Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc picolinate)
22 mg
200%
Top Medical Research Studies
9
We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.
Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.
Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.
Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.
Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.
Read More
9
We explored the potential of a novel biodegradable zinc-based alloy, known as Zn-2Cu-0.5Zr, designed to improve healing in senile osteoporotic fractures. Aging often complicates bone healing due to changes in the bone and immune systems, creating a need for materials that can support recovery in older patients.
The Zn-2Cu-0.5Zr alloy showed not only enhanced mechanical strength but also displayed remarkable biocompatibility, as it did not harm bone marrow stem cells. Furthermore, it exhibited strong anti-inflammatory properties by influencing the behavior of immune cells called macrophages, which play a key role in healing.
In tests involving aged rats, this zinc alloy significantly accelerated the healing process in tibial fractures, confirming its effectiveness in promoting bone repair. The promising results suggest that the Zn-2Cu-0.5Zr alloy may offer a beneficial approach to treating osteoporosis-related fractures in elderly individuals.
The Zn-2Cu-0.5Zr alloy showed not only enhanced mechanical strength but also displayed remarkable biocompatibility, as it did not harm bone marrow stem cells. Furthermore, it exhibited strong anti-inflammatory properties by influencing the behavior of immune cells called macrophages, which play a key role in healing.
In tests involving aged rats, this zinc alloy significantly accelerated the healing process in tibial fractures, confirming its effectiveness in promoting bone repair. The promising results suggest that the Zn-2Cu-0.5Zr alloy may offer a beneficial approach to treating osteoporosis-related fractures in elderly individuals.
Read More
7
We explored how zinc affects bone health, particularly osteoporosis, in patients undergoing chronic hemodialysis. This study included 316 patients and measured their serum zinc levels, along with assessing bone density and microarchitecture.
Findings revealed that about 41% of the participants had low zinc levels, which is classified as zinc deficiency. Interestingly, higher serum zinc levels were linked to better bone microarchitecture, as measured by the trabecular bone score (TBS). This suggests that zinc may play a protective role in maintaining bone quality, even though we did not observe a significant correlation with traditional bone density measurements.
Overall, our analysis indicates that while zinc treatment might not directly enhance bone density, it could benefit bone health by improving microarchitecture in patients with chronic kidney disease, highlighting its potential role in osteoporosis management.
Findings revealed that about 41% of the participants had low zinc levels, which is classified as zinc deficiency. Interestingly, higher serum zinc levels were linked to better bone microarchitecture, as measured by the trabecular bone score (TBS). This suggests that zinc may play a protective role in maintaining bone quality, even though we did not observe a significant correlation with traditional bone density measurements.
Overall, our analysis indicates that while zinc treatment might not directly enhance bone density, it could benefit bone health by improving microarchitecture in patients with chronic kidney disease, highlighting its potential role in osteoporosis management.
Read More
Most Useful Reviews
9
Helpful for osteoporosis
I have been ordering this supplement for years on my endocrinologist's advice. Although I have no severe illnesses, there is a risk of osteoporosis due to my age and premenopausal state. Tests show it is absorbed well and very beneficial, with a natural composition.
Read More
8
Good absorption formula
I currently take this regularly because it aids calcium absorption essential in osteoporosis treatment. The formula is effective for absorption of picolinate, and the dosage is convenient. I am content with it.
Read More
7.5
Bone health support
Founded in 1947, this supplement supports bone health and the musculoskeletal system, while also benefiting the nervous system. Calcium is vital for strong bones, and magnesium helps with its transport, promoting calcium intake by bone tissue. The formula also includes zinc, essential for collagen synthesis and reducing the risk of osteoporosis in later life.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
- All Researches
9
We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.
Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.
Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.
Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.
Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.
Read More
9
We explored the potential of a novel biodegradable zinc-based alloy, known as Zn-2Cu-0.5Zr, designed to improve healing in senile osteoporotic fractures. Aging often complicates bone healing due to changes in the bone and immune systems, creating a need for materials that can support recovery in older patients.
The Zn-2Cu-0.5Zr alloy showed not only enhanced mechanical strength but also displayed remarkable biocompatibility, as it did not harm bone marrow stem cells. Furthermore, it exhibited strong anti-inflammatory properties by influencing the behavior of immune cells called macrophages, which play a key role in healing.
