Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
3 g
1%*
Magnesium (as magnesium malate trihydrate)
425 mg
101%
Sodium
10 mg
<1%
Magnesium Malate Trihydrate
3.75 g
†
Malic Acid (as magnesium malate trihydrate and malic acid)
2.5 g
†
Top Medical Research Studies
8
We explored the impact of levothyroxine sodium tablets on individuals suffering from hypothyroidism, particularly focusing on its effectiveness for those with Hashimoto thyroiditis (HT). This common condition can lead to a range of complications, including serious kidney and muscle injuries, as well as issues with cholesterol and other lipids.
In our examination, we described a specific case involving a 52-year-old woman diagnosed with HT. She faced several health challenges, such as kidney and muscle injuries alongside abnormalities in her lipid profiles. After beginning treatment with levothyroxine, we closely monitored her progress through regular assessments of serum creatinine, creatine kinase, and various cholesterol levels.
Over a two-month treatment period, we observed promising results. The patient experienced significant improvements, with her creatine kinase levels returning to normal. Although her serum creatinine level remained slightly elevated, her kidney function showed restoration, and other lipid levels improved significantly. By alleviating these complications, levothyroxine helped address many of her HT-related symptoms, highlighting its benefits in treating severe hypothyroidism manifestations.
In our examination, we described a specific case involving a 52-year-old woman diagnosed with HT. She faced several health challenges, such as kidney and muscle injuries alongside abnormalities in her lipid profiles. After beginning treatment with levothyroxine, we closely monitored her progress through regular assessments of serum creatinine, creatine kinase, and various cholesterol levels.
Over a two-month treatment period, we observed promising results. The patient experienced significant improvements, with her creatine kinase levels returning to normal. Although her serum creatinine level remained slightly elevated, her kidney function showed restoration, and other lipid levels improved significantly. By alleviating these complications, levothyroxine helped address many of her HT-related symptoms, highlighting its benefits in treating severe hypothyroidism manifestations.
Read More
9
Levothyroxine sodium benefits skin health
We explored the impacts of levothyroxine sodium on a 7-year-old Toy Poodle diagnosed with hypothyroidism. The dog was experiencing several issues, such as exercise intolerance, weight gain, and skin problems, including patches of hair loss.
After starting treatment with levothyroxine sodium, we noticed a significant increase in scaling of the skin after one month. This scaling primarily appeared on the trunk, particularly in areas where hair loss was present. Remarkably, as we reduced the levothyroxine dosage over the following three months, the scales vanished and hair regrowth became evident.
Our observations suggest that while levothyroxine sodium helps to trigger hair regrowth, it may also affect how the skin renews itself, leading to temporary scaling. It's important for pet clinicians to recognize that when such scales appear, they often don’t accompany other skin conditions like itchiness or redness, and typically resolve on their own as hair grows back. Hence, further treatment may not be necessary in these situations.
After starting treatment with levothyroxine sodium, we noticed a significant increase in scaling of the skin after one month. This scaling primarily appeared on the trunk, particularly in areas where hair loss was present. Remarkably, as we reduced the levothyroxine dosage over the following three months, the scales vanished and hair regrowth became evident.
Our observations suggest that while levothyroxine sodium helps to trigger hair regrowth, it may also affect how the skin renews itself, leading to temporary scaling. It's important for pet clinicians to recognize that when such scales appear, they often don’t accompany other skin conditions like itchiness or redness, and typically resolve on their own as hair grows back. Hence, further treatment may not be necessary in these situations.
Read More
9
We explored a unique case involving a 2-year and 7-month-old girl diagnosed with congenital hypothyroidism (CH) alongside alpha thalassemia. This child presented with symptoms that included severe anemia and elevated muscle enzymes, which made her appear dispirited and caused growth delays. Such combined conditions are rare, and this study sheds light on the importance of recognizing them promptly to prevent missed diagnoses.
In addressing her condition, we treated her with levothyroxine sodium, a standard therapy for hypothyroidism, along with interventions to correct her anemia. Remarkably, we observed significant improvement after the treatment. The child's energy, appetite, physical development, and overall well-being were reported to be better than those of her peers.
Our findings emphasize that both hypothyroidism and alpha thalassemia can lead to vague symptoms, potentially leading to misdiagnoses. Therefore, we recommend that children exhibiting anemia and elevated muscle enzymes undergo regular thyroid function testing. Early detection and treatment can significantly enhance their quality of life and health outcomes.
In addressing her condition, we treated her with levothyroxine sodium, a standard therapy for hypothyroidism, along with interventions to correct her anemia. Remarkably, we observed significant improvement after the treatment. The child's energy, appetite, physical development, and overall well-being were reported to be better than those of her peers.
