We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
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9
Magnesium enhances osteoporosis treatment
Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice.
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Nanopowder eggshells improve bone health
Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model.
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
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Most Useful Reviews
9
Bioavailable source
1 people found this helpful
Coral calcium is a readily bioavailable source of calcium and is well absorbed by the body. My doctor prescribed it, and I would recommend it to anyone facing osteoporosis.
Read More
9
Helpful for osteopenia
1 people found this helpful
This product has been great! My mother, diagnosed with osteopenia close to osteoporosis, opted to use these supplements along with vitamin D and hiking instead of prescribed medication. Since starting this regimen, her condition has improved significantly. I believe this calcium supplement, along with other included ingredients, has greatly benefitted her, and I would recommend it to others.
Read More
7.5
Good quality supplement
1 people found this helpful
The quality of this calcium supplement is commendable as it improves the body's calcium levels and helps manage osteoporosis effectively.
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
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9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
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9
Combination therapy for osteoporosis
Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats.
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
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9
Magnesium's role in osteoporosis
Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES.
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
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9
Magnesium improves osteoporotic bone repair
An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation.
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Coral calcium is a readily bioavailable source of calcium and is well absorbed by the body. My doctor prescribed it, and I would recommend it to anyone facing osteoporosis.
Read More
9
Helpful for osteopenia
1 people found this helpful
This product has been great! My mother, diagnosed with osteopenia close to osteoporosis, opted to use these supplements along with vitamin D and hiking instead of prescribed medication. Since starting this regimen, her condition has improved significantly. I believe this calcium supplement, along with other included ingredients, has greatly benefitted her, and I would recommend it to others.
Read More
7.5
Good quality supplement
1 people found this helpful
The quality of this calcium supplement is commendable as it improves the body's calcium levels and helps manage osteoporosis effectively.
Read More
6
Organic and effective
1 people found this helpful
The quality of this organic calcium source is excellent for absorption. I utilise it to combat osteoporosis and to alkalise my body, and I plan to continue with this effective supplement. It has been well tolerated.
Read More
7.5
Helpful nutritional supplements
Coral calcium has proven helpful in my efforts to improve osteoporosis. Buying nutritional supplements like this one has positively impacted my health.
Osteoporosis is a medical condition characterized by weakened bones, making them fragile and more prone to fractures. This condition occurs when the body loses too much bone mass, doesn't make enough bone, or a combination of both. As bones lose density, they can break more easily, often as a result of minor falls or injury. Osteoporosis is often referred to as a "silent disease" because bone loss occurs without any symptoms until a fracture occurs, often in the hip, spine, or wrist.
Risk factors for developing osteoporosis include age, gender (it’s more common in women), family history, low body weight, and certain medical conditions and medications. Lifestyle choices such as smoking, excessive alcohol consumption, and a diet low in calcium and vitamin D can also contribute to bone loss. Regular weight-bearing exercise, ensuring adequate nutrition, and, in some cases, medications can help prevent or manage osteoporosis. If you believe you may be at risk, it is important to consult with a healthcare professional for appropriate screening and intervention options.
Coral calcium is a dietary supplement derived from coral reefs, primarily harvested from marine environments. It contains a blend of calcium and magnesium, along with trace minerals that are also found in the ocean. The idea behind using coral calcium as a supplement is that it provides a natural source of these essential minerals, which are important for maintaining bone health, muscle function, and overall wellness. Proponents of coral calcium argue that it offers superior absorption compared to other forms of calcium, although scientific evidence supporting these claims is mixed.
It is worth noting that the sustainability and environmental impact of harvesting coral calcium has raised concerns among environmentalists. The extraction process can be harmful to coral ecosystems, which are already threatened by climate change and pollution. As with any supplement, it is crucial to consult with a healthcare professional before adding coral calcium to your routine. They can provide personalized advice based on your dietary needs and health goals, ensuring you choose the right form of supplementation for your lifestyle.
Coral calcium is often marketed as a natural supplement that can provide various health benefits, including support for bone health. It is derived from fossilized coral reefs and contains not only calcium but also other minerals and trace elements that are believed to contribute to overall wellness. However, when it comes to osteoporosis, the evidence surrounding coral calcium's efficacy is limited. Most experts agree that while calcium is crucial for maintaining bone density, the best way to prevent or manage osteoporosis includes a balanced intake of calcium and vitamin D coupled with regular weight-bearing exercise.
Current research has not definitively established coral calcium as an effective treatment for osteoporosis. Standard recommendations usually suggest obtaining calcium through dietary sources, such as dairy products, leafy greens, and fortified foods, or through well-studied calcium supplements. If you are considering coral calcium, it is essential to consult a healthcare professional to determine the most effective approach for your bone health needs.
