Overview
SCIENTIFIC SCORE
Questionable
Based on 20 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
9
We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
Read More
8
We set out to explore the effects of omega-3-rich tuna oil, particularly its docosahexaenoic acid (DHA) component, on memory in rats that underwent ovariectomy—a common model for studying menopause. Over a period of 28 days before and 21 days after the surgery, female rats were given various doses of tuna oil to assess its impact on cognitive performance.
Our findings showed that all doses of tuna oil improved memory performance. We also observed increases in beneficial substances like DHA and improvements in enzyme activities linked to brain health, such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). At the same time, harmful factors such as cortisol and inflammatory cytokines decreased, which suggests that tuna oil may help to reduce stress and inflammation in the brain.
Moreover, medium and high doses of tuna oil managed to suppress monoamine oxidase, while a high dose also moderated gamma-aminotransferase, highlighting its intricate role in neurotransmitter regulation. Interestingly, no notable changes in telomere length or estrogen levels were observed, indicating that the benefits of tuna oil in this context may primarily arise from its antioxidant and anti-inflammatory effects.
Overall, our findings indicate that tuna oil could have a positive influence on memory in the context of menopause, primarily through mechanisms that alleviate oxidative stress and inflammation.
Our findings showed that all doses of tuna oil improved memory performance. We also observed increases in beneficial substances like DHA and improvements in enzyme activities linked to brain health, such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). At the same time, harmful factors such as cortisol and inflammatory cytokines decreased, which suggests that tuna oil may help to reduce stress and inflammation in the brain.
Moreover, medium and high doses of tuna oil managed to suppress monoamine oxidase, while a high dose also moderated gamma-aminotransferase, highlighting its intricate role in neurotransmitter regulation. Interestingly, no notable changes in telomere length or estrogen levels were observed, indicating that the benefits of tuna oil in this context may primarily arise from its antioxidant and anti-inflammatory effects.
Overall, our findings indicate that tuna oil could have a positive influence on memory in the context of menopause, primarily through mechanisms that alleviate oxidative stress and inflammation.
Read More
9
We explored the relationship between eicosapentaenoic acid (EPA) intake and estradiol levels in women, specifically focusing on its effects during menopause. The study utilized data from the National Health and Nutrition Examination Survey, which included dietary interviews and serum estradiol level measurements.
Our findings highlighted that higher intakes of EPA were associated with increased estradiol levels in both menopausal and non-menopausal women. Importantly, we noted that EPA intake above a certain threshold was linked to these hormonal changes.
This research suggests that incorporating more EPA into the diet could play a role in regulating estradiol levels, which is particularly beneficial for women's reproductive health during and after menopause. Understanding these connections helps emphasize the importance of nutrition in hormone regulation.
Our findings highlighted that higher intakes of EPA were associated with increased estradiol levels in both menopausal and non-menopausal women. Importantly, we noted that EPA intake above a certain threshold was linked to these hormonal changes.
This research suggests that incorporating more EPA into the diet could play a role in regulating estradiol levels, which is particularly beneficial for women's reproductive health during and after menopause. Understanding these connections helps emphasize the importance of nutrition in hormone regulation.
Read More
Most Useful Reviews
9
Cholesterol improvement
11 people found this helpful
I have angina, and during menopause, LDL cholesterol tends to rise. After taking this fish oil daily, my LDL cholesterol dropped from 130 to 65 within a month. Alongside light exercise and avoiding dairy products, even my doctor was surprised. It was more effective than statins, so I intend to continue.
Read More
7.5
Cholesterol reduction
7 people found this helpful
I previously took other DHA and EPA supplements, but I bought this one, recommended by my doctor on YouTube. During menopause, my LDL cholesterol unexpectedly spiked. After four months on this supplement, my blood results were normal again. I previously thought high readings were due to holiday indulgence, but I now attribute it to omega-3. This product clearly has beneficial ingredients.
Read More
9
Skin improvement
1 people found this helpful
I've used this product for over 3 years, initially on my doctor's advice. The results have been significant with long-term use, as my skin and hair conditions have greatly improved. The dryness of mucous membranes, persistent since menopause, has vanished! The capsules are slightly large, but taking one daily is simple. I highly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 20 Researches
6.9
- All Researches
9
We explored the relationship between eicosapentaenoic acid (EPA) intake and estradiol levels in women, specifically focusing on its effects during menopause. The study utilized data from the National Health and Nutrition Examination Survey, which included dietary interviews and serum estradiol level measurements.
