Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
7
We examined the effects of folic acid on 16 children suffering from migraines linked to certain gene variants. These children also had hyperhomocysteinemia, a condition that can elevate migraine risk.
After the folic acid supplementation, we noted a reduction in migraine attacks. However, the reasons behind this improvement remain unclear. Consequently, we recommend further research, ideally through a randomized double-blind trial, to truly validate these promising initial findings.
After the folic acid supplementation, we noted a reduction in migraine attacks. However, the reasons behind this improvement remain unclear. Consequently, we recommend further research, ideally through a randomized double-blind trial, to truly validate these promising initial findings.
Read More
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
Most Useful Reviews
9
Migraine relief
Great! It normalises sleep (with regular intake of 2 capsules) and improves my migraines. When I start feeling effects, I take my pills as usual, add magnesium, and my migraine eases gently, usually within a few hours. It used to incapacitate me for half a day. The frequency has also reduced, and I have medicinal support. Regular magnesium intake makes PMS and menstruation much easier. Chronic nasopharyngeal pain has barely worsened, though attributing this solely to magnesium is difficult, given my other supplements. If consuming magnesium, lecithin, and protein, the effect of collagen is really noticeable. I was pleasantly surprised by this. We had no issues with allergies, rashes, or stomach problems. The quality is excellent, and the ingredients are natural.
Read More
7
Great for migraines
Excellent! These tiny tablets, up to 250 pcs, are consumed with other vitamins for migraines. There is noticeable improvement, and they last long for me. There’s no taste or smell.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
- All Researches
8
We investigated how folic acid, along with other B vitamins, impacts migraines by looking at specific gene variations. In a 6-month study with 206 women suffering from migraines, those who received vitamin supplementation showed decreased homocysteine levels and less severe headaches compared to those on placebo.
Interestingly, genetic factors mattered. Women with certain gene variants experienced greater headache relief and lower disability levels. Overall, our findings suggest that B vitamin supplementation can reduce migraine symptoms, influenced by individual genetic profiles.
Interestingly, genetic factors mattered. Women with certain gene variants experienced greater headache relief and lower disability levels. Overall, our findings suggest that B vitamin supplementation can reduce migraine symptoms, influenced by individual genetic profiles.
Read More
8
We conducted a randomized, double-blind study to explore how vitamin supplementation affects migraine patients, particularly focusing on folic acid's role in reducing homocysteine levels.
Our results showed that daily intake of folic acid, along with other vitamins, reduced homocysteine significantly and halved migraine disability over six months.
Notably, those with a specific genetic marker experienced even more pronounced benefits. While these findings are promising, further research is needed to confirm the effectiveness of vitamin therapy for everyone.
Our results showed that daily intake of folic acid, along with other vitamins, reduced homocysteine significantly and halved migraine disability over six months.
Notably, those with a specific genetic marker experienced even more pronounced benefits. While these findings are promising, further research is needed to confirm the effectiveness of vitamin therapy for everyone.
Read More
8
We explored the connection between genetic factors related to folate metabolism and the occurrence of migraines in children. Our study involved 54 children aged 7 to 18 who experienced migraines, alongside a control group of 115 children without neurological issues.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
Read More
8
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
8
Vitamin B12 shows promise for migraines
We conducted a study to explore the effects of vitamin B12, when combined with magnesium and high-intensity interval training (HIIT), on alleviating migraine symptoms. Our research involved 60 participants who were divided into four groups: one group practiced HIIT, another consumed vitamin B12 and magnesium supplements, a third group did both HIIT and supplements, and a control group received no intervention.
Over two months, we measured changes in migraine frequency, intensity, and duration, along with serum levels of a specific marker known as calcitonin gene-related peptide (CGRP). We noted that the combination of vitamin B12 and magnesium, coupled with regular exercise, appeared to positively influence inflammation pathways related to migraines, suggesting a potential way to reduce migraine pain.
However, it is important to recognize that the study had limitations in isolating the specific effects of vitamin B12 from the other treatment components. Nonetheless, our findings indicate that incorporating vitamin B12 and magnesium with physical activity could be a promising approach to help those suffering from migraines.
Over two months, we measured changes in migraine frequency, intensity, and duration, along with serum levels of a specific marker known as calcitonin gene-related peptide (CGRP). We noted that the combination of vitamin B12 and magnesium, coupled with regular exercise, appeared to positively influence inflammation pathways related to migraines, suggesting a potential way to reduce migraine pain.
However, it is important to recognize that the study had limitations in isolating the specific effects of vitamin B12 from the other treatment components. Nonetheless, our findings indicate that incorporating vitamin B12 and magnesium with physical activity could be a promising approach to help those suffering from migraines.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Migraine relief
Great! It normalises sleep (with regular intake of 2 capsules) and improves my migraines. When I start feeling effects, I take my pills as usual, add magnesium, and my migraine eases gently, usually within a few hours. It used to incapacitate me for half a day. The frequency has also reduced, and I have medicinal support. Regular magnesium intake makes PMS and menstruation much easier. Chronic nasopharyngeal pain has barely worsened, though attributing this solely to magnesium is difficult, given my other supplements. If consuming magnesium, lecithin, and protein, the effect of collagen is really noticeable. I was pleasantly surprised by this. We had no issues with allergies, rashes, or stomach problems. The quality is excellent, and the ingredients are natural.
Read More
7
Great for migraines
Excellent! These tiny tablets, up to 250 pcs, are consumed with other vitamins for migraines. There is noticeable improvement, and they last long for me. There’s no taste or smell.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. doi:10.1097/MD.0000000000040458
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. doi:10.1186/s10194-016-0652-7
- Menon S, Lea RA, Ingle S, Sutherland M, Wee S, et al. Effects of dietary folate intake on migraine disability and frequency. Headache. 2015;55:301. doi:10.1111/head.12490
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. doi:10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. doi:10.1097/FPC.0b013e32832af5a3
- Di Rosa G, Attinà S, Spanò M, Ingegneri G, Sgrò DL, et al. Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms. Headache. 2007;47:1342.
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. doi:10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. doi:10.3389/fnut.2024.1456502
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735
- Zheng H, Shi YZ, Liang JT, Lu LL, Chen M. Modifiable factors for migraine prophylaxis: A mendelian randomization analysis. Front Pharmacol. 2023;14:1010996. doi:10.3389/fphar.2023.1010996
- Üstün Özek S. A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine. Arq Neuropsiquiatr. 2022;80:586. doi:10.1590/0004-282X-ANP-2021-0192
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. doi:10.1007/s13760-020-01491-3
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- van der Kuy PH, Merkus FW, Lohman JJ, ter Berg JW, Hooymans PM. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia. 2002;22:513.
