Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 6 Reviews
8.2
Supplement Facts
Serving Size:  1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
Total Omega-3 Fatty Acids as TG
1055 mg
EPA (Eicosapentaenoic Acid)
690 mg
DHA (Docosahexaenoic Acid)
310 mg
Other Omega-3 Fatty Acids
55 mg

Top Medical Research Studies

We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.

The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.

However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.

All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
Read More
8
Eicosapentaenoic acid supports hypothyroidism
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.

To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.

Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
Read More
9
Omega 3 aids testicular function
We explored the impact of omega 3 fatty acids (O3FA) on hypothyroidism triggered by bisphenol F (BPF), a chemical known to disrupt endocrine functions. The study involved 20 male Wistar rats, divided into groups to either receive BPF, O3FA, or a combination of both for a duration of 28 days. This design helped us assess the protective effects of O3FA against hypothyroidism-related testicular dysfunction.

Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.

On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Read More

Most Useful Reviews

9
Softened dry skin
1 people found this helpful
I absolutely love this omega! After just a few days of taking it, the difference in my skin and nails is evident. My elbows, often very dry due to hypothyroidism, feel smoother and softer after using this omega. We take it as a family, and I appreciate that one capsule contains 1000 mg of essential fatty acids. The capsule is large but easy to swallow.
Read More
7.5
Nails and hair strengthened
5 people found this helpful
Excellent quality, clean ingredients. I'm 34 and this product is beneficial for me due to my hypothyroidism, compensating for my fish intake. I've noticed an increase in my blood levels and strength in my nails and hair. The package consists of 90 tablets, contains omega, and is suitable for cholesterol patients. It's also helpful for those with gland inflammation and good for heart health. The taste is not an issue for me.
Read More
7.5
Increased daily energy
Having dealt with hypothyroidism for many years, I've found this thyroid cofactor to be of high quality. Its ingredients provide me with the energy I need throughout the day.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
  • All Researches
9
Eicosapentaenoic Acid supports brain development
We investigated the role of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in the context of hypothyroidism and its effects on brain development. Our study used a rat model where hypothyroidism was induced, allowing us to examine how EPA influences neuronal health during this critical phase of development.

Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.

One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.

Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Read More
9
Omega 3 aids testicular function
We explored the impact of omega 3 fatty acids (O3FA) on hypothyroidism triggered by bisphenol F (BPF), a chemical known to disrupt endocrine functions. The study involved 20 male Wistar rats, divided into groups to either receive BPF, O3FA, or a combination of both for a duration of 28 days. This design helped us assess the protective effects of O3FA against hypothyroidism-related testicular dysfunction.

Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.

On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Read More
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.

The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.

However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.

All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
Read More
8
Eicosapentaenoic acid supports hypothyroidism
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.

To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.

Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
Read More
8
Omega-3 benefits in hypothyroidism
We examined the effects of omega-3 fatty acids on heart muscle function in hypothyroid rats through a detailed investigation involving both hypothyroid and euthyroid (normal thyroid) groups. The rats were fed diets rich in either n-6 or n-3 fatty acids to observe how these dietary fats influenced their heart's response to beta-adrenoceptor agonists—substances that stimulate heart contraction.

Our findings revealed that in hypothyroid rats on an n-6 diet, the heart's maximum contractile strength was significantly reduced compared to euthyroid controls. Specifically, their ability to develop tension in response to stimulation was only 54% above resting levels, while euthyroid rats showed a far better response at 160%. Interestingly, hypothyroid rats on the n-3 diet did experience an improvement, with tension levels rising to 105% above resting levels, but this was still lower than the 399% seen in healthy controls.

We also evaluated how the heart's beta-adrenoceptors—the sites that respond to hormones like adrenaline—behaved differently. While the overall number of receptors remained constant regardless of thyroid state or diet, their function appeared to be altered, particularly in hypothyroid rats on the n-6 diet.

Importantly, our observation indicates that incorporating n-3 fatty acids in the diet can enhance heart muscle function in hypothyroid conditions, showing potential for dietary interventions in managing this condition. However, it's clear that other factors also play a significant role in heart health in hypothyroidism.
Read More

