We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Read More
9
RBC folate's role in diabetic nephropathy
Association between RBC folate and diabetic nephropathy in Type2 diabetes mellitus patients: a cross-sectional study.
We explored the potential connection between red blood cell (RBC) folate levels and diabetic nephropathy (DN) in individuals with type 2 diabetes mellitus. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018, we carried out a cross-sectional analysis involving 3,070 adults diagnosed with type 2 diabetes.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Read More
9
Vitamin B12 improves eye movements
The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study.
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
Most Useful Reviews
9
Enhances alertness
5 people found this helpful
The best around! Having PCOS, Type 2 diabetes, and cholesterol, I often experience brain fog. However, this folic acid has kept me alert for over a year. It's easy to swallow with breakfast and has no aftertaste, making it a daily essential.
Read More
9
Prevents type 2 diabetes
Folic acid is vital for our body, helping prevent diabetes by enhancing triglyceride breakdown. It also safeguards against cardiovascular issues by managing homocysteine levels. It boosts immunity, supports heart health, digestion, and the nervous system.
Read More
9
Lowers blood glucose
Recommend for diabetics (Type II). After experimenting with various combinations, I found that taking 4-5 tablets daily effectively reduces post-meal blood glucose spikes after carbohydrate consumption.
We evaluated the impact of 5-methyltetrahydrofolate (5-MTHF) and an aqueous extract on diabetes by examining their effects in a rat model with induced diabetes. Our findings were based on a combination of in silico docking studies and in vitro assays, which indicated that folates bind effectively with proteins that regulate glucose metabolism.
In our tests, we observed that 5-MTHF demonstrated stronger inhibitory action on alpha-amylase than folic acid, indicating its potential for managing blood sugar levels. When we administered 5-MTHF and the aqueous extract to diabetic Wistar rats, both supplements contributed to significant reductions in fasting blood glucose and improvements in glucose tolerance.
Furthermore, alongside controlling blood sugar, we noted that supplementation helped reduce obesity, address hyperlipidemia, and enhance antioxidant enzyme levels. Remarkably, the higher dosage of 5-MTHF provided better results than the aqueous extract and higher doses of folic acid, suggesting its effectiveness as a treatment option. By incorporating the aqueous extract, we also found an increase in serum folate levels, indicating its role as a folate source enriched with other beneficial phytochemicals.
Overall, we highlighted the promising effects of both the aqueous extract and 5-MTHF, emphasizing their potential as dietary supplements for diabetes management and its associated complications.
Read More
9
RBC folate's role in diabetic nephropathy
Association between RBC folate and diabetic nephropathy in Type2 diabetes mellitus patients: a cross-sectional study.
We explored the potential connection between red blood cell (RBC) folate levels and diabetic nephropathy (DN) in individuals with type 2 diabetes mellitus. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018, we carried out a cross-sectional analysis involving 3,070 adults diagnosed with type 2 diabetes.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
Read More
9
Vitamin B12 improves eye movements
The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study.
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
8
Folate may improve diabetes control
Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses.
We examined the impact of folate, a water-soluble vitamin, on glycemic control and insulin resistance in individuals with type 2 diabetes. By systematically reviewing various studies, we uncovered that supplementing with folic acid could enhance insulin sensitivity.
Our analysis included a range of systematic reviews and meta-analyses focusing on the effects of different water-soluble vitamins, like B-1, B-3, biotin, B-9 (folate), and vitamin C. The findings highlighted that vitamin C also shows positive outcomes in managing blood sugar levels, but we observed that folic acid stood out in its ability to combat insulin resistance effectively.
Overall, while folic acid supplementation appears promising, we emphasized the need for further high-quality randomized controlled trials. This will help solidify our understanding and ensure that we can rely on folate as an effective treatment option for diabetes management.
Read More
8
Cognitive health through folate
Synergistically effects of n-3 PUFA and B vitamins prevent diabetic cognitive dysfunction through promoting TET2-mediated active DNA demethylation.
We investigated the potential benefits of folate treatment in connection with diabetes, particularly focusing on how it can influence cognitive function. Our research involved comparing the fatty acid levels and homocysteine levels in diabetic individuals both with and without cognitive dysfunction.
We found that low levels of n-3 polyunsaturated fatty acids (PUFAs), alongside high serum homocysteine, significantly raised the risk of cognitive impairment in those with diabetes. Treating mice with a mix of fish oil, folate, and vitamin B led to notable improvements in their cognitive function and brain structure.
