Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.7
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid benefits hypertension
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
8
Eicosapentaenoic acid lowers blood pressure
We examined the impact of eicosapentaenoic acid (EPA) lactone on hypertension, particularly in a model where rats undergo a 5/6 nephrectomy. This condition is known to induce high blood pressure and related vascular dysfunction. Our research involved administering the EPA lactone to these hypertensive rats over five days while measuring their blood pressure, kidney function, and other relevant health metrics.
Through our study, we found that the EPA lactone significantly lowered blood pressure. It achieved this by promoting improved dilation of the blood vessels, which is essential for maintaining healthy circulation. Notably, the mechanism involved calcium-dependent potassium channels in the endothelium, contributing to better vessel relaxation and function.
Our findings suggest that the EPA lactone may hold promise as a dietary supplement for individuals dealing with hypertension, particularly those experiencing issues related to microvascular dysfunction. This study enhances our understanding of how this specific metabolite can play a role in managing high blood pressure effectively.
Through our study, we found that the EPA lactone significantly lowered blood pressure. It achieved this by promoting improved dilation of the blood vessels, which is essential for maintaining healthy circulation. Notably, the mechanism involved calcium-dependent potassium channels in the endothelium, contributing to better vessel relaxation and function.
Our findings suggest that the EPA lactone may hold promise as a dietary supplement for individuals dealing with hypertension, particularly those experiencing issues related to microvascular dysfunction. This study enhances our understanding of how this specific metabolite can play a role in managing high blood pressure effectively.
Read More
7
In our investigation, we delved into the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on hypertension and its associated heart problems. To understand its impact, we used twelve-week-old spontaneously hypertensive rats, which mimic the conditions seen in humans with high blood pressure.
The rats were divided into two groups, with one group fed a diet enriched with EPA while the other received a standard diet for 20 weeks. Our findings revealed something promising: those on the EPA-enriched diet showed a marked reduction in cardiac fibrosis, a condition where heart tissue becomes stiff and less functional. This was significant, as it also contributed to improved diastolic function, even though blood pressure continued to rise.
However, it’s important to note that EPA did not seem to affect the thickening of the heart muscle, known as hypertrophy. We also found evidence that EPA treatment increased certain factors that typically indicate an anti-inflammatory response, such as M2 macrophages and interleukin-10 levels.
Overall, we observed that EPA appears to prevent further complications related to heart function during sustained high blood pressure, positioning it as a potentially innovative treatment strategy for managing hypertensive heart disease.
The rats were divided into two groups, with one group fed a diet enriched with EPA while the other received a standard diet for 20 weeks. Our findings revealed something promising: those on the EPA-enriched diet showed a marked reduction in cardiac fibrosis, a condition where heart tissue becomes stiff and less functional. This was significant, as it also contributed to improved diastolic function, even though blood pressure continued to rise.
However, it’s important to note that EPA did not seem to affect the thickening of the heart muscle, known as hypertrophy. We also found evidence that EPA treatment increased certain factors that typically indicate an anti-inflammatory response, such as M2 macrophages and interleukin-10 levels.
Overall, we observed that EPA appears to prevent further complications related to heart function during sustained high blood pressure, positioning it as a potentially innovative treatment strategy for managing hypertensive heart disease.
Read More
Most Useful Reviews
9
Essential for hypertension
Excellent! Omega-3 becomes an essential supplement after a certain age, particularly for individuals with hypertension.
Read More
7.5
Supports heart health
I recommend this manufacturer. The capsules are easy to take and have no unpleasant taste. I take one capsule daily with food. It promotes heart health, cleanses blood vessels, supports brain function, and offers antioxidant protection. It helps combat atherosclerosis by lowering bad cholesterol and normalises blood pressure in hypertension. An excellent product.
Read More
7.5
Reduces inflammation
This product is fantastic! Sourced from wild pollock in Alaska, it undergoes a rigorous purification process, resulting in a highly concentrated omega-3 dose without the fishy aftertaste. Omega-3 fatty acids, essential for the body, perform numerous beneficial functions, including thinning the blood, lowering blood pressure in hypertension, and reducing the risk of serious health issues while alleviating inflammation.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.7
- All Researches
9
Eicosapentaenoic acid benefits hypertension
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
9
We explored the impact of Resolvin E1 (RvE1)—a compound derived from eicosapentaenoic acid—on hypertension and the corresponding vascular changes associated with it. This research utilized a model where hypertension was induced in mice through a substance called angiotensin II. We administered RvE1 via injection to see how it affected both blood pressure and blood vessel integrity.