Our findings highlighted that higher intakes of EPA were associated with increased estradiol levels in both menopausal and non-menopausal women. Importantly, we noted that EPA intake above a certain threshold was linked to these hormonal changes.
This research suggests that incorporating more EPA into the diet could play a role in regulating estradiol levels, which is particularly beneficial for women's reproductive health during and after menopause. Understanding these connections helps emphasize the importance of nutrition in hormone regulation.
Our findings highlighted that higher intakes of EPA were associated with increased estradiol levels in both menopausal and non-menopausal women. Importantly, we noted that EPA intake above a certain threshold was linked to these hormonal changes.
This research suggests that incorporating more EPA into the diet could play a role in regulating estradiol levels, which is particularly beneficial for women's reproductive health during and after menopause. Understanding these connections helps emphasize the importance of nutrition in hormone regulation.
Read More
9
We explored the relationship between docosahexaenoic acid (DHA), a type of omega-3 fatty acid, and breast density among postmenopausal women, particularly focusing on those who are obese. Our study aimed to understand how DHA might differentially affect breast density in obese versus nonobese women, using a method called iTRAQ to analyze plasma samples over two years.
During the study, we identified 173 proteins in the plasma samples. Some of these proteins showed different levels of expression based on whether women were obese or lean. Notably, proteins like the vitamin D binding protein and fibronectin were altered, which suggests a connection between DHA intake and reduced inflammation in obese women.
Our findings indicated that there is an inverse relationship between DHA levels and breast density specifically in postmenopausal obese women. This suggests that greater DHA intake could potentially reduce breast density and may decrease breast cancer risk in this demographic. However, it’s important to note that the effect was not observed in nonobese women.
Overall, this research highlights DHA's role in impacting breast health during menopause, particularly for those with obesity. It opens up further discussions on how dietary changes could play a role in cancer prevention strategies for women going through menopause.
During the study, we identified 173 proteins in the plasma samples. Some of these proteins showed different levels of expression based on whether women were obese or lean. Notably, proteins like the vitamin D binding protein and fibronectin were altered, which suggests a connection between DHA intake and reduced inflammation in obese women.
Our findings indicated that there is an inverse relationship between DHA levels and breast density specifically in postmenopausal obese women. This suggests that greater DHA intake could potentially reduce breast density and may decrease breast cancer risk in this demographic. However, it’s important to note that the effect was not observed in nonobese women.
Overall, this research highlights DHA's role in impacting breast health during menopause, particularly for those with obesity. It opens up further discussions on how dietary changes could play a role in cancer prevention strategies for women going through menopause.
Read More
9
We conducted a study to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid found in fish oil, affects plasma lipid levels in healthy pre-menopausal women. This randomized, double-blind, placebo-controlled trial included 53 participants who were given either 0, 0.35, 0.7, or 1 gram of DHA-rich tuna oil, or a placebo for eight weeks.
Our findings showed that only the highest dose of DHA at 1 gram per day significantly reduced plasma triglycerides—by about 23%. This reduction was particularly noted in the very-low-density lipoprotein triglycerides. Additionally, although we identified a slight increase in HDL particle size with DHA supplementation, we did not observe any significant changes in LDL levels.
Overall, our research underscores that while DHA-rich supplementation can lower triglycerides and possibly improve certain lipid profiles in pre-menopausal women, the effects don’t specifically address menopause symptoms.
Our findings showed that only the highest dose of DHA at 1 gram per day significantly reduced plasma triglycerides—by about 23%. This reduction was particularly noted in the very-low-density lipoprotein triglycerides. Additionally, although we identified a slight increase in HDL particle size with DHA supplementation, we did not observe any significant changes in LDL levels.
Overall, our research underscores that while DHA-rich supplementation can lower triglycerides and possibly improve certain lipid profiles in pre-menopausal women, the effects don’t specifically address menopause symptoms.
Read More
9
We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
Read More
8
In our exploration of how eicosapentaenoic acid (a key component of fish oil) impacts women going through menopause, we conducted a well-structured study. This randomized, double-blind, placebo-controlled trial involved 74 women who were either given fish oil, fish oil combined with vitamin E, or a placebo over a three-month period.
We aimed to uncover the effects of these supplements on lipid profiles and oxidative stress markers in women experiencing dyslipidemia during their menopausal transition. Our results showed that supplementation with fish oil and vitamin E led to reductions in total cholesterol and LDL cholesterol levels. However, we noted that the combination of fish oil and vitamin E had different effects on oxidative stress compared to fish oil on its own.
