Last update
5/2/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6
USERS' SCORE
Good
Based on 5 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
7
Folic acid alleviates gastric hypersensitivity
We investigated how folic acid (FA) impacts gastric hypersensitivity caused by prenatal stress. Through a series of experiments involving nerve recordings and molecular analysis, we found that FA significantly alleviated symptoms related to gastric hypersensitivity.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
Read More
4
Methyl donors may increase allergy risk
We examined how late-gestation maternal supplementation with methyl donors impacts allergic sensitivity in offspring from pregnancies with restricted growth (IUGR).
Our study compared allergic responses in three groups of sheep: those from normal pregnancies, those from PR pregnancies without supplementation, and those whose mothers received the supplementation.
Interestingly, while the IUGR pregnancies showed protection against allergies, the methyl donor supplementation did not change this advantage. In fact, it resulted in more upper dermal mast cells but did not alter overall allergic reactions or birth size.
These findings indicate that while IUGR may limit allergy risk, adding methyl donors might potentially increase it instead.
Our study compared allergic responses in three groups of sheep: those from normal pregnancies, those from PR pregnancies without supplementation, and those whose mothers received the supplementation.
Interestingly, while the IUGR pregnancies showed protection against allergies, the methyl donor supplementation did not change this advantage. In fact, it resulted in more upper dermal mast cells but did not alter overall allergic reactions or birth size.
These findings indicate that while IUGR may limit allergy risk, adding methyl donors might potentially increase it instead.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
Most Useful Reviews
10
No issues noted
Excellent! I have no allergies!
Read More
10
Positive energy boost
Perfectly! I took this alongside B12 and am pleased that there was no allergy, unlike with vitamins from another manufacturer. I felt an increase in energy and my mind became somewhat clearer!
Read More
10
No adverse effects
I bought this for my sister. The outcomes weren't verified by analysis, but there were no allergies or side effects observed.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6
- All Researches
7
Folic acid alleviates gastric hypersensitivity
We investigated how folic acid (FA) impacts gastric hypersensitivity caused by prenatal stress. Through a series of experiments involving nerve recordings and molecular analysis, we found that FA significantly alleviated symptoms related to gastric hypersensitivity.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
4
Methyl donors may increase allergy risk
We examined how late-gestation maternal supplementation with methyl donors impacts allergic sensitivity in offspring from pregnancies with restricted growth (IUGR).
Our study compared allergic responses in three groups of sheep: those from normal pregnancies, those from PR pregnancies without supplementation, and those whose mothers received the supplementation.
Interestingly, while the IUGR pregnancies showed protection against allergies, the methyl donor supplementation did not change this advantage. In fact, it resulted in more upper dermal mast cells but did not alter overall allergic reactions or birth size.
These findings indicate that while IUGR may limit allergy risk, adding methyl donors might potentially increase it instead.
Our study compared allergic responses in three groups of sheep: those from normal pregnancies, those from PR pregnancies without supplementation, and those whose mothers received the supplementation.
Interestingly, while the IUGR pregnancies showed protection against allergies, the methyl donor supplementation did not change this advantage. In fact, it resulted in more upper dermal mast cells but did not alter overall allergic reactions or birth size.
These findings indicate that while IUGR may limit allergy risk, adding methyl donors might potentially increase it instead.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
No issues noted
Excellent! I have no allergies!
Read More
10
Positive energy boost
Perfectly! I took this alongside B12 and am pleased that there was no allergy, unlike with vitamins from another manufacturer. I felt an increase in energy and my mind became somewhat clearer!
Read More
10
No adverse effects
I bought this for my sister. The outcomes weren't verified by analysis, but there were no allergies or side effects observed.
Read More
10
No side effects
Good item! The pills are small and easy to swallow. She experienced no side effects or allergies.
Read More
6
No allergic reactions
1 people found this helpful
I had an allergy to the Solgar folic acid, so I stopped taking it. However, since I am planning to conceive soon, I decided to purchase this brand. So far, I haven’t experienced any itching or rashes. Let’s see what happens in a month.
Read More
Frequently Asked Questions
10
No issues noted
Excellent! I have no allergies!
10
No adverse effects
I bought this for my sister. The outcomes weren't verified by analysis, but there were no allergies or side effects observed.
6
No allergic reactions
1 people found this helpful
I had an allergy to the Solgar folic acid, so I stopped taking it. However, since I am planning to conceive soon, I decided to purchase this brand. So far, I haven’t experienced any itching or rashes. Let’s see what happens in a month.
10
Positive energy boost
Perfectly! I took this alongside B12 and am pleased that there was no allergy, unlike with vitamins from another manufacturer. I felt an increase in energy and my mind became somewhat clearer!
10
No side effects
Good item! The pills are small and easy to swallow. She experienced no side effects or allergies.
References
- Wang HJ, Zhang FC, Xu TW, Xu YC, Tian YQ, et al. DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress. CNS Neurosci Ther. 2023;29:1678. 10.1111/cns.14131
- Wooldridge AL, Bischof RJ, Liu H, Heinemann GK, Hunter DS, et al. Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. Am J Physiol Regul Integr Comp Physiol. 2018;314:R22. 10.1152/ajpregu.00549.2016
- El Rhermoul FZ, Mustafa A, Wagner A, Nakonechna A, Kayode OS, et al. Vitamin B Hypersensitivity: A Retrospective Multicenter Study. J Allergy Clin Immunol Pract. 2024;12:699. 10.1016/j.jaip.2023.10.037
