Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Read More
9
We assessed the potential of zinc oxide nanoparticles in combating acne. Using biogenically synthesized zinc oxide, we mixed it with a polymer to create a topical nanogel aimed at treating acne. Through rigorous testing against acne-causing bacteria, we observed that these biogenic nanoparticles showed a promising antibacterial effect, particularly against Gram-positive bacteria.

Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.

Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Read More
We wanted to find out how effective a cleansing gel containing salicylic acid, zinc gluconate, and lipohydroxy acids is for treating truncal acne. Conducted over 84 days, our study included 51 individuals with mild to moderate acne, and we tracked various skin conditions like the number of acne lesions and the overall skin barrier health.

After regular use of the gel, we observed a significant reduction in total acne lesions—over half were improved by the end of the study. While non-inflammatory lesions saw a drop of 64% and inflammatory lesions were reduced by nearly 30%, the key point is that zinc gluconate was part of a trio of ingredients, making it challenging to pinpoint its specific contribution.

When we considered skin barrier function, a notable improvement was also measured—21.26% better at Day 84. Patients reported no significant side effects or intolerances, suggesting that the ingredients within the gel, including zinc, were well tolerated.

Overall, the evidence hints at zinc's potential benefits as part of a combination treatment against acne. But since it was used together with other active ingredients, we can't solely credit zinc for the results observed.
Read More
We aimed to explore how effective zinc sulphate is in treating mild to moderate acne compared to the well-known antibiotic lymecycline. In our study, we involved 100 participants who were randomly assigned to receive either zinc sulphate or lymecycline.

To measure the effectiveness of the treatments, we used the Global Acne Grading System and a special questionnaire focused on acne's impact on quality of life. After four and twelve weeks of treatment, we found that both treatments significantly reduced acne severity.

However, the results showed something interesting. The patients who took zinc sulphate reported greater improvements in their quality of life than those on lymecycline. This indicates that zinc not only helps with acne but may also lead to a better overall experience during treatment.

Our findings suggest that zinc sulphate could be a compelling alternative to lymecycline, providing similar clinical benefits without the risk of antibiotic resistance associated with long-term antibiotic use.
Read More

User Reviews

USERS' SCORE
Good
Based on 121 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Clearer skin
530 people found this helpful
Zinc is essential for improving immunity, especially in autumn and winter. I combined it with selenium and noticed significant skin improvements after two months. My skin became cleaner and less oily in the T-zone, and I no longer needed foundation to cover acne and blemishes. I had no side effects from this zinc, as long as I took it after meals. Highly recommend it for your skin and nails!
Read More
8
Improved immunity
491 people found this helpful
Solgar is a reputable brand, crucial for addressing zinc deficiency, which can lead to various health issues. Symptoms like frequent illness and skin conditions suggest zinc deficiency. I urge everyone to take zinc for better health. A healthy body should prioritize zinc!
Read More
8
Reduced inflammation
338 people found this helpful
Solgar's zinc is a staple for me. It doesn’t cause nausea or bloating, and I take it at night after meals. Zinc has helped heal mucous membranes and clears up acne, controlling oily skin. The tiny tablets are easy to take, and I've noticed the positive changes in my skin health!
Read More
9
Acne relief
297 people found this helpful
After struggling with rashes on my cheeks for a year, zinc transformed my skin. Within a week of use, new acne stopped appearing. Now I use it as needed during menstruation. The results have been remarkable!
Read More
10
Clearer complexion
166 people found this helpful
Zinc is vital for boosting immunity and improving skin health. After taking it for a month and a half, my acne cleared up, my hair stopped shedding, and I regained my sense of smell post-COVID. It has worked wonders for me!
Read More

Frequently Asked Questions

9
Acne relief
297 people found this helpful
After struggling with rashes on my cheeks for a year, zinc transformed my skin. Within a week of use, new acne stopped appearing. Now I use it as needed during menstruation. The results have been remarkable!
9
Quick effects observed
3 people found this helpful
I bought this for my teenage daughter, and within a week, her acne began to clear up!
8
Fewer rashes
80 people found this helpful
I began taking zinc to combat skin rashes as my doctor advised. Over two months, my acne reduced and my skin became more elastic, with no side effects. I’m very pleased with the results!
10
Clearer complexion
166 people found this helpful
Zinc is vital for boosting immunity and improving skin health. After taking it for a month and a half, my acne cleared up, my hair stopped shedding, and I regained my sense of smell post-COVID. It has worked wonders for me!
9
Clearer skin
530 people found this helpful
Zinc is essential for improving immunity, especially in autumn and winter. I combined it with selenium and noticed significant skin improvements after two months. My skin became cleaner and less oily in the T-zone, and I no longer needed foundation to cover acne and blemishes. I had no side effects from this zinc, as long as I took it after meals. Highly recommend it for your skin and nails!
0
Increased acne
8 people found this helpful
My acne worsened while taking zinc for a month. I've heard zinc may increase male hormone levels, possibly causing more rashes on my face. My skin has softened, but it seems oilier than before, suggesting it may not be suitable for me.
8
Reduced inflammation
338 people found this helpful
Solgar's zinc is a staple for me. It doesn’t cause nausea or bloating, and I take it at night after meals. Zinc has helped heal mucous membranes and clears up acne, controlling oily skin. The tiny tablets are easy to take, and I've noticed the positive changes in my skin health!
8
Zinc treatment shows promise for acne
We explored how zinc treatment may help with inflammatory skin conditions like acne vulgaris, rosacea, and hidradenitis suppurativa. These conditions can appear quite similar, which makes diagnosing them a bit tricky. By examining gene expression data across these three disorders, we noticed that certain zinc-binding proteins were consistently elevated in all cases.

