Overview
SCIENTIFIC SCORE
Questionable
Based on 19 Researches
6.7
USERS' SCORE
Good
Based on 3 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Read More
9
We focused on the potential of folic acid supplementation as a way to influence cognitive impairment, especially in Alzheimer's disease (AD) patients. By reviewing multiple randomized controlled trials, we aimed to clarify the effectiveness of folic acid in improving cognitive function for those facing various levels of cognitive decline.
Our analysis revealed that folic acid supplementation may offer benefits for individuals with Mild Cognitive Impairment (MCI), suggesting even modest doses could have a positive impact. Notably, we found that doses of three milligrams or more of folic acid were particularly effective in enhancing cognitive abilities among Alzheimer's patients.
This evidence makes folic acid a promising candidate for helping delay cognitive decline in adults. While more extensive studies may be required, the results provide encouragement for using nutritional strategies as part of a comprehensive approach to managing cognitive impairment.
Our analysis revealed that folic acid supplementation may offer benefits for individuals with Mild Cognitive Impairment (MCI), suggesting even modest doses could have a positive impact. Notably, we found that doses of three milligrams or more of folic acid were particularly effective in enhancing cognitive abilities among Alzheimer's patients.
This evidence makes folic acid a promising candidate for helping delay cognitive decline in adults. While more extensive studies may be required, the results provide encouragement for using nutritional strategies as part of a comprehensive approach to managing cognitive impairment.
Read More
8
We explored the potential benefits of folic acid supplementation in reducing the risk of Alzheimer's disease (AD) through a Mendelian randomization analysis. By analyzing genetic data from recent studies, we assessed the causal relationship between folate intake and AD.
Our findings revealed an encouraging association: both fixed-effect and random-effect models indicated that folic acid supplementation could lead to a reduced risk of developing Alzheimer's, with odds ratios suggesting a significant decrease in risk. This was based on the data from seven specific genetic markers.
However, we also conducted a reverse analysis which showed no causal link between AD and folic acid supplementation. While our results hint at a protective effect of folic acid against Alzheimer's, further research is needed to confirm these findings and determine the underlying mechanisms involved.
Overall, this study sheds light on the potential of folic acid as a preventive strategy for Alzheimer's disease and contributes valuable insights into its etiology.
Our findings revealed an encouraging association: both fixed-effect and random-effect models indicated that folic acid supplementation could lead to a reduced risk of developing Alzheimer's, with odds ratios suggesting a significant decrease in risk. This was based on the data from seven specific genetic markers.
However, we also conducted a reverse analysis which showed no causal link between AD and folic acid supplementation. While our results hint at a protective effect of folic acid against Alzheimer's, further research is needed to confirm these findings and determine the underlying mechanisms involved.
Overall, this study sheds light on the potential of folic acid as a preventive strategy for Alzheimer's disease and contributes valuable insights into its etiology.
Read More
Most Useful Reviews
6
Mixed results
2 people found this helpful
Good for Alzheimer; I've been giving it to my mum for years. It doesn't halt the progression, but after being ill for 8 years, she still recognises us. She also takes melatonin, alpha-lipoic acid, coconut oil, and B12.
Read More
7.5
Menopause relief
After forty, women require folic acid to alleviate menopause symptoms. A sufficient intake will help preserve memory long-term and reduce the risk of Alzheimer's disease.
Read More
7.5
Cognitive impairment reduction
Folic acid restores immunity, supports heart and blood vessel function, and is crucial for blood cell formation when iron is deficient. It plays a role in nucleic and amino acid synthesis. Adequate folic acid can lower the risk of Alzheimer's disease, dementia, and other cognitive impairments. Additionally, it helps control blood sugar levels and reduces the side effects of certain medications.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 19 Researches
6.7
- All Researches
9
Folate shows potential in Alzheimer's
We dove into a fascinating study that looked at the relationship between homocysteine, a compound linked to Alzheimer's disease, and treatments like folic acid (FA) and S-adenosylmethionine (SAM). By evaluating both living rat models and isolated hippocampal neurons, we observed how elevated levels of homocysteine can lead to Alzheimer’s-like changes in the brain.
