Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
We explored how low levels of folic acid (FA) and Vitamin B12 (VB12) relate to high blood pressure (BP) in children and adolescents. Conducting both nested case-control and cohort studies, we focused on primary school participants. In our research, we found that children with elevated BP exhibited lower levels of FA and VB12 compared to those with normal BP.
Interestingly, overweight or obese children with high BP had even lower levels of FA than their counterparts with healthy BP. We also noticed a correlation between FA and healthy lipid profiles, suggesting that adequate FA could help in regulating blood pressure. After adjusting for VB12 levels and homocysteine, FA alone showed a significant relationship with elevated BP.
In the cohort study, we observed that participants with high FA levels consistently had lower systolic and diastolic BP levels compared to those with low FA levels. Our findings indicate that maintaining adequate levels of folic acid and vitamin B12 during childhood is crucial, not only through diet but also possibly via supplementation, to help prevent hypertension in the future.
Interestingly, overweight or obese children with high BP had even lower levels of FA than their counterparts with healthy BP. We also noticed a correlation between FA and healthy lipid profiles, suggesting that adequate FA could help in regulating blood pressure. After adjusting for VB12 levels and homocysteine, FA alone showed a significant relationship with elevated BP.
In the cohort study, we observed that participants with high FA levels consistently had lower systolic and diastolic BP levels compared to those with low FA levels. Our findings indicate that maintaining adequate levels of folic acid and vitamin B12 during childhood is crucial, not only through diet but also possibly via supplementation, to help prevent hypertension in the future.
Read More
8
We investigated the relationship between folate deficiency and the risk of developing hypertension using data from a large UK Biobank study. This research included over 219,000 participants who were initially free of hypertension and allowed us to track who developed this condition over about 13 years.
Our analysis uncovered that individuals with folate deficiency had a significantly higher risk of hypertension, with a hazard ratio of 1.42. This means that they were 42% more likely to develop hypertension compared to those with adequate folate levels.
Moreover, we utilized advanced genetic approaches to examine these associations more closely. Both one-sample and two-sample Mendelian randomization analyses supported the idea that folate deficiency is not just correlated with hypertension but might actually play a causal role in increasing hypertension risk. Higher serum folate levels appeared to have a protective effect on blood pressure.
However, it’s important to note that while we found an association with folate deficiency and hypertension, this study did not specifically evaluate the effects of folate treatment itself on lowering blood pressure or preventing hypertension. Thus, while we have strong evidence linking folate deficiency to higher hypertension risk, the direct impact of folate supplementation remains to be explored further.
Our analysis uncovered that individuals with folate deficiency had a significantly higher risk of hypertension, with a hazard ratio of 1.42. This means that they were 42% more likely to develop hypertension compared to those with adequate folate levels.
Moreover, we utilized advanced genetic approaches to examine these associations more closely. Both one-sample and two-sample Mendelian randomization analyses supported the idea that folate deficiency is not just correlated with hypertension but might actually play a causal role in increasing hypertension risk. Higher serum folate levels appeared to have a protective effect on blood pressure.
However, it’s important to note that while we found an association with folate deficiency and hypertension, this study did not specifically evaluate the effects of folate treatment itself on lowering blood pressure or preventing hypertension. Thus, while we have strong evidence linking folate deficiency to higher hypertension risk, the direct impact of folate supplementation remains to be explored further.
Read More
7
Our study looked closely at how folate could influence hypertension among a rural population in Punjab, India. We examined 2,300 individuals aged 30 to 75, identifying 450 individuals with hypertension and matched them with 450 normotensive ones for a detailed analysis of their blood chemistry and global DNA methylation levels.
We found that those with hypertension had significantly lower levels of global DNA methylation compared to their normotensive counterparts. Interestingly, the individuals in the lowest quartile of global DNA methylation faced a notably higher risk for hypertension. This highlights a potential link between lower DNA methylation levels and increased blood pressure.
