' 
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
Folate intake reduces migraine frequency
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Highly relevant to migraine research
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
8
Serum folate and migraines linked
Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study.
Focused study on folate association
We investigated the connection between serum folate levels and the occurrence of severe headaches or migraines using a large dataset from the National Health and Nutrition Examination Survey. In total, we analyzed information from 13,351 participants, with 2,742 of them reporting severe headaches or migraines within the last three months.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Read More
7
Vitamin B12 deficiency and migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Highly relevant to migraine research
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
Most Useful Reviews
9.5
Migraine relief
Great! It normalises sleep (with regular intake of 2 capsules) and improves my migraines. When I start feeling effects, I take my pills as usual, add magnesium, and my migraine eases gently, usually within a few hours. It used to incapacitate me for half a day. The frequency has also reduced, and I have medicinal support. Regular magnesium intake makes PMS and menstruation much easier. Chronic nasopharyngeal pain has barely worsened, though attributing this solely to magnesium is difficult, given my other supplements. If consuming magnesium, lecithin, and protein, the effect of collagen is really noticeable. I was pleasantly surprised by this. We had no issues with allergies, rashes, or stomach problems. The quality is excellent, and the ingredients are natural.
Read More
8.5
Great for migraines
Excellent! These tiny tablets, up to 250 pcs, are consumed with other vitamins for migraines. There is noticeable improvement, and they last long for me. There’s no taste or smell.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7
- All Researches
9
Vitamin B12 supplementation aids migraines
Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation.
Study notes B12's role
We conducted a comprehensive study to explore the effectiveness of vitamin B supplementation, including B12, in reducing migraine occurrences, particularly in women diagnosed with migraines accompanied by aura. Over a period of six months, we administered daily vitamin B supplements to a group of 206 participants, comparing their results to those taking a placebo.
Our findings were quite promising. Vitamin supplementation notably lowered homocysteine levels, which is linked to migraine severity. We observed significant reductions in headache severity and the degree of migraine-related disability among those taking the vitamins compared to those on the placebo.
Furthermore, when we examined the genetic backgrounds of participants, we found that specific variants in the MTHFR and MTRR genes influenced the response to vitamin B supplementation. Carriers of certain gene variants experienced even greater improvements. Importantly, the positive effects from vitamin treatments seemed independent of the MTHFR variant, suggesting a broader impact of B vitamins on migraines.
Overall, our research indicates that vitamin B supplementation, including B12, holds potential as an effective intervention for reducing migraine symptoms, enhancing the quality of life for those affected.
Our findings were quite promising. Vitamin supplementation notably lowered homocysteine levels, which is linked to migraine severity. We observed significant reductions in headache severity and the degree of migraine-related disability among those taking the vitamins compared to those on the placebo.
Furthermore, when we examined the genetic backgrounds of participants, we found that specific variants in the MTHFR and MTRR genes influenced the response to vitamin B supplementation. Carriers of certain gene variants experienced even greater improvements. Importantly, the positive effects from vitamin treatments seemed independent of the MTHFR variant, suggesting a broader impact of B vitamins on migraines.
Overall, our research indicates that vitamin B supplementation, including B12, holds potential as an effective intervention for reducing migraine symptoms, enhancing the quality of life for those affected.
Read More
9
Migraine relief through vitamin B12
The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability.
Vitamin B12's effect on migraines
We conducted a thorough investigation into the effects of vitamin B12 supplementation on individuals suffering from migraines, specifically those with aura. Our study focused on how daily doses of a vitamin combination, including B12, influenced migraine symptoms and disability levels over six months. We employed a randomized, double-blind, placebo-controlled trial to ensure the reliability of our findings.
Our results were promising. Participants who received vitamin supplementation showed a significant drop in homocysteine levels by 39%, which was markedly more than those in the placebo group. This reduction was linked to a substantial decrease in migraine disability; moving from 60% prevalence at the start to just 30% after six months of treatment.
Furthermore, we noted that headache frequency and pain severity also improved with vitamin supplementation. Notably, those carrying the C allele of the MTHFR (C677T) genotype responded even better to this treatment compared to the TT genotype individuals. This suggests that genotype can play a role in how effective vitamin B12 and its related vitamins can be for migraine sufferers.
While these findings highlight the potential benefits of vitamin B12, more extensive research is necessary to determine if this combination therapy is a safe and effective long-term option for preventing migraines. Our work shines a light on a possible new pathway to relief for many individuals who struggle with this debilitating condition.