Specifically, the study found that high homocysteine levels increased the expression of presenilin 1 (PS1), which is often implicated in the pathology of Alzheimer's, while also decreasing the activity of an important protein phosphatase known as PP2A. The researchers then tested whether FA and SAM could mitigate these harmful effects.
Encouragingly, both FA and SAM showed promise in reducing the neurodegeneration caused by high homocysteine, primarily by adjusting the methylation levels of PS1 and PP2A. This suggests that these treatments may help counteract some of the brain changes associated with Alzheimer's, presenting a potential pathway for further exploration in preventive or therapeutic strategies.
Specifically, the study found that high homocysteine levels increased the expression of presenilin 1 (PS1), which is often implicated in the pathology of Alzheimer's, while also decreasing the activity of an important protein phosphatase known as PP2A. The researchers then tested whether FA and SAM could mitigate these harmful effects.
Encouragingly, both FA and SAM showed promise in reducing the neurodegeneration caused by high homocysteine, primarily by adjusting the methylation levels of PS1 and PP2A. This suggests that these treatments may help counteract some of the brain changes associated with Alzheimer's, presenting a potential pathway for further exploration in preventive or therapeutic strategies.
Read More
9
We focused on the potential of folic acid supplementation as a way to influence cognitive impairment, especially in Alzheimer's disease (AD) patients. By reviewing multiple randomized controlled trials, we aimed to clarify the effectiveness of folic acid in improving cognitive function for those facing various levels of cognitive decline.
Our analysis revealed that folic acid supplementation may offer benefits for individuals with Mild Cognitive Impairment (MCI), suggesting even modest doses could have a positive impact. Notably, we found that doses of three milligrams or more of folic acid were particularly effective in enhancing cognitive abilities among Alzheimer's patients.
This evidence makes folic acid a promising candidate for helping delay cognitive decline in adults. While more extensive studies may be required, the results provide encouragement for using nutritional strategies as part of a comprehensive approach to managing cognitive impairment.
Our analysis revealed that folic acid supplementation may offer benefits for individuals with Mild Cognitive Impairment (MCI), suggesting even modest doses could have a positive impact. Notably, we found that doses of three milligrams or more of folic acid were particularly effective in enhancing cognitive abilities among Alzheimer's patients.
This evidence makes folic acid a promising candidate for helping delay cognitive decline in adults. While more extensive studies may be required, the results provide encouragement for using nutritional strategies as part of a comprehensive approach to managing cognitive impairment.
Read More
8
We examined the relationship between folate and Alzheimer's disease (AD) through a comprehensive analysis combining data from various studies. Our findings indicate that folate may provide protective effects against Alzheimer's, which is promising for those concerned about this challenging condition.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Specifically, we noted that individuals with higher folate levels could experience a decreased risk of developing Alzheimer's. This suggests that ensuring adequate folate intake could be beneficial for brain health.
However, it’s essential to understand that the impact of folate isn't a cure-all. While the association with Alzheimer's is favorable, more research is needed to clarify how folate levels might influence the progression or onset of this complex disorder.
Overall, our analysis underscores the potential of folate as part of a broader strategy for supporting cognitive health as we age.
Read More
8
We explored the potential benefits of enhancing mitochondrial one-carbon metabolism, specifically through folate, to address Alzheimer's disease (AD). The study utilized a fly model where researchers overexpressed a toxic protein associated with AD, known as amyloid β (Aβ).
In our findings, we observed that increasing one-carbon metabolism through a genetic alteration significantly improved mitochondrial function and had neuroprotective effects in these AD models. Notably, we also tested exogenous folate in the form of folinic acid, which showed promise in improving mitochondrial health in both cells and fly models linked to AD.
Furthermore, we discovered a connection between genetic variations in the human equivalent of the fly gene and the risk of AD. Additionally, findings indicated that a higher intake of folate may reduce the risk of developing Alzheimer’s. Overall, our research suggests that enhancing folate-dependent metabolism could serve as a promising strategy in combating the progression of Alzheimer's disease.
In our findings, we observed that increasing one-carbon metabolism through a genetic alteration significantly improved mitochondrial function and had neuroprotective effects in these AD models. Notably, we also tested exogenous folate in the form of folinic acid, which showed promise in improving mitochondrial health in both cells and fly models linked to AD.