When we looked at those on medication, we noticed that hypertensive individuals with well-managed blood pressure exhibited higher global DNA methylation levels compared to those whose hypertension remained uncontrolled. Additionally, folate seemed to play a role here, suggesting that maintaining sufficient folate levels could help improve DNA methylation among hypertensives on medication.
Ultimately, our findings suggest that global DNA hypomethylation might be associated with hypertension, and ensuring adequate folate intake could be beneficial for managing blood pressure in individuals already on treatment.
We found that those with hypertension had significantly lower levels of global DNA methylation compared to their normotensive counterparts. Interestingly, the individuals in the lowest quartile of global DNA methylation faced a notably higher risk for hypertension. This highlights a potential link between lower DNA methylation levels and increased blood pressure.
When we looked at those on medication, we noticed that hypertensive individuals with well-managed blood pressure exhibited higher global DNA methylation levels compared to those whose hypertension remained uncontrolled. Additionally, folate seemed to play a role here, suggesting that maintaining sufficient folate levels could help improve DNA methylation among hypertensives on medication.
Ultimately, our findings suggest that global DNA hypomethylation might be associated with hypertension, and ensuring adequate folate intake could be beneficial for managing blood pressure in individuals already on treatment.
Read More
Most Useful Reviews
9
Lowers blood pressure
Folic acid, a synthetic form of folate, is crucial for the formation of new cells. Insufficient folic acid may heighten the risk of cardiovascular diseases, including hypertension. Research indicates that folic acid might assist in reducing high blood pressure by relaxing arterial walls, hence lowering pressure. The jar is also economically sized. I highly recommend this product.
Read More
9
Improved skin appearance
Folic acid is essential, particularly for women, as it contributes to beauty and youth. This acid contains various B vitamins, serving as a tonic for blood vessels, the heart, hair, skin, and nails. The tablets are small and last a long time. After taking them for about six months, I've noticed significant improvements in my skin, hair, and nails. Additionally, my hypertension has vanished, likely due to these little magic pills.
Read More
9
Easy to take
Recommended by my doctor for hypertension, these small tablets are very easy to swallow and work ideally!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.8
- All Researches
9
We explored how folic acid treatment affects patients with hypertension and coronary heart disease (CHD). In our comprehensive study, we looked at 540 CHD patients who were treated in various groups: those receiving folic acid, those not receiving it, and a control group that received standard treatment without folic acid.
We found that the levels of certain fat proteins—like triglycerides, total cholesterol, and low-density lipoprotein cholesterol—were lower in patients taking folic acid compared to those who weren’t. Additionally, the recurrence of cardiovascular events was significantly reduced in patients receiving folic acid, suggesting that it plays an important role in improving patient outcomes.
Interestingly, our findings indicate that those with the MTHFR C677T gene mutation may benefit particularly from folic acid supplementation with respect to their blood pressure levels and overall clinical prognosis. This shows the potential of folic acid as a valuable addition to hypertension treatment plans.
Overall, our study underscores the importance of considering genetics when managing hypertension and highlights how folic acid can enhance treatment effectiveness and patient care.
We found that the levels of certain fat proteins—like triglycerides, total cholesterol, and low-density lipoprotein cholesterol—were lower in patients taking folic acid compared to those who weren’t. Additionally, the recurrence of cardiovascular events was significantly reduced in patients receiving folic acid, suggesting that it plays an important role in improving patient outcomes.
Interestingly, our findings indicate that those with the MTHFR C677T gene mutation may benefit particularly from folic acid supplementation with respect to their blood pressure levels and overall clinical prognosis. This shows the potential of folic acid as a valuable addition to hypertension treatment plans.
Overall, our study underscores the importance of considering genetics when managing hypertension and highlights how folic acid can enhance treatment effectiveness and patient care.
Read More
8
We investigated the relationship between folate deficiency and the risk of developing hypertension using data from a large UK Biobank study. This research included over 219,000 participants who were initially free of hypertension and allowed us to track who developed this condition over about 13 years.
