Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.7
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
3 g
1%*
Magnesium (as magnesium malate trihydrate)
425 mg
101%
Sodium
10 mg
<1%
Magnesium Malate Trihydrate
3.75 g
†
Malic Acid (as magnesium malate trihydrate and malic acid)
2.5 g
†
Top Medical Research Studies
9
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
7
We explored the relationship between magnesium intake and bone health in postmenopausal black South African women over a two-year period. In this study, which included 144 participants, researchers measured bone mineral density (BMD) at several key sites, alongside various biochemical analyses, including bone turnover markers.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
Read More
7
Magnesium's limited effectiveness on menopause
We reviewed various studies to understand how magnesium and other dietary supplements like B vitamins and essential fatty acids affect stress and anxiety in women. Our search included women aged 18 and older who had their stress levels assessed.
Although magnesium showed potential benefits, particularly in combination with vitamin B6 for premenstrual anxiety, the results overall suggested limited effectiveness in managing menopause-related anxiety when evaluated across all studies.
We found that essential fatty acids could help reduce stress during pregnancy and menopause, but more research is needed to establish more definitive findings.
Although magnesium showed potential benefits, particularly in combination with vitamin B6 for premenstrual anxiety, the results overall suggested limited effectiveness in managing menopause-related anxiety when evaluated across all studies.
We found that essential fatty acids could help reduce stress during pregnancy and menopause, but more research is needed to establish more definitive findings.
Read More
Most Useful Reviews
9
Symptom relief
16 people found this helpful
This product is amazing. I decided to try it based on a newsletter I read. Most adults do not consume enough of this essential nutrient, leading to issues like anxiety and menopausal symptoms. My wife is grappling with menopause-related troubles such as night sweats and restless legs. After 30-60 days of using it, our well-being has markedly improved. I’m sleeping soundly, and my wife is almost symptom-free from her menopause struggles that she had previously encountered. We've shared our positive experiences with everyone we know.
Read More
10
Hot flash relief
Excellent! I love this form of magnesium; it really helped me during menopause when those dreadful hot flashes occurred. It works 100%, and I felt like a human being again. I highly recommend it!
Read More
9
Smooth transition
Two brands of magnesium assisted me in navigating menopause smoothly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
- All Researches
9
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
9
Our exploration centered on the effects of magnesium, particularly from nanofiltrated deep ocean water (DOW), in addressing osteoporosis, a common concern during menopause. In our study, we used ovariectomized female Sprague-Dawley rats, a model that simulates menopausal conditions. We administered varying amounts of DOW daily over eight weeks to observe its impact on bone health.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
Read More
9
Isoflavones, probiotics boost bone health
We explored the impact of a novel red clover extract rich in isoflavones and probiotics on bone health in postmenopausal osteopenic women. In a year-long double-blind trial with 78 participants, we compared this treatment alongside standard supplements against a placebo. Results showed that the extract substantially reduced bone mineral density loss and improved certain estrogen metabolism markers. However, it did not affect other bone turnover indicators significantly. Overall, combining the extract with calcium and magnesium proved beneficial for bone health in this demographic.
Read More
9
We explored the effects of a nutraceutical blend, including magnesium, on menopause symptoms through a crossover trial involving 43 postmenopausal women.
Participants experienced significant reductions in menopause symptoms, as measured by the Menopause Rating Scale, after using the nutraceuticals.
Additionally, improvements were noted in cardiovascular risk factors, such as lower cholesterol levels and blood pressure.
Overall, this study suggests that magnesium, combined with other nutrients, may provide meaningful relief for postmenopausal symptoms.
Participants experienced significant reductions in menopause symptoms, as measured by the Menopause Rating Scale, after using the nutraceuticals.
Additionally, improvements were noted in cardiovascular risk factors, such as lower cholesterol levels and blood pressure.
Overall, this study suggests that magnesium, combined with other nutrients, may provide meaningful relief for postmenopausal symptoms.