Furthermore, we discovered a connection between genetic variations in the human equivalent of the fly gene and the risk of AD. Additionally, findings indicated that a higher intake of folate may reduce the risk of developing Alzheimer’s. Overall, our research suggests that enhancing folate-dependent metabolism could serve as a promising strategy in combating the progression of Alzheimer's disease.
Read More
8
We examined the connection between dietary folate and the risk of developing Alzheimer disease. In a large-scale study with over 192,000 participants, we analyzed data gathered from dietary questionnaires and tracked cases of Alzheimer disease over a median follow-up of 13.35 years.
Our findings highlighted that higher folate intake, along with other 1-carbon metabolism nutrients, is associated with a reduced risk of Alzheimer disease. Specifically, participants who consumed a high amount of folate had their risk of developing Alzheimer disease lowered significantly. The results indicated that for those with lower genetic risk, high folate intake could further decrease their risk of Alzheimer disease by more than 75%.
Although we saw promising associations, it’s important to note that while folate showed a positive correlation with reduced Alzheimer disease risk, we cannot isolate its effects completely from other nutrients. Overall, our research underscores the potential benefits of incorporating folate-rich foods into the diet to combat Alzheimer disease, particularly for individuals at higher genetic risk.
Our findings highlighted that higher folate intake, along with other 1-carbon metabolism nutrients, is associated with a reduced risk of Alzheimer disease. Specifically, participants who consumed a high amount of folate had their risk of developing Alzheimer disease lowered significantly. The results indicated that for those with lower genetic risk, high folate intake could further decrease their risk of Alzheimer disease by more than 75%.
Although we saw promising associations, it’s important to note that while folate showed a positive correlation with reduced Alzheimer disease risk, we cannot isolate its effects completely from other nutrients. Overall, our research underscores the potential benefits of incorporating folate-rich foods into the diet to combat Alzheimer disease, particularly for individuals at higher genetic risk.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
6
Mixed results
2 people found this helpful
Good for Alzheimer; I've been giving it to my mum for years. It doesn't halt the progression, but after being ill for 8 years, she still recognises us. She also takes melatonin, alpha-lipoic acid, coconut oil, and B12.
Read More
7.5
Menopause relief
After forty, women require folic acid to alleviate menopause symptoms. A sufficient intake will help preserve memory long-term and reduce the risk of Alzheimer's disease.
Read More
7.5
Cognitive impairment reduction
Folic acid restores immunity, supports heart and blood vessel function, and is crucial for blood cell formation when iron is deficient. It plays a role in nucleic and amino acid synthesis. Adequate folic acid can lower the risk of Alzheimer's disease, dementia, and other cognitive impairments. Additionally, it helps control blood sugar levels and reduces the side effects of certain medications.
Read More
Frequently Asked Questions
6
Mixed results
2 people found this helpful
Good for Alzheimer; I've been giving it to my mum for years. It doesn't halt the progression, but after being ill for 8 years, she still recognises us. She also takes melatonin, alpha-lipoic acid, coconut oil, and B12.
7.5
Menopause relief
After forty, women require folic acid to alleviate menopause symptoms. A sufficient intake will help preserve memory long-term and reduce the risk of Alzheimer's disease.
7.5
Cognitive impairment reduction
Folic acid restores immunity, supports heart and blood vessel function, and is crucial for blood cell formation when iron is deficient. It plays a role in nucleic and amino acid synthesis. Adequate folic acid can lower the risk of Alzheimer's disease, dementia, and other cognitive impairments. Additionally, it helps control blood sugar levels and reduces the side effects of certain medications.