Folic acid, along with vitamin B, aids in transporting beneficial compounds like docosahexaenoic acid (DHA) to the brain. This transport is particularly crucial as it helps lower harmful homocysteine levels, protecting the brain from neuronal damage. Moreover, these vitamins contribute to maintaining healthy DNA functioning in diabetic brains by enhancing active DNA demethylation processes.
Overall, our study highlights the promising role that combining fish oil, folate, and B vitamins can play in preventing cognitive decline associated with diabetes. It's a significant step in understanding how these nutrients can work together to support brain health in those affected by diabetes.
The best around! Having PCOS, Type 2 diabetes, and cholesterol, I often experience brain fog. However, this folic acid has kept me alert for over a year. It's easy to swallow with breakfast and has no aftertaste, making it a daily essential.
Read More
9
Prevents type 2 diabetes
Folic acid is vital for our body, helping prevent diabetes by enhancing triglyceride breakdown. It also safeguards against cardiovascular issues by managing homocysteine levels. It boosts immunity, supports heart health, digestion, and the nervous system.
Read More
9
Lowers blood glucose
Recommend for diabetics (Type II). After experimenting with various combinations, I found that taking 4-5 tablets daily effectively reduces post-meal blood glucose spikes after carbohydrate consumption.
Read More
7.5
Prevents neuropathy
Excellent folic acid at an affordable price. I utilise it as part of a regimen to prevent neuropathy related to diabetes, helping maintain my health effectively.
Read More
7.5
Improves energy levels
I recommend this drug! I love this company's products—excellent quality and pleasant packaging. Folic acid helps maintain memory, reduces Alzheimer's risk, improves sleep, lowers blood pressure, and decreases diabetes risk. My energy and metabolism have significantly improved.
Diabetes is a chronic medical condition that occurs when the body either does not produce enough insulin or cannot effectively use the insulin it produces. Insulin is a hormone made by the pancreas that helps glucose from food enter the cells, providing them with energy. When diabetes is present, it leads to elevated levels of glucose in the blood, which can cause serious health complications if left unmanaged. There are primarily two types: Type 1 diabetes, which is an autoimmune condition where the body attacks insulin-producing cells, and Type 2 diabetes, which is often associated with lifestyle factors such as obesity and lack of physical activity, leading to insulin resistance.
Managing diabetes typically involves a combination of lifestyle changes, such as a balanced diet and regular exercise, along with monitoring blood sugar levels and, in many cases, medication or insulin therapy. Education is crucial for those with diabetes to understand how their condition works and how to manage it effectively. The goal of diabetes management is to keep blood sugar levels within a target range, helping to prevent complications such as heart disease, nerve damage, and kidney failure. Regular check-ups and consultations with healthcare professionals are essential to ensure optimal care.
Folic acid, also known as vitamin B9, is a water-soluble vitamin that plays a crucial role in many bodily functions, particularly in the synthesis of DNA and RNA. It is essential for cell division and is especially important during periods of rapid growth, such as during pregnancy and infancy. The body cannot produce folic acid on its own, which is why it must be obtained from dietary sources or supplements. Commonly found in leafy green vegetables, legumes, seeds, and fortified foods, folic acid is vital for preventing neural tube defects in developing fetuses and is often recommended for women of childbearing age.
In addition to its key role in pregnancy, folic acid contributes to the production of red blood cells and can help reduce the risk of certain types of anemia. Research has also suggested that adequate folic acid levels may be associated with lowered risk of heart disease and other health issues. Most health organizations recommend a daily intake of 400 micrograms for adults, with higher amounts suggested for pregnant women. Incorporating folate-rich foods into your diet, or considering supplementation, can help ensure you meet your folic acid needs.
Folic acid, a B-vitamin essential for various bodily functions, including DNA synthesis and repair, has been the subject of research regarding its potential benefits for individuals with diabetes. Some studies suggest that folic acid supplementation could help improve insulin sensitivity and overall blood sugar control, particularly in people with certain underlying conditions, such as metabolic syndrome. However, the evidence is not definitive, and the effects of folic acid on diabetes management can vary based on individual health factors.
It’s crucial to note that while adequate folate levels are important for overall health, it's not a replacement for standard diabetes treatments. Integrating folic acid into a balanced diet may provide some benefits, but it should be considered a complementary measure rather than a primary intervention. As with any supplement, it's advisable for individuals with diabetes to consult healthcare professionals before starting folic acid supplementation, particularly to tailor it to their specific health needs.
Based on user reviews, the time it takes to see results from taking this supplement for diabetes can vary. Users report benefits such as reduced post-meal blood glucose spikes after carbohydrate consumption with doses of 4-5 tablets daily, though specific timelines for this effect are not mentioned (Read Review). Some users have taken it consistently for over a year and noted improvements in alertness and health, suggesting that ongoing use is key to seeing sustained results (Read Review).
