Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.8
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Vitamin D (as Ergocalciferol)
10 mcg (400 IU)
50%
Calcium (from Fossilized Coral Calcium)
500 mg
38%
Magnesium (from Magnesium Oxide, Citrate and Aspartate)
250 mg
60%
Fossilized Coral Calcium
1.43 g (1,430 mg)

Top Medical Research Studies

9
Magnesium's role in osteoporosis therapy
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
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9
Magnesium enhances osteoporosis treatment
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.

We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.

However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Nanopowder eggshells improve bone health
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.

In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.

Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.

Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
Read More

Most Useful Reviews

9
Bioavailable source
1 people found this helpful
Coral calcium is a readily bioavailable source of calcium and is well absorbed by the body. My doctor prescribed it, and I would recommend it to anyone facing osteoporosis.
Read More
9
Helpful for osteopenia
1 people found this helpful
This product has been great! My mother, diagnosed with osteopenia close to osteoporosis, opted to use these supplements along with vitamin D and hiking instead of prescribed medication. Since starting this regimen, her condition has improved significantly. I believe this calcium supplement, along with other included ingredients, has greatly benefitted her, and I would recommend it to others.
Read More
7.5
Good quality supplement
1 people found this helpful
The quality of this calcium supplement is commendable as it improves the body's calcium levels and helps manage osteoporosis effectively.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.8
  • All Researches
9
Probiotic support for osteoporosis treatment
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.

Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.

Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.

Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
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9
Calcium complex enhances bone health
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.

We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.

Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
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9
Combination therapy for osteoporosis
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.

The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.

Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
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9
Magnesium's role in osteoporosis
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.

The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.

Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
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9
Magnesium improves osteoporotic bone repair
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.

Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.

Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Read More

User Reviews

USERS' SCORE
Good
Based on 7 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Bioavailable source
1 people found this helpful
Coral calcium is a readily bioavailable source of calcium and is well absorbed by the body. My doctor prescribed it, and I would recommend it to anyone facing osteoporosis.
Read More
9
Helpful for osteopenia
1 people found this helpful
This product has been great! My mother, diagnosed with osteopenia close to osteoporosis, opted to use these supplements along with vitamin D and hiking instead of prescribed medication. Since starting this regimen, her condition has improved significantly. I believe this calcium supplement, along with other included ingredients, has greatly benefitted her, and I would recommend it to others.
Read More
7.5
Good quality supplement
1 people found this helpful
The quality of this calcium supplement is commendable as it improves the body's calcium levels and helps manage osteoporosis effectively.
Read More
6
Organic and effective
1 people found this helpful
The quality of this organic calcium source is excellent for absorption. I utilise it to combat osteoporosis and to alkalise my body, and I plan to continue with this effective supplement. It has been well tolerated.
Read More
7.5
Helpful nutritional supplements
Coral calcium has proven helpful in my efforts to improve osteoporosis. Buying nutritional supplements like this one has positively impacted my health.
Read More

Frequently Asked Questions

9
Helpful for osteopenia
1 people found this helpful
This product has been great! My mother, diagnosed with osteopenia close to osteoporosis, opted to use these supplements along with vitamin D and hiking instead of prescribed medication. Since starting this regimen, her condition has improved significantly. I believe this calcium supplement, along with other included ingredients, has greatly benefitted her, and I would recommend it to others.
7.5
Good quality supplement
1 people found this helpful
The quality of this calcium supplement is commendable as it improves the body's calcium levels and helps manage osteoporosis effectively.
6
Organic and effective
1 people found this helpful
The quality of this organic calcium source is excellent for absorption. I utilise it to combat osteoporosis and to alkalise my body, and I plan to continue with this effective supplement. It has been well tolerated.
7.5
Helpful nutritional supplements
Coral calcium has proven helpful in my efforts to improve osteoporosis. Buying nutritional supplements like this one has positively impacted my health.
7.5
Prevents progression
This good product has helped prevent my osteopenia from progressing into osteoporosis.
We explored the effects of vitamin D supplementation on osteoporosis, especially among individuals at risk for this condition. The Osteoporosis Research and Information Group (GRIO) highlighted the critical difference between daily and intermittent vitamin D dosing.

Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.

Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
4
Vitamin D and osteoporosis treatment risks
We aimed to understand how vitamin D, when taken alongside calcium, affects individuals dealing with osteoporosis. This study involved 204 participants aged between 50 and 89 years, all receiving a specific daily dose of calcium carbonate and alfacalcidol for at least a year.

Our findings reveal an important aspect of this treatment: while calcium and vitamin D can be beneficial for bone health, there's a concerning association with kidney stone formation among users. Particularly, those with a history of recurrent kidney stones seemed to face an increased risk, which may be linked to higher urinary calcium excretion as a result of the supplements.

This highlights a dual-edged sword in osteoporosis treatment—while we seek to strengthen bones, we also have to consider potential harm. Thus, anyone considering or currently using these supplements should consult with their healthcare provider to carefully weigh the benefits against the risks, especially if they have a past of kidney stones.
We explored the connection between magnesium and osteoporosis by examining data from 2,115 participants. A variety of methods, including LASSO regression and logistic regression, were employed to analyze plasma concentrations of 22 different metals and their relationship with osteoporosis.

From our analysis, we found that magnesium plays a notable role in the likelihood of developing osteoporosis. Specifically, it was consistently associated with a reduced risk of this condition. In our findings, magnesium showed a negative correlation with osteoporosis, meaning higher levels of this essential mineral were linked to a lower chance of osteoporosis.

However, we also noted that exposure to metals like aluminum and cadmium was positively associated with an increased risk of osteoporosis, indicating that a combination of various metal exposures could influence bone health adversely. While magnesium appears to offer protective benefits, the interplay of different metals complicates the overall picture.
9
Magnesium enhances osteoporosis treatment
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.

We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.

However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.

References

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