Our findings showed that RvE1 could lower high blood pressure and reduce certain harmful changes in the blood vessels. Specifically, it lessened the thickening of artery walls and decreased the buildup of scar tissue in these areas. These improvements were linked to RvE1’s ability to reduce the presence of immune cells that can cause inflammation, which is crucial in the development of hypertension.
We noted that RvE1 works by activating specific cellular pathways that help mediate immune responses and cell growth. Interestingly, levels of RvE1 were found to be lower in patients suffering from hypertension, suggesting that restoring this compound could have therapeutic benefits.
In summary, RvE1 derived from eicosapentaenoic acid shows promise as a potential treatment avenue for managing hypertension and its associated vascular challenges by promoting a healthy resolution of inflammation and regulating cell behavior.
Our findings showed that RvE1 could lower high blood pressure and reduce certain harmful changes in the blood vessels. Specifically, it lessened the thickening of artery walls and decreased the buildup of scar tissue in these areas. These improvements were linked to RvE1’s ability to reduce the presence of immune cells that can cause inflammation, which is crucial in the development of hypertension.
We noted that RvE1 works by activating specific cellular pathways that help mediate immune responses and cell growth. Interestingly, levels of RvE1 were found to be lower in patients suffering from hypertension, suggesting that restoring this compound could have therapeutic benefits.
In summary, RvE1 derived from eicosapentaenoic acid shows promise as a potential treatment avenue for managing hypertension and its associated vascular challenges by promoting a healthy resolution of inflammation and regulating cell behavior.
Read More
9
We set out to investigate how eicosapentaenoic acid (EPA) enriched in phospholipids—termed EPA-PL—affects hypertension and kidney health, particularly in spontaneously hypertensive rats (SHRs). Our research focused on understanding whether dietary EPA-PL could provide protective benefits against kidney damage associated with chronic high blood pressure.
Over three weeks, we treated SHRs with EPA-PL and observed a significant reduction in blood pressure. This drop in blood pressure appeared to be linked to its regulation of the renin-angiotensin system, an important player in blood pressure management. In addition to improved blood pressure, we found notable improvements in kidney function. Measurements of plasma creatinine, blood urea nitrogen, and 24-hour proteinuria showed that EPA-PL treatment led to less kidney dysfunction.
Further investigation into the microscopic structure of the kidneys revealed that EPA-PL helps alleviate renal injury and tubulointerstitial fibrosis, conditions that are often detrimental in hypertensive kidney disease. Mechanistically, we observed that the treatment inhibited a protein called TGF-β, while also affecting other important pathways related to cell survival and inflammatory responses, leading to less oxidative stress in the kidneys.
Overall, our findings suggest that EPA-PL holds promising potential as a therapeutic approach for preventing and alleviating the damaging effects of hypertension on kidney health.
Over three weeks, we treated SHRs with EPA-PL and observed a significant reduction in blood pressure. This drop in blood pressure appeared to be linked to its regulation of the renin-angiotensin system, an important player in blood pressure management. In addition to improved blood pressure, we found notable improvements in kidney function. Measurements of plasma creatinine, blood urea nitrogen, and 24-hour proteinuria showed that EPA-PL treatment led to less kidney dysfunction.
Further investigation into the microscopic structure of the kidneys revealed that EPA-PL helps alleviate renal injury and tubulointerstitial fibrosis, conditions that are often detrimental in hypertensive kidney disease. Mechanistically, we observed that the treatment inhibited a protein called TGF-β, while also affecting other important pathways related to cell survival and inflammatory responses, leading to less oxidative stress in the kidneys.
Overall, our findings suggest that EPA-PL holds promising potential as a therapeutic approach for preventing and alleviating the damaging effects of hypertension on kidney health.
Read More
9
Exercise aids hypertension-related BBB issues
We investigated how hypertension affects the blood-brain barrier (BBB) and whether exercise training could improve its function. Our study involved spontaneously hypertensive rats (SHR) and Wistar rats, which we divided into groups that either underwent treadmill training or remained sedentary for four weeks. We found that hypertension led to an increase in blood pressure and heart rate, as well as a decrease in the protective Mfsd2a protein, which plays a crucial role in maintaining BBB integrity.
