' 
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Medium or Average
Based on 10 Reviews
6.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9.5
Vitamin B12 causes acne-like eruptions
Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.
Study highlights vitamin B12 effects
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
Read More
9.5
Vitamin B12 influences acne development
Vitamin B12 induced acneiform eruption.
Highly relevant case study
We observed a fascinating case involving a 47-year-old man who developed a skin condition after starting vitamin B12 treatment for pernicious anemia. Just six weeks into his weekly injections of hydroxocobalamin, he experienced a sudden and widespread outbreak of inflammatory acne-like bumps on his face and trunk. This skin eruption was not only extensive but also caused significant itching and included comedones, commonly known as blackheads, particularly on his chest.
Upon closer examination, the medical team diagnosed him with a vitamin B12-induced acneiform eruption, which is different from typical acne vulgaris. This distinction came from several unique factors, including the patient's age, the sudden onset of the condition, and the presence of pruritus (itching) alongside a uniform type of lesions across non-seborrheic areas.
After normalizing his vitamin B12 levels, the hydroxocobalamin injections were stopped, and lymecycline—a type of antibiotic—was introduced. Remarkably, this led to a complete resolution of his skin lesions within three months. This case highlights how vitamin B12 can have an unusual, but significant impact on skin health, demonstrating that its effects are not just limited to its role in blood health but can extend into dermatological issues as well.
Upon closer examination, the medical team diagnosed him with a vitamin B12-induced acneiform eruption, which is different from typical acne vulgaris. This distinction came from several unique factors, including the patient's age, the sudden onset of the condition, and the presence of pruritus (itching) alongside a uniform type of lesions across non-seborrheic areas.
After normalizing his vitamin B12 levels, the hydroxocobalamin injections were stopped, and lymecycline—a type of antibiotic—was introduced. Remarkably, this led to a complete resolution of his skin lesions within three months. This case highlights how vitamin B12 can have an unusual, but significant impact on skin health, demonstrating that its effects are not just limited to its role in blood health but can extend into dermatological issues as well.
Read More
4
Vitamin B12 affects acne mechanisms
Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis.
Significant insights into acne pathogenesis
We explored how vitamin B12 influences the skin microbiota and its potential connection to acne development. By analyzing the skin microbiota of acne patients and healthy individuals, we found that there are significant differences in the transcriptional profiles of these groups. Specifically, we noticed that the pathway responsible for vitamin B12 biosynthesis in a skin bacterium called Propionibacterium acnes was less active in those with acne.
To dive deeper, we conducted an experiment with healthy subjects who were given vitamin B12 supplements. Our findings showed that this supplementation suppressed the expression of vitamin B12 production genes in P. acnes and altered the overall activity of the skin microbiota. Interestingly, one participant developed acne just a week after starting the supplements, shedding light on a possible mechanism behind the observed connections.
Additionally, we identified that vitamin B12 supplemented P. acnes cultures led to an increased production of porphyrins, compounds known to trigger inflammation associated with acne. This suggests a novel pathway through which vitamin B12 may influence acne development, aligning with clinical observations that some individuals experience breakouts following vitamin B12 supplementation.
Overall, our study emphasizes the complex interplay between vitamin B12 and the skin microbiota, hinting at its pivotal role in acne pathogenesis.
To dive deeper, we conducted an experiment with healthy subjects who were given vitamin B12 supplements. Our findings showed that this supplementation suppressed the expression of vitamin B12 production genes in P. acnes and altered the overall activity of the skin microbiota. Interestingly, one participant developed acne just a week after starting the supplements, shedding light on a possible mechanism behind the observed connections.
Additionally, we identified that vitamin B12 supplemented P. acnes cultures led to an increased production of porphyrins, compounds known to trigger inflammation associated with acne. This suggests a novel pathway through which vitamin B12 may influence acne development, aligning with clinical observations that some individuals experience breakouts following vitamin B12 supplementation.
Overall, our study emphasizes the complex interplay between vitamin B12 and the skin microbiota, hinting at its pivotal role in acne pathogenesis.
Read More
Most Useful Reviews
9.5
Chin acne disappeared
I bought it for fertility, but it remarkably improved my acne. I previously took Chocola BB for my skin, but this time started with different intentions, only to be pleased with the outcome. My chin acne, which typically flared before my period, has vanished. The small grain is easy to take, and I continue to use one daily.