This suggests that while eicosapentaenoic acid can be beneficial for lipid management during menopause, its interaction with vitamin E alters its effectiveness regarding oxidative stress. Overall, our findings highlight the importance of considering both the benefits and potential complexities of dietary supplements in managing menopause-related health changes.
We aimed to uncover the effects of these supplements on lipid profiles and oxidative stress markers in women experiencing dyslipidemia during their menopausal transition. Our results showed that supplementation with fish oil and vitamin E led to reductions in total cholesterol and LDL cholesterol levels. However, we noted that the combination of fish oil and vitamin E had different effects on oxidative stress compared to fish oil on its own.
This suggests that while eicosapentaenoic acid can be beneficial for lipid management during menopause, its interaction with vitamin E alters its effectiveness regarding oxidative stress. Overall, our findings highlight the importance of considering both the benefits and potential complexities of dietary supplements in managing menopause-related health changes.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cholesterol improvement
11 people found this helpful
I have angina, and during menopause, LDL cholesterol tends to rise. After taking this fish oil daily, my LDL cholesterol dropped from 130 to 65 within a month. Alongside light exercise and avoiding dairy products, even my doctor was surprised. It was more effective than statins, so I intend to continue.
Read More
7.5
Cholesterol reduction
7 people found this helpful
I previously took other DHA and EPA supplements, but I bought this one, recommended by my doctor on YouTube. During menopause, my LDL cholesterol unexpectedly spiked. After four months on this supplement, my blood results were normal again. I previously thought high readings were due to holiday indulgence, but I now attribute it to omega-3. This product clearly has beneficial ingredients.
Read More
9
Skin improvement
1 people found this helpful
I've used this product for over 3 years, initially on my doctor's advice. The results have been significant with long-term use, as my skin and hair conditions have greatly improved. The dryness of mucous membranes, persistent since menopause, has vanished! The capsules are slightly large, but taking one daily is simple. I highly recommend it!
Read More
9
Perfect for menopause
Great! The Omega content is one of the highest, ideal for women in peri-menopause. A fantastic product!
Read More
7.5
Overall health improvement
During menopause, I noticed improvements in hair thinning, growth, and heart palpitations after taking this product. My overall condition has markedly improved.
Read More
Frequently Asked Questions
9
Cholesterol improvement
11 people found this helpful
I have angina, and during menopause, LDL cholesterol tends to rise. After taking this fish oil daily, my LDL cholesterol dropped from 130 to 65 within a month. Alongside light exercise and avoiding dairy products, even my doctor was surprised. It was more effective than statins, so I intend to continue.
7.5
Cholesterol reduction
7 people found this helpful
I previously took other DHA and EPA supplements, but I bought this one, recommended by my doctor on YouTube. During menopause, my LDL cholesterol unexpectedly spiked. After four months on this supplement, my blood results were normal again. I previously thought high readings were due to holiday indulgence, but I now attribute it to omega-3. This product clearly has beneficial ingredients.
9
Skin improvement
1 people found this helpful
I've used this product for over 3 years, initially on my doctor's advice. The results have been significant with long-term use, as my skin and hair conditions have greatly improved. The dryness of mucous membranes, persistent since menopause, has vanished! The capsules are slightly large, but taking one daily is simple. I highly recommend it!
7.5
Overall health improvement
During menopause, I noticed improvements in hair thinning, growth, and heart palpitations after taking this product. My overall condition has markedly improved.
9
Perfect for menopause
Great! The Omega content is one of the highest, ideal for women in peri-menopause. A fantastic product!
7
Mood enhancement
Excellent! Although the large grains are slightly hard to swallow, I manage to take them twice daily. There are no issues with taste or smell. I experience mood swings and depression from menopause, but I feel my condition has improved with continued use.
9
We explored the relationship between eicosapentaenoic acid (EPA) intake and estradiol levels in women, specifically focusing on its effects during menopause. The study utilized data from the National Health and Nutrition Examination Survey, which included dietary interviews and serum estradiol level measurements.
Our findings highlighted that higher intakes of EPA were associated with increased estradiol levels in both menopausal and non-menopausal women. Importantly, we noted that EPA intake above a certain threshold was linked to these hormonal changes.
This research suggests that incorporating more EPA into the diet could play a role in regulating estradiol levels, which is particularly beneficial for women's reproductive health during and after menopause. Understanding these connections helps emphasize the importance of nutrition in hormone regulation.