Interestingly, when the hypertensive rats participated in exercise training, we noticed a restoration of Mfsd2a levels, a reduction in another protein called caveolin-1, and importantly, a normalization of BBB permeability in the paraventricular nucleus of the hypothalamus. This change was also accompanied by improvements in heart rate and blood pressure variability, indicating enhanced autonomic control.
However, we saw no significant changes in the Wistar group between training and sedentary states, suggesting that the exercise's effects were specific to the hypertensive condition. This highlights that while docosahexaenoic acid (DHA) transport through Mfsd2a is beneficial, the direct impact of DHA alone on hypertension wasn't the focus of our study.
Ultimately, we concluded that exercise training is an effective way to improve both the BBB function and autonomic regulation in hypertensive individuals. It emphasizes the potential therapeutic benefits of lifestyle interventions, like regular exercise, in managing hypertension-related complications.
Interestingly, when the hypertensive rats participated in exercise training, we noticed a restoration of Mfsd2a levels, a reduction in another protein called caveolin-1, and importantly, a normalization of BBB permeability in the paraventricular nucleus of the hypothalamus. This change was also accompanied by improvements in heart rate and blood pressure variability, indicating enhanced autonomic control.
However, we saw no significant changes in the Wistar group between training and sedentary states, suggesting that the exercise's effects were specific to the hypertensive condition. This highlights that while docosahexaenoic acid (DHA) transport through Mfsd2a is beneficial, the direct impact of DHA alone on hypertension wasn't the focus of our study.
Ultimately, we concluded that exercise training is an effective way to improve both the BBB function and autonomic regulation in hypertensive individuals. It emphasizes the potential therapeutic benefits of lifestyle interventions, like regular exercise, in managing hypertension-related complications.
Read More
8
We observed that eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, plays an interesting role in managing high blood pressure (hypertension). This naturally occurring fatty acid is recognized for its potential benefits in reducing blood pressure levels, particularly in those struggling with hypertension.
In our exploration of the latest findings, we noted that several studies suggest EPA could positively influence blood pressure through various mechanisms. These include reducing inflammation and improving vascular function, which are both significant factors in managing hypertension. It seems that consuming EPA could serve as a dietary recommendation for those aiming to lower their blood pressure.
However, it’s important to be aware that the existing research around EPA's effectiveness is still evolving. While some fatty acids are associated with a reduction in blood pressure, the overall relationship is not absolutely conclusive, and further studies are still needed to fully understand how EPA interacts with blood pressure management.
We encourage a balanced approach that also considers other lifestyle factors, such as diet and physical activity, when looking at how fatty acids like EPA can fit into a hypertension management plan.
In our exploration of the latest findings, we noted that several studies suggest EPA could positively influence blood pressure through various mechanisms. These include reducing inflammation and improving vascular function, which are both significant factors in managing hypertension. It seems that consuming EPA could serve as a dietary recommendation for those aiming to lower their blood pressure.
However, it’s important to be aware that the existing research around EPA's effectiveness is still evolving. While some fatty acids are associated with a reduction in blood pressure, the overall relationship is not absolutely conclusive, and further studies are still needed to fully understand how EPA interacts with blood pressure management.
We encourage a balanced approach that also considers other lifestyle factors, such as diet and physical activity, when looking at how fatty acids like EPA can fit into a hypertension management plan.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for hypertension
Excellent! Omega-3 becomes an essential supplement after a certain age, particularly for individuals with hypertension.
Read More
7.5
Supports heart health
I recommend this manufacturer. The capsules are easy to take and have no unpleasant taste. I take one capsule daily with food. It promotes heart health, cleanses blood vessels, supports brain function, and offers antioxidant protection. It helps combat atherosclerosis by lowering bad cholesterol and normalises blood pressure in hypertension. An excellent product.
Read More
7.5
Reduces inflammation
This product is fantastic! Sourced from wild pollock in Alaska, it undergoes a rigorous purification process, resulting in a highly concentrated omega-3 dose without the fishy aftertaste. Omega-3 fatty acids, essential for the body, perform numerous beneficial functions, including thinning the blood, lowering blood pressure in hypertension, and reducing the risk of serious health issues while alleviating inflammation.
Read More
7.5
High DHA and EPA
Personally, I really like this fish oil. The high content of DHA and EPA is very beneficial for patients with hypertension and hyperlipidemia. I will definitely continue to repurchase it.