Our findings emphasize that both hypothyroidism and alpha thalassemia can lead to vague symptoms, potentially leading to misdiagnoses. Therefore, we recommend that children exhibiting anemia and elevated muscle enzymes undergo regular thyroid function testing. Early detection and treatment can significantly enhance their quality of life and health outcomes.
Read More
Most Useful Reviews
9
Energy boost experienced
21 people found this helpful
Gave me my energy back! Having hypothyroidism and Hashimoto's disease left me exhausted. After researching magnesium's benefits, I decided to try it. Within a week, I noticed a significant increase in energy levels, even hiking 7 miles in a day! Previously, I struggled to get out of bed, but if I forget a dose, the sluggishness returns immediately. This product has genuinely changed my life; if you suffer from hypothyroidism, give it a try!
Read More
9
Pain relief noted
5 people found this helpful
Life-changing! I have fibromyalgia, chronic fatigue syndrome, and hypothyroidism. With just one dose, I noticed about 95% of my pain disappeared! I went 12 hours without thinking about my pain after taking the magnesium pill. Normally, I take tramadol for relief, but the magnesium seems to work better. Although I experienced some nausea initially, I felt fine thereafter. This could truly change my life, and I’m excited!
Read More
7.5
Supports digestive health
3 people found this helpful
Good magnesium! It has worked well for me in treating subclinical hypothyroidism. Compared to other brands, I found this one superior. I have struggled with gastrointestinal issues all my life, and since starting magnesium, everything has improved. Sleep quality also enhanced within the first week of taking it. These benefits are quite remarkable!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
9
We explored the interaction between magnesium sulfate and levothyroxine in managing inflammation related to hypothyroidism. In this study, we used 60 male rats, dividing them into six different groups. These included normals, those given magnesium, hypothyroid rats, and various combinations of treatments with levothyroxine and magnesium.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Read More
9
Levothyroxine sodium benefits skin health
We explored the impacts of levothyroxine sodium on a 7-year-old Toy Poodle diagnosed with hypothyroidism. The dog was experiencing several issues, such as exercise intolerance, weight gain, and skin problems, including patches of hair loss.
After starting treatment with levothyroxine sodium, we noticed a significant increase in scaling of the skin after one month. This scaling primarily appeared on the trunk, particularly in areas where hair loss was present. Remarkably, as we reduced the levothyroxine dosage over the following three months, the scales vanished and hair regrowth became evident.
Our observations suggest that while levothyroxine sodium helps to trigger hair regrowth, it may also affect how the skin renews itself, leading to temporary scaling. It's important for pet clinicians to recognize that when such scales appear, they often don’t accompany other skin conditions like itchiness or redness, and typically resolve on their own as hair grows back. Hence, further treatment may not be necessary in these situations.
After starting treatment with levothyroxine sodium, we noticed a significant increase in scaling of the skin after one month. This scaling primarily appeared on the trunk, particularly in areas where hair loss was present. Remarkably, as we reduced the levothyroxine dosage over the following three months, the scales vanished and hair regrowth became evident.
Our observations suggest that while levothyroxine sodium helps to trigger hair regrowth, it may also affect how the skin renews itself, leading to temporary scaling. It's important for pet clinicians to recognize that when such scales appear, they often don’t accompany other skin conditions like itchiness or redness, and typically resolve on their own as hair grows back. Hence, further treatment may not be necessary in these situations.
Read More
9
We explored a unique case involving a 2-year and 7-month-old girl diagnosed with congenital hypothyroidism (CH) alongside alpha thalassemia. This child presented with symptoms that included severe anemia and elevated muscle enzymes, which made her appear dispirited and caused growth delays. Such combined conditions are rare, and this study sheds light on the importance of recognizing them promptly to prevent missed diagnoses.
In addressing her condition, we treated her with levothyroxine sodium, a standard therapy for hypothyroidism, along with interventions to correct her anemia. Remarkably, we observed significant improvement after the treatment. The child's energy, appetite, physical development, and overall well-being were reported to be better than those of her peers.
Our findings emphasize that both hypothyroidism and alpha thalassemia can lead to vague symptoms, potentially leading to misdiagnoses. Therefore, we recommend that children exhibiting anemia and elevated muscle enzymes undergo regular thyroid function testing. Early detection and treatment can significantly enhance their quality of life and health outcomes.
In addressing her condition, we treated her with levothyroxine sodium, a standard therapy for hypothyroidism, along with interventions to correct her anemia. Remarkably, we observed significant improvement after the treatment. The child's energy, appetite, physical development, and overall well-being were reported to be better than those of her peers.
Our findings emphasize that both hypothyroidism and alpha thalassemia can lead to vague symptoms, potentially leading to misdiagnoses. Therefore, we recommend that children exhibiting anemia and elevated muscle enzymes undergo regular thyroid function testing. Early detection and treatment can significantly enhance their quality of life and health outcomes.