Read More
0
Acne worsened initially
Acid and not folate acid did not appeal to me from the outset. The very next day after starting, I experienced an outburst of acne that made it difficult to leave the house. Each day, the acne worsened, spreading beyond my face. I ceased taking it, and within one to two weeks, all the breakouts vanished.
Read More
5
B12 caused acne
The quality is great; however, the high level of B12 caused acne for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
- All Researches
9.5
Vitamin B12 influences acne development
Vitamin B12 induced acneiform eruption.
Highly relevant case study
We observed a fascinating case involving a 47-year-old man who developed a skin condition after starting vitamin B12 treatment for pernicious anemia. Just six weeks into his weekly injections of hydroxocobalamin, he experienced a sudden and widespread outbreak of inflammatory acne-like bumps on his face and trunk. This skin eruption was not only extensive but also caused significant itching and included comedones, commonly known as blackheads, particularly on his chest.
Upon closer examination, the medical team diagnosed him with a vitamin B12-induced acneiform eruption, which is different from typical acne vulgaris. This distinction came from several unique factors, including the patient's age, the sudden onset of the condition, and the presence of pruritus (itching) alongside a uniform type of lesions across non-seborrheic areas.
After normalizing his vitamin B12 levels, the hydroxocobalamin injections were stopped, and lymecycline—a type of antibiotic—was introduced. Remarkably, this led to a complete resolution of his skin lesions within three months. This case highlights how vitamin B12 can have an unusual, but significant impact on skin health, demonstrating that its effects are not just limited to its role in blood health but can extend into dermatological issues as well.
Upon closer examination, the medical team diagnosed him with a vitamin B12-induced acneiform eruption, which is different from typical acne vulgaris. This distinction came from several unique factors, including the patient's age, the sudden onset of the condition, and the presence of pruritus (itching) alongside a uniform type of lesions across non-seborrheic areas.
After normalizing his vitamin B12 levels, the hydroxocobalamin injections were stopped, and lymecycline—a type of antibiotic—was introduced. Remarkably, this led to a complete resolution of his skin lesions within three months. This case highlights how vitamin B12 can have an unusual, but significant impact on skin health, demonstrating that its effects are not just limited to its role in blood health but can extend into dermatological issues as well.
Read More
9.5
Vitamin B12 causes acne-like eruptions
Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.
Study highlights vitamin B12 effects
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
Read More
9
Tracnil™ improves acne in PCOS
Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study.
Combination treatment complicates folate assessment
We evaluated the effectiveness of Tracnil™, a treatment combining myo-inositol, folic acid, and vitamin D3, specifically addressing acne in women with normal hormone levels who exhibit signs of polycystic ovary syndrome (PCOS). Conducting a single-arm study with 33 participants, we monitored acne symptoms, hirsutism, and menstrual irregularities over the course of eight weeks, along with hormone level assessments and safety evaluations.
Our findings suggested that Tracnil™ significantly reduced both inflammatory and non-inflammatory acne lesions. Additionally, it appeared to improve symptoms of hirsutism and help regulate menstrual cycles. While the exact mechanisms remain somewhat unclear, we believe that folic acid, in conjunction with the other components, plays a role in enhancing acne treatment responses, possibly by influencing receptor sensitivities to hormones.
Notably, throughout the study period, participants experienced minimal adverse reactions, and no severe side effects were identified. Even among those with normal hormonal levels, the combination therapy with myo-inositol and vitamin D3 underlined the potential benefits of Tracnil™ in managing dermatological signs associated with PCOS.
This research highlights the practicality of incorporating Tracnil™ into dermatological practice as a first-line approach for acne related to PCOS, broadening treatment options even in the absence of significant hormonal abnormalities.
Our findings suggested that Tracnil™ significantly reduced both inflammatory and non-inflammatory acne lesions. Additionally, it appeared to improve symptoms of hirsutism and help regulate menstrual cycles. While the exact mechanisms remain somewhat unclear, we believe that folic acid, in conjunction with the other components, plays a role in enhancing acne treatment responses, possibly by influencing receptor sensitivities to hormones.
Notably, throughout the study period, participants experienced minimal adverse reactions, and no severe side effects were identified. Even among those with normal hormonal levels, the combination therapy with myo-inositol and vitamin D3 underlined the potential benefits of Tracnil™ in managing dermatological signs associated with PCOS.