Read More
7
Improves immune function
The quality of these vitamins is exceptional, and I use them regularly. They reduce the risk of cardiovascular issues and enhance brain function while strengthening bones and the immune system. While there's limited evidence of fish oil preventing heart attacks, it positively impacts good cholesterol levels, lowers triglycerides, reduces blood pressure in hypertension, and mitigates the risk of thrombosis and arrhythmias.
Read More
Frequently Asked Questions
6
Improved mood observed
My husband appreciates this product; he has hypertension and was advised to take Omega-3. We’ve noticed slight improvements in his mood and energy levels. However, he dislikes taking it before bed due to the fishy aftertaste, but overall it seems effective.
7.5
High DHA and EPA
Personally, I really like this fish oil. The high content of DHA and EPA is very beneficial for patients with hypertension and hyperlipidemia. I will definitely continue to repurchase it.
7
Improves immune function
The quality of these vitamins is exceptional, and I use them regularly. They reduce the risk of cardiovascular issues and enhance brain function while strengthening bones and the immune system. While there's limited evidence of fish oil preventing heart attacks, it positively impacts good cholesterol levels, lowers triglycerides, reduces blood pressure in hypertension, and mitigates the risk of thrombosis and arrhythmias.
7.5
Supports heart health
I recommend this manufacturer. The capsules are easy to take and have no unpleasant taste. I take one capsule daily with food. It promotes heart health, cleanses blood vessels, supports brain function, and offers antioxidant protection. It helps combat atherosclerosis by lowering bad cholesterol and normalises blood pressure in hypertension. An excellent product.
7.5
Highly concentrated omega
One of the finest options for concentrated omega-3 online! Sports Research offers a variant in triglyceride form, currently at a 50% discount. There's also California Gold Nutrition's Omega 800, which has a higher concentration of EPA and DHA. Both are excellent and suitable for those requiring high doses of PUFA due to cardiovascular issues, hypertension, or high cholesterol. This discounted option is certainly worth it!
7
We conducted a thorough network meta-analysis to examine how eicosapentaenoic acid (EPA) and other dietary supplements might reduce blood pressure in older adults with hypertension. Analyzing 12 studies that met our criteria, we explored various supplements’ effects on systolic and diastolic blood pressure in individuals aged 65 and older.
Our findings revealed that EPA, along with docosahexaenoic acid (DHA) and other supplements like inorganic nitrates and tart cherry juice, appeared to be more effective than a placebo in lowering systolic blood pressure. However, while EPA shows promise, the overall effect on diastolic blood pressure wasn't as clearly impactful when compared to other options.
Importantly, we noted that the effects of tart cherry juice and resveratrol were smaller than the pooled placebo effects. Even though some dietary supplements demonstrated effectiveness, the results lacked statistical significance among the various treatments examined. This suggests that while there's potential to explore EPA's role further, we also need to proceed with caution, especially given the noted risk of bias in nearly half of the studies included in our analysis.
Our findings revealed that EPA, along with docosahexaenoic acid (DHA) and other supplements like inorganic nitrates and tart cherry juice, appeared to be more effective than a placebo in lowering systolic blood pressure. However, while EPA shows promise, the overall effect on diastolic blood pressure wasn't as clearly impactful when compared to other options.
Importantly, we noted that the effects of tart cherry juice and resveratrol were smaller than the pooled placebo effects. Even though some dietary supplements demonstrated effectiveness, the results lacked statistical significance among the various treatments examined. This suggests that while there's potential to explore EPA's role further, we also need to proceed with caution, especially given the noted risk of bias in nearly half of the studies included in our analysis.
9
Eicosapentaenoic acid benefits hypertension
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
8
We explored how eicosapentaenoic acid, often combined with docosahexaenoic acid, impacts hypertension. Our analysis focused on a robust collection of randomized controlled trials involving nearly 5,000 participants, which provided us with valuable insights into the relationship between omega-3 fatty acids and blood pressure.
From our findings, we noted the most effective daily intake of omega-3s for lowering blood pressure appeared to be between 2 and 3 grams. This moderate intake showed promising results in reducing both systolic and diastolic blood pressure. Interestingly, we discovered that this effect was particularly pronounced in groups that were older, had hypertension, or suffered from high cholesterol.
However, we also observed a J-shaped dose-response curve, which suggests that while lower doses are effective, higher doses might not yield additional benefits and could even be less effective for some people. This emphasizes the importance of adhering to recommended doses, especially for those at risk for cardiovascular diseases.