Our analysis uncovered that individuals with folate deficiency had a significantly higher risk of hypertension, with a hazard ratio of 1.42. This means that they were 42% more likely to develop hypertension compared to those with adequate folate levels.
Moreover, we utilized advanced genetic approaches to examine these associations more closely. Both one-sample and two-sample Mendelian randomization analyses supported the idea that folate deficiency is not just correlated with hypertension but might actually play a causal role in increasing hypertension risk. Higher serum folate levels appeared to have a protective effect on blood pressure.
However, it’s important to note that while we found an association with folate deficiency and hypertension, this study did not specifically evaluate the effects of folate treatment itself on lowering blood pressure or preventing hypertension. Thus, while we have strong evidence linking folate deficiency to higher hypertension risk, the direct impact of folate supplementation remains to be explored further.
Our analysis uncovered that individuals with folate deficiency had a significantly higher risk of hypertension, with a hazard ratio of 1.42. This means that they were 42% more likely to develop hypertension compared to those with adequate folate levels.
Moreover, we utilized advanced genetic approaches to examine these associations more closely. Both one-sample and two-sample Mendelian randomization analyses supported the idea that folate deficiency is not just correlated with hypertension but might actually play a causal role in increasing hypertension risk. Higher serum folate levels appeared to have a protective effect on blood pressure.
However, it’s important to note that while we found an association with folate deficiency and hypertension, this study did not specifically evaluate the effects of folate treatment itself on lowering blood pressure or preventing hypertension. Thus, while we have strong evidence linking folate deficiency to higher hypertension risk, the direct impact of folate supplementation remains to be explored further.
Read More
8
Folate and vitamin B12 reduce homocysteine
We investigated how genetic variations might influence both homocysteine levels and hypertension in a group of 1,304 Chinese adults. This study focused on the connections between common genetic polymorphisms and the impact of essential nutrients, particularly folate and vitamin B12.
Our findings indicated that having adequate amounts of folate and vitamin B12 in the diet significantly decreased serum homocysteine levels. Furthermore, these nutrients appeared to lessen the effects of certain genetic variations on homocysteine levels.
While the study did not isolate the specific effects of folate on hypertension alone, it highlighted that a combined approach using both folate and vitamin B12 can help manage cardiovascular risks linked with high homocysteine levels. Therefore, nutritional interventions could be vital in addressing hypertension in this population.
Our findings indicated that having adequate amounts of folate and vitamin B12 in the diet significantly decreased serum homocysteine levels. Furthermore, these nutrients appeared to lessen the effects of certain genetic variations on homocysteine levels.
While the study did not isolate the specific effects of folate on hypertension alone, it highlighted that a combined approach using both folate and vitamin B12 can help manage cardiovascular risks linked with high homocysteine levels. Therefore, nutritional interventions could be vital in addressing hypertension in this population.
Read More
8
We explored how low levels of folic acid (FA) and Vitamin B12 (VB12) relate to high blood pressure (BP) in children and adolescents. Conducting both nested case-control and cohort studies, we focused on primary school participants. In our research, we found that children with elevated BP exhibited lower levels of FA and VB12 compared to those with normal BP.
Interestingly, overweight or obese children with high BP had even lower levels of FA than their counterparts with healthy BP. We also noticed a correlation between FA and healthy lipid profiles, suggesting that adequate FA could help in regulating blood pressure. After adjusting for VB12 levels and homocysteine, FA alone showed a significant relationship with elevated BP.
In the cohort study, we observed that participants with high FA levels consistently had lower systolic and diastolic BP levels compared to those with low FA levels. Our findings indicate that maintaining adequate levels of folic acid and vitamin B12 during childhood is crucial, not only through diet but also possibly via supplementation, to help prevent hypertension in the future.
Interestingly, overweight or obese children with high BP had even lower levels of FA than their counterparts with healthy BP. We also noticed a correlation between FA and healthy lipid profiles, suggesting that adequate FA could help in regulating blood pressure. After adjusting for VB12 levels and homocysteine, FA alone showed a significant relationship with elevated BP.
