We observed a fascinating case of a young woman with diabetes who experienced chronic hives after switching her insulin type. Initially, she moved from a standard isophane insulin to a beef-pork version, which then triggered her hives. Even after she returned to her original insulin, the hives continued to be a problem.
During her hospital stay, we noted that her hives reappeared daily after insulin injections. This situation changed when we introduced a purer form of insulin called zinc single-peak beef insulin suspension. Surprisingly, the urticaria cleared up quickly after this switch.
Through skin testing, we discovered her sensitivity was primarily to the beef and pork forms of the isophane insulin. However, she showed no sensitivity to the zinc insulin forms. Although she did experience a brief return of the hives after taking antibiotics, this time they did not reappear at the insulin injection sites.
This case provides valuable insight into how certain insulin components can lead to hives, and how switching to a zinc preparation offered the young woman some relief.