References
- Ye M, Yang X, Yan J, Yao Y, Lv H, et al. Causal relationship between B vitamins and neuropsychiatric disorders: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2025;170:106068. doi:10.1016/j.neubiorev.2025.106068
- Irum I, Khan F, Sufyan M, Benish Ali SH, Rehman S. Developing multifaceted drug synergistic therapeutic strategy against neurological disorders. Comput Biol Med. 2025;185:109495. doi:10.1016/j.compbiomed.2024.109495
- Yu Y, Chen CZ, Celardo I, Tan BWZ, Hurcomb JD, et al. Enhancing mitochondrial one-carbon metabolism is neuroprotective in Alzheimer's disease models. Cell Death Dis. 2024;15:856. doi:10.1038/s41419-024-07179-3
- Liu W, Zheng D, Li X, Wang T, Wang L, et al. Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial. J Prev Alzheimers Dis. 2024;11:1626. doi:10.14283/jpad.2024.165
- Bai D, Fan J, Li M, Dong C, Gao Y, et al. Cognitive Function After Stopping Folic Acid and DHA Intervention: An Extended Follow-Up Results from the Randomized, Double Blind, Placebo-Controlled Trial in Older Adults with Mild Cognitive Impairment. J Alzheimers Dis Rep. 2024;8:1285. doi:10.3233/ADR-240033
- Wang Y, Mi N, Liao K, Li Y, Sun Y, et al. Associations among dietary 1-carbon metabolism nutrients, genetic risk, and Alzheimer disease: a prospective cohort study. Am J Clin Nutr. 2024;120:1009. doi:10.1016/j.ajcnut.2024.08.027
- Li T, Steibel JP, Willette AA. Vitamin B6, B12, and Folate's Influence on Neural Networks in the UK Biobank Cohort. Nutrients. 2024;16. doi:10.3390/nu16132050
- Wang M, Fang M, Zang W. Effects of folic acid supplementation on cognitive function and inflammation in elderly patients with mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials. Arch Gerontol Geriatr. 2024;126:105540. doi:10.1016/j.archger.2024.105540
- Sun S, Lu W, Zhang C, Wang G, Hou Y, et al. Folic acid and S-adenosylmethionine reverse Homocysteine-induced Alzheimer's disease-like pathological changes in rat hippocampus by modulating PS1 and PP2A methylation levels. Brain Res. 2024;1841:149095. doi:10.1016/j.brainres.2024.149095
- Tang Y, Zhou X, Cao J, Li Z, Yin W, et al. Synergistic effect of folate and MTHFR C677T on hippocampal subfields and perfusion in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2024;134:111071. doi:10.1016/j.pnpbp.2024.111071
- Lee CY, Chan L, Hu CJ, Hong CT, Chen JH. Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials. Aging (Albany NY). 2024;16:7856. doi:10.18632/aging.205788
- Xu M, Zhu Y, Chen J, Li J, Qin J, et al. Effects of folic acid supplementation on cognitive impairment: A meta-analysis of randomized controlled trials. J Evid Based Med. 2024;17:134. doi:10.1111/jebm.12588
- Sun X, He C, Yang S, Li W, Qu H. Mendelian randomization to evaluate the effect of folic acid supplement on the risk of Alzheimer disease. Medicine (Baltimore). 2024;103:e37021. doi:10.1097/MD.0000000000037021
- Ling Y, Yuan S, Huang X, Tan S, Cheng H, et al. Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants. J Gerontol A Biol Sci Med Sci. 2024;79. doi:10.1093/gerona/glad266
- Tu MC, Chung HW, Hsu YH, Yang JJ, Wu WC. Neurovascular Correlates of Cobalamin, Folate, and Homocysteine in Dementia. J Alzheimers Dis. 2023;96:1329. doi:10.3233/JAD-230763
- Ekundayo BE, Adewale OB, Obafemi BA, Ntwasa MM, Lebelo SL, et al. Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats. Cell Biochem Funct. 2024;42:e70028. doi:10.1002/cbf.70028
- Hooshmand B, Appold F, Fissler P, Perneczky R, Otto M, et al. Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance. Ann Neurol. 2023;94:223. doi:10.1002/ana.26673
- Wang L, Zhou C, Yu H, Hao L, Ju M, et al. Vitamin D, Folic Acid and Vitamin B Can Reverse Vitamin D Deficiency-Induced Learning and Memory Impairment by Altering 27-Hydroxycholesterol and S-Adenosylmethionine. Nutrients. 2022;15. doi:10.3390/nu15010132
- Song Y, Quan M, Li T, Jia J. Serum Homocysteine, Vitamin B12, Folate, and Their Association with Mild Cognitive Impairment and Subtypes of Dementia. J Alzheimers Dis. 2022;90:681. doi:10.3233/JAD-220410