Our hypothesis centers around these proteins possibly sequestering zinc, which could promote inflammation due to local zinc deficiency. To investigate this further, we identified high-dose dietary zinc as a potential therapeutic option. This was tested and validated in an acne mouse model, showing promising results for its effectiveness in reducing the inflammation associated with acne.

Although the study specifically highlighted the isolated effect of zinc, it strongly suggests that incorporating high doses of dietary zinc might offer a new avenue for treatment. This could be an encouraging option for those struggling with acne, pointing to a novel approach grounded in scientific findings.
8
Zinc effective for acne treatment
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.

Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.

However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.

Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
5
Zinc and isotretinoin treatment study
We explored the potential benefits of adding oral zinc to low-dose isotretinoin therapy for those dealing with acne vulgaris (AV). By comparing two groups of participants, one receiving zinc along with a lower dose of isotretinoin and another group on the standard dosage, we aimed to see if this combination could enhance treatment outcomes and reduce side effects.

After monitoring sixty AV patients, it was found that both groups showed similar reductions in acne lesions and grading scores, meaning the zinc didn’t provide an additional benefit in clearing up acne compared to the standard treatment alone. However, patients who took zinc experienced significantly fewer treatment-related side effects, with only 20% reporting issues versus 76.7% in the standard isotretinoin group.

In terms of patient satisfaction and relapse rates, there was no notable difference between the two groups. While we did observe improvements in both groups, the addition of zinc appeared to serve primarily as a means to lessen the adverse effects of isotretinoin rather than significantly enhancing treatment efficacy. Thus, while the findings are promising for a more tolerable treatment pathway, more research is necessary to fully understand zinc's impact when combined with isotretinoin at varying dosages.

References

  1. Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high-dose dietary zinc as a therapeutic agent. Exp Dermatol. 2024;33:e15145. doi:10.1111/exd.15145
  2. Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. doi:10.1007/s00403-024-02895-4
  3. Akman TC, Yazici M, Atila A, Mertoglu C. Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects. Biol Trace Elem Res. 2024;202:4858. doi:10.1007/s12011-023-04053-9
  4. Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent. medRxiv. 2023. doi:10.1101/2023.11.28.23299152
  5. Shields A, Ly S, Wafae B, Chang YF, Manjaly P, et al. Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review. JAMA Dermatol. 2023;159:1373. doi:10.1001/jamadermatol.2023.3949
  6. Tan YY, Wong LS, Nyam KL, Wittayanarakul K, Zawawi NA, et al. Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using and Its Effect on Acne Vulgaris. Molecules. 2023;28. doi:10.3390/molecules28196749
  7. Xiang Y, Lu J, Mao C, Zhu Y, Wang C, et al. Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment. Sci Adv. 2023;9:eadf0854. doi:10.1126/sciadv.adf0854
  8. Towersey L, Correia P, Fajgenbaum Feiges M, Euzébio Gonçalves Junior J, Sant'Anna B, et al. Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study. Clin Cosmet Investig Dermatol. 2023;16:119. doi:10.2147/CCID.S394123
  9. Salah E. Oral Zinc as a Novel Adjuvant and Sparing Therapy for Systemic Isotretinoin in Acne Vulgaris: A Preliminary Comparative Study. J Clin Aesthet Dermatol. 2022;15:58.
  10. Naji HH, Al-Azawi RSA, Ibrahim NJ, Kzar HH. Investigation of the Role of Zn/Cu Index and its Correlation with Physiological Activity of SOD 1 and GRx in Males with Acne Vulgaris. Arch Razi Inst. 2022;77:623. doi:10.22092/ARI.2021.356857.1928
  11. Searle T, Ali FR, Al-Niaimi F. Zinc in dermatology. J Dermatolog Treat. 2022;33:2455. doi:10.1080/09546634.2022.2062282
  12. Poizeau F, Plantier F, Bell H, Moyal-Barracco M. Vulvar Fordyce adenitis: A cohort of 45 women. Ann Dermatol Venereol. 2021;148:221. doi:10.1016/j.annder.2021.04.001
  13. Tolino E, Skroza N, Mambrin A, Proietti I, Bernardini N, et al. An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris. J Clin Aesthet Dermatol. 2021;14:56.
  14. Maillard A, Pastor D, Merat R. Anti-PD-1-Induced Hidradenitis Suppurativa. Dermatopathology (Basel). 2021;8:37. doi:10.3390/dermatopathology8010007
  15. Abendrot M, Płuciennik E, Felczak A, Zawadzka K, Piątczak E, et al. Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations. Int J Mol Sci. 2021;22. doi:10.3390/ijms22041641
  16. Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. doi:10.1111/dth.14252
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