Read More
7
Magnesium aids menopausal metabolism
We conducted a study to understand how magnesium, along with other supplements, could influence metabolic health during menopause. Our research involved 42 adult female rats that were either ovariectomized or kept as controls. We divided them into seven groups to assess the effects of various treatments, including magnesium, boric acid, vitamin D3, extra virgin olive oil, and combinations of these supplements.
The results were promising. We observed significant improvements in markers related to inflammation, oxidative stress, and various metabolic parameters when magnesium was included in the treatment plans. Interestingly, the rats receiving magnesium, especially as part of a combined treatment, showed better results than those given individual supplements. This suggests that magnesium could play a valuable role in supporting metabolic health during menopause.
However, it’s worth noting that while magnesium demonstrated beneficial effects, the comprehensive impact of each supplement used individually wasn’t singled out for analysis. Thus, while magnesium appears to contribute positively, we cannot decisively state its specific role in isolation. Overall, our findings hint at a promising therapeutic potential for magnesium in managing menopausal symptoms, particularly when used alongside other beneficial nutrients.
The results were promising. We observed significant improvements in markers related to inflammation, oxidative stress, and various metabolic parameters when magnesium was included in the treatment plans. Interestingly, the rats receiving magnesium, especially as part of a combined treatment, showed better results than those given individual supplements. This suggests that magnesium could play a valuable role in supporting metabolic health during menopause.
However, it’s worth noting that while magnesium demonstrated beneficial effects, the comprehensive impact of each supplement used individually wasn’t singled out for analysis. Thus, while magnesium appears to contribute positively, we cannot decisively state its specific role in isolation. Overall, our findings hint at a promising therapeutic potential for magnesium in managing menopausal symptoms, particularly when used alongside other beneficial nutrients.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Symptom relief
16 people found this helpful
This product is amazing. I decided to try it based on a newsletter I read. Most adults do not consume enough of this essential nutrient, leading to issues like anxiety and menopausal symptoms. My wife is grappling with menopause-related troubles such as night sweats and restless legs. After 30-60 days of using it, our well-being has markedly improved. I’m sleeping soundly, and my wife is almost symptom-free from her menopause struggles that she had previously encountered. We've shared our positive experiences with everyone we know.
Read More
10
Hot flash relief
Excellent! I love this form of magnesium; it really helped me during menopause when those dreadful hot flashes occurred. It works 100%, and I felt like a human being again. I highly recommend it!
Read More
9
Smooth transition
Two brands of magnesium assisted me in navigating menopause smoothly.
Read More
8.5
Relieves nervousness
7 people found this helpful
I have been using magnesium for quite some time, and it effectively helps with my nervousness due to menopause. I'm pleased with iHerb as they offer a wide selection of products at competitive prices, and their shipping costs are very reasonable, particularly since I live in Europe.
Read More
9
Improves sleep quality
I am currently in menopause and have been struggling with sleepless nights. Since I began taking this supplement, I sleep excellently at night. It's simply an amazing product.
Read More
Frequently Asked Questions
10
Hot flash relief
Excellent! I love this form of magnesium; it really helped me during menopause when those dreadful hot flashes occurred. It works 100%, and I felt like a human being again. I highly recommend it!
8.5
Relieves nervousness
7 people found this helpful
I have been using magnesium for quite some time, and it effectively helps with my nervousness due to menopause. I'm pleased with iHerb as they offer a wide selection of products at competitive prices, and their shipping costs are very reasonable, particularly since I live in Europe.
9
Improves sleep quality
I am currently in menopause and have been struggling with sleepless nights. Since I began taking this supplement, I sleep excellently at night. It's simply an amazing product.
9
Smooth transition
Two brands of magnesium assisted me in navigating menopause smoothly.