Read More
8
Magnesium shows potential benefits
We conducted a randomized double-blind study to see how supplementation with zinc, magnesium, and vitamin A might affect hypothyroidism.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
Read More
8
We explored the impact of levothyroxine sodium tablets on individuals suffering from hypothyroidism, particularly focusing on its effectiveness for those with Hashimoto thyroiditis (HT). This common condition can lead to a range of complications, including serious kidney and muscle injuries, as well as issues with cholesterol and other lipids.
In our examination, we described a specific case involving a 52-year-old woman diagnosed with HT. She faced several health challenges, such as kidney and muscle injuries alongside abnormalities in her lipid profiles. After beginning treatment with levothyroxine, we closely monitored her progress through regular assessments of serum creatinine, creatine kinase, and various cholesterol levels.
Over a two-month treatment period, we observed promising results. The patient experienced significant improvements, with her creatine kinase levels returning to normal. Although her serum creatinine level remained slightly elevated, her kidney function showed restoration, and other lipid levels improved significantly. By alleviating these complications, levothyroxine helped address many of her HT-related symptoms, highlighting its benefits in treating severe hypothyroidism manifestations.
In our examination, we described a specific case involving a 52-year-old woman diagnosed with HT. She faced several health challenges, such as kidney and muscle injuries alongside abnormalities in her lipid profiles. After beginning treatment with levothyroxine, we closely monitored her progress through regular assessments of serum creatinine, creatine kinase, and various cholesterol levels.
Over a two-month treatment period, we observed promising results. The patient experienced significant improvements, with her creatine kinase levels returning to normal. Although her serum creatinine level remained slightly elevated, her kidney function showed restoration, and other lipid levels improved significantly. By alleviating these complications, levothyroxine helped address many of her HT-related symptoms, highlighting its benefits in treating severe hypothyroidism manifestations.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Energy boost experienced
21 people found this helpful
Gave me my energy back! Having hypothyroidism and Hashimoto's disease left me exhausted. After researching magnesium's benefits, I decided to try it. Within a week, I noticed a significant increase in energy levels, even hiking 7 miles in a day! Previously, I struggled to get out of bed, but if I forget a dose, the sluggishness returns immediately. This product has genuinely changed my life; if you suffer from hypothyroidism, give it a try!
Read More
9
Pain relief noted
5 people found this helpful
Life-changing! I have fibromyalgia, chronic fatigue syndrome, and hypothyroidism. With just one dose, I noticed about 95% of my pain disappeared! I went 12 hours without thinking about my pain after taking the magnesium pill. Normally, I take tramadol for relief, but the magnesium seems to work better. Although I experienced some nausea initially, I felt fine thereafter. This could truly change my life, and I’m excited!
Read More
7.5
Supports digestive health
3 people found this helpful
Good magnesium! It has worked well for me in treating subclinical hypothyroidism. Compared to other brands, I found this one superior. I have struggled with gastrointestinal issues all my life, and since starting magnesium, everything has improved. Sleep quality also enhanced within the first week of taking it. These benefits are quite remarkable!
Read More
7.5
Better sleep quality
1 people found this helpful
This magnesium pill is large and challenging to swallow, yet it’s effective. At 41 and living with hypothyroidism, my doctor prescribed a daily intake of 500 mg for three months. Magnesium is critical for metabolism and eases stress, affecting overall health, especially weight and mood. I take it in the evening, and I generally sleep better with an improved mood. However, the large size has caused me to pause taking it. Despite this, it has an excellent formulation with magnesium malate.
Read More
7.5
Curbing cravings
1 people found this helpful
Magnesium malate has been excellent for my hypothyroidism; I’ve noticed an improvement in my wellbeing. When I'm low on magnesium, I crave chocolate, but after taking this supplement, that craving vanishes, making it easier to avoid sweets.
Read More
Frequently Asked Questions
7.5
Supports digestive health
3 people found this helpful
Good magnesium! It has worked well for me in treating subclinical hypothyroidism. Compared to other brands, I found this one superior. I have struggled with gastrointestinal issues all my life, and since starting magnesium, everything has improved. Sleep quality also enhanced within the first week of taking it. These benefits are quite remarkable!
7.5
Better sleep quality
1 people found this helpful
This magnesium pill is large and challenging to swallow, yet it’s effective. At 41 and living with hypothyroidism, my doctor prescribed a daily intake of 500 mg for three months. Magnesium is critical for metabolism and eases stress, affecting overall health, especially weight and mood. I take it in the evening, and I generally sleep better with an improved mood. However, the large size has caused me to pause taking it. Despite this, it has an excellent formulation with magnesium malate.