In tests involving aged rats, this zinc alloy significantly accelerated the healing process in tibial fractures, confirming its effectiveness in promoting bone repair. The promising results suggest that the Zn-2Cu-0.5Zr alloy may offer a beneficial approach to treating osteoporosis-related fractures in elderly individuals.
The Zn-2Cu-0.5Zr alloy showed not only enhanced mechanical strength but also displayed remarkable biocompatibility, as it did not harm bone marrow stem cells. Furthermore, it exhibited strong anti-inflammatory properties by influencing the behavior of immune cells called macrophages, which play a key role in healing.
In tests involving aged rats, this zinc alloy significantly accelerated the healing process in tibial fractures, confirming its effectiveness in promoting bone repair. The promising results suggest that the Zn-2Cu-0.5Zr alloy may offer a beneficial approach to treating osteoporosis-related fractures in elderly individuals.
Read More
8
We aimed to explore how zinc oxide nanoparticles (ZnO-NPs) can impact the growth and health benefits of a medicinal plant known for its powerful antioxidant properties. By administering ZnO-NPs as foliar sprays to plants under greenhouse conditions, we wanted to see if these nanoparticles could boost the production of silymarin, particularly silybin, which is essential for its soothing effects on the liver and potential benefits in combating osteoporosis.
Our findings were quite promising. The foliar application of ZnO-NPs resulted in increased levels of silybin in the plant's fruit, enhancing its overall medicinal value. We noticed notable improvements in plant growth and yield, alongside higher concentrations of crucial nutrients like nitrogen, phosphorus, potassium, and zinc. The most substantial benefits appeared with a higher concentration of ZnO-NPs (20.0 mg/L).
Notably, the extracts from these treated plants showed promise against osteoporosis in an experimental setting. When administered to rats subjected to dexamethasone-induced osteoporosis, the extracts helped stimulate bone formation and inhibit bone resorption, suggesting a protective effect against bone loss.
While we did not isolate zinc's direct effect on osteoporosis independently, the results hint at its supportive role through enhanced plant-sourced bioactive compounds. Ultimately, our study illustrates the potential of using zinc treatments to enrich medicinal plants, potentially offering new avenues for managing osteoporosis through natural products.
Our findings were quite promising. The foliar application of ZnO-NPs resulted in increased levels of silybin in the plant's fruit, enhancing its overall medicinal value. We noticed notable improvements in plant growth and yield, alongside higher concentrations of crucial nutrients like nitrogen, phosphorus, potassium, and zinc. The most substantial benefits appeared with a higher concentration of ZnO-NPs (20.0 mg/L).
Notably, the extracts from these treated plants showed promise against osteoporosis in an experimental setting. When administered to rats subjected to dexamethasone-induced osteoporosis, the extracts helped stimulate bone formation and inhibit bone resorption, suggesting a protective effect against bone loss.
While we did not isolate zinc's direct effect on osteoporosis independently, the results hint at its supportive role through enhanced plant-sourced bioactive compounds. Ultimately, our study illustrates the potential of using zinc treatments to enrich medicinal plants, potentially offering new avenues for managing osteoporosis through natural products.
Read More
8
We investigated how dietary zinc intake influences osteoporosis, particularly in elderly patients with hypertension. Using data from the National Health and Nutrition Examination Survey, we assessed the dietary habits of over 5,000 participants. Our analysis focused on the relationship between zinc intake and bone mineral density, which is critical for identifying osteoporosis and osteopenia.
After looking at patients' dietary copper, iron, selenium, and zinc levels, we found that those consuming zinc at recommended levels showed a positive correlation with better bone mineral density in areas like the total femur and femoral neck. This indicates that higher zinc intake could help improve bone health and potentially lower the chances of developing osteoporosis.
However, we want to emphasize that while zinc appears to have beneficial effects on bone density for hypertensive patients, it is essential to view these findings within a broader context of overall dietary health and medical guidance. Hence, increasing zinc intake, alongside other nutrients like copper, may be beneficial for our bones as we age.
After looking at patients' dietary copper, iron, selenium, and zinc levels, we found that those consuming zinc at recommended levels showed a positive correlation with better bone mineral density in areas like the total femur and femoral neck. This indicates that higher zinc intake could help improve bone health and potentially lower the chances of developing osteoporosis.