Overall, it appears that while some users may notice immediate changes in their energy or mood, the more significant benefits related to diabetes management might take consistent use over weeks or months. It's important to integrate the supplement into a broader health regimen and consult with a healthcare provider for personalized guidance on timing and dosage.
Folic acid supplementation has shown promising potential in the management of diabetes, particularly concerning insulin resistance and glycemic control. A systematic review of various studies indicated that folic acid could enhance insulin sensitivity in individuals with type 2 diabetes, suggesting its role as a supportive treatment option. However, the review also pointed out the necessity for further high-quality randomized controlled trials to validate these findings and solidify folate's efficacy as a viable treatment for diabetes management [1].
In addition to glycemic control, folate has exhibited potential benefits in the context of diabetic-related complications. For instance, research indicated a relationship between folate metabolites and diabetic kidney disease, where higher folate levels were associated with a lower risk of this complication [4]. Conversely, another study revealed that certain forms of folate could be linked to an increased risk of kidney issues in diabetes, emphasizing that not all folate forms are supportive in diabetes management [5]. These findings highlight the importance of tailoring folate intake to maximize benefits while minimizing risks for individuals with diabetes.
Users report a range of improvements in their symptoms after incorporating folic acid into their daily regimen, particularly related to diabetes management and overall well-being. Many individuals with diabetes have noted reductions in post-meal blood glucose spikes, especially when taking 4-5 tablets daily as part of their routine (Read Review). Additionally, users with conditions like PCOS and Type 2 diabetes have experienced enhanced alertness and cognitive clarity, indicating that consistent use may contribute to better mental focus over time (Read Review).
Beyond diabetes, several reviews highlight benefits such as improved sleep quality, reduced risk of Alzheimer’s, and stabilization of blood pressure, all of which underline the multifaceted health advantages of folic acid. Users emphasize its role in maintaining overall health and well-being, suggesting that while individual results can vary, a consistent intake could lead to noticeable improvements in various aspects of health, particularly for those over 40 or managing chronic conditions (Read Review).
Users report that combining folic acid with other supplements can enhance its effectiveness in managing diabetes and supporting overall health. Many individuals, specifically those with Type 2 diabetes, have discovered that taking 4-5 tablets of folic acid daily significantly reduces post-meal blood glucose spikes when incorporated into their daily routine (Read Review). One user mentioned having successfully experimented with various combinations, finding that this dosage worked well in controlling their blood sugar levels after carbohydrate consumption.
Additionally, users appreciate the broader health benefits of folic acid, such as its ability to prevent neuropathy related to diabetes and improve memory and overall well-being. Some reviews highlight that it plays a vital role in cardiovascular health and supports various bodily functions. For individuals over 40, integrating folic acid into a regimen with other supplements may further enhance memory, stabilize blood pressure, and contribute to preventing complications associated with diabetes (Read ReviewRead ReviewRead Review).
Users report a range of experiences regarding the appropriate dosage of folic acid for managing diabetes. One reviewer suggests that after testing various combinations, taking 4-5 tablets daily significantly reduced post-meal blood glucose spikes, particularly after consuming carbohydrates Read Review. This anecdotal evidence hints at a higher dosage being effective for some individuals, especially those managing Type II diabetes.
Additionally, several users emphasize the broader health benefits of folic acid, including its role in stabilizing blood pressure and its potential in reducing the risk of diabetes Read Review. While specific dosages weren't consistently stated across reviews, it appears that some users advocate for higher intake levels, particularly when combined with overall health regimens aimed at managing diabetes effectively. However, the optimal dose may vary based on individual health conditions and should ideally be discussed with a healthcare professional.
9
Lowers blood glucose
Recommend for diabetics (Type II). After experimenting with various combinations, I found that taking 4-5 tablets daily effectively reduces post-meal blood glucose spikes after carbohydrate consumption.
9
Enhances alertness
5 people found this helpful
The best around! Having PCOS, Type 2 diabetes, and cholesterol, I often experience brain fog. However, this folic acid has kept me alert for over a year. It's easy to swallow with breakfast and has no aftertaste, making it a daily essential.
6
Supports diabetes prevention
Folic acid reduces the risk of diabetes and preserves the health of skin and hair. After 40, it helps maintain memory and lowers the risk of Alzheimer's, improves sleep, and stabilises blood pressure. A sufficient amount is essential for overall well-being.
7.5
Prevents neuropathy
Excellent folic acid at an affordable price. I utilise it as part of a regimen to prevent neuropathy related to diabetes, helping maintain my health effectively.