9
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
7
Magnesium aids menopausal metabolism
We conducted a study to understand how magnesium, along with other supplements, could influence metabolic health during menopause. Our research involved 42 adult female rats that were either ovariectomized or kept as controls. We divided them into seven groups to assess the effects of various treatments, including magnesium, boric acid, vitamin D3, extra virgin olive oil, and combinations of these supplements.
The results were promising. We observed significant improvements in markers related to inflammation, oxidative stress, and various metabolic parameters when magnesium was included in the treatment plans. Interestingly, the rats receiving magnesium, especially as part of a combined treatment, showed better results than those given individual supplements. This suggests that magnesium could play a valuable role in supporting metabolic health during menopause.
However, it’s worth noting that while magnesium demonstrated beneficial effects, the comprehensive impact of each supplement used individually wasn’t singled out for analysis. Thus, while magnesium appears to contribute positively, we cannot decisively state its specific role in isolation. Overall, our findings hint at a promising therapeutic potential for magnesium in managing menopausal symptoms, particularly when used alongside other beneficial nutrients.
The results were promising. We observed significant improvements in markers related to inflammation, oxidative stress, and various metabolic parameters when magnesium was included in the treatment plans. Interestingly, the rats receiving magnesium, especially as part of a combined treatment, showed better results than those given individual supplements. This suggests that magnesium could play a valuable role in supporting metabolic health during menopause.
However, it’s worth noting that while magnesium demonstrated beneficial effects, the comprehensive impact of each supplement used individually wasn’t singled out for analysis. Thus, while magnesium appears to contribute positively, we cannot decisively state its specific role in isolation. Overall, our findings hint at a promising therapeutic potential for magnesium in managing menopausal symptoms, particularly when used alongside other beneficial nutrients.
9
Our exploration centered on the effects of magnesium, particularly from nanofiltrated deep ocean water (DOW), in addressing osteoporosis, a common concern during menopause. In our study, we used ovariectomized female Sprague-Dawley rats, a model that simulates menopausal conditions. We administered varying amounts of DOW daily over eight weeks to observe its impact on bone health.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
7
We explored the relationship between magnesium intake and bone health in postmenopausal black South African women over a two-year period. In this study, which included 144 participants, researchers measured bone mineral density (BMD) at several key sites, alongside various biochemical analyses, including bone turnover markers.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
References
- Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04476-y
- Zhang J, Mai CL, Xiong Y, Lin ZJ, Jie YT, et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice. J Inflamm Res. 2021;14:6633. doi:10.2147/JIR.S330894
- Chen PC, Lee YC, Jao HY, Wang CP, Jacobs A, et al. Supplementation of nanofiltrated deep ocean water ameliorate the progression of osteoporosis in ovariectomized rat via regulating osteoblast differentiation. J Food Biochem. 2020;44:e13236. doi:10.1111/jfbc.13236
- Kolanu BR, Vadakedath S, Boddula V, Kandi V. Activities of Serum Magnesium and Thyroid Hormones in Pre-, Peri-, and Post-menopausal Women. Cureus. 2020;12:e6554. doi:10.7759/cureus.6554
- Wright HH, Kruger MC, Schutte WD, Wentzel-Viljoen E, Kruger IM, et al. Magnesium Intake Predicts Bone Turnover in Postmenopausal Black South African Women. Nutrients. 2019;11. doi:10.3390/nu11102519
- Lambert MNT, Thybo CB, Lykkeboe S, Rasmussen LM, Frette X, et al. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Am J Clin Nutr. 2017;106:909. doi:10.3945/ajcn.117.153353
- McCabe D, Lisy K, Lockwood C, Colbeck M. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. JBI Database System Rev Implement Rep. 2017;15:402. doi:10.11124/JBISRIR-2016-002965
- Trimarco V, Rozza F, Izzo R, De Leo V, Cappelli V, et al. Effects of a new combination of nutraceuticals on postmenopausal symptoms and metabolic profile: a crossover, randomized, double-blind trial. Int J Womens Health. 2016;8:581.