This research highlights the practicality of incorporating Tracnil™ into dermatological practice as a first-line approach for acne related to PCOS, broadening treatment options even in the absence of significant hormonal abnormalities.
Read More
9
Folate helps with isotretinoin pain
Successful Treatment of Isotretinoin Induced Musculoskeletal Pain by Vitamin B12 and Folic Acid.
Focus on folate's role
We've discovered that folate supplementation may play a role in managing musculoskeletal pain associated with isotretinoin, a medication commonly used for acne treatment. In our investigation involving six patients suffering from nodulocystic acne, we closely observed their experiences after starting isotretinoin. Each patient reported developing pain in their muscles and joints, a side effect that can significantly affect quality of life.
The patients were treated with daily doses of folic acid and vitamin B12, leading to successful pain relief. This suggests that these supplements could be beneficial in alleviating discomfort without halting the use of isotretinoin itself. It’s important to note that while our findings are promising, extensive trials with larger sample sizes are still necessary to confirm these results.
As we move forward, we encourage our peers to consider offering B12 and folate to patients experiencing musculoskeletal pain from isotretinoin. This could help maintain treatment effectiveness while addressing uncomfortable side effects. Our study sheds light on an important aspect of acne treatment and patient care, urging further investigation into the benefits of these vitamins for overall treatment satisfaction.
The patients were treated with daily doses of folic acid and vitamin B12, leading to successful pain relief. This suggests that these supplements could be beneficial in alleviating discomfort without halting the use of isotretinoin itself. It’s important to note that while our findings are promising, extensive trials with larger sample sizes are still necessary to confirm these results.
As we move forward, we encourage our peers to consider offering B12 and folate to patients experiencing musculoskeletal pain from isotretinoin. This could help maintain treatment effectiveness while addressing uncomfortable side effects. Our study sheds light on an important aspect of acne treatment and patient care, urging further investigation into the benefits of these vitamins for overall treatment satisfaction.
Read More
9
Vitamin B12's unclear acne efficacy
Successful re-introduction of vitamin B12 after using isotretinoin to treat severe acne medicamentosa.
Study design limited effectiveness clarity
We explored the impact of reintroducing vitamin B12 in individuals who had undergone treatment with isotretinoin for severe acne, known as acne medicamentosa. This study aimed to examine whether vitamin B12 could help improve acne conditions after completing isotretinoin therapy.
Although we discussed the effects of vitamin B12, the study’s structure didn’t isolate it from other treatments, which might make it hard to gauge vitamin B12's full effectiveness on its own.
We observed that while vitamin B12 had some interaction in the treatment process, the overall conclusion about its significant benefits for acne remains unclear due to the lack of controlled conditions in the study design.
Therefore, while reintroducing vitamin B12 after isotretinoin treatment shows some potential, it does not provide strong enough evidence to confirm a notable impact on acne improvement alone.
Although we discussed the effects of vitamin B12, the study’s structure didn’t isolate it from other treatments, which might make it hard to gauge vitamin B12's full effectiveness on its own.
We observed that while vitamin B12 had some interaction in the treatment process, the overall conclusion about its significant benefits for acne remains unclear due to the lack of controlled conditions in the study design.
Therefore, while reintroducing vitamin B12 after isotretinoin treatment shows some potential, it does not provide strong enough evidence to confirm a notable impact on acne improvement alone.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 10 Reviews
6.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Chin acne disappeared
I bought it for fertility, but it remarkably improved my acne. I previously took Chocola BB for my skin, but this time started with different intentions, only to be pleased with the outcome. My chin acne, which typically flared before my period, has vanished. The small grain is easy to take, and I continue to use one daily.
Read More
0
Acne worsened initially
Acid and not folate acid did not appeal to me from the outset. The very next day after starting, I experienced an outburst of acne that made it difficult to leave the house. Each day, the acne worsened, spreading beyond my face. I ceased taking it, and within one to two weeks, all the breakouts vanished.
Read More
5
B12 caused acne
The quality is great; however, the high level of B12 caused acne for me.
1
Acne post-medication
Prescribed by the doctor. Acne appeared after taking these pills, and I cannot recommend them.
8.8
Fewer breakouts observed
Folic acid was recommended to me by a doctor due to my complaints about the periodic appearance of acne during artificial menopause. Since starting it, my breakouts have lessened!