Our findings highlighted that higher intakes of EPA were associated with increased estradiol levels in both menopausal and non-menopausal women. Importantly, we noted that EPA intake above a certain threshold was linked to these hormonal changes.
This research suggests that incorporating more EPA into the diet could play a role in regulating estradiol levels, which is particularly beneficial for women's reproductive health during and after menopause. Understanding these connections helps emphasize the importance of nutrition in hormone regulation.
2
We examined the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on menopausal symptoms, particularly those pesky vasomotor symptoms (VMS) like hot flashes. In our 12-week study, we conducted a well-structured trial with 355 women, randomly assigning them to receive either eicosapentaenoic acid or a placebo.
Each participant in the omega-3 group received 1.8 grams daily, while keeping some additional participants engaged in yoga, aerobic exercise, or their usual activities. Our main goal was to see whether the omega-3 treatment could lessen the frequency and discomfort of VMS, along with looking at sleep quality, depression, and anxiety levels.
After analyzing the results, we found no substantial differences in VMS frequency or bother when comparing the omega-3 group to the placebo group. In fact, the average reduction in the number of hot flashes per day was quite similar for both groups. Additionally, there were no significant changes reported in sleep quality or mood among those taking omega-3s.
In conclusion, while omega-3s like eicosapentaenoic acid are popular for various health benefits, this study revealed that they do not provide relief from menopause symptoms for sedentary women. We hope our findings can guide future discussions about effective treatments for menopausal discomfort.
Each participant in the omega-3 group received 1.8 grams daily, while keeping some additional participants engaged in yoga, aerobic exercise, or their usual activities. Our main goal was to see whether the omega-3 treatment could lessen the frequency and discomfort of VMS, along with looking at sleep quality, depression, and anxiety levels.
After analyzing the results, we found no substantial differences in VMS frequency or bother when comparing the omega-3 group to the placebo group. In fact, the average reduction in the number of hot flashes per day was quite similar for both groups. Additionally, there were no significant changes reported in sleep quality or mood among those taking omega-3s.
In conclusion, while omega-3s like eicosapentaenoic acid are popular for various health benefits, this study revealed that they do not provide relief from menopause symptoms for sedentary women. We hope our findings can guide future discussions about effective treatments for menopausal discomfort.
7
We aimed to understand how a dairy product enriched with eicosapentaenoic acid (EPA) and other beneficial nutrients affects postmenopausal women, particularly those at moderate risk for cardiovascular issues. In our study, we involved 117 healthy postmenopausal women, dividing them into two groups. One group consumed a specially prepared low-lactose milk rich in EPA, oleic acid, and vitamins, while the other group drank a standard semiskimmed milk with added vitamins.
After 12 months, we found promising results among the women who consumed the EPA-enriched milk. They experienced significant improvements in their lipid profiles, including lower total cholesterol and LDL cholesterol levels. Additionally, a decrease in a marker of inflammation (hs-CRP) was noted, suggesting some cardiovascular benefits. However, we didn’t detect any significant changes regarding bone turnover markers, indicating that while the cardiovascular outcomes were influenced, bone health wasn't notably affected during this period.
Overall, this study highlights the potential of incorporating EPA-rich dairy into the diets of postmenopausal women to support heart health, showcasing a practical dietary strategy to address some health risks associated with menopause.
After 12 months, we found promising results among the women who consumed the EPA-enriched milk. They experienced significant improvements in their lipid profiles, including lower total cholesterol and LDL cholesterol levels. Additionally, a decrease in a marker of inflammation (hs-CRP) was noted, suggesting some cardiovascular benefits. However, we didn’t detect any significant changes regarding bone turnover markers, indicating that while the cardiovascular outcomes were influenced, bone health wasn't notably affected during this period.
Overall, this study highlights the potential of incorporating EPA-rich dairy into the diets of postmenopausal women to support heart health, showcasing a practical dietary strategy to address some health risks associated with menopause.
4
We investigated the role of eicosapentaenoic acid (EPA) in addressing the effects of menopause in ovariectomized rats. This study aimed to understand how EPA, along with other supplements like α-lipoic acid (LA) and docosahexaenoic acid (DHA), affects oxidative stress in the liver after menopause-related hormone changes.
After administering these supplements for 16 weeks, we observed that while EPA helped recover some antioxidant activities and reduce certain types of protein damage, its impact on lipid oxidation was nuanced. Notably, the levels of the lipid peroxidation marker malondialdehyde increased in the EPA group compared to the ovariectomized group, indicating that there might not be a protective effect against lipid damage in this instance.
