Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
Read More
9
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Read More
9
We explored how vitamin B12, specifically methylcobalamin, could help treat persistent sleep-wake disorders in adolescents. In this study, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—struggled with sleep issues that significantly impacted their daily lives and school attendance.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Read More
Most Useful Reviews
9
Relieved insomnia
87 people found this helpful
I had suffered from insomnia for years, initially thinking it was stress-related due to my job. However, feeling exhausted with no improvement led me to suspect I needed proper rest.
Read More
10
Insomnia gone
Fantastic! My insomnia has disappeared. My skin has improved, and my libido has increased, helping to regulate my menstrual cycle.
Read More
10
Improved insomnia
Good product! My insomnia is gone, my skin noticeably improves, and my libido increases. It helps with menstrual cycle regulation as well.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
- All Researches
9
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Read More
9
We explored how vitamin B12, specifically methylcobalamin, could help treat persistent sleep-wake disorders in adolescents. In this study, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—struggled with sleep issues that significantly impacted their daily lives and school attendance.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Read More
8
We explored how serum total folic acid levels might influence the experience of severe difficulty falling asleep among adults in the United States. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) across two cycles, we divided participants into two groups: those with severe difficulty falling asleep and those without.
Our findings revealed that higher levels of folic acid in the blood were associated with lower odds of experiencing severe difficulty in falling asleep. Specifically, those in the highest quartile of folic acid levels had significantly reduced odds of insomnia symptoms. This trend was more pronounced among specific subgroups, such as males, smokers, and people without diabetes, suggesting that they may benefit the most from adequate folate levels.
Overall, these results indicate that folic acid might play a protective role against insomnia. We suggest that folic acid supplementation could be a valuable option for preventing and potentially treating sleep difficulties.
Our findings revealed that higher levels of folic acid in the blood were associated with lower odds of experiencing severe difficulty in falling asleep. Specifically, those in the highest quartile of folic acid levels had significantly reduced odds of insomnia symptoms. This trend was more pronounced among specific subgroups, such as males, smokers, and people without diabetes, suggesting that they may benefit the most from adequate folate levels.
Overall, these results indicate that folic acid might play a protective role against insomnia. We suggest that folic acid supplementation could be a valuable option for preventing and potentially treating sleep difficulties.
Read More
8
We explored the relationship between vitamin B12 levels and insomnia in a case involving a woman experiencing excessive daytime sleepiness alternating with insomnia. This case fit the criteria for a non-24-hour sleep-wake disorder, where traditional treatments failed to provide relief.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Upon further examination, we discovered deficiencies not just in vitamin B12, but also in vitamin D3 and folic acid. After addressing these deficiencies through supplementation, the subject reported a return to a 24-hour sleep-wake cycle.
However, it's essential to note that the improvement in sleep patterns remained detached from the external light-dark environment. This raises the intriguing question of whether vitamin B12's influence is direct or if it simply coexists with other factors influencing sleep.
While there were notable changes after treatment, isolating the specific effect of vitamin B12 on insomnia from the other vitamins administered remains a challenge. Thus, we observe that while vitamin B12 is part of the bigger picture, its individual effectiveness in treating insomnia cannot be confirmed from this study alone.
Read More
8
In our exploration of insomnia treatment, we worked with 60 patients diagnosed with the condition. They were split into two groups: one received the Magnesium-melatonin-vitamin B complex, while the other acted as a control. The specific goal was to determine if this combination, which included Vitamin B12, could effectively improve sleep quality over a three-month period.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
We found that participants receiving the Magnesium-melatonin-vitamin B complex reported a reduction in insomnia symptoms, as indicated by the Athens Insomnia Scale scores. Initially, the average sleep problem scores were quite similar between both groups, showing they were compatible at the start. However, after three months, the treatment group saw their insomnia scores significantly drop, suggesting that the supplement had a beneficial impact.
While the findings point to the treatment's effectiveness, it's essential to note that Vitamin B12 was part of a combination therapy. This means we cannot isolate its specific contribution to the improvement seen. As such, while we can say that the combination helped with insomnia, we need further studies to understand the exact role of Vitamin B12 in this context.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieved insomnia
87 people found this helpful
I had suffered from insomnia for years, initially thinking it was stress-related due to my job. However, feeling exhausted with no improvement led me to suspect I needed proper rest.