Based on user reviews, the timeline for noticing results from taking calcium supplements for osteoporosis can vary. Several users report significant improvements after starting their regimen, although specific time frames are not always mentioned. One user noted that their mother saw considerable improvement in her condition after incorporating the calcium supplement along with other lifestyle changes, which suggests that users may start to see benefits within a few months of consistent use (Read Review).
Others have emphasized the importance of hydration and additional dietary factors in conjunction with the supplement for better results (Read Review, Read Review). While specific durations are often not cited, users generally highlight the supplement's effectiveness in improving calcium levels and managing osteoporosis, indicating that benefits may be observed over weeks to months.Read Review
Based on current scientific research, certain supplements, particularly those involving vitamin D and calcium, are supported for their role in managing osteoporosis. For instance, a systematic exploration revealed that vitamin D supplementation is critical for maintaining bone density, especially in populations vulnerable to osteoporosis. Studies have shown that a daily dose of 800-1000 IU can significantly reduce falls and non-vertebral fractures in elderly individuals with vitamin D deficiency ([5]). Furthermore, the interaction between calcium and vitamin D appears to be important as both nutrients are crucial for bone health, although a balance must be maintained due to the potential risk of kidney stones associated with supplementation ([6]).
On the other hand, magnesium has also garnered attention for its influence on bone health. Evidence indicates that adequate magnesium levels are associated with a reduced risk of osteoporosis ([25]). Research has consistently highlighted that magnesium plays a significant role in bone formation and maintenance, and its deficiency can lead to increased bone loss. Different methods of supplementing magnesium, such as through innovative delivery systems, have shown promise in promoting bone regeneration and managing osteoporosis-related complications, suggesting a multi-faceted approach may be necessary ([27]). Overall, more targeted studies are warranted to continue exploring the efficacy and mechanisms of these supplements in the context of osteoporosis.
Users have reported a range of improvements in their symptoms after taking calcium supplements for osteoporosis. Some individuals, like one reviewer whose mother was diagnosed with osteopenia approaching osteoporosis, noted significant health improvements attributed to the supplement combined with lifestyle changes such as increased physical activity (Read Review). Others emphasize the effectiveness of the supplement in managing their calcium levels, leading to better overall bone health and a reduction in symptoms associated with osteoporosis (Read Review).
Additionally, several users highlighted that the coral calcium's bioavailability enhances its absorption, making it a recommendable solution for osteoporosis. One user shared that taking the supplement had helped in preventing the progression of their osteopenia into full-blown osteoporosis (Read Review). Overall, while experiences vary, many users express a positive shift in their bone health and management of osteoporosis symptoms, often crediting these supplements as a critical part of their regimen.
Based on user reviews, many individuals have reported positive outcomes when combining calcium supplements with other nutrients and lifestyle modifications for managing osteoporosis. One user highlighted that their mother improved significantly by taking the calcium supplement alongside vitamin D and engaging in physical activities like hiking, rather than relying solely on prescribed medications (Read Review). This suggests that a holistic approach, incorporating both supplements and lifestyle changes, may enhance the effectiveness of the treatment.
Users also spoke highly of the calcium supplement's bioavailability, which enhances its absorption and efficacy in managing osteoporosis. Several reviewers indicated that they were taking the supplement as part of a broader regimen to combat their condition, with one noting its effectiveness in preventing the progression of osteopenia to full-blown osteoporosis, highlighting the importance of combining it with other health-conscious decisions (Read Review). Overall, while individual experiences vary, many users recommend integrating this calcium supplement with additional nutrients or supplements to maximize bone health benefits.
Users report that Coral Calcium has been helpful in managing osteoporosis, with some highlighting that it effectively improves calcium levels and supports bone health. Several reviews mention that the supplement is well-absorbed by the body, enhancing its effectiveness in treating osteopenia and osteoporosis symptoms. For instance, one user noted significant improvement in their mother’s condition after including Coral Calcium with vitamin D and exercise in her regimen Read Review.
While specific dosage recommendations were not provided in the user reviews, the general consensus leans toward Coral Calcium being a beneficial addition to one’s routine for those dealing with osteoporosis or at risk of it. Users expressed satisfaction with the quality and absorption rate of this organic calcium source Read Review, reinforcing its status as a good nutritional supplement Read Review. Ultimately, incorporating Coral Calcium appears to yield positive results, but for optimal dosing and health advice, consulting with a healthcare provider is advisable.
9
Helpful for osteopenia
1 people found this helpful
This product has been great! My mother, diagnosed with osteopenia close to osteoporosis, opted to use these supplements along with vitamin D and hiking instead of prescribed medication. Since starting this regimen, her condition has improved significantly. I believe this calcium supplement, along with other included ingredients, has greatly benefitted her, and I would recommend it to others.
