5/29/2025
Last update
5/29/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Read More
8
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
Read More
7
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
Read More
Most Useful Reviews
9
Reliable menopause aid
I've repeatedly ordered this brand due to its excellent quality and tested ingredients over the years. It serves as a vital aid for women during menopause—an indispensable supplement. I plan to keep buying this product as I've consistently observed improvements in my health at any age. The large packaging lasts long, which is a bonus.
Read More
9
Eases hot flashes
Folic acid helps during menopause, making it easier to tolerate hot flashes.
Read More
7.5
Effective menopause support
I trust the NOW brand and purchased this product based on positive reviews. It’s beneficial for consumption during menopause due to the small tablet size, making it easy to take. The brand's quality is consistently high, and the large quantity in the package means it will last a long time. The ingredients are natural which is essential for me!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
- All Researches
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Read More
9
Vitamin B12 may aid menopause relief
We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
Read More
9
vitamin B12 aids menopause dry eye
We explored the impact of vitamin B12, alongside hyaluronic acid and electrolytes, on menopausal women suffering from moderate dry eye disease. In this study, thirty female participants, aged between 45 to 65, received drops that contained 0.3% sodium hyaluronate, vitamin B12, and other electrolytes for a duration of 30 days.
Throughout this period, we tracked their symptoms and performed several tests to gauge the severity of dry eye, including the Ocular Surface Disease Index (OSDI) questionnaire and tear film assessments. Our findings indicated that the combination of these treatments significantly decreased the symptoms of dry eye disease. Specifically, we noted a substantial improvement in the scores from the OSDI questionnaire and enhancements in both the tear volume and stability.
The results suggest that vitamin B12 plays a supportive role in alleviating dry eye symptoms during menopause, contributing positively when used with other treatments. While it’s hard to isolate the specific benefits of vitamin B12 due to the combination used, its inclusion in the eye drops appears to aid in improving overall eye health for menopausal women dealing with dryness.
Throughout this period, we tracked their symptoms and performed several tests to gauge the severity of dry eye, including the Ocular Surface Disease Index (OSDI) questionnaire and tear film assessments. Our findings indicated that the combination of these treatments significantly decreased the symptoms of dry eye disease. Specifically, we noted a substantial improvement in the scores from the OSDI questionnaire and enhancements in both the tear volume and stability.
The results suggest that vitamin B12 plays a supportive role in alleviating dry eye symptoms during menopause, contributing positively when used with other treatments. While it’s hard to isolate the specific benefits of vitamin B12 due to the combination used, its inclusion in the eye drops appears to aid in improving overall eye health for menopausal women dealing with dryness.
Read More
8
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
Read More
7
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reliable menopause aid
I've repeatedly ordered this brand due to its excellent quality and tested ingredients over the years. It serves as a vital aid for women during menopause—an indispensable supplement. I plan to keep buying this product as I've consistently observed improvements in my health at any age. The large packaging lasts long, which is a bonus.
Read More
9
Eases hot flashes
Folic acid helps during menopause, making it easier to tolerate hot flashes.
Read More
7.5
Effective menopause support
I trust the NOW brand and purchased this product based on positive reviews. It’s beneficial for consumption during menopause due to the small tablet size, making it easy to take. The brand's quality is consistently high, and the large quantity in the package means it will last a long time. The ingredients are natural which is essential for me!
Read More
7.5
Eases menopause effects
Folic acid is exceptionally beneficial for women's health. I started taking it on my doctor's recommendation to cope with menopause more comfortably.
Read More
7.5
Good for menopause
Folic acid is crucial during pregnancy for neural tube development; however, it is also advisable for women during menopause as it mitigates symptoms and positively impacts skin and hair health. It is recommended to take one capsule or tablet after meals for 3-4 months.
Read More
Frequently Asked Questions
7.5
Good for menopause
Folic acid is crucial during pregnancy for neural tube development; however, it is also advisable for women during menopause as it mitigates symptoms and positively impacts skin and hair health. It is recommended to take one capsule or tablet after meals for 3-4 months.
6
Mood improvement
Folic acid promotes cell growth and DNA integrity, protecting DNA cells. It also strengthens the immune system. I purchased it for my hair and nails but did not observe the same results as PABA. However, there were no negative effects. Replenishing vitamin B9 improves women's mood, particularly useful during PMS and menopause. It likely works cumulatively. I will order more.
9
Eases hot flashes
Folic acid helps during menopause, making it easier to tolerate hot flashes.