This study highlights that while EPA does have some positive effects on liver health post-menopause, the results also suggest it may not confer the same level of protection against all forms of oxidative stress as its counterparts. Therefore, while it offers some benefits, its specific role and effectiveness in managing menopause symptoms may require further exploration.
After administering these supplements for 16 weeks, we observed that while EPA helped recover some antioxidant activities and reduce certain types of protein damage, its impact on lipid oxidation was nuanced. Notably, the levels of the lipid peroxidation marker malondialdehyde increased in the EPA group compared to the ovariectomized group, indicating that there might not be a protective effect against lipid damage in this instance.
This study highlights that while EPA does have some positive effects on liver health post-menopause, the results also suggest it may not confer the same level of protection against all forms of oxidative stress as its counterparts. Therefore, while it offers some benefits, its specific role and effectiveness in managing menopause symptoms may require further exploration.
7
We explored the effects of eicosapentaenoic acid (EPA), along with docosahexaenoic acid (DHA) and α-lipoic acid (LA), on heart health in a rat model mimicking menopause. This study focused on how these supplements could help in lowering oxidative stress, which is linked to cardiovascular risk, particularly after ovariectomy—a surgical procedure often used to induce menopause in animal studies.
Interestingly, the ovariectomy did not increase markers of heart damage, such as malondialdehyde and carbonyl levels. Instead, we found that supplementing with LA reduced these damage markers. Ovariectomy did elevate levels of some natural antioxidants in the heart, like glutathione and vitamin C, but all supplements notably restored these antioxidants to healthier levels.
While EPA’s isolated effects cannot be fully determined from this study, we observed that it contributes to a positive change in the overall antioxidant system without worsening lipid or protein damage. Thus, while the study shows some benefits, it does not highlight a significant isolated effect of EPA alone in managing menopausal symptoms or heart health.
Overall, we learned that the combination of DHA, EPA, and LA can help modulate the heart's antioxidant response, with LA showing additional protective effects against heart damage. This suggests a potential dietary approach to support heart health during menopause.
Interestingly, the ovariectomy did not increase markers of heart damage, such as malondialdehyde and carbonyl levels. Instead, we found that supplementing with LA reduced these damage markers. Ovariectomy did elevate levels of some natural antioxidants in the heart, like glutathione and vitamin C, but all supplements notably restored these antioxidants to healthier levels.
While EPA’s isolated effects cannot be fully determined from this study, we observed that it contributes to a positive change in the overall antioxidant system without worsening lipid or protein damage. Thus, while the study shows some benefits, it does not highlight a significant isolated effect of EPA alone in managing menopausal symptoms or heart health.
Overall, we learned that the combination of DHA, EPA, and LA can help modulate the heart's antioxidant response, with LA showing additional protective effects against heart damage. This suggests a potential dietary approach to support heart health during menopause.
7
We explored how the quality of dietary fats, specifically eicosapentaenoic acid (EPA), impacts menopausal symptoms in postmenopausal women. In a recent study involving 393 Iranian women, we assessed their dietary intake alongside the severity of their menopausal symptoms using established questionnaires.
Our findings revealed that women with higher intakes of n-3 polyunsaturated fatty acids, like EPA, showed reduced somatic and psychological symptoms. For instance, those in the highest quartiles of n-3 PUFA and EPA had notably fewer reported symptoms compared to those with lower intakes. This suggests that incorporating more n-3 fats into one's diet could be beneficial during menopause.
Conversely, a higher intake of monounsaturated fatty acids (MUFA) was linked to increased somatic symptoms, indicating that not all fats are created equal when it comes to managing menopause. Overall, we observed that a balanced, diet low in MUFA and high in n-3 PUFA could play a significant role in alleviating menopausal discomfort.
Our findings revealed that women with higher intakes of n-3 polyunsaturated fatty acids, like EPA, showed reduced somatic and psychological symptoms. For instance, those in the highest quartiles of n-3 PUFA and EPA had notably fewer reported symptoms compared to those with lower intakes. This suggests that incorporating more n-3 fats into one's diet could be beneficial during menopause.
Conversely, a higher intake of monounsaturated fatty acids (MUFA) was linked to increased somatic symptoms, indicating that not all fats are created equal when it comes to managing menopause. Overall, we observed that a balanced, diet low in MUFA and high in n-3 PUFA could play a significant role in alleviating menopausal discomfort.