In the cohort study, we observed that participants with high FA levels consistently had lower systolic and diastolic BP levels compared to those with low FA levels. Our findings indicate that maintaining adequate levels of folic acid and vitamin B12 during childhood is crucial, not only through diet but also possibly via supplementation, to help prevent hypertension in the future.
Read More
8
We explored the long-term associations between metal mixtures present during pregnancy and the development of hypertension in mid-life women, particularly focusing on the role of vitamin B12. Our findings come from a cohort of women enrolled in Project Viva, where we measured essential metals like copper, manganese, and vitamin B12 in red blood cells during pregnancy.
One interesting outcome showed that higher levels of vitamin B12 were linked to lower blood pressure. Specifically, a doubling of vitamin B12 levels corresponded with a reduction of about 3.64 mm Hg in systolic blood pressure and 2.52 mm Hg in diastolic pressure. This suggests that having adequate vitamin B12 during pregnancy might help mitigate the risk of developing hypertension later in life.
However, while our results were promising in terms of vitamin B12’s protective effect against high blood pressure, the study also indicated that there were no significant interactions between metal levels and other dietary nutrients. Hence, while we solidly observed that optimizing vitamin B12 could be beneficial, the relationship isn't solely dependent on it in conjunction with other factors.
One interesting outcome showed that higher levels of vitamin B12 were linked to lower blood pressure. Specifically, a doubling of vitamin B12 levels corresponded with a reduction of about 3.64 mm Hg in systolic blood pressure and 2.52 mm Hg in diastolic pressure. This suggests that having adequate vitamin B12 during pregnancy might help mitigate the risk of developing hypertension later in life.
However, while our results were promising in terms of vitamin B12’s protective effect against high blood pressure, the study also indicated that there were no significant interactions between metal levels and other dietary nutrients. Hence, while we solidly observed that optimizing vitamin B12 could be beneficial, the relationship isn't solely dependent on it in conjunction with other factors.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Lowers blood pressure
Folic acid, a synthetic form of folate, is crucial for the formation of new cells. Insufficient folic acid may heighten the risk of cardiovascular diseases, including hypertension. Research indicates that folic acid might assist in reducing high blood pressure by relaxing arterial walls, hence lowering pressure. The jar is also economically sized. I highly recommend this product.
Read More
9
Improved skin appearance
Folic acid is essential, particularly for women, as it contributes to beauty and youth. This acid contains various B vitamins, serving as a tonic for blood vessels, the heart, hair, skin, and nails. The tablets are small and last a long time. After taking them for about six months, I've noticed significant improvements in my skin, hair, and nails. Additionally, my hypertension has vanished, likely due to these little magic pills.
Read More
9
Easy to take
Recommended by my doctor for hypertension, these small tablets are very easy to swallow and work ideally!
Read More
6
Good therapeutic effect
Folic acid has a beneficial therapeutic effect on patients with high homocysteine levels in hypertension, and prolonged use can lead to improvements.
Read More
Frequently Asked Questions
9
Improved skin appearance
Folic acid is essential, particularly for women, as it contributes to beauty and youth. This acid contains various B vitamins, serving as a tonic for blood vessels, the heart, hair, skin, and nails. The tablets are small and last a long time. After taking them for about six months, I've noticed significant improvements in my skin, hair, and nails. Additionally, my hypertension has vanished, likely due to these little magic pills.
6
Good therapeutic effect
Folic acid has a beneficial therapeutic effect on patients with high homocysteine levels in hypertension, and prolonged use can lead to improvements.
9
Easy to take
Recommended by my doctor for hypertension, these small tablets are very easy to swallow and work ideally!
9
Lowers blood pressure
Folic acid, a synthetic form of folate, is crucial for the formation of new cells. Insufficient folic acid may heighten the risk of cardiovascular diseases, including hypertension. Research indicates that folic acid might assist in reducing high blood pressure by relaxing arterial walls, hence lowering pressure. The jar is also economically sized. I highly recommend this product.