7.5
Regenerates skin
Folic acid restores immunity and supports heart and blood vessel function, aiding the formation of blood cells in cases of iron deficiency. It plays a role in synthesising nucleic and amino acids. This remarkable vitamin helps regenerate new cells while preserving older ones, keeping skin fresh and smooth, hair thick and shiny, and nails strong. Regularly replenishing vitamin B9 notably enhances a woman's mood, especially helpful with PMS and menopause.
7.5
Eases menopause effects
Folic acid is exceptionally beneficial for women's health. I started taking it on my doctor's recommendation to cope with menopause more comfortably.
7
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
8
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
7
Folate impacts menopause bone density
We investigated whether folates, vitamin B12, or homocysteine levels predict changes in bone density among postmenopausal women. Over five years, we measured these factors in 161 healthy volunteers, focusing on vertebral bone mineral density (BMD).
Our findings revealed that folates were significantly associated with BMD changes, indicating that low folate levels could contribute to bone density decline. However, we found no significant link between variations in BMD and homocysteine or vitamin B12 levels.
This highlights the potential importance of folate levels in supporting bone health during menopause.
Our findings revealed that folates were significantly associated with BMD changes, indicating that low folate levels could contribute to bone density decline. However, we found no significant link between variations in BMD and homocysteine or vitamin B12 levels.
This highlights the potential importance of folate levels in supporting bone health during menopause.
7
We examined how folic acid supplements impact homocysteine levels in postmenopausal women over six months. Our findings suggest that after menopause, homocysteine levels rise significantly, presenting a cardiovascular risk.
While folic acid is a safe and affordable option, our study indicates that it may help lower homocysteine, potentially offering some protection against heart disease in this group. However, more research is needed to fully understand its effectiveness.
While folic acid is a safe and affordable option, our study indicates that it may help lower homocysteine, potentially offering some protection against heart disease in this group. However, more research is needed to fully understand its effectiveness.
References
- Asadi M, Riazi H, Abbasinazari M, Majd HA, Montazeri A. Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial. J Sex Med. 2023;20:1180. 10.1093/jsxmed/qdad086
- Almassinokiani F, Kashanian M, Akbari P, Mossayebi E, Sadeghian E. Folic acid supplementation reduces plasma homocysteine in postmenopausal women. J Obstet Gynaecol. 2016;36:492. 10.3109/01443615.2015.1091811
- Bani S, Hasanpour S, Farzad Rik L, Hasankhani H, Sharami SH. The effect of folic Acid on menopausal hot flashes: a randomized clinical trial. J Caring Sci. 2013;2:131. 10.5681/jcs.2013.016
- Sultan N, Khan MA, Malik S. Effect of folic acid supplementation on homocysteine level in postmenopausal women. J Ayub Med Coll Abbottabad. 2007;19:78.
- Cagnacci A, Bagni B, Zini A, Cannoletta M, Generali M, et al. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone. 2008;42:314. 10.1016/j.bone.2007.10.022
- Rejnmark L, Vestergaard P, Hermann AP, Brot C, Eiken P, et al. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women. Calcif Tissue Int. 2008;82:1. 10.1007/s00223-007-9087-0
- Villa P, Suriano R, Costantini B, Macrì F, Ricciardi L, et al. Hyperhomocysteinemia and cardiovascular risk in postmenopausal women: the role of folate supplementation. Clin Chem Lab Med. 2007;45:130.
- Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra Y, Planells E. Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population. J Trace Elem Med Biol. 2022;71:126942. 10.1016/j.jtemb.2022.126942
- Ewies A, Ahmed I, Al-Azzawi F, Pitkin J, Gupta P, et al. Folic acid supplementation in postmenopausal women with hot flushes: phase III randomised double-blind placebo-controlled trial. BJOG. 2021;128:2024. 10.1111/1471-0528.16739
- Palacios S, Mustata C, Rizo JM, Regidor PA. Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9. Eur Rev Med Pharmacol Sci. 2023;27:8180. 10.26355/eurrev_202309_33578
- De-Hita-Cantalejo C, Sánchez-González MC, Silva-Viguera C, García-Romera MC, Feria-Mantero R, et al. Efficacy of hyaluronic acid 0.3%, cyanocobalamin, electrolytes, and P-Plus in menopause patients with moderate dry eye disease. Graefes Arch Clin Exp Ophthalmol. 2022;260:529. 10.1007/s00417-021-05415-6
