Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Vitamin D (as Ergocalciferol)
10 mcg (400 IU)
50%
Calcium (from Fossilized Coral Calcium)
500 mg
38%
Magnesium (from Magnesium Oxide, Citrate and Aspartate)
250 mg
60%
Fossilized Coral Calcium
1.43 g (1,430 mg)

Top Medical Research Studies

8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.

Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.

This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.

Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
9
Magnesium aids menopause-related issues
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.

We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.

Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.

In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
8
Vitamin D critical for fracture prevention
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.

Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.

This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More

Most Useful Reviews

9
Effective for bones
A highly absorbable calcium supplement safe with vegetable capsules. This Coral Calcium Plus stands out due to its high absorption rate. I feel it helps maintain my bone and teeth health. Recently, my dentist praised the improvement in my teeth. It contains magnesium and vitamin D, which aid calcium absorption. Though the price may seem high, it's reasonable considering its quality and effectiveness. I recommend this to women after menopause who are concerned about bone health.
Read More
9
No side effects
Excellent calcium that I take constantly, as menopause requires additional calcium. There are no unpleasant side effects when taking it.
Read More
9
High-quality product
I am in menopause and experience many uncomfortable symptoms. My doctor advised me to supplement calcium. Since Now Foods' coral calcium compound is natural and easy to absorb, I bought it and alternated with another brand. After half a month, I felt very good effects. The price is excellent; I can buy four bottles at a time to share with my family. It's truly a high-quality product.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.3
  • All Researches
9
Magnesium aids menopause-related issues
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.

We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.

Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.

In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
9
Magnesium's impact on bone health
Our exploration centered on the effects of magnesium, particularly from nanofiltrated deep ocean water (DOW), in addressing osteoporosis, a common concern during menopause. In our study, we used ovariectomized female Sprague-Dawley rats, a model that simulates menopausal conditions. We administered varying amounts of DOW daily over eight weeks to observe its impact on bone health.

We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.

In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
Read More
9
Isoflavones, probiotics boost bone health
We explored the impact of a novel red clover extract rich in isoflavones and probiotics on bone health in postmenopausal osteopenic women. In a year-long double-blind trial with 78 participants, we compared this treatment alongside standard supplements against a placebo. Results showed that the extract substantially reduced bone mineral density loss and improved certain estrogen metabolism markers. However, it did not affect other bone turnover indicators significantly. Overall, combining the extract with calcium and magnesium proved beneficial for bone health in this demographic.
Read More
9
Magnesium reduces menopause symptoms
We explored the effects of a nutraceutical blend, including magnesium, on menopause symptoms through a crossover trial involving 43 postmenopausal women.

Participants experienced significant reductions in menopause symptoms, as measured by the Menopause Rating Scale, after using the nutraceuticals.

Additionally, improvements were noted in cardiovascular risk factors, such as lower cholesterol levels and blood pressure.

Overall, this study suggests that magnesium, combined with other nutrients, may provide meaningful relief for postmenopausal symptoms.
Read More
8
Vitamin D critical for fracture prevention
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.

Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.

This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More

User Reviews

USERS' SCORE
Good
Based on 5 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective for bones
A highly absorbable calcium supplement safe with vegetable capsules. This Coral Calcium Plus stands out due to its high absorption rate. I feel it helps maintain my bone and teeth health. Recently, my dentist praised the improvement in my teeth. It contains magnesium and vitamin D, which aid calcium absorption. Though the price may seem high, it's reasonable considering its quality and effectiveness. I recommend this to women after menopause who are concerned about bone health.
Read More
9
No side effects
Excellent calcium that I take constantly, as menopause requires additional calcium. There are no unpleasant side effects when taking it.
Read More
9
High-quality product
I am in menopause and experience many uncomfortable symptoms. My doctor advised me to supplement calcium. Since Now Foods' coral calcium compound is natural and easy to absorb, I bought it and alternated with another brand. After half a month, I felt very good effects. The price is excellent; I can buy four bottles at a time to share with my family. It's truly a high-quality product.
Read More
8
Improved bone quality
I have purchased many times. For women, calcium is easily lost, especially after menopause. I have been using this product continuously and achieved good results in the bone quality test three months ago.
Read More
8
Necessary supplement
Menopause can cause calcium deficiency; thus, it is a necessary health supplement!
Read More