Read More
10
Insomnia gone
Fantastic! My insomnia has disappeared. My skin has improved, and my libido has increased, helping to regulate my menstrual cycle.
Read More
10
Improved insomnia
Good product! My insomnia is gone, my skin noticeably improves, and my libido increases. It helps with menstrual cycle regulation as well.
Read More
0
Resulted in insomnia
I used it to lower my methylation, but it didn’t suit me. My brain felt out of control, and I experienced insomnia and headaches.
Read More
7.5
Aids insomnia relief
Folic acid is essential for women, and it can assist in weight loss. It synthesises glycine, which serves as an excellent sedative for my insomnia, and it helps me immensely. The positive effects of B vitamins on the nervous system are well-documented.
Read More
Frequently Asked Questions
10
Insomnia gone
Fantastic! My insomnia has disappeared. My skin has improved, and my libido has increased, helping to regulate my menstrual cycle.
10
Improved insomnia
Good product! My insomnia is gone, my skin noticeably improves, and my libido increases. It helps with menstrual cycle regulation as well.
0
Resulted in insomnia
I used it to lower my methylation, but it didn’t suit me. My brain felt out of control, and I experienced insomnia and headaches.
7.5
Aids insomnia relief
Folic acid is essential for women, and it can assist in weight loss. It synthesises glycine, which serves as an excellent sedative for my insomnia, and it helps me immensely. The positive effects of B vitamins on the nervous system are well-documented.
8
We explored how serum total folic acid levels might influence the experience of severe difficulty falling asleep among adults in the United States. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) across two cycles, we divided participants into two groups: those with severe difficulty falling asleep and those without.
Our findings revealed that higher levels of folic acid in the blood were associated with lower odds of experiencing severe difficulty in falling asleep. Specifically, those in the highest quartile of folic acid levels had significantly reduced odds of insomnia symptoms. This trend was more pronounced among specific subgroups, such as males, smokers, and people without diabetes, suggesting that they may benefit the most from adequate folate levels.
Overall, these results indicate that folic acid might play a protective role against insomnia. We suggest that folic acid supplementation could be a valuable option for preventing and potentially treating sleep difficulties.
Our findings revealed that higher levels of folic acid in the blood were associated with lower odds of experiencing severe difficulty in falling asleep. Specifically, those in the highest quartile of folic acid levels had significantly reduced odds of insomnia symptoms. This trend was more pronounced among specific subgroups, such as males, smokers, and people without diabetes, suggesting that they may benefit the most from adequate folate levels.
Overall, these results indicate that folic acid might play a protective role against insomnia. We suggest that folic acid supplementation could be a valuable option for preventing and potentially treating sleep difficulties.
9
We've explored how folic acid supplementation can potentially alleviate the effects of insomnia, particularly its impact on aging at the cellular level. By establishing a mouse model of sleep deprivation, we observed that lack of sleep leads to oxidative stress and a harmful aging process, evidenced by shortened telomeres and a rise in inflammation-related markers known as the senescence-associated secretory phenotype (SASP).
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
Interestingly, our study found that adding folic acid to the diets of sleep-deprived mice improved telomere health and reduced the harmful cytokines associated with aging. In humans, those with higher baseline levels of folic acid in their blood appeared to be better protected against the telomere shortening caused by lack of sleep.
These findings suggest that folic acid could be a valuable ally in fighting the negative effects of insomnia, possibly enhancing the overall prognosis for individuals struggling with sleeplessness. In summary, incorporating folic acid may offer a promising approach to protect against the cellular age-related damage often linked to sleep deprivation.
7
We aimed to understand the relationship between vitamin B12 levels and insomnia in patients with type 2 diabetes mellitus (T2DM). In our study, we examined 418 individuals living with T2DM, some of whom experienced insomnia and others who did not.
The findings revealed that insomnia was present in about 24% of the participants, and those suffering from insomnia had notably higher levels of vitamin B12 compared to their peers without sleep issues.
Importantly, our analysis indicated that increased vitamin B12 levels could be an independent risk factor for insomnia. We identified a specific cut-off value of 517.50 pg/ml of vitamin B12 that could predict insomnia risk, showcasing its potential significance in managing sleep disturbances among diabetic patients.