7.5
Good quality supplement
1 people found this helpful
The quality of this calcium supplement is commendable as it improves the body's calcium levels and helps manage osteoporosis effectively.
6
Organic and effective
1 people found this helpful
The quality of this organic calcium source is excellent for absorption. I utilise it to combat osteoporosis and to alkalise my body, and I plan to continue with this effective supplement. It has been well tolerated.
7.5
Helpful nutritional supplements
Coral calcium has proven helpful in my efforts to improve osteoporosis. Buying nutritional supplements like this one has positively impacted my health.
7.5
Prevents progression
This good product has helped prevent my osteopenia from progressing into osteoporosis.
7
Vitamin D and osteoporosis insight
Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO.
We explored the effects of vitamin D supplementation on osteoporosis, especially among individuals at risk for this condition. The Osteoporosis Research and Information Group (GRIO) highlighted the critical difference between daily and intermittent vitamin D dosing.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
4
Vitamin D and osteoporosis treatment risks
Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study.
We aimed to understand how vitamin D, when taken alongside calcium, affects individuals dealing with osteoporosis. This study involved 204 participants aged between 50 and 89 years, all receiving a specific daily dose of calcium carbonate and alfacalcidol for at least a year.
Our findings reveal an important aspect of this treatment: while calcium and vitamin D can be beneficial for bone health, there's a concerning association with kidney stone formation among users. Particularly, those with a history of recurrent kidney stones seemed to face an increased risk, which may be linked to higher urinary calcium excretion as a result of the supplements.
This highlights a dual-edged sword in osteoporosis treatment—while we seek to strengthen bones, we also have to consider potential harm. Thus, anyone considering or currently using these supplements should consult with their healthcare provider to carefully weigh the benefits against the risks, especially if they have a past of kidney stones.
8
Magnesium may prevent osteoporosis
Association Between Combined Polymetallic Exposure and Osteoporosis.
We explored the connection between magnesium and osteoporosis by examining data from 2,115 participants. A variety of methods, including LASSO regression and logistic regression, were employed to analyze plasma concentrations of 22 different metals and their relationship with osteoporosis.
From our analysis, we found that magnesium plays a notable role in the likelihood of developing osteoporosis. Specifically, it was consistently associated with a reduced risk of this condition. In our findings, magnesium showed a negative correlation with osteoporosis, meaning higher levels of this essential mineral were linked to a lower chance of osteoporosis.
However, we also noted that exposure to metals like aluminum and cadmium was positively associated with an increased risk of osteoporosis, indicating that a combination of various metal exposures could influence bone health adversely. While magnesium appears to offer protective benefits, the interplay of different metals complicates the overall picture.
9
Magnesium enhances osteoporosis treatment
Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice.
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
References
Banu J, Varela E, Guerra JM, Halade G, Williams PJ, et al. Dietary coral calcium and zeolite protects bone in a mouse model for postmenopausal bone loss. Nutr Res. 2012;32:965. doi:10.1016/j.nutres.2012.09.009
Afonso ML, Capelas ML, Pimenta NM, Santos T, Mäkitie A, et al. A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?. Nutrients. 2025;17. doi:10.3390/nu17040634
Wang H, Tian G, Pei Z, Yu X, Wang Y, et al. increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice. mSphere. 2025. doi:10.1128/msphere.01039-24
Skubica P, Hoffmanova I, Dankova P. Chronically increased osteoclastogenesis in adult celiac disease patients does not hinder improvement in bone health induced by gluten-free diet: Role of vitamin D, OPG and IL-6. J Nutr Biochem. 2025. doi:10.1016/j.jnutbio.2025.109871
Pickering ME, Souberbielle JC, Boutten A, Breuil V, Briot K, et al. Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO. Joint Bone Spine. 2025;92:105858. doi:10.1016/j.jbspin.2025.105858
Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. doi:10.1136/bmjopen-2024-092901
Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
Yang C, Chen L, Guo X, Sun H, Miao D. The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. J Orthop Translat. 2025;50:211. doi:10.1016/j.jot.2024.10.011
Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. doi:10.1248/bpb.b24-00536
McCarrison S, Abdelrahman S, Quinlivan R, Keen R, Wong SC. Pharmacological and non-pharmacological therapies for prevention and treatment of osteoporosis in Duchenne Muscular Dystrophy: A systematic review. Bone. 2025;193:117410. doi:10.1016/j.bone.2025.117410
Ma M, Zhang Y, Liu J, Tian C, Duan Z, et al. Associations of the serum 25-hydroxyvitamin D with mortality among patients in osteopenia or osteoporosis. Bone. 2025. doi:10.1016/j.bone.2025.117408
Wang JC, Chung SM, Wu PT, Tu YK, Lai PC, et al. Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials. EClinicalMedicine. 2025;81:103103. doi:10.1016/j.eclinm.2025.103103
Chen L, Lin S, He X, Ye J, Huang Y, et al. A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Int J Biol Macromol. 2025. doi:10.1016/j.ijbiomac.2025.141634
Ma R, Romano E, Ashworth M, Vancampfort D, Solmi M, et al. Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study. Gen Hosp Psychiatry. 2025;94:56. doi:10.1016/j.genhosppsych.2025.02.009
Chen J, Wang J, Jia W, Zhang Y, Li H, et al. Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats. Eur J Med Res. 2025;30:115. doi:10.1186/s40001-025-02384-y
Joris V, Balmayor ER, van Griensven M. miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells. Mol Ther Nucleic Acids. 2025;36:102446. doi:10.1016/j.omtn.2024.102446
Hu W, Feng X, Wen C. Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES. Medicine (Baltimore). 2024;103:e40768. doi:10.1097/MD.0000000000040768
Li D, Dai D, Wang J, Zhang C. Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy. Small. 2024;20:e2403907. doi:10.1002/smll.202403907
Zhou H, He Z, Cao Y, Chu L, Liang B, et al. An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation. Theranostics. 2024;14:3739. doi:10.7150/thno.97412
Liu L, Luo P, Wen P, Xu P. The role of magnesium in the pathogenesis of osteoporosis. Front Endocrinol (Lausanne). 2024;15:1406248. doi:10.3389/fendo.2024.1406248
Huang L, Cai P, Bian M, Yu J, Xiao L, et al. Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects. Mater Today Bio. 2024;26:101092. doi:10.1016/j.mtbio.2024.101092
Weng Z, Ye J, Cai C, Liu Z, Liu Y, et al. Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy. J Nanobiotechnology. 2024;22:314. doi:10.1186/s12951-024-02581-7
Dai Q, Wang Z, Liu C, Chen X, Cao X. High performance injectable Mg doped bioactive glass bone cement for the regulation of osteogenic immune microenvironment. Biomater Adv. 2024;160:213864. doi:10.1016/j.bioadv.2024.213864
Li J, Chen Y, Zha D, Wu C, Li X, et al. Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. Lipids Health Dis. 2024;23:88. doi:10.1186/s12944-024-02083-3
Qin L, Liu Q, Zhang T, Tang X, Mo X, et al. Association Between Combined Polymetallic Exposure and Osteoporosis. Biol Trace Elem Res. 2024;202:3945. doi:10.1007/s12011-023-04002-6
Ma T, Guan Y, Feng J, Yang Y, Chen J, et al. Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate. Biomater Res. 2023;27:128. doi:10.1186/s40824-023-00474-8
Zhang C, Du B, Deng G, Zhang S, Yu T, et al. Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice. Chin Med J (Engl). 2024;137:1762. doi:10.1097/CM9.0000000000002877
Zhao Y, Liu J, Hu L, Yao X, Tu R, et al. Novel "hot spring"-mimetic scaffolds for sequential neurovascular network reconstruction and osteoporosis reversion. Biomaterials. 2025;320:123191. doi:10.1016/j.biomaterials.2025.123191
Al-Garawi ZS, Al-Qaisi AHI, Al-Shamari KA, Öztürkkan FE, Necefoğlu H. The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study. Bioprocess Biosyst Eng. 2024;47:753. doi:10.1007/s00449-024-03012-5
Düğer H, Uçan B, Çalışkan M, Bostan H, Demirci T, et al. Hypomagnesemia may be associated with symptomatic disease in patients with primary hyperparathyroidism. Endocrine. 2024;83:466. doi:10.1007/s12020-023-03577-3
Han H, Chen S, Wang X, Jin J, Li X, et al. Association of the composite dietary antioxidant index with bone mineral density in the United States general population: data from NHANES 2005-2010. J Bone Miner Metab. 2023;41:631. doi:10.1007/s00774-023-01438-7
Zhu Y, Jia G, Yang Y, Weng J, Liu S, et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway. ACS Biomater Sci Eng. 2023;9:3435. doi:10.1021/acsbiomaterials.2c01097
Fouhy LE, Mangano KM, Zhang X, Hughes BD, Tucker KL, et al. Association between a Calcium-to-Magnesium Ratio and Osteoporosis among Puerto Rican Adults. J Nutr. 2023;153:2642. doi:10.1016/j.tjnut.2023.05.009
Xie Y, Bao Z, Wang Z, Du D, Chen G, et al. Magnesium Ascorbyl Phosphate Promotes Bone Formation Via CaMKII Signaling. J Bone Miner Res. 2023;38:1015. doi:10.1002/jbmr.4820
Salama RHM, Ali SS, Salama THM, Almged MA, Alsanory TA, et al. Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model. Appl Biochem Biotechnol. 2023;195:5034. doi:10.1007/s12010-022-04038-9