User Reviews

USERS' SCORE
Good
Based on 6 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Softened dry skin
1 people found this helpful
I absolutely love this omega! After just a few days of taking it, the difference in my skin and nails is evident. My elbows, often very dry due to hypothyroidism, feel smoother and softer after using this omega. We take it as a family, and I appreciate that one capsule contains 1000 mg of essential fatty acids. The capsule is large but easy to swallow.
Read More
7.5
Nails and hair strengthened
5 people found this helpful
Excellent quality, clean ingredients. I'm 34 and this product is beneficial for me due to my hypothyroidism, compensating for my fish intake. I've noticed an increase in my blood levels and strength in my nails and hair. The package consists of 90 tablets, contains omega, and is suitable for cholesterol patients. It's also helpful for those with gland inflammation and good for heart health. The taste is not an issue for me.
Read More
7.5
Increased daily energy
Having dealt with hypothyroidism for many years, I've found this thyroid cofactor to be of high quality. Its ingredients provide me with the energy I need throughout the day.
Read More
7.5
Strengthened hair results
After trying this for a month, I recently bought a three-month supply. My hypothyroidism was causing weakness in my hair and nails, and I hope this will help. My first month showed promising results, and I look forward to experiencing further improvements.
Read More
7.5
Nails and hair improved
This product boasts excellent quality and clean ingredients. At 34, I find it useful for my hypothyroidism, compensating for my fish intake. With 90 pills per package, I've seen enhancements in my blood count and the strength of my nails and hair, largely due to the omega included.
Read More

Frequently Asked Questions

9
Softened dry skin
1 people found this helpful
I absolutely love this omega! After just a few days of taking it, the difference in my skin and nails is evident. My elbows, often very dry due to hypothyroidism, feel smoother and softer after using this omega. We take it as a family, and I appreciate that one capsule contains 1000 mg of essential fatty acids. The capsule is large but easy to swallow.
7.5
Strengthened hair results
After trying this for a month, I recently bought a three-month supply. My hypothyroidism was causing weakness in my hair and nails, and I hope this will help. My first month showed promising results, and I look forward to experiencing further improvements.
7.5
Increased daily energy
Having dealt with hypothyroidism for many years, I've found this thyroid cofactor to be of high quality. Its ingredients provide me with the energy I need throughout the day.
7.5
Nails and hair strengthened
5 people found this helpful
Excellent quality, clean ingredients. I'm 34 and this product is beneficial for me due to my hypothyroidism, compensating for my fish intake. I've noticed an increase in my blood levels and strength in my nails and hair. The package consists of 90 tablets, contains omega, and is suitable for cholesterol patients. It's also helpful for those with gland inflammation and good for heart health. The taste is not an issue for me.
7.5
Consistent with no side effects
This is a good supplement, with excellent dosage in each capsule. I take it regularly with AIT and manage my hypothyroidism without any side effects.
8
Eicosapentaenoic acid supports hypothyroidism
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.

To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.

Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
9
Eicosapentaenoic Acid supports brain development
We investigated the role of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in the context of hypothyroidism and its effects on brain development. Our study used a rat model where hypothyroidism was induced, allowing us to examine how EPA influences neuronal health during this critical phase of development.

Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.

One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.

Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.

The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.

However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.

All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.

References

  1. Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, et al. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci. 2009;27:377. doi:10.1016/j.ijdevneu.2009.02.003
  2. Makino M, Oda N, Miura N, Imamura S, Yamamoto K, et al. Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. J Endocrinol. 2001;171:259.
  3. Simonides WS, van Hardeveld C. Effects of hypothyroidism on the distribution and fatty acyl composition of phospholipids in sarcoplasmic reticulum of fast skeletal muscle of the rat. Biochim Biophys Acta. 1987;924:204.
  4. Odetayo AF, Olayaki LA. Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities. JBRA Assist Reprod. 2024;28:471. doi:10.5935/1518-0557.20240033
  5. Abd Allah ES, Gomaa AM, Sayed MM. The effect of omega-3 on cognition in hypothyroid adult male rats. Acta Physiol Hung. 2014;101:362. doi:10.1556/APhysiol.101.2014.3.11
  6. Walter R, Dunn ME, d'Anjou MA, Lécuyer M. Nonsurgical resolution of gallbladder mucocele in two dogs. J Am Vet Med Assoc. 2008;232:1688. doi:10.2460/javma.232.11.1688
  7. Serebriakova OV, Govorin AV, Prosianik VI, Baksheeva EV. [Fatty acid composition of the blood serum and erythrocyte membrane lipids in patients with hypothyroidism and left ventricular diastolic dysfunction]. Klin Med (Mosk). 2008;86:40.
  8. Pehowich DJ. Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak. Biochim Biophys Acta. 1999;1411:192.
  9. Pehowich DJ. Hypothyroid state and membrane fatty acid composition influence cardiac mitochondrial pyruvate oxidation. Biochim Biophys Acta. 1995;1235:231.
  10. Awumey EM, Paton DM, Pehowich DJ. Thyroid status and dietary fatty acids affect beta-adrenoceptor agonist stimulation of tension development in rat myocardium. J Auton Pharmacol. 1995;15:73.
  11. Awumey EM, Pehowich DJ. N-3 and N-6 fatty acids modulate the inotropic response to calcium in hypothyroid rat papillary muscle. J Cardiovasc Pharmacol. 1995;25:473.
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