Frequently Asked Questions

9
High-quality product
I am in menopause and experience many uncomfortable symptoms. My doctor advised me to supplement calcium. Since Now Foods' coral calcium compound is natural and easy to absorb, I bought it and alternated with another brand. After half a month, I felt very good effects. The price is excellent; I can buy four bottles at a time to share with my family. It's truly a high-quality product.
8
Improved bone quality
I have purchased many times. For women, calcium is easily lost, especially after menopause. I have been using this product continuously and achieved good results in the bone quality test three months ago.
9
Effective for bones
A highly absorbable calcium supplement safe with vegetable capsules. This Coral Calcium Plus stands out due to its high absorption rate. I feel it helps maintain my bone and teeth health. Recently, my dentist praised the improvement in my teeth. It contains magnesium and vitamin D, which aid calcium absorption. Though the price may seem high, it's reasonable considering its quality and effectiveness. I recommend this to women after menopause who are concerned about bone health.
9
No side effects
Excellent calcium that I take constantly, as menopause requires additional calcium. There are no unpleasant side effects when taking it.
8
Necessary supplement
Menopause can cause calcium deficiency; thus, it is a necessary health supplement!
8
Vitamin D critical for fracture prevention
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.

Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.

This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.

Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.

This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.

Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
4
High-dose vitamin D effects unclear
Our study examined how high-dose vitamin D, specifically cholecalciferol, influences postmenopausal women. We designed a rigorous trial with a randomized, double-blind, controlled approach involving three distinct oral doses: 50,000 IU, 150,000 IU, and a hefty 500,000 IU. Participants included healthy postmenopausal women who were vitamin D deficient, and we also recruited a control group that had adequate vitamin D levels.

We carefully measured various important outcomes over three months, including total and free vitamin D levels, key bone turnover markers, and even assessed muscle strength and physical function. Initial findings showed that total and free vitamin D levels increased in response to the doses, with a proportional rise in related metabolites. However, we observed no significant effects on physical function or blood pressure regulation, which might explain why some women experience increased falls after high doses.

Interestingly, after administering the highest dosage of 500,000 IU, there was a temporary spike in bone turnover markers. However, the clinical significance of this short-term increase remains uncertain. Overall, while we documented changes in vitamin D levels after supplementation, the treatment didn’t lead to meaningful benefits regarding menopausal symptoms or outcomes specifically related to overall health.
We conducted a retrospective analysis examining how vitamin D treatment influences COVID-19 infection among postmenopausal women.

In our study, we looked at the clinical outcomes of 124,393 women over 50 living in Italy's Veneto region. This included their experiences with SARS-CoV-2 infections, hospitalizations, and mortality rates while undergoing various treatments for menopausal symptoms.

Among these women, those receiving vitamin D3—either alone or with calcium—showed a notable 26% lower risk of SARS-CoV-2 infections compared to other treatments. However, this benefit came with a caveat: they also faced a heightened risk of hospitalization due to the infection.

Our findings shed light on the ongoing discussions about vitamin D's role in preventing COVID-19 and its implications for managing menopause. While vitamin D may help reduce infection rates, its association with a greater risk of hospitalization prompts further investigation into how we approach treatment options during this transitional life stage.