However, we want to emphasize that while zinc appears to have beneficial effects on bone density for hypertensive patients, it is essential to view these findings within a broader context of overall dietary health and medical guidance. Hence, increasing zinc intake, alongside other nutrients like copper, may be beneficial for our bones as we age.
Read More
8
We observed a fascinating connection between zinc and osteoporosis in the context of a recent study that isolated the role of metallothionein 3 (MT3) in osteoclasts, the cells responsible for bone absorption. Throughout our investigation, we discovered that MT3 is uniquely expressed in osteoclasts and significantly increased during their differentiation. This upregulation was not only validated through experimental means, but it was also supported by advanced ATAC sequencing techniques.
When we knocked down or knocked out MT3, we noted a troubling increase in osteoclast formation, leading to accelerated bone loss, particularly in models that mimic menopause-related osteoporosis. Our transcriptome analysis of MT3-deficient osteoclasts indicated that pathways related to oxidative stress and redox balance were particularly active.
Furthermore, we found that MT3 has a pivotal role in regulating reactive oxygen species levels, which are crucial for maintaining bone health. We identified that MT3 modulates the activity of a protein known as SP1, which becomes hyperactive when MT3 is absent. SP1, in turn, regulates critical pathways that lead to osteoclast formation. In summary, this study highlights the important role of MT3 and suggests that increasing MT3 could be a promising therapeutic approach for treating bone disorders like osteoporosis.
When we knocked down or knocked out MT3, we noted a troubling increase in osteoclast formation, leading to accelerated bone loss, particularly in models that mimic menopause-related osteoporosis. Our transcriptome analysis of MT3-deficient osteoclasts indicated that pathways related to oxidative stress and redox balance were particularly active.
Furthermore, we found that MT3 has a pivotal role in regulating reactive oxygen species levels, which are crucial for maintaining bone health. We identified that MT3 modulates the activity of a protein known as SP1, which becomes hyperactive when MT3 is absent. SP1, in turn, regulates critical pathways that lead to osteoclast formation. In summary, this study highlights the important role of MT3 and suggests that increasing MT3 could be a promising therapeutic approach for treating bone disorders like osteoporosis.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Helpful for osteoporosis
I have been ordering this supplement for years on my endocrinologist's advice. Although I have no severe illnesses, there is a risk of osteoporosis due to my age and premenopausal state. Tests show it is absorbed well and very beneficial, with a natural composition.
Read More
8
Good absorption formula
I currently take this regularly because it aids calcium absorption essential in osteoporosis treatment. The formula is effective for absorption of picolinate, and the dosage is convenient. I am content with it.
Read More
7.5
Bone health support
Founded in 1947, this supplement supports bone health and the musculoskeletal system, while also benefiting the nervous system. Calcium is vital for strong bones, and magnesium helps with its transport, promoting calcium intake by bone tissue. The formula also includes zinc, essential for collagen synthesis and reducing the risk of osteoporosis in later life.
Read More
6
Optimises bone health
The product is well packaged and economical. It aids in optimising bone health, maintaining electrolyte balance, and can help reduce osteoporosis.
Read More
Frequently Asked Questions
9
Helpful for osteoporosis
I have been ordering this supplement for years on my endocrinologist's advice. Although I have no severe illnesses, there is a risk of osteoporosis due to my age and premenopausal state. Tests show it is absorbed well and very beneficial, with a natural composition.
8
Good absorption formula
I currently take this regularly because it aids calcium absorption essential in osteoporosis treatment. The formula is effective for absorption of picolinate, and the dosage is convenient. I am content with it.
7.5
Bone health support
Founded in 1947, this supplement supports bone health and the musculoskeletal system, while also benefiting the nervous system. Calcium is vital for strong bones, and magnesium helps with its transport, promoting calcium intake by bone tissue. The formula also includes zinc, essential for collagen synthesis and reducing the risk of osteoporosis in later life.
6
Optimises bone health
The product is well packaged and economical. It aids in optimising bone health, maintaining electrolyte balance, and can help reduce osteoporosis.