Interestingly, the higher vitamin B12 levels in insomniac patients were also linked to the use of mecobalamin, suggesting a possible connection, though further investigation would be needed to fully establish this relationship. Ultimately, our study highlights the complex interplay between vitamin B12 and sleep health in individuals with T2DM, suggesting that elevation in serum vitamin B12 may enhance the risk of insomnia in this population.
The findings revealed that insomnia was present in about 24% of the participants, and those suffering from insomnia had notably higher levels of vitamin B12 compared to their peers without sleep issues.
Importantly, our analysis indicated that increased vitamin B12 levels could be an independent risk factor for insomnia. We identified a specific cut-off value of 517.50 pg/ml of vitamin B12 that could predict insomnia risk, showcasing its potential significance in managing sleep disturbances among diabetic patients.
Interestingly, the higher vitamin B12 levels in insomniac patients were also linked to the use of mecobalamin, suggesting a possible connection, though further investigation would be needed to fully establish this relationship. Ultimately, our study highlights the complex interplay between vitamin B12 and sleep health in individuals with T2DM, suggesting that elevation in serum vitamin B12 may enhance the risk of insomnia in this population.
9
We explored how vitamin B12, specifically methylcobalamin, could help treat persistent sleep-wake disorders in adolescents. In this study, two patients—a 15-year-old girl with delayed sleep phase syndrome and a 17-year-old boy with hypernychthemeral syndrome—struggled with sleep issues that significantly impacted their daily lives and school attendance.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
Upon administration of high doses of methylcobalamin (3,000 micrograms per day), we observed immediate improvements in their sleep-wake patterns. Notably, the girl's sleep duration reduced from ten hours to seven, while her sleep onset time shifted from 2 a.m. to midnight. The boy’s sleep-wake cycle also improved, with a decrease in the cycle duration from 24.6 hours to 24 hours.
Interestingly, neither patient showed any signs of vitamin B12 deficiency, and their serum B12 levels were in the normal range or higher during treatment. This suggests that high-dose vitamin B12 might play a role in resetting and improving sleep-wake schedules in these adolescents, linking to the circadian rhythms that govern sleep.
While more research is needed, these findings present a promising perspective on how vitamin B12 may help alleviate certain insomnia symptoms in young people.
References
- An H, Xue Q, Zhang J. The association between serum total folic acid concentration and severe difficulty falling asleep in US adults: NHANES 2005-2008. Front Neurol. 2023;14:1225403. doi:10.3389/fneur.2023.1225403
- Zhang X, Wang Y, Zhao R, Hu X, Zhang B, et al. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP). Oxid Med Cell Longev. 2019;2019:4569614. doi:10.1155/2019/4569614
- Beydoun MA, Gamaldo AA, Canas JA, Beydoun HA, Shah MT, et al. Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys. PLoS One. 2014;9:e103490. doi:10.1371/journal.pone.0103490
- Bouloukaki I, Lampou M, Raouzaiou KM, Lambraki E, Schiza S, et al. Association of Vitamin B12 Levels with Sleep Quality, Insomnia, and Sleepiness in Adult Primary Healthcare Users in Greece. Healthcare (Basel). 2023;11. doi:10.3390/healthcare11233026
- Radlberger RF, Kunz AB. Vitamin D deficiency promoting non-24 h sleep-wake disorder: a case report. Front Neurol. 2023;14:1141835. doi:10.3389/fneur.2023.1141835
- Xiong S, Liu Z, Yao N, Zhang X, Ge Q. The independent association between vitamin B12 and insomnia in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Nutr Diabetes. 2022;12:3. doi:10.1038/s41387-022-00181-8
- Djokic G, Vojvodić P, Korcok D, Agic A, Rankovic A, et al. The Effects of Magnesium - Melatonin - Vit B Complex Supplementation in Treatment of Insomnia. Open Access Maced J Med Sci. 2019;7:3101. doi:10.3889/oamjms.2019.771
- Chang HY, Sei H, Morita Y. Effects of intravenously administered vitamin B12 on sleep in the rat. Physiol Behav. 1995;57:1019.
- Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.
- Okawa M, Mishima K, Nanami T, Shimizu T, Iijima S, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13:15.