From our findings, we noted the most effective daily intake of omega-3s for lowering blood pressure appeared to be between 2 and 3 grams. This moderate intake showed promising results in reducing both systolic and diastolic blood pressure. Interestingly, we discovered that this effect was particularly pronounced in groups that were older, had hypertension, or suffered from high cholesterol.
However, we also observed a J-shaped dose-response curve, which suggests that while lower doses are effective, higher doses might not yield additional benefits and could even be less effective for some people. This emphasizes the importance of adhering to recommended doses, especially for those at risk for cardiovascular diseases.
References
- Arghavani H, Bilodeau JF, Rudkowska I. Association Between Circulating Fatty Acids and Blood Pressure: A Review. Curr Nutr Rep. 2025;14:15. doi:10.1007/s13668-024-00602-3
- Kujawska A, Bromage S, Simoes JA, Zupkauskienė J, McMahon N, et al. The impact of dietary supplements on blood pressure in older adults: A network meta-analysis of randomized controlled trials. Heliyon. 2024;10:e25615. doi:10.1016/j.heliyon.2024.e25615
- Asulin M, Gorodetzer N, Fridman R, Shelly Ben-Shushan R, Cohen Z, et al. 5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway. Biochem Biophys Res Commun. 2024;700:149585. doi:10.1016/j.bbrc.2024.149585
- Chen H, Leng X, Liu S, Zeng Z, Huang F, et al. Association between dietary intake of omega-3 polyunsaturated fatty acids and all-cause and cardiovascular mortality among hypertensive adults: Results from NHANES 1999-2018. Clin Nutr. 2023;42:2434. doi:10.1016/j.clnu.2023.09.011
- Zhang J, Yin Z, Xu Y, Wei C, Peng S, et al. Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice. Hypertension. 2023;80:2650. doi:10.1161/HYPERTENSIONAHA.123.21348
- Pipingas A, Reddan JM, Gauci S, Young LM, Kennedy G, et al. Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study. Nutrients. 2023;15. doi:10.3390/nu15092198
- Brosolo G, Da Porto A, Marcante S, Picci A, Capilupi F, et al. Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?. Int J Mol Sci. 2023;24. doi:10.3390/ijms24119520
- Imig JD. Bioactive lipids in hypertension. Adv Pharmacol. 2023;97:1. doi:10.1016/bs.apha.2023.01.001
- Bercea C, Limbu R, Behnam K, Ng KE, Aziz Q, et al. Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels. Front Physiol. 2022;13:1033216. doi:10.3389/fphys.2022.1033216
- Zavala MR, Longarzo ML, Vázquez RF, Vélez Rueda O, Maté SM, et al. Polyunsaturated ω3 fatty acids prevent the cardiac hypertrophy in hypertensive rats. Biochim Biophys Acta Gen Subj. 2023;1867:130278. doi:10.1016/j.bbagen.2022.130278
- Gharraee N, Wang Z, Pflum A, Medina-Hernandez D, Herrington D, et al. Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats. J Lipid Res. 2022;63:100292. doi:10.1016/j.jlr.2022.100292
- Pinhas S, Amram E, Slutsky-Smith E, Ertracht O, Atar S, et al. Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation. Prostaglandins Other Lipid Mediat. 2022;162:106665. doi:10.1016/j.prostaglandins.2022.106665
- Zhang X, Ritonja JA, Zhou N, Chen BE, Li X. Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2022;11:e025071. doi:10.1161/JAHA.121.025071
- Shi HH, Zhang LY, Chen LP, Yang JY, Wang CC, et al. EPA-Enriched Phospholipids Alleviate Renal Interstitial Fibrosis in Spontaneously Hypertensive Rats by Regulating TGF-β Signaling Pathways. Mar Drugs. 2022;20. doi:10.3390/md20020152
- Ni S, Zhong Z, Wei J, Zhou J, Cai L, et al. Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: A cross-sectional study using data from NHANES 2009-2016. Hypertens Res. 2022;45:516. doi:10.1038/s41440-021-00849-1
- Barsheshet M, Ertracht O, Boginya A, Reuveni T, Atar S, et al. Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:159031. doi:10.1016/j.bbalip.2021.159031
- Nestel PJ, Mori TA. Diet to Stop Hypertension: Should Fats be Included?. Curr Hypertens Rep. 2024;26:409. doi:10.1007/s11906-024-01310-7
- Perego SM, Raquel HA, Candido VB, Masson GS, Martins MM, et al. Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries. Am J Physiol Regul Integr Comp Physiol. 2023;325:R299. doi:10.1152/ajpregu.00049.2023