7.5
Improves energy levels
I recommend this drug! I love this company's products—excellent quality and pleasant packaging. Folic acid helps maintain memory, reduces Alzheimer's risk, improves sleep, lowers blood pressure, and decreases diabetes risk. My energy and metabolism have significantly improved.
7.5
Aids memory preservation
After 40, a sufficient amount of folic acid aids memory and reduces Alzheimer's risk, improves sleep, stabilises blood pressure, decreases diabetes risk, and maintains skin and hair health. One of my preferred brands!
8
Folate may improve diabetes control
Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses.
We examined the impact of folate, a water-soluble vitamin, on glycemic control and insulin resistance in individuals with type 2 diabetes. By systematically reviewing various studies, we uncovered that supplementing with folic acid could enhance insulin sensitivity.
Our analysis included a range of systematic reviews and meta-analyses focusing on the effects of different water-soluble vitamins, like B-1, B-3, biotin, B-9 (folate), and vitamin C. The findings highlighted that vitamin C also shows positive outcomes in managing blood sugar levels, but we observed that folic acid stood out in its ability to combat insulin resistance effectively.
Overall, while folic acid supplementation appears promising, we emphasized the need for further high-quality randomized controlled trials. This will help solidify our understanding and ensure that we can rely on folate as an effective treatment option for diabetes management.
7
Folate's Role in Diabetes Management
The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011-2020 cycles of the NHANES.
We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
9
RBC folate's role in diabetic nephropathy
Association between RBC folate and diabetic nephropathy in Type2 diabetes mellitus patients: a cross-sectional study.
We explored the potential connection between red blood cell (RBC) folate levels and diabetic nephropathy (DN) in individuals with type 2 diabetes mellitus. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018, we carried out a cross-sectional analysis involving 3,070 adults diagnosed with type 2 diabetes.
Our findings reveal a noteworthy positive relationship between RBC folate levels and the risk of developing diabetic nephropathy. Specifically, even after adjusting for various influencing factors, our analysis indicated that higher levels of RBC folate were linked to an increased risk of DN, with a significant odds ratio of 1.38. This suggests that as RBC folate levels rise, so does the likelihood of experiencing complications related to kidney function in diabetes.
Furthermore, our subgroup analysis supported these findings, showing consistent patterns across different groups. The curve fitting we conducted also pointed to a linear relationship between RBC folate and diabetic nephropathy, indicating that higher folate concentrations in the blood are indeed associated with heightened risk.
Overall, our study suggests that RBC folate might serve as an important indicator of folate status and its implications for kidney health in those with type 2 diabetes. As we delve deeper into the implications of these findings, it becomes clear that folate levels deserve consideration in the broader context of diabetes management.
References
Chai Y, Chen C, Yin X, Wang X, Yu W, et al. Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses. Asia Pac J Clin Nutr. 2025;34:118. doi:10.6133/apjcn.202502_34(1).0012
Chen L, Liu R, He X, Fang J, Zhou L, et al. Synergistically effects of n-3 PUFA and B vitamins prevent diabetic cognitive dysfunction through promoting TET2-mediated active DNA demethylation. Clin Nutr. 2025;45:111. doi:10.1016/j.clnu.2025.01.002
Pathikkal A, Bhaskar TK, Prasanthan A, Haritha PK, Puthusseri B, et al. 5-Methyltetrahydrofolate and aqueous extract of () ameliorate diabetes and associated complications in STZ-induced diabetic rats. 3 Biotech. 2025;15:15. doi:10.1007/s13205-024-04170-9
Liang Y, Ding L, Tao M, Zhu Y. The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011-2020 cycles of the NHANES. Ren Fail. 2024;46:2420830. doi:10.1080/0886022X.2024.2420830
Yu P, Ji Y, Wang H, Liu K. Association between RBC folate and diabetic nephropathy in Type2 diabetes mellitus patients: a cross-sectional study. Sci Rep. 2024;14:24692. doi:10.1038/s41598-024-76456-0
N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. doi:10.7759/cureus.75656
Abu-Zahab ZA, Qureshi H, Adham GM, Elzefzafy WM, Zalam SS, et al. Frequency of comorbid diseases with high serum Vitamin B12 levels in patients attending King Salman Medical City (KSAMC), at Madinah. Int J Health Sci (Qassim). 2025;19:15.
Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. doi:10.1111/1753-0407.70045
Asghar S, Tanvir H, Riaz A, Ejaz MH, Akram M, et al. Prevalence of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus on Metformin Therapy: A Cross-Sectional Study. Cureus. 2024;16:e72184. doi:10.7759/cureus.72184