7
We aimed to understand how dietary zinc intake relates to the prevalence of osteoporosis in middle-aged and elderly individuals. By analyzing data from over 7,300 participants aged 45 and older, we found that those diagnosed with osteoporosis had significantly lower zinc intake compared to those without the condition.
Our results, derived from comprehensive statistical analyses, indicate that higher dietary zinc levels are associated with lower odds of developing osteoporosis. Even when adjusting for various factors, the connection remained strong. This suggests that zinc may play an important role in bone health.
However, it’s essential to note that while lower levels of dietary zinc correlate with a higher prevalence of osteoporosis, the study did not directly address the impact of zinc treatment on improving osteoporosis outcomes. Therefore, while the data points to a relationship, we cannot conclusively say that increasing zinc intake will treat osteoporosis effectively.
Our results, derived from comprehensive statistical analyses, indicate that higher dietary zinc levels are associated with lower odds of developing osteoporosis. Even when adjusting for various factors, the connection remained strong. This suggests that zinc may play an important role in bone health.
However, it’s essential to note that while lower levels of dietary zinc correlate with a higher prevalence of osteoporosis, the study did not directly address the impact of zinc treatment on improving osteoporosis outcomes. Therefore, while the data points to a relationship, we cannot conclusively say that increasing zinc intake will treat osteoporosis effectively.
7
We explored how zinc affects bone health, particularly osteoporosis, in patients undergoing chronic hemodialysis. This study included 316 patients and measured their serum zinc levels, along with assessing bone density and microarchitecture.
Findings revealed that about 41% of the participants had low zinc levels, which is classified as zinc deficiency. Interestingly, higher serum zinc levels were linked to better bone microarchitecture, as measured by the trabecular bone score (TBS). This suggests that zinc may play a protective role in maintaining bone quality, even though we did not observe a significant correlation with traditional bone density measurements.
Overall, our analysis indicates that while zinc treatment might not directly enhance bone density, it could benefit bone health by improving microarchitecture in patients with chronic kidney disease, highlighting its potential role in osteoporosis management.
Findings revealed that about 41% of the participants had low zinc levels, which is classified as zinc deficiency. Interestingly, higher serum zinc levels were linked to better bone microarchitecture, as measured by the trabecular bone score (TBS). This suggests that zinc may play a protective role in maintaining bone quality, even though we did not observe a significant correlation with traditional bone density measurements.
Overall, our analysis indicates that while zinc treatment might not directly enhance bone density, it could benefit bone health by improving microarchitecture in patients with chronic kidney disease, highlighting its potential role in osteoporosis management.
8
We explored the impacts of zinc deficiency and zinc supplementation in women with osteoporosis who were undergoing treatment with denosumab (DMAb) and eldecalcitol. Our research focused on examining whether zinc levels play any role in enhancing the effectiveness of these commonly prescribed osteoporosis medications.
Conducted as a retrospective study at a single hospital, we followed a group of female patients between April 2019 and April 2020. They were categorized based on their zinc intake and serum zinc levels after twelve months on dietary advice that included zinc-rich foods. We found that while dietary guidance alone didn’t significantly change the serum zinc levels, introducing zinc supplements did make a difference.
Notably, women suffering from zinc deficiency but receiving zinc supplements showed improvements in bone mineral density (BMD) that matched those of other groups, unlike those with insufficient zinc who did not take supplements. Moreover, none of the patients with hypozincemia on zinc medication experienced fractures, offering a promising insight into fracture prevention. However, we also noted that factors like thyroid disease hampered treatment responses.
Ultimately, we observed that hypozincemia can hinder the benefits of DMAb and eldecalcitol in boosting BMD and preventing fractures, emphasizing the importance of managing zinc levels in osteoporosis treatment.
Conducted as a retrospective study at a single hospital, we followed a group of female patients between April 2019 and April 2020. They were categorized based on their zinc intake and serum zinc levels after twelve months on dietary advice that included zinc-rich foods. We found that while dietary guidance alone didn’t significantly change the serum zinc levels, introducing zinc supplements did make a difference.
Notably, women suffering from zinc deficiency but receiving zinc supplements showed improvements in bone mineral density (BMD) that matched those of other groups, unlike those with insufficient zinc who did not take supplements. Moreover, none of the patients with hypozincemia on zinc medication experienced fractures, offering a promising insight into fracture prevention. However, we also noted that factors like thyroid disease hampered treatment responses.