References
- Guo L, Nan Y, Liang K, Yao L, Li J. Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women. Front Nutr. 2024;11:1500705. doi:10.3389/fnut.2024.1500705
- So J, Yao JH, Magadmi R, Matthan NR, Lamon-Fava S. Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2024;203:102655. doi:10.1016/j.plefa.2024.102655
- Putti JS, Engers VK, Heemann FM, Salomon TB, Benfato MS, et al. Effects of lipoic acid and ω-3 long-chain polyunsaturated fatty acids on the kidney in the ovariectomized rat model of menopause. Nutrition. 2019;66:173. doi:10.1016/j.nut.2019.05.003
- Marinho PM, Salomon TB, Andrade AS, Behling CS, Putti JS, et al. The effect of n-3 long-chain polyunsaturated fatty acids and lipoic acid on the heart in the ovariectomized rat model of menopause. Free Radic Res. 2019;53:669. doi:10.1080/10715762.2019.1620938
- Abshirini M, Siassi F, Koohdani F, Qorbani M, Khosravi S, et al. Higher intake of dietary n-3 PUFA and lower MUFA are associated with fewer menopausal symptoms. Climacteric. 2019;22:195. doi:10.1080/13697137.2018.1547700
- Schüller ÁK, Mena Canata DA, Hackenhaar FS, Engers VK, Heemann FM, et al. Effects of lipoic acid and n-3 long-chain polyunsaturated fatty acid on the liver ovariectomized rat model of menopause. Pharmacol Rep. 2018;70:263. doi:10.1016/j.pharep.2017.10.006
- Fonolla-Joya J, Reyes-García R, García-Martín A, López-Huertas E, Muñoz-Torres M. Daily Intake of Milk Enriched with n-3 Fatty Acids, Oleic Acid, and Calcium Improves Metabolic and Bone Biomarkers in Postmenopausal Women. J Am Coll Nutr. 2016;35:529.
- Alves Luzia L, Mendes Aldrighi J, Teixeira Damasceno NR, Rodrigues Sampaio G, Aparecida Manólio Soares R, et al. FISH OIL AND VITAMIN E CHANGE LIPID PROFILES AND ANTI-LDL-ANTIBODIES IN TWO DIFFERENT ETHNIC GROUPS OF WOMEN TRANSITIONING THROUGH MENOPAUSE. Nutr Hosp. 2015;32:165. doi:10.3305/nh.2015.32.1.9079
- Dong H, Hutchins-Wiese H, Kleppinger A, Annis K, Liva E, et al. Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women. Int J Vitam Nutr Res. 2014;84:124. doi:10.1024/0300-9831/a000199
- Cohen LS, Joffe H, Guthrie KA, Ensrud KE, Freeman M, et al. Efficacy of omega-3 for vasomotor symptoms treatment: a randomized controlled trial. Menopause. 2014;21:347. doi:10.1097/GME.0b013e31829e40b8
- Hutchins-Wiese HL, Kleppinger A, Annis K, Liva E, Lammi-Keefe CJ, et al. The impact of supplemental n-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women. J Nutr Health Aging. 2013;17:76. doi:10.1007/s12603-012-0415-3
- Scuderi G, Contestabile MT, Gagliano C, Iacovello D, Scuderi L, et al. Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial. Can J Ophthalmol. 2012;47:489. doi:10.1016/j.jcjo.2012.08.019
- Gao H, Ying Y, Sun J, Huang Y, Li X, et al. Genetically Determined Plasma Docosahexaenoic Acid Showed a Causal Association with Female Reproductive Longevity-Related Phenotype: A Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16234103
- Wattanathorn J, Thukham-Mee W. Omega-3-Rich Tuna Oil Derived from By-Products of the Canned Tuna Industry Enhances Memory in an Ovariectomized Rat Model of Menopause. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13060637
- Félix-Soriano E, Martínez-Gayo A, Cobo MJ, Pérez-Chávez A, Ibáñez-Santos J, et al. Effects of DHA-Rich n-3 Fatty Acid Supplementation and/or Resistance Training on Body Composition and Cardiometabolic Biomarkers in Overweight and Obese Post-Menopausal Women. Nutrients. 2021;13. doi:10.3390/nu13072465
- Konuri A, Bhat KMR, Rai KS, Gourishetti K, Phaneendra M YS. Supplementation of fenugreek with choline-docosahexaenoic acid attenuates menopause induced memory loss, BDNF and dendritic arborization in ovariectomized rats. Anat Sci Int. 2021;96:197. doi:10.1007/s12565-020-00574-8
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