8
We investigated the relationship between folate deficiency and the risk of developing hypertension using data from a large UK Biobank study. This research included over 219,000 participants who were initially free of hypertension and allowed us to track who developed this condition over about 13 years.
Our analysis uncovered that individuals with folate deficiency had a significantly higher risk of hypertension, with a hazard ratio of 1.42. This means that they were 42% more likely to develop hypertension compared to those with adequate folate levels.
Moreover, we utilized advanced genetic approaches to examine these associations more closely. Both one-sample and two-sample Mendelian randomization analyses supported the idea that folate deficiency is not just correlated with hypertension but might actually play a causal role in increasing hypertension risk. Higher serum folate levels appeared to have a protective effect on blood pressure.
However, it’s important to note that while we found an association with folate deficiency and hypertension, this study did not specifically evaluate the effects of folate treatment itself on lowering blood pressure or preventing hypertension. Thus, while we have strong evidence linking folate deficiency to higher hypertension risk, the direct impact of folate supplementation remains to be explored further.
Our analysis uncovered that individuals with folate deficiency had a significantly higher risk of hypertension, with a hazard ratio of 1.42. This means that they were 42% more likely to develop hypertension compared to those with adequate folate levels.
Moreover, we utilized advanced genetic approaches to examine these associations more closely. Both one-sample and two-sample Mendelian randomization analyses supported the idea that folate deficiency is not just correlated with hypertension but might actually play a causal role in increasing hypertension risk. Higher serum folate levels appeared to have a protective effect on blood pressure.
However, it’s important to note that while we found an association with folate deficiency and hypertension, this study did not specifically evaluate the effects of folate treatment itself on lowering blood pressure or preventing hypertension. Thus, while we have strong evidence linking folate deficiency to higher hypertension risk, the direct impact of folate supplementation remains to be explored further.
7
Our study looked closely at how folate could influence hypertension among a rural population in Punjab, India. We examined 2,300 individuals aged 30 to 75, identifying 450 individuals with hypertension and matched them with 450 normotensive ones for a detailed analysis of their blood chemistry and global DNA methylation levels.
We found that those with hypertension had significantly lower levels of global DNA methylation compared to their normotensive counterparts. Interestingly, the individuals in the lowest quartile of global DNA methylation faced a notably higher risk for hypertension. This highlights a potential link between lower DNA methylation levels and increased blood pressure.
When we looked at those on medication, we noticed that hypertensive individuals with well-managed blood pressure exhibited higher global DNA methylation levels compared to those whose hypertension remained uncontrolled. Additionally, folate seemed to play a role here, suggesting that maintaining sufficient folate levels could help improve DNA methylation among hypertensives on medication.
Ultimately, our findings suggest that global DNA hypomethylation might be associated with hypertension, and ensuring adequate folate intake could be beneficial for managing blood pressure in individuals already on treatment.
We found that those with hypertension had significantly lower levels of global DNA methylation compared to their normotensive counterparts. Interestingly, the individuals in the lowest quartile of global DNA methylation faced a notably higher risk for hypertension. This highlights a potential link between lower DNA methylation levels and increased blood pressure.
When we looked at those on medication, we noticed that hypertensive individuals with well-managed blood pressure exhibited higher global DNA methylation levels compared to those whose hypertension remained uncontrolled. Additionally, folate seemed to play a role here, suggesting that maintaining sufficient folate levels could help improve DNA methylation among hypertensives on medication.
Ultimately, our findings suggest that global DNA hypomethylation might be associated with hypertension, and ensuring adequate folate intake could be beneficial for managing blood pressure in individuals already on treatment.
7
We aimed to understand how elevated levels of total homocysteine (tHcy) and a specific genetic variant (the MTHFR C677T polymorphism) relate to hypertension. Although previous studies linked these factors to higher blood pressure, we explored whether the l-Arginine metabolic pathway serves as an intermediary in this relationship.