Ultimately, we observed that hypozincemia can hinder the benefits of DMAb and eldecalcitol in boosting BMD and preventing fractures, emphasizing the importance of managing zinc levels in osteoporosis treatment.
7
We looked into how zinc, along with other metals, impacts the risk of osteoporosis among middle-aged and elderly individuals. Our study involved 4,924 participants and measured plasma levels of 23 different metals using advanced scientific methods. By analyzing these levels, we aimed to understand how they correlate with osteoporosis, which is characterized by low bone density.
Interestingly, we found that zinc was positively associated with osteoporosis risk in females. When we compared those with the highest zinc levels to those with the lowest, results showed that women with elevated zinc levels were at a significantly higher risk. This relationship was striking, with a nearly twofold increase in likelihood for developing osteoporosis.
While we focused largely on zinc, it's essential to note that arsenic also increased the risk of osteoporosis in males. Overall, our findings suggest that managing metal exposure, particularly zinc, could be crucial for preventing osteoporosis, especially in women. However, further research is necessary to confirm these trends and explore the underlying mechanisms.
Interestingly, we found that zinc was positively associated with osteoporosis risk in females. When we compared those with the highest zinc levels to those with the lowest, results showed that women with elevated zinc levels were at a significantly higher risk. This relationship was striking, with a nearly twofold increase in likelihood for developing osteoporosis.
While we focused largely on zinc, it's essential to note that arsenic also increased the risk of osteoporosis in males. Overall, our findings suggest that managing metal exposure, particularly zinc, could be crucial for preventing osteoporosis, especially in women. However, further research is necessary to confirm these trends and explore the underlying mechanisms.
References
- Zhang X, Zhang J, Shen L, Ni B, Wang C. Association between dietary zinc intake amount and prevalence of osteoporosis in middle-aged and elderly individuals: a cross-sectional study. Ir J Med Sci. 2025. doi:10.1007/s11845-025-03910-x
- Hori M, Takahashi H, Kondo C, Takeda A, Morozumi K, et al. Association between Serum Zinc Levels and Trabecular Bone Scores among Patients Undergoing Chronic Hemodialysis. Am J Nephrol. 2025. doi:10.1159/000543756
- Fahad Almulhim B, Sherif FE, Younis NS, Safwat Y, Khattab S. Foliar spraying with zinc oxide nanoparticles enhances the anti-osteoporotic efficacy of the fruit extracts of L. by stimulating silybin production. Front Plant Sci. 2024;15:1421485. doi:10.3389/fpls.2024.1421485
- Liu L, Liu H, Lu X, Yin Z, Zhang W, et al. Palladium-Based Nanocomposites Remodel Osteoporotic Microenvironment by Bone-Targeted Hydrogen Enrichment and Zincum Repletion. Research (Wash D C). 2024;7:0540. doi:10.34133/research.0540
- Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. doi:10.1186/s12891-024-07768-5
- Chen M, Jia L, Gao R. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study. Front Nutr. 2024;11:1419379. doi:10.3389/fnut.2024.1419379
- Mo S, Kim MK, Jang JS, Lee SH, Hong SJ, et al. Unique expression and critical role of metallothionein 3 in the control of osteoclastogenesis and osteoporosis. Exp Mol Med. 2024;56:1791. doi:10.1038/s12276-024-01290-3
- Ji H, Shen G, Liu H, Liu Y, Qian J, et al. Biodegradable Zn-2Cu-0.5Zr alloy promotes the bone repair of senile osteoporotic fractures via the immune-modulation of macrophages. Bioact Mater. 2024;38:422. doi:10.1016/j.bioactmat.2024.05.003
- Ishizu H, Shimizu T, Ohashi Y, Kusunoki K, Kanayama M, et al. Zinc improves Denosumab and eldecalcitol efficacy for bone mineral density in patients with hypozincemia. J Bone Miner Metab. 2024;42:233. doi:10.1007/s00774-024-01498-3
- Xu X, Lyu J, Long P, Liu K, Wang H, et al. Associations of multiple plasma metals with osteoporosis: findings from the Dongfeng-Tongji cohort. Environ Sci Pollut Res Int. 2023;30:120903. doi:10.1007/s11356-023-30816-x