Our results were promising. Participants who received vitamin supplementation showed a significant drop in homocysteine levels by 39%, which was markedly more than those in the placebo group. This reduction was linked to a substantial decrease in migraine disability; moving from 60% prevalence at the start to just 30% after six months of treatment.
Furthermore, we noted that headache frequency and pain severity also improved with vitamin supplementation. Notably, those carrying the C allele of the MTHFR (C677T) genotype responded even better to this treatment compared to the TT genotype individuals. This suggests that genotype can play a role in how effective vitamin B12 and its related vitamins can be for migraine sufferers.
While these findings highlight the potential benefits of vitamin B12, more extensive research is necessary to determine if this combination therapy is a safe and effective long-term option for preventing migraines. Our work shines a light on a possible new pathway to relief for many individuals who struggle with this debilitating condition.
Read More
8
Folate metabolism's role in migraines
[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].
Relevant but inconclusive findings
We explored the connection between genetic factors related to folate metabolism and the occurrence of migraines in children. Our study involved 54 children aged 7 to 18 who experienced migraines, alongside a control group of 115 children without neurological issues.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
We focused on specific genetic variations in folate cycle enzyme genes, testing for several polymorphisms and assessing vitamin B levels along with plasma homocysteine levels. Notably, we found that children with migraines had a higher prevalence of the rare homozygous 677TT genotype, which corresponds with elevated plasma homocysteine levels and is often linked to folate deficiency.
In addition to our genetic findings, we administered Cortexin, a treatment aimed at improving patients' symptoms. The results indicated significant improvements, with reported reductions in headaches, fatigue, and emotional instability among the patients involved.
While our study underscores the relationship between genetics and migraine in children, particularly the role of folate metabolism, the specific effects of folate alone on migraine were not fully dissected. Nonetheless, these insights contribute valuable information about potential pathways for understanding and treating migraines in young patients.
Read More
8
Folate intake reduces migraine frequency
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Highly relevant to migraine research
We set out to explore how dietary folate intake might influence severe headaches and migraines. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004, we included a substantial sample of 4,107 participants in our analysis.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Our findings revealed that 704 individuals, which represents about 17.14%, reported experiencing severe headaches or migraines. After accounting for various factors, we found a noteworthy association between higher folate intake and reduced occurrences of these conditions. Specifically, the results showed that increasing levels of dietary folate were linked to a lower odds ratio of experiencing migraines—particularly pronounced among those with the highest folate intake.
The data suggested a linear and negative relationship, meaning that as folate intake increased, the likelihood of suffering from migraines decreased. This trend remained consistent across different analysis methods, indicating a robust connection worth noting for those seeking dietary strategies to manage or potentially reduce migraine occurrences.
Read More
8
Serum folate and migraines linked
Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study.
Focused study on folate association
We investigated the connection between serum folate levels and the occurrence of severe headaches or migraines using a large dataset from the National Health and Nutrition Examination Survey. In total, we analyzed information from 13,351 participants, with 2,742 of them reporting severe headaches or migraines within the last three months.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Our findings indicated that lower serum folate levels were associated with a higher likelihood of experiencing severe headaches or migraines. Specifically, we found that for every increase in serum folate, there was a significant decrease in the odds of having these painful episodes, with an odds ratio of 0.5. This means that individuals with higher folate levels were less likely to suffer from migraines.
The analysis further revealed that this relationship was particularly strong among women, those aged between 20 to 50 years, and non-Hispanic White participants. For instance, women with higher serum folate had an even lower likelihood of experiencing migraines, with an odds ratio of 0.38.
While we established a clear association, it’s important to note that our study didn’t specifically investigate folate treatment effectiveness. Further research is essential to confirm our findings and explore how folate could potentially be incorporated into treatment strategies for migraine sufferers.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Migraine relief
Great! It normalises sleep (with regular intake of 2 capsules) and improves my migraines. When I start feeling effects, I take my pills as usual, add magnesium, and my migraine eases gently, usually within a few hours. It used to incapacitate me for half a day. The frequency has also reduced, and I have medicinal support. Regular magnesium intake makes PMS and menstruation much easier. Chronic nasopharyngeal pain has barely worsened, though attributing this solely to magnesium is difficult, given my other supplements. If consuming magnesium, lecithin, and protein, the effect of collagen is really noticeable. I was pleasantly surprised by this. We had no issues with allergies, rashes, or stomach problems. The quality is excellent, and the ingredients are natural.
Read More
8.5
Great for migraines
Excellent! These tiny tablets, up to 250 pcs, are consumed with other vitamins for migraines. There is noticeable improvement, and they last long for me. There’s no taste or smell.
