SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%

Top Medical Research Studies

9
Folic acid reduces menopausal hot flashes
The effect of folic Acid on menopausal hot flashes: a randomized clinical trial.
Higher relevance for menopause care
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.

Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Read More
8
Folic acid lowers homocysteine levels
Folic acid supplementation reduces plasma homocysteine in postmenopausal women.
Strong relevance to menopause health
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).

However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
Read More
7
Folic acid and sexual function
Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial.
Moderate relevance due to limitations
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.

While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
Read More

Most Useful Reviews

9.5
Reliable menopause aid
I've repeatedly ordered this brand due to its excellent quality and tested ingredients over the years. It serves as a vital aid for women during menopause—an indispensable supplement. I plan to keep buying this product as I've consistently observed improvements in my health at any age. The large packaging lasts long, which is a bonus.
Read More
8.8
Effective menopause support
I trust the NOW brand and purchased this product based on positive reviews. It’s beneficial for consumption during menopause due to the small tablet size, making it easy to take. The brand's quality is consistently high, and the large quantity in the package means it will last a long time. The ingredients are natural which is essential for me!
Read More
8.3
Eases hot flashes
Folic acid helps during menopause, making it easier to tolerate hot flashes.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
  • All Researches
9
Folic acid reduces menopausal hot flashes
The effect of folic Acid on menopausal hot flashes: a randomized clinical trial.
Higher relevance for menopause care
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.

Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Read More
9
Vitamin B12 may aid menopause relief
Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9.
Moderate relevance due to combination effects
We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.

After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.

However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
Read More
9
vitamin B12 aids menopause dry eye
Efficacy of hyaluronic acid 0.3%, cyanocobalamin, electrolytes, and P-Plus in menopause patients with moderate dry eye disease.
Combination limits specific effect
We explored the impact of vitamin B12, alongside hyaluronic acid and electrolytes, on menopausal women suffering from moderate dry eye disease. In this study, thirty female participants, aged between 45 to 65, received drops that contained 0.3% sodium hyaluronate, vitamin B12, and other electrolytes for a duration of 30 days.

Throughout this period, we tracked their symptoms and performed several tests to gauge the severity of dry eye, including the Ocular Surface Disease Index (OSDI) questionnaire and tear film assessments. Our findings indicated that the combination of these treatments significantly decreased the symptoms of dry eye disease. Specifically, we noted a substantial improvement in the scores from the OSDI questionnaire and enhancements in both the tear volume and stability.

The results suggest that vitamin B12 plays a supportive role in alleviating dry eye symptoms during menopause, contributing positively when used with other treatments. While it’s hard to isolate the specific benefits of vitamin B12 due to the combination used, its inclusion in the eye drops appears to aid in improving overall eye health for menopausal women dealing with dryness.
Read More
8
Folic acid lowers homocysteine levels
Folic acid supplementation reduces plasma homocysteine in postmenopausal women.
Strong relevance to menopause health
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).

However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
Read More
7
Folic acid and sexual function
Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial.
Moderate relevance due to limitations
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.

While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
Read More

User Reviews

USERS' SCORE
Good
Based on 7 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Reliable menopause aid
I've repeatedly ordered this brand due to its excellent quality and tested ingredients over the years. It serves as a vital aid for women during menopause—an indispensable supplement. I plan to keep buying this product as I've consistently observed improvements in my health at any age. The large packaging lasts long, which is a bonus.
Read More
8.8
Effective menopause support
I trust the NOW brand and purchased this product based on positive reviews. It’s beneficial for consumption during menopause due to the small tablet size, making it easy to take. The brand's quality is consistently high, and the large quantity in the package means it will last a long time. The ingredients are natural which is essential for me!
Read More
8.3
Eases hot flashes
Folic acid helps during menopause, making it easier to tolerate hot flashes.
8.8
Eases menopause effects
Folic acid is exceptionally beneficial for women's health. I started taking it on my doctor's recommendation to cope with menopause more comfortably.
7.5
Good for menopause
Folic acid is crucial during pregnancy for neural tube development; however, it is also advisable for women during menopause as it mitigates symptoms and positively impacts skin and hair health. It is recommended to take one capsule or tablet after meals for 3-4 months.

Frequently Asked Questions

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