References

  1. Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
  2. Binkley N, Sempos CT, Borchardt G, Larsen J, Stacey ML, et al. Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women. Osteoporos Int. 2025;36:255. doi:10.1007/s00198-024-07310-2
  3. Cocetta V, Zorzi M, Bejor S, Cesta MC, De Pizzol M, et al. Retrospective Analysis of the Effect of Postmenopausal Women Medications on SARS-CoV-2 Infection Progression. Life (Basel). 2024;14. doi:10.3390/life14091107
  4. Bowles SD, Jacques R, Hill TR, Eastell R, Walsh JS. Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function. Nutrients. 2024;16. doi:10.3390/nu16172888
  5. Korkmaz H, Pehlivanoğlu B. Is Vitamin D a Crucial Molecule for Musculoskeletal and Cardiovascular Systems in Postmenopausal Women?. Front Biosci (Landmark Ed). 2024;29:281. doi:10.31083/j.fbl2908281
  6. Rusu ME, Bigman G, Ryan AS, Popa DS. Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies. Nutrients. 2024;16. doi:10.3390/nu16142356
  7. Occhiuto M, Pepe J, Colangelo L, Lucarelli M, Angeloni A, et al. Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency. Nutrients. 2024;16. doi:10.3390/nu16111754
  8. G Siregar MF, Jabbar F, Effendi IH, Alhair T, Prabudi MO, et al. Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. Narra J. 2024;4:e452. doi:10.52225/narra.v4i1.452
  9. Joo NS, Shin SH, Kim KN, Lee SH, Jung S, et al. Home Meal Replacement Fortified with Eggshell Powder and Vitamin D Prevents Bone Loss in Postmenopausal Women: A Randomized, Double-Blind, Controlled Study. Nutrients. 2024;16. doi:10.3390/nu16081152
  10. Suehiro D, Ikeda N, Hirooka K, Ihara A, Fukami K, et al. Decrease in Facial Bone Density with Aging and Maintenance Effect of Calcium Maltobionate Ingestion in Japanese Adult Women: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial. Nutrients. 2025;17. doi:10.3390/nu17020262
  11. Hou J, Mao H, Xie P, Cui Y, Rong M. The effect of different traditional Chinese exercises on bone mineral density in menopausal women: a systematic review and network meta-analysis. Front Public Health. 2024;12:1430608. doi:10.3389/fpubh.2024.1430608
  12. Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04476-y
  13. Zhang J, Mai CL, Xiong Y, Lin ZJ, Jie YT, et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice. J Inflamm Res. 2021;14:6633. doi:10.2147/JIR.S330894
  14. Chen PC, Lee YC, Jao HY, Wang CP, Jacobs A, et al. Supplementation of nanofiltrated deep ocean water ameliorate the progression of osteoporosis in ovariectomized rat via regulating osteoblast differentiation. J Food Biochem. 2020;44:e13236. doi:10.1111/jfbc.13236
  15. Kolanu BR, Vadakedath S, Boddula V, Kandi V. Activities of Serum Magnesium and Thyroid Hormones in Pre-, Peri-, and Post-menopausal Women. Cureus. 2020;12:e6554. doi:10.7759/cureus.6554
  16. Wright HH, Kruger MC, Schutte WD, Wentzel-Viljoen E, Kruger IM, et al. Magnesium Intake Predicts Bone Turnover in Postmenopausal Black South African Women. Nutrients. 2019;11. doi:10.3390/nu11102519
  17. Lambert MNT, Thybo CB, Lykkeboe S, Rasmussen LM, Frette X, et al. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Am J Clin Nutr. 2017;106:909. doi:10.3945/ajcn.117.153353
  18. McCabe D, Lisy K, Lockwood C, Colbeck M. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. JBI Database System Rev Implement Rep. 2017;15:402. doi:10.11124/JBISRIR-2016-002965
  19. Trimarco V, Rozza F, Izzo R, De Leo V, Cappelli V, et al. Effects of a new combination of nutraceuticals on postmenopausal symptoms and metabolic profile: a crossover, randomized, double-blind trial. Int J Womens Health. 2016;8:581.
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