In a cross-sectional study involving 788 adults, we measured various components, including tHcy, plasma folate, and the l-Arginine pathway metabolites. Our findings showed that higher tHcy levels were associated with increased asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), two metabolites related to blood pressure regulation. Interestingly, we noticed a negative correlation between tHcy and an important ratio indicating the l-Arginine pathway's functionality, suggesting potential disruption in this pathway could be a concern for those with hypertension.
While we found that individuals with the CT genotype had lower levels of ADMA and SDMA, especially those under 50, the key takeaway was that each increase in the l-Arginine/ADMA ratio correlated with reduced hypertension risk. We also identified that tHcy and ADMA acted as mediators between the genetic variant and hypertension, reinforcing the idea that disruptions in one-carbon metabolism could influence blood pressure via the l-Arginine pathway. These insights underscore the complex interplay between genetics, metabolism, and hypertension but do not directly support, nor disprove, the effectiveness of folate treatment specifically for hypertension.
In a cross-sectional study involving 788 adults, we measured various components, including tHcy, plasma folate, and the l-Arginine pathway metabolites. Our findings showed that higher tHcy levels were associated with increased asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), two metabolites related to blood pressure regulation. Interestingly, we noticed a negative correlation between tHcy and an important ratio indicating the l-Arginine pathway's functionality, suggesting potential disruption in this pathway could be a concern for those with hypertension.
While we found that individuals with the CT genotype had lower levels of ADMA and SDMA, especially those under 50, the key takeaway was that each increase in the l-Arginine/ADMA ratio correlated with reduced hypertension risk. We also identified that tHcy and ADMA acted as mediators between the genetic variant and hypertension, reinforcing the idea that disruptions in one-carbon metabolism could influence blood pressure via the l-Arginine pathway. These insights underscore the complex interplay between genetics, metabolism, and hypertension but do not directly support, nor disprove, the effectiveness of folate treatment specifically for hypertension.
References
- Zhang Y, Gao D, Liang J, Ji M, Zhang W, et al. Association between folate deficiency and hypertension: evidence from an observational and Mendelian randomization study. Eur J Prev Cardiol. 2024. doi:10.1093/eurjpc/zwae386
- Ramos-Rodríguez C, Rojas-Gomez A, Santos-Calderón LA, Ceruelo S, Ríos L, et al. The l-Arginine pathway may act as a mediator in the association between impaired one-carbon metabolism and hypertension. Biochimie. 2025;230:86. doi:10.1016/j.biochi.2024.11.006
- Kaushik A, Bhattacharjee D, Chaudhary V, Dahal S, Devi NK, et al. Hypertension and global DNA methylation: a population-based study in rural, Punjab, India. Sci Rep. 2024;14:25826. doi:10.1038/s41598-024-77437-z
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Turner-McGrievy G, Wirth MD, Okpara N, Jones M, Kim Y, et al. Similar changes in diet quality indices, but not nutrients, among African American participants randomized to follow one of the three dietary patterns of the US Dietary Guidelines: A secondary analysis. Nutr Res. 2024;131:27. doi:10.1016/j.nutres.2024.09.005
- Siddiqi SM, Liu L, Du Y, Song Y, Chen P, et al. Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension. J Nutr. 2024. doi:10.1016/j.tjnut.2024.09.003
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. doi:10.1038/s41371-024-00955-w
- Zhang M, Aris IM, Cardenas A, Rifas-Shiman SL, Lin PD, et al. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study. Hypertension. 2025. doi:10.1161/HYPERTENSIONAHA.124.23980
- Bao D, Yang H, Yin Y, Wang S, Li Y, et al. Late-onset renal TMA and tubular injury in cobalamin C disease: a report of three cases and literature review. BMC Nephrol. 2024;25:340. doi:10.1186/s12882-024-03774-w
- Tudpor K, Chinnakhot P, Boonsorn M, Lomthaisong W, Kareechum W, et al. Relationship Between Dietary Intakes and Elevated Diastolic Blood Pressure Among Children: A Cross-Sectional Study Using Wearable Devices. Stud Health Technol Inform. 2024;313:129. doi:10.3233/SHTI240024