8
Quick effect
This magnesium is particularly beneficial for hypothyroidism. It provides a noticeable energy boost in the mornings, and I appreciate its high quality and effect. The pills are not small but are manageable for me.
7.5
Health improvement
I began taking magnesium according to Kornilova's treatment plan for hypothyroidism and noticed an improvement in my health. It has made my menstrual symptoms more manageable.
7.5
Curbing cravings
1 people found this helpful
Magnesium malate has been excellent for my hypothyroidism; I’ve noticed an improvement in my wellbeing. When I'm low on magnesium, I crave chocolate, but after taking this supplement, that craving vanishes, making it easier to avoid sweets.
9
Increased energy
This high-quality magnesium has great ingredients and packaging. When I'm fatigued or have sore muscles, it helps activate my energy. Taking 4-5 capsules in the morning improves my sleep. I will continue purchasing it as it is very necessary, especially with my hypothyroidism!
We explored how magnesium, as part of a broader supplementation strategy, influences thyroid function and overall well-being in patients with hypothyroidism. In a well-structured study, 104 individuals receiving traditional treatment with levothyroxine and vitamin D were randomly divided into two groups. One group received a combination of essential micronutrients, including magnesium, while the other received placebos over an 8-week period.
Our observations highlighted changes in insulin resistance and quality of life after the intervention, suggesting that micronutrient supplementation could have a bearing on these aspects of health. However, the specifics regarding magnesium's isolated effect on thyroid function were less clear due to the multi-nutritional approach taken in this trial.
While we acknowledge promising results related to quality of life, we must clarify that the study does not provide concrete evidence that magnesium alone significantly improves thyroid function. Further, more focused clinical trials are necessary to ascertain the role of magnesium, allowing for a better understanding of its potential benefits in hypothyroid patients.
Our observations highlighted changes in insulin resistance and quality of life after the intervention, suggesting that micronutrient supplementation could have a bearing on these aspects of health. However, the specifics regarding magnesium's isolated effect on thyroid function were less clear due to the multi-nutritional approach taken in this trial.
While we acknowledge promising results related to quality of life, we must clarify that the study does not provide concrete evidence that magnesium alone significantly improves thyroid function. Further, more focused clinical trials are necessary to ascertain the role of magnesium, allowing for a better understanding of its potential benefits in hypothyroid patients.
9
We explored the interaction between magnesium sulfate and levothyroxine in managing inflammation related to hypothyroidism. In this study, we used 60 male rats, dividing them into six different groups. These included normals, those given magnesium, hypothyroid rats, and various combinations of treatments with levothyroxine and magnesium.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
8
Magnesium shows potential benefits
We conducted a randomized double-blind study to see how supplementation with zinc, magnesium, and vitamin A might affect hypothyroidism.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
References
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. doi:10.47176/mjiri.38.133
- Abbas AM, Sakr HF. Effect of magnesium sulfate and thyroxine on inflammatory markers in a rat model of hypothyroidism. Can J Physiol Pharmacol. 2016;94:426. doi:10.1139/cjpp-2015-0247
- Moncayo R, Moncayo H. Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation. BBA Clin. 2015;3:113. doi:10.1016/j.bbacli.2014.12.005
- Liu S, Huang W, Lin Y, Wang Y, Li H, et al. Machine learning-based exploration of the associations between multiple minerals' intake and thyroid dysfunction: data from the National Health and Nutrition Examination Survey. Front Nutr. 2025;12:1522232. doi:10.3389/fnut.2025.1522232
- Rabbani E, Golgiri F, Janani L, Moradi N, Fallah S, et al. Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism. Biol Trace Elem Res. 2021;199:4074. doi:10.1007/s12011-020-02548-3
- Kasuga Y, Murayama N. Scales in a dog after levothyroxine sodium treatment: A case report. Open Vet J. 2024;14:2707. doi:10.5455/OVJ.2024.v14.i10.21
- Zhang Y, Li X, Wang XJ, Yang JP, Li JM, et al. A case report on congenital hypothyroidism and alpha thalassemia in children with anemia and muscle damage as the main manifestation. Medicine (Baltimore). 2024;103:e39446. doi:10.1097/MD.0000000000039446
- Li X, Cao C. Levothyroxine sodium tablets reversed Hashimoto thyroiditis-induced kidney injury, muscle injury, and lipid metabolism disorder: A case report and literature review. Medicine (Baltimore). 2024;103:e39190. doi:10.1097/MD.0000000000039190
- Li X, Liang K, Dong Y, Li S, Gao Z, et al. Effects and Action Mode of Oleic Acid and Azone on Release and Penetration Process of Levothyroxine Sodium Patches. AAPS PharmSciTech. 2024;25:180. doi:10.1208/s12249-024-02875-x
